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  1. Article ; Online: Diagnostic Challenges and Emerging Pathogeneses of Selected Glomerulopathies.

    Andeen, Nicole K / Hou, Jean

    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

    2024  , Page(s) 10935266241237656

    Abstract: Recent progress in glomerular immune complex and complement-mediated diseases have refined diagnostic categories and informed mechanistic understanding of disease development in pediatric patients. Herein, we discuss selected advances in 3 categories. ... ...

    Abstract Recent progress in glomerular immune complex and complement-mediated diseases have refined diagnostic categories and informed mechanistic understanding of disease development in pediatric patients. Herein, we discuss selected advances in 3 categories. First, membranous nephropathy antigens are increasingly utilized to characterize disease in pediatric patients and include phospholipase A2 receptor (PLA2R), Semaphorin 3B (Sema3B), neural epidermal growth factor-like 1 (NELL1), and protocadherin FAT1, as well as the lupus membranous-associated antigens exostosin 1/2 (EXT1/2), neural cell adhesion molecule 1 (NCAM1), and transforming growth factor beta receptor 3 (TGFBR3). Second, we examine advances in techniques for paraffin and light chain immunofluorescence (IF), including the former's function as a salvage technique and their necessity for diagnosis in adolescent cases of membranous-like glomerulopathy with masked IgG kappa deposits (MGMID) and proliferative glomerulonephritis with monotypic Ig deposits (PGNMID), respectively. Finally, progress in understanding the roles of complement in pediatric glomerular disease is reviewed, with specific attention to overlapping clinical, histologic, and genetic or functional alternative complement pathway (AP) abnormalities among C3 glomerulopathy (C3G), infection-related and post-infectious GN, "atypical" post-infectious GN, immune complex mediated membranoproliferative glomerulonephritis (IC-MPGN), and atypical hemolytic uremic syndrome (aHUS).
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463498-3
    ISSN 1615-5742 ; 1093-5266
    ISSN (online) 1615-5742
    ISSN 1093-5266
    DOI 10.1177/10935266241237656
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5063: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: NELL1 membranous nephropathy: clinical associations provide mechanistic clues.

    Andeen, Nicole K / Kung, Vanderlene L / Avasare, Rupali S

    Frontiers in nephrology

    2024  Volume 4, Page(s) 1323432

    Abstract: Neural epidermal growth factor-like 1 (NELL1) membranous nephropathy (MN) is notable for its segmental deposit distribution, IgG1 dominant deposits, and comparatively high rate of spontaneous remission. It has been associated with a variety of exposures ... ...

    Abstract Neural epidermal growth factor-like 1 (NELL1) membranous nephropathy (MN) is notable for its segmental deposit distribution, IgG1 dominant deposits, and comparatively high rate of spontaneous remission. It has been associated with a variety of exposures and secondary conditions, specifically use of thiol-containing medications - including lipoic acid, bucillamine, and tiopronin - as well as traditional indigenous medications (TIM) particularly those with high mercury content, and non-steroid anti-inflammatory drugs (NSAIDs). Malignancies, graft
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2813-0626
    ISSN (online) 2813-0626
    DOI 10.3389/fneph.2024.1323432
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  3. Article ; Online: Elevated serum concentrations of DNAJB9 in fibrillary glomerulonephritis: another step toward understanding a progressive disease.

    Andeen, Nicole K

    Kidney international

    2019  Volume 95, Issue 5, Page(s) 1025–1026

    Abstract: DnaJ homolog subfamily B member 9 (DNAJB9) is a sensitive and specific marker of fibrillary glomerulonephritis (FGN) in kidney biopsies. In this issue, Nasr and Dasari et al. demonstrate significantly elevated concentrations of DNAJB9 in serum from ... ...

    Abstract DnaJ homolog subfamily B member 9 (DNAJB9) is a sensitive and specific marker of fibrillary glomerulonephritis (FGN) in kidney biopsies. In this issue, Nasr and Dasari et al. demonstrate significantly elevated concentrations of DNAJB9 in serum from patients with FGN. This advances our understanding of DNAJB9 as a biomarker in FGN and reframes questions about pathogenesis and potential clinical applications of DNAJB9 serum testing.
    MeSH term(s) Biomarkers ; Glomerulonephritis ; Humans
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-04-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.01.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: DNA J homolog subfamily B member 9 and other advances in fibrillary glomerulonephritis.

    Andeen, Nicole K / Avasare, Rupali S

    Current opinion in nephrology and hypertension

    2021  Volume 30, Issue 3, Page(s) 294–302

    Abstract: Purpose of review: Fibrillary glomerulonephritis (FGN) involves ∼1% of native kidney biopsies and is characterized by glomerular deposition of fibrils larger than amyloid (12-24 nm diameter) composed of polyclonal immunoglobulin G (IgG). The recent ... ...

