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Article ; Online: At Last, One Indication for Left Ventricular Assist Devices-A Bridge to a Better and Longer Life.

Anderson, Allen S

JAMA cardiology

2020 Volume 5, Issue 3, Page(s) 251–252

MeSH term(s)	Heart Failure/surgery ; Heart Transplantation ; Heart-Assist Devices ; Humans ; Technology
Language	English
Publishing date	2020-01-14
Publishing country	United States
Document type	Editorial ; Comment
ISSN	2380-6591
ISSN (online)	2380-6591
DOI	10.1001/jamacardio.2019.5592
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Article: A Comprehensive Review of Calcineurin Inhibitors Used for Immunosuppression in Cardiac Transplantation.

Engwenyu, Lydia R / Anderson, Allen S

Handbook of experimental pharmacology

2021 Volume 272, Page(s) 27–38

Abstract: Calcineurin inhibitors (CNIs) have been the foundation of immunosuppression in solid organ transplantation since the 1980s. Cyclosporine A (CSA), the first in class, was identified as the metabolite of the soil fungus Tolypocladium inflatum Gams as part ... ...

Abstract	Calcineurin inhibitors (CNIs) have been the foundation of immunosuppression in solid organ transplantation since the 1980s. Cyclosporine A (CSA), the first in class, was identified as the metabolite of the soil fungus Tolypocladium inflatum Gams as part of a larger program of screening for naturally occurring fungal metabolites with biologic activity in the 1970s. Significant immunosuppressive effects were discovered and consequently CSA was trialed as an immunosuppressant in renal transplantation. This initial success led to its widespread study and adoption in solid organ transplantation. This novel agent yielded significant improvements in both 1 year and longer-term allograft and patient survival. Subsequently, a similar and more potent CNI, tacrolimus was developed. Today, it is the principal CNI used for prevention of allograft rejection. Like all other immunosuppressives, the benefits of CNIs are counterbalanced by side effects and complications resulting from drug toxicity. This chapter comprehensively reviews the clinical use of CNIs in cardiac transplantation.
MeSH term(s)	Calcineurin Inhibitors/therapeutic use ; Cyclosporine/therapeutic use ; Graft Rejection/prevention & control ; Heart Transplantation ; Humans ; Immunosuppression Therapy ; Immunosuppressive Agents/therapeutic use ; Tacrolimus/therapeutic use
Chemical Substances	Calcineurin Inhibitors ; Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2021-12-04
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	0171-2004
ISSN	0171-2004
DOI	10.1007/164_2021_549
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Article ; Online: Sex Differences in Outcomes of LVAD Patients Bridged to Transplant: The Problem of Selection Bias.

Wehbe, Ramsey M / Anderson, Allen S

JACC. Heart failure

2019 Volume 7, Issue 8, Page(s) 731

MeSH term(s)	Female ; Heart Failure ; Heart Transplantation ; Heart-Assist Devices ; Humans ; Male ; Selection Bias ; Sex Characteristics
Language	English
Publishing date	2019-08-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2019.04.017
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Article ; Online: Is it too early to investigate survival outcomes of the new US heart allocation system?

Parker, William F / Churpek, Matthew M / Anderson, Allen S

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2020 Volume 39, Issue 7, Page(s) 726

MeSH term(s)	Heart ; Heart Transplantation ; Humans ; Tissue Donors ; Tissue and Organ Procurement ; United States/epidemiology ; Waiting Lists
Language	English
Publishing date	2020-01-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2020.01.1343
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Zs.A 2056: Show issues

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Article ; Online: Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB.

Rico-Mesa, Juan Simon / White, Averi / Anderson, Allen S

Current cardiology reports

2020 Volume 22, Issue 5, Page(s) 31

Abstract: Purpose of review: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the aggressive coronavirus disease (COVID-19) pandemic. Recently, investigators have stipulated that COVID-19 patients receiving angiotensin- ... ...

