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Book: Kompendium Sucht

Andersohn, Frank / Krausz, Michael

18 Tabellen

2004

Author's details	hrsg. von Michael Krausz ... Mit Beitr. von Frank Andersohn
Keywords	Sucht ; Therapie
Subject	Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Suchtkrankheit ; Suchterkrankung
Language	German
Size	XI, 160 S. : graph. Darst.
Publisher	Thieme
Publishing place	Stuttgart u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT013800130
ISBN	3-13-128261-4 ; 978-3-13-128261-3
Database	Catalogue ZB MED Medicine, Health

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2003 A 4461	order for loan	Magazin

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Book ; Thesis: Auswirkung des Alkoholentzugs auf die Plasmakonzentrationen von atrialem natriuretischen Hormon und Cortisol

Andersohn, Frank

2001

Author's details	vorgelegt von Frank Andersohn
Language	German
Size	53 Bl. : graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hamburg, Univ., Diss., 2001
HBZ-ID	HT013929616
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Effect on survival of whole-body CT during trauma resuscitation.

Andersohn, Frank

Lancet (London, England)

2009 Volume 374, Issue 9685, Page(s) 197; author reply 198–9

MeSH term(s)	Bias ; Humans ; Proportional Hazards Models ; Research Design ; Resuscitation/methods ; Time Factors ; Tomography, X-Ray Computed ; Whole Body Imaging ; Wounds, Nonpenetrating/diagnostic imaging ; Wounds, Nonpenetrating/mortality
Language	English
Publishing date	2009-07-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(09)61321-0
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Article ; Online: Clinical outcomes and characteristics of patients hospitalized for Influenza or COVID-19 in Germany.

Ludwig, Marion / Jacob, Josephine / Basedow, Frederike / Andersohn, Frank / Walker, Jochen

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 103, Page(s) 316–322

Abstract: Objectives: Since the beginning of the severe acute respiratory syndrome coronavirus 2 pandemic, there is a discussion about the severity of coronavirus disease-2019 (COVID-19) in comparison to infections with seasonal Influenza. The objective of this ... ...

Abstract	Objectives: Since the beginning of the severe acute respiratory syndrome coronavirus 2 pandemic, there is a discussion about the severity of coronavirus disease-2019 (COVID-19) in comparison to infections with seasonal Influenza. The objective of this study was to compare clinical and demographic characteristics of German patients hospitalized for infection with either SARS-CoV-2 or Influenza. Methods: This study used anonymized German healthcare claims data. Patients with a confirmed COVID-19 or Influenza diagnosis, for whom a complete hospital course was available (i.e., the patient was discharged or died in hospital) were included. The data set included detailed information on patient characteristics and hospital treatment. Patients were grouped according to whether they were transferred to the intensive care unit (ICU), received mechanical ventilation (MV), or had a severe course of the disease (SD). Charlson Comorbidity Index in the eight quarters prior to hospitalization and secondary diagnoses during hospitalization were analyzed. Results: A total of 2343 hospitalized patients with COVID-19 and 6762 hospitalized patients with Influenza were included. Fifty-four percent of the patients were male patients, with men being twice as frequent in the COVID-19 severe groups. For both diseases, patients >49 years accounted for almost three-quarters of hospital cases and hypertension, diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease were the most common comorbidities. The proportion of cases with ICU, MV, and SD was substantially higher for patients with COVID-19 (ICU+: 21 vs. 13 %; MV+: 15 vs. 9%; and SD+: 28 vs. 16%). Overall inhospital mortality was more than two-fold higher in COVID-19 vs. Influenza (14 vs. 6%).). The length of ventilation and hospitalization, and the proportion of patients diagnosed with acute respiratory distress syndrome, systemic inflammatory response syndrome, or acute kidney injury were considerably higher in patients with COVID-19. Conclusions: COVID-19 resulted in higher inhospital mortality and worse clinical outcomes than Influenza. This was not attributable to demographic characteristics, preexisting comorbidities, or patient triage, because the German healthcare system had not reached its limits in the pandemic. Discussions suggesting that COVID-19 and seasonal Influenza have similar severity cannot be based on clinical evidence.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/mortality ; COVID-19/physiopathology ; COVID-19/therapy ; Comorbidity ; Female ; Germany ; Hospital Mortality ; Hospitalization ; Humans ; Influenza, Human/mortality ; Influenza, Human/physiopathology ; Influenza, Human/therapy ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Treatment Outcome
Language	English
Publishing date	2020-12-31
Publishing country	Canada
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.11.204
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Zs.A 4516: Show issues

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Article ; Online: Characteristics and external validity of the German Health Risk Institute (HRI) Database.

Andersohn, Frank / Walker, Jochen

Pharmacoepidemiology and drug safety

2016 Volume 25, Issue 1, Page(s) 106–109

Abstract: Purpose: The aim of this study was to describe characteristics and external validity of the German Health Risk Institute (HRI) Database.: Methods: The HRI Database is an anonymized healthcare database with longitudinal data from approximately six Mio ...

