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  1. Article ; Online: [No title information]

    Brandt, Christian Thomas / Andersen, Christian Østergaard

    Ugeskrift for laeger

    2024  Volume 186, Issue 14

    Title translation Begrænset evidens af nye behandlingstiltag ved bakteriel meningitis.
    Language Danish
    Publishing date 2024-04-01
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    DOI 10.61409/V205171
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  2. Article ; Online: Pathogen distribution and antimicrobial resistance in infections in migrants and nonmigrants in Denmark, a cross-sectional study.

    Nielsen, Rikke Thoft / Köse, Güldas / Sloth, Louise / Andersen, Christian Østergaard / Petersen, Jørgen Holm / Norredam, Marie

    Tropical medicine & international health : TM & IH

    2022  Volume 27, Issue 11, Page(s) 999–1008

    Abstract: Objective: To investigate differences in bacterial distribution and resistance patterns of relevant pathogens in skin and tissue infections among migrants compared to nonmigrants.: Methods: The population is based on a cohort of migrants who obtained ...

    Abstract Objective: To investigate differences in bacterial distribution and resistance patterns of relevant pathogens in skin and tissue infections among migrants compared to nonmigrants.
    Methods: The population is based on a cohort of migrants who obtained residence as refugees or family-reunited migrants in Denmark between January 1993 and December 2015. The cohort was linked to positive swabs and tissue cultures collected from hospitals and general practitioners between the years 2000 and 2016 at the Department of Microbiology, University Hospital Hvidovre, Denmark. We calculated odds ratios for pathogen distribution and resistance patterns using logistic regression by comparing migrants with nonmigrants.
    Results: In total, 43,770 pathogens from 37,276 individuals were included, with Staphylococcus aureus being the most common bacterium. Migrants had higher odds of infections with Enterobacterales than nonmigrants (OR 1.42, 95% CI: 1.23-1.63) and lower odds of beta-haemolytic Streptococci (OR 0.79, 95% CI: 0.73-0.86). Family-reunited migrants and refugees had higher odds of methicillin-resistant S. aureus (MRSA) than nonmigrants (OR 5.01, 95% CI: 3.73-6.73 and OR 3.66, 95% CI: 2.61-5.13). This was more pronounced in female migrants. The odds of ciprofloxacin-resistant Enterobacterales were higher in both family-reunited migrants and refugees than in nonmigrants (OR 2.21, 95% CI: 1.34-3.64 and OR 2.17, 95% CI: 1.34-3.52).
    Conclusions: The prevalence of MRSA and ciprofloxacin-resistant Enterobacterales was higher among family-reunited migrants and refugees than in nonmigrants. Our findings suggest an increased awareness for AMR in migrants.
    MeSH term(s) Female ; Humans ; Transients and Migrants ; Cross-Sectional Studies ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Methicillin-Resistant Staphylococcus aureus ; Drug Resistance, Bacterial ; Staphylococcal Infections/microbiology ; Ciprofloxacin ; Denmark/epidemiology
    Chemical Substances Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U)
    Language English
    Publishing date 2022-10-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1314080-2
    ISSN 1365-3156 ; 1360-2276
    ISSN (online) 1365-3156
    ISSN 1360-2276
    DOI 10.1111/tmi.13820
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  3. Article ; Online: Differences in the distribution of pathogens and antimicrobial resistance in bloodstream infections in migrants compared with non-migrants in Denmark.

    Nielsen, Rikke Thoft / Andersen, Christian Østergaard / Schønheyder, Henrik Carl / Petersen, Jørgen Holm / Knudsen, Jenny Dahl / Jarløv, Jens Otto / Norredam, Marie

    Infectious diseases (London, England)

    2022  Volume 55, Issue 3, Page(s) 165–174

    Abstract: Background: We wish to study disparities in bloodstream infections in migrants and non-migrants by comparing the distribution of pathogens and their resistance patterns in long-term migrants with that in non-migrants in Denmark.: Methods: The study ... ...

