LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Anders Tveita"
  2. AU="Joseph O. Fadare"
  3. AU="Koech, O K"
  4. AU="Kapp, William"
  5. AU="Argañaraz, Gustavo A."
  6. AU="Winters, Adrienna"
  7. AU="Iman Mamdouh Talaat"
  8. AU="Benjamin Kingsley Harley"
  9. AU="Cirio, Maria Cecilia"
  10. AU="Rodriguez-Rodriguez, Alvaro Manuel"
  11. AU="Anna Maria Aloisi"
  12. AU="Na, Li"
  13. AU="Beatriz Aguiar Jordão Paranhos"
  14. AU="johnson, Michael"
  15. AU=Hunt S A
  16. AU="Gniazdowski, Victoria"
  17. AU="Griffin, Matthew E"
  18. AU="Bean, Paris"
  19. AU="Elomaa, Paula"
  20. AU="Robert Fowler"
  21. AU="Nielsen, Stine"
  22. AU="Chabartier, Cyrille"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity

    Peter Szodoray / Tor Kristian Andersen / Julia Heinzelbecker / John F. Imbery / Peter C. Huszthy / Stephanie M. Stanford / Bjarne Bogen / Ole B. Landsverk / Nunzio Bottini / Anders Tveita / Ludvig A. Munthe / Britt Nakken

    Cell Reports, Vol 36, Iss 6, Pp 109525- (2021)

    2021  

    Abstract: Summary: Humoral immunity relies on the efficient differentiation of memory B cells (MBCs) into antibody-secreting cells (ASCs). T helper (Th) signals upregulate B cell receptor (BCR) signaling by potentiating Src family kinases through increasing CD45 ... ...

    Abstract Summary: Humoral immunity relies on the efficient differentiation of memory B cells (MBCs) into antibody-secreting cells (ASCs). T helper (Th) signals upregulate B cell receptor (BCR) signaling by potentiating Src family kinases through increasing CD45 phosphatase activity (CD45 PA).In this study, we show that high CD45 PA in MBCs enhances BCR signaling and is essential for their effective ASC differentiation. Mechanistically, Th signals upregulate CD45 PA through intensifying the surface binding of a CD45 ligand, Galectin-1. CD45 PA works as a sensor of T cell help and defines high-affinity germinal center (GC) plasma cell (PC) precursors characterized by IRF4 expression in vivo. Increasing T cell help in vitro results in an incremental CD45 PA increase and enhances ASC differentiation by facilitating effective induction of the transcription factors IRF4 and BLIMP1. This study connects Th signals with BCR signaling through Galectin-1-dependent regulation of CD45 PA and provides a mechanism for efficient ASC differentiation of MBCs.
    Schlagwörter B cell memory ; B cell receptor signaling ; antibody-secreting cell ; CD45 phosphatase activity ; IRF4 ; BLIMP1 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models

    Jo Waaler / Line Mygland / Anders Tveita / Martin Frank Strand / Nina Therese Solberg / Petter Angell Olsen / Aleksandra Aizenshtadt / Marte Fauskanger / Kaja Lund / Shoshy Alam Brinch / Max Lycke / Elisabeth Dybing / Vegard Nygaard / Sigurd Læines Bøe / Karen-Marie Heintz / Eivind Hovig / Clara Hammarström / Alexandre Corthay / Stefan Krauss

    Communications Biology, Vol 3, Iss 1, Pp 1-

    2020  Band 13

    Abstract: Waaler et al. show that a tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling, sensitizing tumors to anti-PD-1 immune checkpoint therapy in mice. This study suggests that a combinatorial therapy using tankyrase inhibition can be used ... ...

    Abstract Waaler et al. show that a tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling, sensitizing tumors to anti-PD-1 immune checkpoint therapy in mice. This study suggests that a combinatorial therapy using tankyrase inhibition can be used to overcome β-catenin-mediated resistance to immune checkpoint blockade in melanoma.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2020-04-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang