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  1. Article: Nanomaterials in Drug Delivery Applications.

    Moreira, André Ferreira

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 20

    Abstract: The "magic bullet" concept paved the way for nanomaterials' development and innovation [ ... ]. ...

    Abstract The "magic bullet" concept paved the way for nanomaterials' development and innovation [...].
    Language English
    Publishing date 2022-10-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12203565
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  2. Article ; Online: Not so Mutually Exclusive Diseases

    Filipa Taborda / Duarte André Ferreira / Teresa Mendonça / Fátima Farinha

    European Journal of Case Reports in Internal Medicine (2023)

    A Case of Co-occurrence of Inflammatory Spondyloarthritis and Diffuse Skeletal Hyperostosis in a Young Patient

    2023  

    Abstract: Diffuse idiopathic skeletal hyperostosis (DISH) and axial spondyloarthritis (axial SpA) are differential diagnoses of lower back pain. While the latter is considered to be an inflammatory disease, DISH is thought to be a metabolic condition. The authors ... ...

    Abstract Diffuse idiopathic skeletal hyperostosis (DISH) and axial spondyloarthritis (axial SpA) are differential diagnoses of lower back pain. While the latter is considered to be an inflammatory disease, DISH is thought to be a metabolic condition. The authors report a case of a 34-year-old man who presented with a one-year history of axial lower back pain associated to migratory polyarthritis, buttock and heel pain. Imaging revealed contiguous calcification of the anterior longitudinal ligament of the cervical segment, meeting major criteria for DISH. However, he also exhibited signs of bilateral sacroiliitis highly suggestive of axial SpA for which he initiated biological therapy.
    Keywords diffuse idiopathic skeletal hyperostosis ; dish ; ankylosing spondylitis ; spondyloarthritis ; spa ; Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Generation of Synthetic Rat Brain MRI Scans with a 3D Enhanced Alpha Generative Adversarial Network

    André Ferreira / Ricardo Magalhães / Sébastien Mériaux / Victor Alves

    Applied Sciences, Vol 12, Iss 4844, p

    2022  Volume 4844

    Abstract: Translational brain research using Magnetic Resonance Imaging (MRI) is becoming increasingly popular as animal models are an essential part of scientific studies and more ultra-high-field scanners are becoming available. Some disadvantages of MRI are the ...

    Abstract Translational brain research using Magnetic Resonance Imaging (MRI) is becoming increasingly popular as animal models are an essential part of scientific studies and more ultra-high-field scanners are becoming available. Some disadvantages of MRI are the availability of MRI scanners and the time required for a full scanning session. Privacy laws and the 3Rs ethics rule also make it difficult to create large datasets for training deep learning models. To overcome these challenges, an adaptation of the alpha Generative Adversarial Networks (GANs) architecture was used to test its ability to generate realistic 3D MRI scans of the rat brain in silico. As far as the authors are aware, this was the first time a GAN-based approach was used to generate synthetic MRI data of the rat brain. The generated scans were evaluated using various quantitative metrics, a Turing test, and a segmentation test. The last two tests proved the realism and applicability of the generated scans to real problems. Therefore, by using the proposed new normalisation layer and loss functions, it was possible to improve the realism of the generated rat MRI scans, and it was shown that using the generated data improved the segmentation model more than using the conventional data augmentation.
    Keywords alpha generative adversarial network ; data augmentation ; synthetic data ; MRI rat brain ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A review of recent developments on drought characterization, propagation, and influential factors.

    Raposo, Vinícius de Matos Brandão / Costa, Veber Afonso Figueiredo / Rodrigues, André Ferreira

    The Science of the total environment

    2023  Volume 898, Page(s) 165550

    Abstract: Droughts have impacted human society throughout its history. However, the occurrence of severe drought events in the last century and the concerns on the potential effects of climate change have prompted remarkable advances in drought conceptualization ... ...

    Abstract Droughts have impacted human society throughout its history. However, the occurrence of severe drought events in the last century and the concerns on the potential effects of climate change have prompted remarkable advances in drought conceptualization and modeling in recent years. This review intends to present the state-of-the-art on drought characterization and propagation, as well as providing insights on how climate dynamics and anthropogenic activities might affect this phenomenon. For this purpose, we first address the distinct concepts of droughts and their relationships. Next, we present two frequently utilized methods based on the run theory for drought characterization and explain the development and recovery stages of droughts. Then, we discuss potential drivers for drought occurrence and propagation, with focus on meteorological factors, catchments' physical characteristics and human activities. Later, we describe how droughts can affect several parameters of water quality. This review also addressed flash droughts, encompassing their definitions, commonly used indices, and potential drivers. Finally, we briefly address the roles of climate change and long-term persistence on future drought scenarios. This review may be useful for researchers and stakeholders for attaining a broader understanding on drought dynamics and impacts.
    Language English
    Publishing date 2023-07-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.165550
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  5. Article: Intrapelvic Migration of Prosthetic Femoral Head after Revision Total Hip Arthroplasty - A Case Report.

    Pita, Sérgio / Pato, Tiago / Dos Santos, André Ferreira

    Journal of orthopaedic case reports

    2022  Volume 12, Issue 9, Page(s) 78–83

    Abstract: Introduction: Intrapelvic migration of the femoral head is a rare complication of total hip arthroplasty (THA).: Case report: A 54-year-old Caucasian female was submitted to revision THA. She suffered an anterior dislocation and avulsion of the ... ...

    Abstract Introduction: Intrapelvic migration of the femoral head is a rare complication of total hip arthroplasty (THA).
    Case report: A 54-year-old Caucasian female was submitted to revision THA. She suffered an anterior dislocation and avulsion of the prosthetic femoral head that required open reduction. Intraoperatively, the femoral head migrated into the pelvis, along the psoas aponeurosis. The migrated component was retrieved on a subsequent procedure, through an anterior approach to the iliac wing. The patient had a good post-operative course and 2 years after surgery she has no complains related to this complication.
    Conclusion: Most of the cases described in the literature are of intraoperative migration of trial components. The authors found only one case described involving a definitive prosthetic head, but during primary THA. No case was found due to post-operative dislocation or definitive femoral head migration after revision surgery. Due to the lack of long-term studies of intra pelvic implant retention, we recommend to remove these implants, particularly in younger patients.
    Language English
    Publishing date 2022-12-14
    Publishing country India
    Document type Case Reports
    ZDB-ID 2658169-3
    ISSN 2250-0685
    ISSN 2250-0685
    DOI 10.13107/jocr.2022.v12.i09.3326
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  6. Article ; Online: A review of recent developments on drought characterization, propagation, and influential factors

    de Matos Brandão Raposo, Vinícius / Costa, Veber Afonso Figueiredo / Rodrigues, André Ferreira

    Science of the Total Environment. 2023 July 17, p.165550-

    2023  , Page(s) 165550–

    Abstract: Droughts have impacted human society throughout its history. However, the occurrence of severe drought events in the last century and the concerns on the potential effects of climate change have prompted remarkable advances in drought conceptualization ... ...

    Abstract Droughts have impacted human society throughout its history. However, the occurrence of severe drought events in the last century and the concerns on the potential effects of climate change have prompted remarkable advances in drought conceptualization and modeling in recent years. This review intends to present the state-of-the-art on drought characterization and propagation, as well as providing insights on how climate dynamics and anthropogenic activities might affect this phenomenon. For this purpose, we first address the distinct concepts of droughts and their relationships. Next, we present two frequently utilized methods based on the run theory for drought characterization and explain the development and recovery stages of droughts. Then, we discuss potential drivers for drought occurrence and propagation, with focus on meteorological factors, catchments' physical characteristics and human activities. Later, we describe how droughts can affect several parameters of water quality. This review also addressed flash droughts, encompassing their definitions, commonly used indices, and potential drivers. Finally, we briefly address the roles of climate change and long-term persistence on future drought scenarios. This review may be useful for researchers and stakeholders for attaining a broader understanding on drought dynamics and impacts.
    Keywords climate ; climate change ; drought ; environment ; humans ; stakeholders ; water quality ; Standardized indices ; Threshold level method ; Controlling factors ; Atmospheric circulation anomalies
    Language English
    Dates of publication 2023-0717
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.165550
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  7. Article: Pneumocephalus Following an Accidental Dural Puncture, Treated Using Hyperbaric Oxygen Therapy. A Case Report.