    Abstract Background: We wish to study disparities in bloodstream infections in migrants and non-migrants by comparing the distribution of pathogens and their resistance patterns in long-term migrants with that in non-migrants in Denmark.
    Methods: The study is based on a cohort of migrants, who received residency in Denmark between 1993 and 2015 and a control group of non-migrants. The cohort was linked to a database of bloodstream infections from 2000 to 2015 covering two regions in Denmark. First-time bloodstream infections in individuals ≥18 years of age at the time of sampling were included. We calculated odds ratios adjusted for age, sex, year of sampling, comorbidity, and place of acquisition (hospital- or community-acquired).
    Results: We identified 4,703 bloodstream infection cases. Family-reunified migrants and refugees had higher odds of
    Conclusions: Migrants had a higher proportion of community-acquired bloodstream infections with
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial ; Ciprofloxacin ; Escherichia coli ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/epidemiology ; Sepsis/drug therapy ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/drug therapy ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; Denmark/epidemiology
    Chemical Substances Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U)
    Language English
    Publishing date 2022-12-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2022.2151643
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  4. Article ; Online: Validation of a risk score to differentiate autoimmune and viral encephalitis: a Nationwide Cohort Study in Denmark.

    Fjordside, Lasse / Nissen, Mette Scheller / Florescu, Anna Maria / Storgaard, Merete / Larsen, Lykke / Wiese, Lothar / von Lüttichau, Hans Rudolf / Jepsen, Micha Phill Grønholm / Hansen, Birgitte Rønde / Andersen, Christian Østergaard / Bodilsen, Jacob / Nielsen, Henrik / Blaabjerg, Morten / Lebech, Anne-Mette / Mens, Helene

    Journal of neurology

    2024  

    Abstract: Background: A score to differentiate autoimmune (AE) and viral encephalitis (VE) early upon admission has recently been developed but needed external validation. The objective of this study was to evaluate the performance of the score in a larger and ... ...

    Abstract Background: A score to differentiate autoimmune (AE) and viral encephalitis (VE) early upon admission has recently been developed but needed external validation. The objective of this study was to evaluate the performance of the score in a larger and more diagnostically diverse patient cohort.
    Methods: We conducted a retrospective nationwide and population-based cohort study including all adults with encephalitis of definite viral (2015-2022) or autoimmune aetiology (2009-2022) in Denmark. Variables included in the score-model were extracted from patient records and individual risk scores were assessed. The performance of the score was assessed by receiver-operating characteristics (ROC) curve analyses and calculation of the area under the curve (AUC).
    Results: A total of 496 patients with encephalitis [AE n = 90, VE n = 287 and presumed infectious encephalitis (PIE) n = 119] were included in the study. The score was highly accurate in predicting cases of AE reaching an AUC of 0.94 (95% CI 0.92-0.97). Having a score ≥ 3 predicted AE with a PPV of 87% and an NPV of 91%. The risk score was found to perform well across aetiological subgroups and applied to the PIE cohort resulted in an AUC of 0.88 (95% CI 0.84-0.93).
    Conclusion: The excellent performance of the score as reported in the development study was confirmed in this significantly larger and more diverse cohort of patients with encephalitis in Denmark. These results should prompt further prospective testing with wider inclusion criteria.
    Language English
    Publishing date 2024-05-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-024-12392-3
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  5. Article ; Online: Clinical features and prognostic factors in adults with viral meningitis.

    Petersen, Pelle Trier / Bodilsen, Jacob / Jepsen, Micha Phill Grønholm / Larsen, Lykke / Storgaard, Merete / Hansen, Birgitte Rønde / Helweg-Larsen, Jannik / Wiese, Lothar / Lüttichau, Hans Rudolf / Andersen, Christian Østergaard / Nielsen, Henrik / Brandt, Christian Thomas

    Brain : a journal of neurology

    2023  Volume 146, Issue 9, Page(s) 3816–3825

    Abstract: Clinical features applicable to the entire spectrum of viral meningitis are limited, and prognostic factors for adverse outcomes are undetermined. This nationwide population-based prospective cohort study included all adults with presumed and ... ...