Abstract	Purpose: The aim of this study was to describe characteristics and external validity of the German Health Risk Institute (HRI) Database. Methods: The HRI Database is an anonymized healthcare database with longitudinal data from approximately six Mio Germans. In addition to demographic information (gender, age, region of residence), data on persistence of insurants over time, hospitalization rates, mortality rates and drug prescription rates were extracted from the HRI database for 2013. Corresponding national reference data were obtained from official sources. Results: The proportion of men and women was similar in the HRI Database and Germany, but the database population was slightly younger (mean 40.4 vs 43.7 years). The proportion of insurants living in the eastern part of Germany was lower in the HRI Database (10.1% vs 19.7%). There was good accordance to German reference data with respect to hospitalization rates, overall mortality rate and prescription rates for the 20 most often reimbursed drug classes, with the overall burden of morbidity being slightly lower in the HRI database. From insurants insured on 1 January 2009 (N = 6.2 Mio), a total of 70.6% survived and remained continuously insured with the same statutory health insurance until 31 December 2013. This proportion increased to 77.5% if only insurants ≥40 years were considered. Conclusions: There was good overall accordance of the HRI database and the German population in terms of measures of morbidity, mortality and drug usage. Persistence of insurants with the database over time was high, indicating suitability of the data source for longitudinal epidemiological analyses.
MeSH term(s)	Adult ; Databases, Factual ; Drug Prescriptions/statistics & numerical data ; Female ; Germany ; Health Status Indicators ; Hospitalization/statistics & numerical data ; Humans ; Insurance, Health/statistics & numerical data ; Male ; National Health Programs/organization & administration ; National Health Programs/statistics & numerical data ; Rural Population/statistics & numerical data ; Urban Population/statistics & numerical data
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1099748-9
ISSN	1099-1557 ; 1053-8569
ISSN (online)	1099-1557
ISSN	1053-8569
DOI	10.1002/pds.3895
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Zs.A 3395: Show issues

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Article ; Online: Sodium-glucose co-transporter-2 inhibitors and the risk of fractures of the upper or lower limbs in patients with type 2 diabetes: A nested case-control study.

Schmedt, Niklas / Andersohn, Frank / Walker, Jochen / Garbe, Edeltraut

Diabetes, obesity & metabolism

2018 Volume 21, Issue 1, Page(s) 52–60

Abstract: Aims: To investigate whether the use of SGLT-2 inhibitors is associated with an increased risk of fractures.: Material and methods: We conducted a cohort study with nested case-control analysis based on the InGef database between November 2011 and ... ...

Abstract	Aims: To investigate whether the use of SGLT-2 inhibitors is associated with an increased risk of fractures. Material and methods: We conducted a cohort study with nested case-control analysis based on the InGef database between November 2011 and December 2016 among patients with type 2 diabetes who were initiating treatment with, switching to, or adding a new class of non-insulin antidiabetic drug. Patients with a hospital or ambulatory diagnosis of fractures of the upper or lower limbs were included and were matched to up to 40 randomly sampled control subjects. Conditional logistic regression was used to estimate confounder adjusted odds ratios (ORs) of fractures, comparing current use of metformin plus SGLT-2 inhibitor or metformin plus another antidiabetic drug class to metformin plus DPP-4 inhibitor as reference. Results: The cohort comprised 210 042 new users of non-insulin antidiabetic drugs. For the nested case-control analysis, 7522 patients with fractures were matched to 296 845 control subjects. In the crude and confounder adjusted analyses, current use of metformin plus SGLT-2 inhibitor compared to current use of metformin plus DPP-4 inhibitor was not associated with fractures (OR: 1.00; 95% CI: 0.72-1.39 and OR: 0.99; 95% CI: 0.71-1.37, respectively). Similarly, no statistically significant association was found for current use of metformin plus another antidiabetic drug class. No treatment effect modification was observed after stratification by number of documented risk factors for falls and fractures (< 4 vs ≥ 4) and age (< 75 vs ≥ 75 years). Conclusion: Our study suggests that use of SGLT-2 inhibitors and other antidiabetic drug classes are not associated with an increased risk of fractures of the upper or lower limbs compared to use of DPP-4 inhibitors in patients with type 2 diabetes.
MeSH term(s)	Aged ; Aged, 80 and over ; Case-Control Studies ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Fractures, Bone/epidemiology ; Fractures, Bone/etiology ; Germany/epidemiology ; Humans ; Male ; Middle Aged ; Risk Factors ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
Chemical Substances	Sodium-Glucose Transporter 2 Inhibitors
Language	English
Publishing date	2018-08-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.13480
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Zs.A 5442: Show issues

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Article: Cerebrovascular events after discontinuation of rofecoxib treatment.

