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Article: Determination of Indolepropionic Acid and Related Indoles in Plasma, Plasma Ultrafiltrate, and Saliva.

Anderson, George M

2023 Volume 13, Issue 5

Abstract: The microbial metabolite indolepropionic acid (IPA) and related indolic metabolites, including indolecarboxylic acid (ICA), indolelactic acid (ILA), indoleacetic acid (IAA), indolebutyric acid (IBA), indoxylsulfate (ISO4), and indole, were determined in ... ...

Abstract	The microbial metabolite indolepropionic acid (IPA) and related indolic metabolites, including indolecarboxylic acid (ICA), indolelactic acid (ILA), indoleacetic acid (IAA), indolebutyric acid (IBA), indoxylsulfate (ISO4), and indole, were determined in human plasma, plasma ultrafiltrate (UF), and saliva. The compounds were separated on a 150 × 3 mm column of 3 μm Hypersil C18 eluted with a mobile phase of 80% pH 5 0.01 M sodium acetate containing 1.0 g/L of tert-butylammonium chloride/20% acetonitrile and then detected fluorometrically. Levels of IPA in human plasma UF and of ILA in saliva are reported for the first time. The determination of IPA in plasma UF enables the first report of free plasma IPA, the presumed physiologically active pool of this important microbial metabolite of tryptophan. Plasma and salivary ICA and IBA were not detected, consistent with the absence of any prior reported values. Observed levels or limits of detection for other indolic metabolites usefully supplement limited prior reports.
Language	English
Publishing date	2023-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13050602
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Web Exclusive. Annals Graphic Medicine - Pre Scrub.

Anderson, George M

Annals of internal medicine

2023 Volume 176, Issue 5, Page(s) eG220043

Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/G22-0043
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Article ; Online: Fluvoxamine, melatonin and COVID-19.

Anderson, George M

Psychopharmacology

2021 Volume 238, Issue 2, Page(s) 611

MeSH term(s)	COVID-19 ; Clinical Deterioration ; Fluvoxamine ; Humans ; Melatonin ; Outpatients ; SARS-CoV-2
Chemical Substances	Melatonin (JL5DK93RCL) ; Fluvoxamine (O4L1XPO44W)
Language	English
Publishing date	2021-01-04
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-020-05753-z
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Article ; Online: "The quantitative determination of indolic microbial tryptophan metabolites in human and rodent samples: A systematic review".

Anderson, George M

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2021 Volume 1186, Page(s) 123008

Abstract: Concentrations reported for indolic microbial metabolites of tryptophan in human and rodent brain, cerebrospinal fluid, plasma, saliva and feces were compiled and discussed. A systematic review of the literature was accomplished by key word searches of ... ...

Abstract	Concentrations reported for indolic microbial metabolites of tryptophan in human and rodent brain, cerebrospinal fluid, plasma, saliva and feces were compiled and discussed. A systematic review of the literature was accomplished by key word searches of Pubmed, Google Scholar and the Human Metabolome Data Base (HMDB), and by searching bibliographies of identified publications including prior reviews. The review was prompted by the increasing appreciation of the physiological importance of the indolic compounds in human health and disease. The compounds included were indoleacetic acid (IAA), indole propionic acid (IPA), indoleacrylic acid (IACR), indolelactic acid (ILA) indolepyruvic acid (IPY), indoleacetaldehyde (IAALD), indolealdehyde (IALD), tryptamine (TAM), indole (IND) and skatole (SKT). The undertaking aimed to vet and compare existing reports, to resolve apparent discrepancies, to draw biological inferences from the consideration of multiple analytes across sample types, to survey the analytical methodologies used, and to point out areas in need of greater attention.
MeSH term(s)	Animals ; Brain/metabolism ; Brain Chemistry ; Cerebrospinal Fluid/chemistry ; Cerebrospinal Fluid/metabolism ; Humans ; Indoles/chemistry ; Indoles/metabolism ; Plasma/chemistry ; Plasma/metabolism ; Rodentia ; Saliva/chemistry ; Saliva/metabolism ; Tryptophan/chemistry ; Tryptophan/metabolism
Chemical Substances	Indoles ; Tryptophan (8DUH1N11BX)
Language	English
Publishing date	2021-10-30
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2021.123008
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Article ; Online: Autism Risk and Serotonin Reuptake Inhibitors.