    Abstract Clinical features applicable to the entire spectrum of viral meningitis are limited, and prognostic factors for adverse outcomes are undetermined. This nationwide population-based prospective cohort study included all adults with presumed and microbiologically confirmed viral meningitis in Denmark from 2015 until 2020. Prognostic factors for an unfavourable outcome (Glasgow Outcome Scale score of 1-4) 30 days after discharge were examined by modified Poisson regression. In total, 1066 episodes of viral meningitis were included, yielding a mean annual incidence of 4.7 episodes per 100 000 persons. Pathogens were enteroviruses in 419/1066 (39%), herpes simplex virus type 2 in 171/1066 (16%), varicella-zoster virus in 162/1066 (15%), miscellaneous viruses in 31/1066 (3%) and remained unidentified in 283/1066 (27%). The median age was 33 years (IQR 27-44), and 576/1066 (54%) were females. In herpes simplex virus type 2 meningitis, 131/171 (77%) were females. Immunosuppression [32/162 (20%)] and shingles [90/149 (60%)] were frequent in varicella-zoster virus meningitis. The triad of headache, neck stiffness and hyperacusis or photophobia was present in 264/960 (28%). The median time until lumbar puncture was 3.0 h (IQR 1.3-7.1), and the median CSF leucocyte count was 160 cells/µl (IQR 60-358). The outcome was unfavourable in 216/1055 (20%) 30 days after discharge. Using unidentified pathogen as the reference, the adjusted relative risk of an unfavourable outcome was 1.34 (95% CI 0.95-1.88) for enteroviruses, 1.55 (95% CI 1.00-2.41) for herpes simplex virus type 2, 1.51 (95% CI 0.98-2.33) for varicella-zoster virus and 1.37 (95% CI 0.61-3.05) for miscellaneous viruses. The adjusted relative risk of an unfavourable outcome was 1.34 (95% CI 1.03-1.75) for females. Timing of acyclovir or valacyclovir was not associated with the outcome in meningitis caused by herpes simplex virus type 2 or varicella-zoster virus. In summary, the outcome of viral meningitis was similar among patients with different aetiologies, including those with presumed viral meningitis but without an identified pathogen. Females had an increased risk of an unfavourable outcome. Early antiviral treatment was not associated with an improved outcome in meningitis caused by herpes simplex virus type 2 or varicella-zoster virus.
    MeSH term(s) Female ; Humans ; Adult ; Male ; Prospective Studies ; Prognosis ; Meningitis, Viral/epidemiology ; Meningitis, Viral/drug therapy ; Herpesvirus 3, Human
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awad089
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  6. Article ; Online: Mortality and exacerbations associated with Stenotrophomonas maltophilia in chronic obstructive pulmonary disease. A regional cohort study of 22,689 outpatients.

    Rønn, Christian / Kamstrup, Peter / Eklöf, Josefin / Toennesen, Louise Lindhardt / Boel, Jonas Bredtoft / Andersen, Christian Ostergaard / Dessau, Ram Benny / Wilcke, Jon Torgny / Sivapalan, Pradeesh / Ulrik, Charlotte Suppli / Jensen, Jens-Ulrik Stæhr

    Respiratory research

    2023  Volume 24, Issue 1, Page(s) 232

    Abstract: Objectives: The clinical significance of Stenotrophomonas maltophilia in patients with COPD is poorly understood. We aimed to determine whether a lower respiratory tract culture positive for S. maltophilia in COPD patients was independently associated ... ...

    Abstract Objectives: The clinical significance of Stenotrophomonas maltophilia in patients with COPD is poorly understood. We aimed to determine whether a lower respiratory tract culture positive for S. maltophilia in COPD patients was independently associated with increased risk of death and hospitalisation for exacerbation of COPD.
    Methods: An observational cohort study following outpatients with COPD in Eastern Denmark between 2010 and 2018, with a follow-up period of five years. Presence of S. maltophilia was treated as a time-varying exposure, where patients were considered exposed at the time of the first isolation of S. maltophilia from the lower respiratory tract. The hazard ratio (HR) of death and hospitalisation for acute exacerbations of COPD was assessed using a Cox proportional hazards regression.
    Results: Of the total 22,689 patients 459 (2.0%) had a lower respiratory sample positive for S. maltophilia. A total of 7,649 deaths (S. maltophilia positive: 243 (52.9%) and S. maltophilia negative: 7,406 (34.4%)) and 24,912 hospitalisations for exacerbation of COPD (S. maltophilia positive: 1,100 in 459 patients and S. maltophilia negative: 23,821 in 22,230 patients) were registered during the study period. We found that a lower respiratory tract culture positive for S. maltophilia was associated with both increased mortality: HR 3.3 (95% CI 2.6-4.3), and hospitalisation for exacerbation of COPD: HR 3.4 (95% CI 2.8-4.1).
    Conclusions: A lower respiratory tract culture positive for S. maltophilia in COPD patients was associated with a substantially increased mortality and hospitalisation for exacerbation of COPD. Randomised controlled trials are proposed to determine whether S. maltophilia should be the target of antibiotic treatment.
    MeSH term(s) Humans ; Outpatients ; Stenotrophomonas maltophilia ; Cohort Studies ; Clinical Relevance ; Pulmonary Disease, Chronic Obstructive/diagnosis
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02544-w
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  7. Article ; Online: [Therapeutic drug monitoring of β-lactam antibiotics].