Andersohn, Frank

Cardiovascular drugs and therapy

2007 Volume 21, Issue 2, Page(s) 77–79

MeSH term(s)	Brain Ischemia/chemically induced ; Brain Ischemia/epidemiology ; Cyclooxygenase 2 Inhibitors/administration & dosage ; Cyclooxygenase 2 Inhibitors/adverse effects ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Humans ; Incidence ; Lactones/administration & dosage ; Lactones/adverse effects ; Lactones/therapeutic use ; Risk ; Stroke/chemically induced ; Stroke/epidemiology ; Sulfones/administration & dosage ; Sulfones/adverse effects ; Sulfones/therapeutic use
Chemical Substances	Cyclooxygenase 2 Inhibitors ; Lactones ; Sulfones ; rofecoxib (0QTW8Z7MCR)
Language	English
Publishing date	2007-04
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	639068-7
ISSN	1573-7241 ; 0920-3206
ISSN (online)	1573-7241
ISSN	0920-3206
DOI	10.1007/s10557-007-6022-6
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Book ; Online ; Thesis: Identifizierung unerwünschter Arzneimittelwirkungen nach Marktzulassung

Andersohn, Frank [Verfasser]

2011

Author's details	Frank Andersohn
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Medizinische Fakultät Charité - Universitätsmedizin Berlin
Publishing place	Berlin
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Frequency and clinical relevance of potential cytochrome P450 drug interactions in a psychiatric patient population - an analysis based on German insurance claims data.

Ostermann, Julia K / Berghöfer, Anne / Andersohn, Frank / Fischer, Felix

BMC health services research

2016 Volume 16, Page(s) 482

Abstract: Background: Numerous drugs used in the treatment of psychiatric disorders are substrates of cytochrome P450 enzymes and are potential candidates for drug-drug interactions (DDIs).: Methods: Claims data of a German statutory health insurance company ... ...

Abstract	Background: Numerous drugs used in the treatment of psychiatric disorders are substrates of cytochrome P450 enzymes and are potential candidates for drug-drug interactions (DDIs). Methods: Claims data of a German statutory health insurance company from severely mentally ill patients who registered in an integrated care contract from August 2004 to December 2009 were analysed. We measured time periods of concomitant prescription of drugs that have been reported to interact via cytochrome P450, with a focus on drugs acting as strong inhibitors. Such drug-drug exposure (DDE) is an incontrovertible precursor of DDIs. We assessed whether potential DDIs were considered clinically relevant based on the prescribing information of the respective drugs. Results: Among all 1221 patients, 186 patients (15.2 %; Clopper-Pearson 95 % confidence interval (CI): 13.3-17.4 %) had at least one DDE prescription, and 58 patients (4.8 %; 95 % CI 3.6-6.1) had at least one DDE prescription involving a strong cytochrome P450 inhibitor. In 59 patients, (4.8 %; 95 % CI: 3.7-6.2 %) five or more DDEs were identified, and five or more DDEs with a strong inhibitor were identified in 18 patients (1.5 %; 95 % CI: 0.9-2.3). The rates of DDEs were 0.27 (Garwood 95%CI: 0.25-0.28) per person-year and 0.07 (95 % CI: 0.07-0.08) for strong-inhibitor DDEs. Four of the ten most frequent DDEs were identified as clinically relevant, and seven of the eight most frequent DDEs involving a strong inhibitor were clinically relevant. Conclusions: The number of patients with DDEs was not alarmingly high in our sample. Nevertheless, prescription information showed that some prescribed drug combinations could result in serious adverse consequences that are known to weaken or strengthen the effect of the drugs and should therefore be avoided.
MeSH term(s)	Adult ; Aged ; Antipsychotic Agents/metabolism ; Antipsychotic Agents/pharmacology ; Cytochrome P-450 Enzyme System/metabolism ; Databases, Factual ; Drug Interactions ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Female ; Germany ; Humans ; Insurance, Health/statistics & numerical data ; Male ; Middle Aged ; Practice Patterns, Physicians' ; Psychotic Disorders/drug therapy
Chemical Substances	Antipsychotic Agents ; Enzyme Inhibitors ; Cytochrome P-450 Enzyme System (9035-51-2)
Language	English
Publishing date	2016-09-08
Publishing country	England
Document type	Journal Article
ISSN	1472-6963
ISSN (online)	1472-6963
DOI	10.1186/s12913-016-1724-8
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Article ; Online: Interaction of serotonin reuptake inhibitors with tamoxifen.

Andersohn, Frank / Willich, Stefan N

BMJ (Clinical research ed.)

2010 Volume 340, Page(s) c783

MeSH term(s)	Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy ; Depressive Disorder/drug therapy ; Drug Interactions ; Female ; Humans ; Paroxetine/adverse effects ; Serotonin Uptake Inhibitors/adverse effects ; Tamoxifen/therapeutic use
Chemical Substances	Antineoplastic Agents, Hormonal ; Serotonin Uptake Inhibitors ; Tamoxifen (094ZI81Y45) ; Paroxetine (41VRH5220H)
Language	English
Publishing date	2010-02-08
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.c783
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