Anderson, George M

JAMA psychiatry

2019 Volume 76, Issue 5, Page(s) 547–548

MeSH term(s)	Autism Spectrum Disorder ; Autistic Disorder ; Female ; Humans ; Neurotransmitter Agents ; Pregnancy ; Prenatal Exposure Delayed Effects ; Serotonin Uptake Inhibitors
Chemical Substances	Neurotransmitter Agents ; Serotonin Uptake Inhibitors
Language	English
Publishing date	2019-02-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2701203-7
ISSN	2168-6238 ; 2168-622X
ISSN (online)	2168-6238
ISSN	2168-622X
DOI	10.1001/jamapsychiatry.2019.0073
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Article: “The quantitative determination of indolic microbial tryptophan metabolites in human and rodent samples: A systematic review”

Anderson, George M.

Journal of chromatography. 2021 Dec. 01, v. 1186

2021

Abstract	Concentrations reported for indolic microbial metabolites of tryptophan in human and rodent brain, cerebrospinal fluid, plasma, saliva and feces were compiled and discussed. A systematic review of the literature was accomplished by key word searches of Pubmed, Google Scholar and the Human Metabolome Data Base (HMDB), and by searching bibliographies of identified publications including prior reviews. The review was prompted by the increasing appreciation of the physiological importance of the indolic compounds in human health and disease. The compounds included were indoleacetic acid (IAA), indole propionic acid (IPA), indoleacrylic acid (IACR), indolelactic acid (ILA) indolepyruvic acid (IPY), indoleacetaldehyde (IAALD), indolealdehyde (IALD), tryptamine (TAM), indole (IND) and skatole (SKT). The undertaking aimed to vet and compare existing reports, to resolve apparent discrepancies, to draw biological inferences from the consideration of multiple analytes across sample types, to survey the analytical methodologies used, and to point out areas in need of greater attention.
Keywords	brain ; cerebrospinal fluid ; chemical species ; chromatography ; databases ; feces ; human health ; humans ; indole acetic acid ; metabolites ; metabolome ; propionic acid ; quantitative analysis ; rodents ; saliva ; skatole ; systematic review ; tryptamine ; tryptophan
Language	English
Dates of publication	2021-1201
Publishing place	Elsevier B.V.
Document type	Article
ISSN	1570-0232
DOI	10.1016/j.jchromb.2021.123008
Database	NAL-Catalogue (AGRICOLA)

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Article: Long COVID-19 and Peripheral Serotonin: A Commentary and Reconsideration.

Anderson, George M / Cook, Edwin H / Blakely, Randy D / Sutcliffe, James S / Veenstra-VanderWeele, Jeremy

Journal of inflammation research

2024 Volume 17, Page(s) 2169–2172

Abstract: We believe there are serious problems with a recently published and highly publicized paper entitled "Serotonin reduction in post-acute sequelae of viral infection." The blood centrifugation procedure reportedly used by Wong et al would produce plasma ... ...