    Marino, Flávio / Simões, André Ferreira / Simas, Ângela / Pereira, João Gonçalves

    Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)

    2021  Volume 7, Issue 3, Page(s) 237–240

    Abstract: Introduction: Neuraxial techniques, including epidural anaesthesia, are often used for perioperative pain control and are generally safe. However, both transient, mild and even severe, life-threatening neurologic complications can occur.: Case ... ...

    Abstract Introduction: Neuraxial techniques, including epidural anaesthesia, are often used for perioperative pain control and are generally safe. However, both transient, mild and even severe, life-threatening neurologic complications can occur.
    Case presentation: A seventy-eight-year-old man was admitted to the hospital for a radical nephrectomy plus transurethral resection due to kidney and bladder cancer. During the epidural exploration, an accidental dural puncture was noted. This was followed by the patient complaining of an intense headache. The epidural catheter was placed in a different location, and surgery was performed uneventfully. The patient presented with confusion, agitation, vertical nystagmus, vision loss, and paraparesis about two hours later. The epidural levobupivacaine and morphine infusion were stopped, followed by motor block resolution. A computerized head-tomography scan showed extra-axial multiple air spots involving the frontal and temporal lobes. Emergent hyperbaric oxygen therapy was commenced. After a single session, there was complete resolution of all symptoms and a marked reduction in the number and volume of the extra-axial air visible on the CT scan.
    Conclusions: Although rare, pneumocephalus is a well-recognized complication of a dural puncture. Its rapid recognition in a patient with new-onset neurological symptoms and early treatment with hyperbaric oxygen therapy allows rapid clinical and imaging resolution and an improved prognosis.
    Language English
    Publishing date 2021-08-05
    Publishing country Poland
    Document type Journal Article
    ISSN 2393-1809
    ISSN 2393-1809
    DOI 10.2478/jccm-2021-0017
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  8. Article ; Online: Quality of life in children and adolescents with hemophilia A: A systematic review and meta-analysis.

    Azeredo-da-Silva, André Ferreira / Zanotto, Bruna Stella / Kuwabara, Yukie Sato / Mata, Verónica Elizabeth

    Research and practice in thrombosis and haemostasis

    2022  Volume 7, Issue 1, Page(s) 100008

    Abstract: Background: Various instruments have been used to assess health-related quality of life (HRQoL) in children and adolescents with hemophilia A.: Objective: We systematically reviewed the literature to summarize HRQoL measurement instruments and ... ...

    Abstract Background: Various instruments have been used to assess health-related quality of life (HRQoL) in children and adolescents with hemophilia A.
    Objective: We systematically reviewed the literature to summarize HRQoL measurement instruments and outcomes in this population.
    Methods: MEDLINE, Embase, Cochrane CENTRAL, and LILACS databases were searched. Studies published from 2010 to 2021, reporting HRQoL assessed by generic or hemophilia-specific instruments in individuals aged 0 to 18 years were included. Two independent reviewers performed screening, selection, and data abstraction. Data were meta-analyzed using the generic inverse variance method with the random-effects model for single-arm studies reporting instrument-specific mean total HRQoL scores. Prespecified subgroup meta-analyses were performed. Heterogeneity among studies was assessed using the
    Results: Six instruments were identified in 29 studies meeting the following inclusion criteria: 4 generic instruments (PedsQL [5 studies], EQ-5D-3L [3 studies], KIDSCREEN-52 [1 study], and KINDL [1 study]) and 2 hemophilia-specific instruments (Haemo-QoL [17 studies] and CHO-KLAT [3 studies]). The overall risk of bias was moderate to low. There was a substantial variability in the primary outcome (mean total HRQoL score) among studies using the same instrument (Haemo-QoL), with scores ranging from 24.10 to 89.58 on a scale from 0 to 100 (higher scores indicating higher HRQoL). Meta-regression with 14 studies using the Haemo-QoL questionnaire demonstrated that 79.34% (
    Conclusion: HRQoL assessment in young people with hemophilia A is heterogeneous and context specific. The proportion of patients on effective prophylactic treatment is positively correlated with HRQoL. The review protocol was registered prospectively with PROSPERO (CRD42021235453).
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2022.100008
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  9. Article ; Online: EXERCISE IN THE PHYSICAL REHABILITATION OF CIRROTICS: A RANDOMIZED PILOT STUDY.