    Abstract Purpose of review: Fibrillary glomerulonephritis (FGN) involves ∼1% of native kidney biopsies and is characterized by glomerular deposition of fibrils larger than amyloid (12-24 nm diameter) composed of polyclonal immunoglobulin G (IgG). The recent discovery of DNA J homolog subfamily B member 9 (DNAJB9) in FGN glomerular deposits has contributed a specific and sensitive biomarker, informing morphologic classification and pathogenesis. This review will consider contemporary FGN incidence and genetics, pathogenesis, (lack of) paraprotein association, variants, treatment, and transplantation.
    Recent findings: DNAJB9 tissue assays have enabled the identification of morphologic variants and improved classification of fibrillary-like glomerular diseases. Together with paraffin immunofluorescence and IgG subclass studies, these have established that FGN is only rarely monoclonal and these patients usually do not have an monoclonal gammopathy. The discovery of DNAJB9 opens new avenues of investigation into FGN pathogenesis, especially those of the unfolded protein response. Treatment for FGN remains empiric, with some encouraging data on rituximab-based therapy. Transplantation is a good option for patients progressing to end-stage kidney disease.
    Summary: Advances building on the discovery of DNAJB9 in FGN should lead to long-term evolution in targeted treatment and outcome of this glomerular disease.
    MeSH term(s) Glomerulonephritis/diagnosis ; Glomerulonephritis/genetics ; Glomerulonephritis/therapy ; HSP40 Heat-Shock Proteins ; Humans ; Membrane Proteins ; Molecular Chaperones
    Chemical Substances DNAJB9 protein, human ; HSP40 Heat-Shock Proteins ; Membrane Proteins ; Molecular Chaperones
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000706
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    Zs.A 3686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: NELL1-Positive HIV-Associated Lupus-Like Membranous Nephropathy with Spontaneous Remission.

    Dinesh, Kumar P / Charu, Vivek / Troxell, Megan L / Andeen, Nicole K

    Glomerular diseases

    2022  Volume 2, Issue 4, Page(s) 184–188

    Abstract: Introduction: Kidney biopsy findings in patients with human immunodeficiency virus (HIV) are diverse, and optimal therapy for the various immune complex diseases in the setting of HIV is unknown.: Case presentation: A man with well-controlled HIV ... ...

    Abstract Introduction: Kidney biopsy findings in patients with human immunodeficiency virus (HIV) are diverse, and optimal therapy for the various immune complex diseases in the setting of HIV is unknown.
    Case presentation: A man with well-controlled HIV developed nephrotic range proteinuria, and kidney biopsy revealed lupus-like glomerulonephritis with a predominantly membranous pattern of injury. He opted for conservative therapy and experienced spontaneous and sustained remission. Subsequent testing revealed neural epidermal growth factor-like 1 (NELL1)-positive glomerular immune deposits. NELL1-positive glomerular immune deposits were identified in a total of 2 of 5 tested HIV-associated membranous nephropathy (MN), which were morphologically dissimilar and one of which weakly co-expressed phospholipase A2 receptor (PLA2R).
    Discussion: This case suggests potentially different outcomes in patients with immune complex diseases in the setting of HIV based on disease etiology and histopathology. HIV-associated MN is occasionally NELL1-positive.
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2673-3633
    ISSN (online) 2673-3633
    DOI 10.1159/000525541
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  6. Article ; Online: Worsening Kidney Function, Proteinuria, and Hematuria in a Patient with CLL.

    Chopra, Pavan / Andeen, Nicole K / Spurgeon, Stephen E

    Kidney360

    2021  Volume 2, Issue 5, Page(s) 916–917

    MeSH term(s) Hematuria/diagnosis ; Humans ; Kidney/diagnostic imaging ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Proteinuria/diagnosis
    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0003452020
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  7. Article: Parental recovered acute kidney injury causes prenatal renal dysfunction and fetal growth restriction with sexually dimorphic implications for adult offspring.

    Hebert, Jessica F / Funahashi, Yoshio / Emathinger, Jacqueline M / Nickerson, Megan N / Groat, Tahnee / Andeen, Nicole K / Gurley, Susan B / Hutchens, Michael P

    Frontiers in physiology

    2024  Volume 15, Page(s) 1357932

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2024.1357932
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  8. Article ; Online: The role of HLA antigens in recurrent primary focal segmental glomerulosclerosis.