Abstract	We believe there are serious problems with a recently published and highly publicized paper entitled "Serotonin reduction in post-acute sequelae of viral infection." The blood centrifugation procedure reportedly used by Wong et al would produce plasma that is substantially (over 95%) depleted of platelets. Given this, their published mean plasma serotonin values of 1.2 uM and 2.4 uM for the control/contrast groups appear to be at least 30 to 60 times too high and should be disregarded. The plasma serotonin values reported for the long COVID and viremia patients also should be disregarded, as should any comparisons to the control/contrast groups. We also note that the plasma serotonin means for the two control/contrast groups are not in good agreement. In the "Discussion" section, Wong et al state that their results tend to support the use of selective serotonin reuptake inhibitors (SSRIs) for the treatment of COVID-19, and they encourage further clinical trials of SSRIs. While they state that, "Our animal models demonstrate that serotonin levels can be restored and memory impairment reversed by precursor supplementation or SSRI treatment", it should be noted that no data are presented showing an increase or restoration in circulating serotonin with SSRI administration. In fact, one would expect a marked decline in platelet serotonin due to SSRIs' effective inhibition of the platelet serotonin transporter. Wong et al hypothesize that problems of long COVID arise from too little peripheral serotonin. However, given the frequent presence of a hyperaggregation state in long COVID, and the known augmenting effects of platelet serotonin on platelet aggregation, it is plausible to suggest that reductions in platelet serotonin might be associated with a lessening of the cardiovascular sequelae of COVID-19.
Language	English
Publishing date	2024-04-11
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S456000
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Article ; Online: Systematic review of studies using platelet serotonin content to assess bioeffect of serotonin reuptake inhibitors at the serotonin transporter.

Anderson, George M / Bruno-Pacella, Isabella

Psychopharmacology

2022

Abstract: Rationale: Assessment of the bioeffect of serotonin reuptake inhibitors (SRIs, including both selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs)) at the serotonin transporter (SERT) in patients and ... ...

Abstract	Rationale: Assessment of the bioeffect of serotonin reuptake inhibitors (SRIs, including both selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs)) at the serotonin transporter (SERT) in patients and healthy controls can have important theoretical and clinical implications. Objectives: Bioeffect at SERT has been assessed by neuroimaging of brain SERT occupancy, through in vitro measurements of platelet serotonin (5-HT) uptake, and by measuring platelet 5-HT content pre- and post-initiation of SRI administration. Studies of platelet 5-HT content were reviewed in order to (1) determine the overall apparent bioeffect of SRIs; (2) compare bioeffect across types of SRIs; (3) compare the three approaches to assessing SRI bioeffect; and (4) determine how the findings might inform clinical practice. Methods: We performed a systematic review of the published studies that measured platelet 5-HT content to assess SRI bioeffect at the platelet SERT. Studies using neuroimaging and in vitro platelet 5-HT uptake to assess SRI bioeffect were reviewed for comparison purposes. Results: Clinical doses of SRIs typically resulted in 70-90% reductions in platelet 5-HT content. The observed bioeffect at the platelet SERT appeared similar among different SSRIs and SNRIs. The bioeffect estimations based on platelet 5-HT content were consistent with those obtained using neuroimaging to assess brain SERT occupancy and those based on the in vitro measurement of platelet 5-HT uptake. Conclusions: In general, excellent agreement was seen in the apparent SRI bioeffect (70-90% inhibition) among the platelet 5-HT content studies and across the three bioeffect approaches. Theoretical and practical clinical implications are discussed.
Language	English
Publishing date	2022-11-18
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-022-06276-5
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Article ; Online: Baseline platelet serotonin in a multi-site treatment study of depression in veterans administration patients: Distribution and effects of demographic variables and serotonin reuptake inhibitors.

Anderson, George M / Ramsey, Christine M / Lynch, Kevin G / Gelernter, Joel / Oslin, David W

Journal of affective disorders

2023 Volume 327, Page(s) 368–377

Abstract: Background: The objectives of the study were: (1) to examine the overall distribution of baseline platelet serotonin (5-hydroxytryptamine, 5-HT) values in patients seeking treatment for depression and to define subgroups based on the apparent presence ... ...