    Rossi, Danusa / D'Avila, André Ferreira / Galant, Lucas Homercher / Marroni, Claudio Augusto

    Arquivos de gastroenterologia

    2022  Volume 59, Issue 3, Page(s) 408–413

    Abstract: Background: Physical exercise delays the sarcopenic process and can reverse the loss of muscle strength, improve quality of life and prognosis in cirrhotic patients.: Objective: The aim was to verify the effects of face-to-face versus home aerobic ... ...

    Abstract Background: Physical exercise delays the sarcopenic process and can reverse the loss of muscle strength, improve quality of life and prognosis in cirrhotic patients.
    Objective: The aim was to verify the effects of face-to-face versus home aerobic exercise on the variables fatigue, respiratory and peripheral muscle strength, functional capacity and quality of life in patients with compensated cirrhosis.
    Methods: Patients were selected by convenience, stratified and randomized into supervised face-to-face exercise (n=13) and home exercise without daily supervision (n=12). Patients were submitted to a program of aerobic physical exercises, with progressive duration of 30 to 50 minutes, twice a week for twelve weeks. Before starting the program and every four weeks, all patients in both groups were assessed for fatigue (fatigue severity scale), respiratory (Pimáx and Pemáx) and peripheral (concentric quadriceps peak torque) muscle strength, functional capacity (6-minute walking distance) and quality of life (Short Form-36 Health Survey questionnaire).
    Results: The face-to-face group showed reduced fatigue (P<0.001), increased inspiratory (P<0.001), expiratory (P<0.001) and peripheral (P<0.001) muscle strength of the 6MWD (P<0.001) and improved quality of life. The home group showed no significant improvement in these variables.
    Conclusion: A face-to-face program of moderate aerobic exercise in patients with compensated cirrhosis reduces fatigue, improves functional capacity and quality of life and increases respiratory and peripheral muscle strength. Home physical exercises do not cause the same adaptive effects in this population.
    MeSH term(s) Exercise ; Exercise Therapy ; Fatigue ; Humans ; Liver Cirrhosis ; Pilot Projects ; Quality of Life
    Language English
    Publishing date 2022-09-09
    Publishing country Brazil
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 137743-7
    ISSN 1678-4219 ; 0004-2803
    ISSN (online) 1678-4219
    ISSN 0004-2803
    DOI 10.1590/S0004-2803.202203000-73
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 450: Show issues Location:
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  10. Article ; Online: Effect of foraminal enlargement on microcrack formation and apical transportation: a nano-CT assessment.

    Pinto, Jader Camilo / de Faria-Vasconcelos, Karla / Leite, André Ferreira / Pedano, Mariano Simón / Guerreiro-Tanomaru, Juliane / Jacobs, Reinhilde / Tanomaru-Filho, Mario

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 4881

    Abstract: The aim of this study was to evaluate the foraminal enlargement and its influence on microcrack formation and apical transportation in root canals with apical curvature. Eighteen maxillary lateral incisors with apical curvature were selected by using ... ...

    Abstract The aim of this study was to evaluate the foraminal enlargement and its influence on microcrack formation and apical transportation in root canals with apical curvature. Eighteen maxillary lateral incisors with apical curvature were selected by using micro-CT images. Root canals were randomly divided in two groups (n = 9) according to root canal preparation using two working lengths: 1 mm short of the apical foramen (control group) and 1 mm beyond the apical foramen (foraminal enlargement). For both groups Reciproc Blue R40 was used for root canal instrumentation. Specimens were scanned by nano-CT (UniTOM HR) before and after root canal preparation. Percentage, length, and width of microcracks, and apical transportation were assessed. Kappa, chi-square and McNemar tests were used for qualitative analyses while paired and unpaired t-test were used for quantitative analyses (α = 0.05). For both groups, rather similar and low percentages of microcracks were observed before root canal preparation (P > 0.05). The foraminal enlargement promoted new microcracks, not observed in the control group. An increase in microcrack length was observed when the foraminal enlargement was performed (P < 0.05). Higher apical transportation was observed when foraminal enlargement was performed (P < 0.05). Foraminal enlargement using a heat-treated reciprocating file size 40 promoted microcracks and higher apical transportation than root canal preparation up to 1 mm short of apical foramen.
    MeSH term(s) Hot Temperature ; Root Canal Preparation ; Tooth Apex/diagnostic imaging ; X-Ray Microtomography ; Humans
    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-31595-8
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