Abstract	Purpose of review: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the aggressive coronavirus disease (COVID-19) pandemic. Recently, investigators have stipulated that COVID-19 patients receiving angiotensin-converting-enzyme inhibitors (ACEI) may be subject to poorer outcomes. This editorial presents the available evidence to guide treatment practices during this pandemic. Recent findings: Recent studies from Wuhan cohorts provide valuable information about COVID-19. A cohort with 52 critically ill patients revealed cardiac injury in 12% of patients. Worse outcomes appear to be more prevalent in patients with hypertension and diabetes mellitus (DM), possibly due to overexpression of angiotensin-converting enzyme 2 (ACE2) receptor in airway alveolar epithelial cells. Investigators suspect that SARS-CoV-2 uses the ACE2 receptor to enter the lungs in a mechanism similar to SARS-CoV. Several hypotheses have been proposed to date regarding the net effect of ACEI/ARB on COVID-19 infections. Positive effects include ACE2 receptor blockade, disabling viral entry into the heart and lungs, and an overall decrease in inflammation secondary to ACEI/ARB. Negative effects include a possible retrograde feedback mechanism, by which ACE2 receptors are upregulated. Even though physiological models of SARS-CoV infection show a theoretical benefit of ACEI/ARB, these findings cannot be extrapolated to SARS-CoV-2 causing COVID-19. Major cardiology scientific associations, including ACC, HFSA, AHA, and ESC Hypertension Council, have rejected these correlation hypotheses. After an extensive literature review, we conclude that there is no significant evidence to support an association for now, but given the rapid evolvement of this pandemic, findings may change.
MeSH term(s)	Alveolar Epithelial Cells/metabolism ; Angiotensin Receptor Antagonists/adverse effects ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus/drug effects ; Coronavirus/isolation & purification ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Pandemics ; Peptidyl-Dipeptidase A/adverse effects ; Peptidyl-Dipeptidase A/therapeutic use ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Practice Guidelines as Topic ; SARS-CoV-2
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-04-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055373-0
ISSN	1534-3170 ; 1523-3782
ISSN (online)	1534-3170
ISSN	1523-3782
DOI	10.1007/s11886-020-01291-4
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Article ; Online: The Accuracy of Initial U.S. Heart Transplant Candidate Rankings.

Pelzer, Kenley M / Zhang, Kevin C / Lazenby, Kevin A / Narang, Nikhil / Churpek, Matthew M / Anderson, Allen S / Parker, William F

JACC. Heart failure

2023 Volume 11, Issue 5, Page(s) 504–512

Abstract: Background: The U.S. heart allocation system ranks candidates with only 6 treatment-based categorical "statuses" and ignores many objective patient characteristics.: Objectives: This study sought to determine the effectiveness of the standard 6- ... ...

Abstract	Background: The U.S. heart allocation system ranks candidates with only 6 treatment-based categorical "statuses" and ignores many objective patient characteristics. Objectives: This study sought to determine the effectiveness of the standard 6-status ranking system and several novel prediction models in identifying the most urgent heart transplant candidates. Methods: The primary outcome was death before receipt of a heart transplant. The accuracy of the 6-status system was evaluated using Harrell's C-index and log-rank tests of Kaplan-Meier estimated survival by status for candidates listed postpolicy (November 2018 to March 2020) in the Scientific Registry of Transplant Recipients data set. The authors then developed Cox proportional hazards models and random survival forest models using prepolicy data (2010-2017). The predictor variables included age, diagnosis, laboratory measurements, hemodynamics, and supportive treatment at the time of listing. The performance of these models was compared with the candidate's 6-status ranking in the postpolicy data. Results: Since policy implementation, the 6-status ranking at listing has had moderate ability to rank-order candidates (C-index: 0.67). Statuses 4 and 6 had no significant difference in survival (P = 0.80), and status 5 had lower survival than status 4 (P < 0.001). Novel multivariable prediction models derived with prepolicy data ranked candidates correctly more often than the 6-status rankings (Cox proportional hazards model C-index: 0.76; random survival forest model C-index: 0.74). Objective physiologic measurements, such as glomerular filtration rate, had high variable importance. Conclusions: The treatment-based 6-status heart allocation system has only moderate ability to rank-order candidates by medical urgency. Predictive models that incorporate physiologic measurements can more effectively rank-order heart transplant candidates by urgency.
MeSH term(s)	Humans ; Heart Failure/surgery ; Heart Transplantation ; Proportional Hazards Models ; Registries ; Time Factors ; Waiting Lists ; Retrospective Studies
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2023.02.005
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Article: Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB

Rico-Mesa, Juan Simon / White, Averi / Anderson, Allen S

Curr Cardiol Rep

Abstract: PURPOSE OF REVIEW: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the aggressive coronavirus disease (COVID-19) pandemic. Recently, investigators have stipulated that COVID-19 patients receiving angiotensin- ... ...

Abstract	PURPOSE OF REVIEW: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the aggressive coronavirus disease (COVID-19) pandemic. Recently, investigators have stipulated that COVID-19 patients receiving angiotensin-converting-enzyme inhibitors (ACEI) may be subject to poorer outcomes. This editorial presents the available evidence to guide treatment practices during this pandemic. RECENT FINDINGS: Recent studies from Wuhan cohorts provide valuable information about COVID-19. A cohort with 52 critically ill patients revealed cardiac injury in 12% of patients. Worse outcomes appear to be more prevalent in patients with hypertension and diabetes mellitus (DM), possibly due to overexpression of angiotensin-converting enzyme 2 (ACE2) receptor in airway alveolar epithelial cells. Investigators suspect that SARS-CoV-2 uses the ACE2 receptor to enter the lungs in a mechanism similar to SARS-CoV. Several hypotheses have been proposed to date regarding the net effect of ACEI/ARB on COVID-19 infections. Positive effects include ACE2 receptor blockade, disabling viral entry into the heart and lungs, and an overall decrease in inflammation secondary to ACEI/ARB. Negative effects include a possible retrograde feedback mechanism, by which ACE2 receptors are upregulated. Even though physiological models of SARS-CoV infection show a theoretical benefit of ACEI/ARB, these findings cannot be extrapolated to SARS-CoV-2 causing COVID-19. Major cardiology scientific associations, including ACC, HFSA, AHA, and ESC Hypertension Council, have rejected these correlation hypotheses. After an extensive literature review, we conclude that there is no significant evidence to support an association for now, but given the rapid evolvement of this pandemic, findings may change.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #46694
Database	COVID19

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Article ; Online: Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB

Rico-Mesa, Juan Simon / White, Averi / Anderson, Allen S.

Current Cardiology Reports

2020 Volume 22, Issue 5

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2055373-0
ISSN	1523-3782
ISSN	1523-3782
DOI	10.1007/s11886-020-01291-4
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cardiac complications of COVID-19: Incidence and outcomes.

Pillarisetti, Jayasree / Cheema, Mubeen S / Haloot, Justin / Panday, Manoj / Badin, Auroa / Mehta, Anjlee / Anderson, Allen S / Prasad, Anand

Indian heart journal

2022 Volume 74, Issue 3, Page(s) 170–177

Abstract: Background: Coronavirus disease-2019 (COVID-19) has been associated with pre-existing cardiac conditions as well as cardiovascular complications. The incidence rates of cardiac complications, age, and gender differences in this population are unknown.!## ...