Abstract	Background: The objectives of the study were: (1) to examine the overall distribution of baseline platelet serotonin (5-hydroxytryptamine, 5-HT) values in patients seeking treatment for depression and to define subgroups based on the apparent presence or absence of drug exposure; (2) to assess the bioeffect of 5-HT reuptake inhibitors (SRIs) at the platelet 5-HT transporter; and (3) to examine the relationships of demographic variables including population (ancestry), sex, age, and season of sampling to platelet 5-HT concentration. Methods: Platelet 5-HT levels were measured in a cross-sectional study of 1433 Veterans Administration (VA) patients participating in a pragmatic multi-site pharmacogenomic treatment study of depression. Patients were characterized medically and demographically using VA health records and self-report. Results: A clearly bimodal distribution was observed for platelet 5-HT levels with the lower mode associated with patients exposed to SRIs at baseline. Median transporter blockade bioeffects were similar across the various selective 5-HT reuptake inhibitors (SSRIs) and 5-HT/norepinephrine reuptake inhibitors (SNRIs). In a subset of patients apparently not exposed to an SRI, significant effects of population and sex were observed with group mean platelet 5-HT levels being 25 % greater (p < 0.001) in African-American (AA) individuals compared to European-Americans (EAs). The female group mean was 14 % (p < 0.001) greater than male group mean. An effect of age was observed (r = -0.11, p < 0.001) and no effect of season or month of sampling was seen. Conclusions: Further research is warranted to understand the bases and clinical implications of the population and sex differences. The apparent similarity in bioeffect at the 5-HT transporter across SSRIs and when comparing SSRIs and SNRIs informs discussions about initiating, dose adjustment and switching of 5-HT reuptake inhibitors.
MeSH term(s)	United States ; Humans ; Female ; Male ; Selective Serotonin Reuptake Inhibitors ; Serotonin ; Serotonin and Noradrenaline Reuptake Inhibitors ; Depression/drug therapy ; Cross-Sectional Studies ; United States Department of Veterans Affairs ; Membrane Transport Proteins ; Demography
Chemical Substances	Selective Serotonin Reuptake Inhibitors ; Serotonin (333DO1RDJY) ; Serotonin and Noradrenaline Reuptake Inhibitors ; Membrane Transport Proteins
Language	English
Publishing date	2023-02-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.02.017
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Article ; Online: Autism biomarkers: challenges, pitfalls and possibilities.

Anderson, George M

Journal of autism and developmental disorders

2014 Volume 45, Issue 4, Page(s) 1103–1113

Abstract: Network perspectives, in their emphasis on components and their interactions, might afford the best approach to the complexities of the ASD realm. Categorical approaches are unlikely to be fruitful as one should not expect to find a single or even ... ...

Abstract	Network perspectives, in their emphasis on components and their interactions, might afford the best approach to the complexities of the ASD realm. Categorical approaches are unlikely to be fruitful as one should not expect to find a single or even predominant underlying cause of autism behavior across individuals. It is possible that the complex, highly interactive, heterogeneous and individualistic nature of the autism realm is intractable in terms of identifying clinically useful biomarker tests. It is hopeful from an emergenic perspective that small corrective changes in a single component of a deleterious network/configuration might have large beneficial consequences on developmental trajectories and in later treatment. It is suggested that the relationship between ASD and intellectual disability might be fundamentally different in single-gene versus nonsyndromic ASD. It is strongly stated that available biomarker "tests" for autism/ASD will do more harm than good. Finally, the serotonin-melatonin-oxidative stress-placental intersection might be an especially fruitful area of biological investigation.
MeSH term(s)	Autistic Disorder/diagnosis ; Autistic Disorder/metabolism ; Autistic Disorder/psychology ; Biomarkers/metabolism ; Child ; Child Development Disorders, Pervasive/diagnosis ; Child Development Disorders, Pervasive/metabolism ; Child Development Disorders, Pervasive/psychology ; Humans ; Oxidative Stress/physiology ; Oxytocin/metabolism ; Serotonin/metabolism
Chemical Substances	Biomarkers ; Serotonin (333DO1RDJY) ; Oxytocin (50-56-6)
Language	English
Publishing date	2014-09-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-014-2225-4
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