    Tanha, Nima / Bathum, Lise / Munk, Jens Kristian / Frimodt-Møller, Niels / Andersen, Christian Østergaard / Benfield, Thomas

    Ugeskrift for laeger

    2020  Volume 182, Issue 39

    Abstract: Traditional β-lactam antibiotic dosing does not consider physiological changes in medical conditions such as sepsis. Optimal antibiotic exposure could be achieved by therapeutic drug monitoring (TDM). This review gives a brief summary. Current studies ... ...

    Abstract Traditional β-lactam antibiotic dosing does not consider physiological changes in medical conditions such as sepsis. Optimal antibiotic exposure could be achieved by therapeutic drug monitoring (TDM). This review gives a brief summary. Current studies are sparse, but suggestive of a potential beneficial role of TDM to patients with reduced renal function, obese patients and the critically ill. TDM can potentially reduce adverse effects and optimise antibiotic exposure. However, standardised TDM methods are lacking and randomised clinical studies are warranted in order to prove clinical benefit.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Critical Illness ; Drug Monitoring ; Humans ; Obesity/drug therapy ; beta-Lactams
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams
    Language Danish
    Publishing date 2020-09-30
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  8. Article ; Online: Viral lumbosacral radiculitis (Elsberg syndrome) in Denmark.

    Petersen, Pelle Trier / Bodilsen, Jacob / Jepsen, Micha Phill Grønholm / Larsen, Lykke / Storgaard, Merete / Hansen, Birgitte Rønde / Lüttichau, Hans Rudolf / Helweg-Larsen, Jannik / Wiese, Lothar / Andersen, Christian Østergaard / Nielsen, Henrik / Brandt, Christian Thomas

    Infection

    2023  

    Abstract: Purpose: To describe clinical features and outcomes of viral lumbosacral radiculitis (Elsberg syndrome).: Methods: Nationwide population-based cohort study of all adults hospitalised for viral lumbosacral radiculitis at departments of infectious ... ...

    Abstract Purpose: To describe clinical features and outcomes of viral lumbosacral radiculitis (Elsberg syndrome).
    Methods: Nationwide population-based cohort study of all adults hospitalised for viral lumbosacral radiculitis at departments of infectious diseases in Denmark from 2015 to 2020.
    Results: Twenty-eight patients with viral lumbosacral radiculitis were included (mean annual incidence: 1.2/1,000,000 adults). The median age was 35 years (IQR 27-43), and 22/28 (79%) were female. All patients had urinary retention, with 17/28 (61%) needing a catheter. On admission, at least one sign or symptom of meningitis (headache, neck stiffness, photophobia/hyperacusis) was present in 18/22 (82%). Concurrent genital herpetic lesions were present in 11/24 (46%). The median cerebrospinal fluid leukocyte count was 153 cells/µL (IQR 31-514). Magnetic resonance imaging showed radiculitis/myelitis in 5/19 (26%). The microbiological diagnosis was herpes simplex virus type 2 in 19/28 (68%), varicella-zoster virus in 2/28 (7%), and unidentified in 7/28 (25%). Aciclovir/valaciclovir was administered in 27/28 (96%). At 30 days after discharge, 3/27 (11%) had persistent urinary retention with need of catheter. At 180 days after discharge, moderate disabilities (Glasgow Outcome Scale score of 4) were observed in 5/25 (20%).
    Conclusions: Urinary retention resolved within weeks in most patients with viral lumbosacral radiculitis, but moderate disabilities according to the Glasgow Outcome Scale were common at the end of follow-up.
    Language English
    Publishing date 2023-11-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-023-02113-9
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  9. Article ; Online: Recurrence of bacteremia and infective endocarditis according to bacterial species of index endocarditis episode.

    Østergaard, Lauge / Voldstedlund, Marianne / Bruun, Niels Eske / Bundgaard, Henning / Iversen, Kasper / Pries-Heje, Mia Marie / Hadji-Turdeghal, Katra / Graversen, Peter L / Moser, Claus / Andersen, Christian Østergaard / Søgaard, Kirstine Kobberøe / Køber, Lars / Fosbøl, Emil Loldrup

    Infection

    2023  Volume 51, Issue 6, Page(s) 1739–1747

    Abstract: Purpose: In patients surviving infective endocarditis (IE) recurrence of bacteremia or IE is feared. However, knowledge is sparse on the incidence and risk factors for the recurrence of bacteremia or IE.: Methods: Using Danish nationwide registries ( ... ...