Abstract	Background: Coronavirus disease-2019 (COVID-19) has been associated with pre-existing cardiac conditions as well as cardiovascular complications. The incidence rates of cardiac complications, age, and gender differences in this population are unknown. Objectives: We wanted to study the incidence of cardiac complications and mortality in patients with COVID-19. Methods: Data from the TriNetX COVID-19 global research network platform was used to identify COVID-19 patients. We compared patients with and without cardiac complications in patients with COVID-19 and obtained survival data. Results: The final cohort was composed of 81,844 patients with COVID-19. Cardiac complications occurred in 9.3% of patients as follows: acute coronary syndromes in 1.3%, heart failure in 4.4%, atrial fibrillation in 4.5%, sinus bradycardia 1.9%, ventricular tachycardia in 0.5% and complete heart block in 0.01%. Mortality was significantly higher in patients with the cardiac complications mentioned (20%) than in those without them (2.9%) (odds ratio 7.2, 95% CI, 6.7-7.7; p < 0.0001). Older males seem to have higher incidence of cardiac complications and mortality. Conclusions: Patients with COVID-19 who have cardiac complications have a higher risk of mortality when compared to those without cardiac complications.
MeSH term(s)	Acute Coronary Syndrome/epidemiology ; Atrial Fibrillation ; COVID-19/complications ; COVID-19/epidemiology ; Heart Failure/epidemiology ; Humans ; Incidence ; Male
Language	English
Publishing date	2022-04-29
Publishing country	India
Document type	Journal Article
ZDB-ID	604366-5
ISSN	2213-3763 ; 0019-4832
ISSN (online)	2213-3763
ISSN	0019-4832
DOI	10.1016/j.ihj.2022.04.008
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Zs.A 616: Show issues

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Article ; Online: Practice Changes at U.S. Transplant Centers After the New Adult Heart Allocation Policy.

Parker, William F / Chung, Kevin / Anderson, Allen S / Siegler, Mark / Huang, Elbert S / Churpek, Matthew M

Journal of the American College of Cardiology

2020 Volume 75, Issue 23, Page(s) 2906–2916

Abstract: Background: In October 2018, the U.S. heart allocation system expanded the number of priority "status" tiers from 3 to 6 and added cardiogenic shock requirements for some heart transplant candidates listed with specific types of treatments.: ... ...

Abstract	Background: In October 2018, the U.S. heart allocation system expanded the number of priority "status" tiers from 3 to 6 and added cardiogenic shock requirements for some heart transplant candidates listed with specific types of treatments. Objectives: This study sought to determine the impact of the new policy on the treatment practices of transplant centers. Methods: Initial listing data on all adult heart candidates listed from December 1, 2017 to April 30, 2019 were collected from the Scientific Registry of Transplant Recipients. The status-qualifying treatments (or exception requests) and hemodynamic values at listing of a post-policy cohort (December 2018 to April 2019) were compared with a seasonally matched pre-policy cohort (December 2017 to April 2018). Candidates in the pre-policy cohort were reclassified into the new priority system statuses by using treatment, diagnosis, and hemodynamics. Results: Comparing the post-policy cohort (N = 1,567) with the pre-policy cohort (N = 1,606), there were significant increases in listings with extracorporeal membrane oxygenation (+1.2%), intra-aortic balloon pumps (+ 4 %), and exceptions (+ 12%). Listings with low-dose inotropes (-18%) and high-dose inotropes (-3%) significantly decreased. The new priority status distribution had more status 2 (+14%) candidates than expected and fewer status 3 (-5%), status 4 (- 4%) and status 6 (-8%) candidates than expected (p values <0.01 for all comparisons). Conclusions: After implementation of the new heart allocation policy, transplant centers listed more candidates with extracorporeal membrane oxygenation, intra-aortic balloon pumps, and exception requests and fewer candidates with inotrope therapy than expected, thus leading to significantly more high-priority status listings than anticipated. If these early trends persist, the new allocation system may not function as intended.
MeSH term(s)	Adult ; Cardiotonic Agents/therapeutic use ; Extracorporeal Membrane Oxygenation ; Female ; Heart Failure/therapy ; Heart Transplantation ; Humans ; Intra-Aortic Balloon Pumping ; Male ; Middle Aged ; Registries ; Tissue and Organ Procurement ; Waiting Lists
Chemical Substances	Cardiotonic Agents
Language	English
Publishing date	2020-06-11
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2020.01.066
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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