    Batal, Ibrahim / Khairallah, Pascale / Weins, Astrid / Andeen, Nicole K / Stokes, Michael B

    Frontiers in immunology

    2023  Volume 14, Page(s) 1124249

    Abstract: Primary focal segmental glomerulosclerosis (FSGS), typically characterized by diffuse podocyte foot process effacement and nephrotic syndrome (diffuse podocytopathy), is generally attributed to a circulating permeability factor. Primary FSGS can recur ... ...

    Abstract Primary focal segmental glomerulosclerosis (FSGS), typically characterized by diffuse podocyte foot process effacement and nephrotic syndrome (diffuse podocytopathy), is generally attributed to a circulating permeability factor. Primary FSGS can recur after transplantation where it manifests as diffuse foot process effacement in the early stages, with subsequent evolution of segmental sclerotic lesions. Previous published literature has been limited by the lack of stringent selection criteria to define primary FSGS. Although immunogenetic factors play an important role in many glomerular diseases, their role in recurrent primary FSGS post-transplantation has not been systematically investigated. To address this, we retrospectively studied a multicenter cohort of 74 kidney allograft recipients with end stage kidney disease due to primary FSGS, confirmed by clinical and histologic parameters. After adjusting for race/ethnicity, there was a numeric higher frequency of HLA-A30 antigen in primary FSGS (19%) compared to each of 22,490 healthy controls (7%, adjusted OR=2.0, P=0.04) and 296 deceased kidney donors (10%, OR=2.1, P=0.03). Within the group of transplant patients with end stage kidney disease due to primary FSGS, donor HLA-A30 was associated with recurrent disease (OR=9.1, P=0.02). Multivariable time-to-event analyses revealed that recipients who self-identified as Black people had lower risk of recurrent disease, probably reflecting enrichment of these recipients with
    MeSH term(s) Humans ; Glomerulosclerosis, Focal Segmental/pathology ; Kidney Transplantation ; Retrospective Studies ; Genome-Wide Association Study ; Kidney Failure, Chronic/complications ; HLA Antigens ; Apolipoprotein L1
    Chemical Substances HLA Antigens ; APOL1 protein, human ; Apolipoprotein L1
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1124249
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  9. Article ; Online: ANCA-associated kidney disease preceded by orbital pseudotumor.

    Oleson, Ileisa / Fecker, Adeline / Richardson, Kelsey / Bauer, Abbie / Andeen, Nicole K / Kung, Vanderlene L

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 39, Issue 3, Page(s) 741–744

    Abstract: Introduction: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and IgG4-related disease (IgG4-RD) are distinct immune disorders with overlapping clinical and laboratory features. While ANCA positivity excludes IgG4-RD in the 2019 ... ...

    Abstract Introduction: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and IgG4-related disease (IgG4-RD) are distinct immune disorders with overlapping clinical and laboratory features. While ANCA positivity excludes IgG4-RD in the 2019 ACR/EULAR classification, this criterion is not uniformly applied, and AAV can form inflammatory masses in various organs and show increase in IgG4 + plasma cells, similar to IgG4-RD.
    Case diagnosis/treatment: A 5-year-old female with history of orbital mass diagnosed as IgG4-RD presents with acute kidney injury. She has a myeloperoxidase ANCA, and kidney biopsy shows pauci-immune crescentic glomerulonephritis and acute tubulointerstitial nephritis with increased IgG4 + plasma cells and tubular basement membrane (TBM) deposits.
    Conclusion: In isolation, TBM deposits and increased IgG4 + plasma cells are suggestive of IgG4-RD. In the context of a positive ANCA and pauci-immune crescentic glomerulonephritis, however, increased IgG4 + plasma cells due to AAV are favored. In cases with features of IgG4-RD, ANCA positivity suggests an alternate diagnosis of AAV to be more likely.
    MeSH term(s) Female ; Humans ; Child, Preschool ; Antibodies, Antineutrophil Cytoplasmic ; Orbital Pseudotumor/pathology ; Immunoglobulin G4-Related Disease/diagnosis ; Kidney/pathology ; Nephritis, Interstitial/complications ; Nephritis, Interstitial/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Immunoglobulin G ; Glomerulonephritis/complications ; Glomerulonephritis/diagnosis
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Immunoglobulin G
    Language English
    Publishing date 2023-10-19
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-06172-w
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    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: AKI and Hypercalcemia in a Patient with Weakness and Fatigue.

    Rahimi, Cheyenne / Stroemel, Mathias / Andeen, Nicole K

    Kidney360

    2020  Volume 1, Issue 11, Page(s) 1328–1329

    MeSH term(s) Acute Kidney Injury/diagnosis ; Fatigue/diagnosis ; Humans ; Hypercalcemia/complications ; Nephritis, Interstitial ; Sarcoidosis
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0002282020
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