    Abstract Purpose: In patients surviving infective endocarditis (IE) recurrence of bacteremia or IE is feared. However, knowledge is sparse on the incidence and risk factors for the recurrence of bacteremia or IE.
    Methods: Using Danish nationwide registries (2010-2020), we identified patients with first-time IE which were categorized by bacterial species (Staphylococcus aureus, Enterococcus spp., Streptococcus spp., coagulase-negative staphylococci [CoNS], 'Other' microbiological etiology). Recurrence of bacteremia (including IE episodes) or IE with the same bacterial species was estimated at 12 months and 5 years, considering death as a competing risk. Cox regression models were used to compute adjusted hazard ratios of the recurrence of bacteremia or IE.
    Results: We identified 4086 patients with IE; 1374 (33.6%) with S. aureus, 813 (19.9%) with Enterococcus spp., 1366 (33.4%) with Streptococcus spp., 284 (7.0%) with CoNS, and 249 (6.1%) with 'Other'. The overall 12-month incidence of recurrent bacteremia with the same bacterial species was 4.8% and 2.6% with an accompanying IE diagnosis, while this was 7.7% and 4.0%, respectively, with 5 years of follow-up. S. aureus, Enterococcus spp., CoNS, chronic renal failure, and liver disease were associated with an increased rate of recurrent bacteremia or IE with the same bacterial species.
    Conclusion: Recurrent bacteremia with the same bacterial species within 12 months, occurred in almost 5% and 2.6% for recurrent IE. S. aureus, Enterococcus spp., and CoNS were associated with recurrent infections with the same bacterial species.
    MeSH term(s) Humans ; Staphylococcus aureus ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/microbiology ; Endocarditis ; Bacteria ; Staphylococcal Infections/microbiology ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Staphylococcus ; Enterococcus ; Streptococcus
    Language English
    Publishing date 2023-07-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-023-02068-x
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  10. Article ; Online: Benign recurrent lymphocytic meningitis (Mollaret's meningitis) in Denmark: a nationwide cohort study.

    Petersen, Pelle Trier / Bodilsen, Jacob / Jepsen, Micha Phill Grønholm / Hansen, Birgitte Rønde / Storgaard, Merete / Larsen, Lykke / Helweg-Larsen, Jannik / Wiese, Lothar / Lüttichau, Hans Rudolf / Andersen, Christian Østergaard / Mogensen, Trine Hyrup / Nielsen, Henrik / Brandt, Christian Thomas

    European journal of neurology

    2023  Volume 31, Issue 1, Page(s) e16081

    Abstract: Background and purpose: Data on clinical features and outcomes of benign recurrent lymphocytic meningitis (BRLM) are limited.: Methods: This was a nationwide population-based cohort study of all adults hospitalized for BRLM associated with herpes ... ...

    Abstract Background and purpose: Data on clinical features and outcomes of benign recurrent lymphocytic meningitis (BRLM) are limited.
    Methods: This was a nationwide population-based cohort study of all adults hospitalized for BRLM associated with herpes simplex virus type 2 (HSV-2) at the departments of infectious diseases in Denmark from 2015 to 2020. Patients with single-episode HSV-2 meningitis were included for comparison.
    Results: Forty-seven patients with BRLM (mean annual incidence 1.2/1,000,000 adults) and 118 with single-episode HSV-2 meningitis were included. The progression risk from HSV-2 meningitis to BRLM was 22% (95% confidence interval [CI] 15%-30%). The proportion of patients with the triad of headache, neck stiffness and photophobia/hyperacusis was similar between BRLM and single-episode HSV-2 meningitis (16/43 [37%] vs. 46/103 [45%]; p = 0.41), whilst the median cerebrospinal fluid leukocyte count was lower in BRLM (221 cells vs. 398 cells; p = 0.02). Unfavourable functional outcomes (Glasgow Outcome Scale score of 1-4) were less frequent in BRLM at all post-discharge follow-up visits. During the study period, 10 (21%) patients with BRLM were hospitalized for an additional recurrence (annual rate 6%, 95% CI 3%-12%). The hazard ratio for an additional recurrence was 3.93 (95% CI 1.02-15.3) for patients with three or more previous episodes of meningitis.
    Conclusions: Clinical features of BRLM were similar to those of single-episode HSV-2 meningitis, whilst post-discharge outcomes were more favourable. Patients with three or more previous episodes of meningitis had higher risk of an additional recurrence.
    MeSH term(s) Adult ; Humans ; Cohort Studies ; Meningitis, Viral/epidemiology ; Aftercare ; Polymerase Chain Reaction ; Recurrence ; Patient Discharge ; Meningitis, Aseptic ; Herpesvirus 2, Human/genetics ; Denmark/epidemiology
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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