Article ; Online: Influence of the menstrual cycle on the incidence of nausea and vomiting after laparoscopic gynecological surgery: a pilot study.
Journal of clinical anesthesia
2012 Volume 24, Issue 3, Page(s) 185–192
Abstract: Study objective: To investigate whether the phase of menstrual cycle influences the incidence of postoperative nausea and vomiting (PONV) in women undergoing general anesthesia for elective laparoscopic gynecological surgery.: Design: Prospective, ... ...
| Abstract | Study objective: To investigate whether the phase of menstrual cycle influences the incidence of postoperative nausea and vomiting (PONV) in women undergoing general anesthesia for elective laparoscopic gynecological surgery. Design: Prospective, observational, blinded study. Setting: General hospital, Postanesthesia Care Unit, and gynecologic floor room. Patients: 111 ASA physical status 1 and 2 women, aged 18 to 53 years. Interventions: Patients were classified into three groups according to the phase of menstrual cycle at the time of anesthesia: Group F1: follicular phase (menstrual days 1-8; n = 34); Group O2: ovulatory phase (days 9-15; n = 40); and Group L3: luteal phase (days 16 to end of cycle; n = 37). Anesthetic, postoperative pain management, and antiemetic regimens were standardized. Measurements: Frequency of nausea, vomiting, or both were assessed for early (0-2 hrs). Late PONV (2-24 hrs) along with the use of rescue antiemetic, severity of nausea, and pain. Main results: In the follicular (n = 34), ovulatory (n = 40) and luteal phase (n = 37) groups, the frequencies of PONV over 24 hours were 35%, 38%, and 14% (P = 0.04), respectively. This was due to differences in the early postoperative period where the frequencies were 21%, 25%, and 3% (P = 0.02), respectively, as frequencies were similar in the late period (15%, 20% and 14%, P = 0.71), respectively. Nausea scores, rescue antiemetic usage, pain scores, and opioid consumption were similar in the groups. Conclusion: Patients in the luteal phase of their menstrual cycle may have a decreased risk of PONV after laparoscopic gynecological surgery in the early postoperative period. |
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| MeSH term(s) | Adolescent ; Adult ; Anesthesia, General/methods ; Antiemetics/therapeutic use ; Elective Surgical Procedures/methods ; Female ; Follicular Phase/physiology ; Gynecologic Surgical Procedures/methods ; Hospitals, General ; Humans ; Incidence ; Laparoscopy/methods ; Luteal Phase/physiology ; Middle Aged ; Ovulation/physiology ; Pain, Postoperative/epidemiology ; Pilot Projects ; Postoperative Nausea and Vomiting/epidemiology ; Prospective Studies ; Risk ; Severity of Illness Index ; Single-Blind Method ; Young Adult |
| Chemical Substances | Antiemetics |
| Language | English |
| Publishing date | 2012-05 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1011618-7 |
| ISSN | 1873-4529 ; 0952-8180 |
| ISSN (online) | 1873-4529 |
| ISSN | 0952-8180 |
| DOI | 10.1016/j.jclinane.2011.07.011 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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