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  1. Article: Ala

    Andrés-Iglesias, Cristina / Fernandez-Bueno, Ivan / Pastor-Idoate, Salvador / Coco-Martin, Rosa M / Pastor, J Carlos

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1310463

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1310463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rank-Based Ant System with Originality Reinforcement and Pheromone Smoothing

    Sara Pérez-Carabaza / Akemi Gálvez / Andrés Iglesias

    Applied Sciences, Vol 12, Iss 11219, p

    2022  Volume 11219

    Abstract: Ant Colony Optimization (ACO) encompasses a family of metaheuristics inspired by the foraging behaviour of ants. Since the introduction of the first ACO algorithm, called Ant System (AS), several ACO variants have been proposed in the literature. Owing ... ...

    Abstract Ant Colony Optimization (ACO) encompasses a family of metaheuristics inspired by the foraging behaviour of ants. Since the introduction of the first ACO algorithm, called Ant System (AS), several ACO variants have been proposed in the literature. Owing to their superior performance over other alternatives, the most popular ACO algorithms are Rank-based Ant System (AS <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mrow></mrow><mrow><mi>R</mi><mi>a</mi><mi>n</mi><mi>k</mi></mrow></msub></semantics></math> ), Max-Min Ant System (MMAS) and Ant Colony System (ACS). While AS <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mrow></mrow><mrow><mi>R</mi><mi>a</mi><mi>n</mi><mi>k</mi></mrow></msub></semantics></math> shows a fast convergence to high-quality solutions, its performance is improved by other more widely used ACO variants such as MMAS and ACS, which are currently considered the state-of-the-art ACO algorithms for static combinatorial optimization problems. With the purpose of diversifying the search process and avoiding early convergence to a local optimal, the proposed approach extends AS <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mrow></mrow><mrow><mi>R</mi><mi>a</mi><mi>n</mi><mi>k</mi></mrow></msub></semantics></math> with an originality reinforcement strategy of the top-ranked solutions and a pheromone smoothing mechanism that is triggered before the algorithm reaches stagnation. The approach is tested on several symmetric and asymmetric Traveling Salesman Problem and Sequential Ordering Problem instances from TSPLIB benchmark. Our experimental results show that the proposed ...
    Keywords ant colony optimization ; metaheuristics ; pheromone smoothing ; originality reinforcement ; combinatorial optimization ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 511
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Silicone oil safety is not only a purity question.

    Andrés-Iglesias, Cristina / Pastor, José Carlos

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2020  Volume 259, Issue 1, Page(s) 269–270

    MeSH term(s) Benchmarking ; Humans ; Retinal Detachment/diagnosis ; Retinal Detachment/surgery ; Silicone Oils/adverse effects ; Vitrectomy
    Chemical Substances Silicone Oils
    Language English
    Publishing date 2020-10-09
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-020-04965-5
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    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.15: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Acute intraocular toxicity caused by perfluorocarbon liquids: safety control systems of medical devices.

    Srivastava, Girish K / Kalaiselvan, Vivekanandan / Andrés-Iglesias, Cristina / Shukla, Shatrunajay / Saxena, Rohit / Pastor, Jose Carlos

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2022  Volume 260, Issue 7, Page(s) 2103–2110

    Abstract: Background: Acute retinal toxicity has been demonstrated to be associated with the intraoperative use of perfluorocarbon liquids (PFCLs), especially perfluorooctane (PFO). Recently, several cases of PFO-associated blindness have been reported in Spain, ... ...

    Abstract Background: Acute retinal toxicity has been demonstrated to be associated with the intraoperative use of perfluorocarbon liquids (PFCLs), especially perfluorooctane (PFO). Recently, several cases of PFO-associated blindness have been reported in Spain, Holland, France, Italy, the Middle East, and South America.
    Methods: As a result, a new ISO guideline (ISO 16672:2020) was drafted, discussed, approved, and released in 2019. This recent ISO16672:2020 guideline recommends performing direct cytotoxicity tests as an option along with chemical analysis to measure PFCL quality (purity and safety).
    Results: In this review paper, it has been emphasized why an appropriate biological test, specifically direct exposure of PFCL to live cells, for measuring cytotoxicity must be performed with each PFCL batch along with chemical analysis.
    Conclusions: The paper intends to compile all available information to discuss possible approaches for avoiding adverse clinical cases in future.
    MeSH term(s) Fluorocarbons/toxicity ; France ; Humans ; Italy ; Middle East ; Retinal Detachment/chemically induced ; Retinal Detachment/surgery ; Spain
    Chemical Substances Fluorocarbons
    Language English
    Publishing date 2022-02-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-022-05578-w
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    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.15: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Reply to Letter to the Director: "Artificial Intelligence and new language models in Ophthalmology: Complications of the use of silicone oil in vitreoretinal surgery".

    Valentín-Bravo, F J / Mateos-Álvarez, E / Usategui-Martín, R / Andrés-Iglesias, C / Pastor-Jimeno, J C / Pastor-Idoate, S

    Archivos de la Sociedad Espanola de Oftalmologia

    2023  Volume 98, Issue 8, Page(s) 488–489

    MeSH term(s) Humans ; Ophthalmology ; Silicone Oils/adverse effects ; Vitreoretinal Surgery/adverse effects ; Artificial Intelligence ; Retinal Detachment/surgery
    Chemical Substances Silicone Oils
    Language English
    Publishing date 2023-06-21
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2173-5794
    ISSN (online) 2173-5794
    DOI 10.1016/j.oftale.2023.06.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Artificial Intelligence and new language models in Ophthalmology: Complications of the use of silicone oil in vitreoretinal surgery.

    Valentín-Bravo, F J / Mateos-Álvarez, E / Usategui-Martín, R / Andrés-Iglesias, C / Pastor-Jimeno, J C / Pastor-Idoate, S

    Archivos de la Sociedad Espanola de Oftalmologia

    2023  Volume 98, Issue 5, Page(s) 298–303

    Abstract: Artificial intelligence (AI) is an emerging technology that facilitates everyday tasks and automates tasks in various fields such as medicine. However, the emergence of a language model in academia has generated a lot of interest. This paper evaluates ... ...

    Abstract Artificial intelligence (AI) is an emerging technology that facilitates everyday tasks and automates tasks in various fields such as medicine. However, the emergence of a language model in academia has generated a lot of interest. This paper evaluates the potential of ChatGPT, a language model developed by OpenAI, and DALL-E 2, an image generator, in the writing of scientific articles in ophthalmology. The selected topic is the complications of the use of silicone oil in vitreoretinal surgery. ChatGPT was used to generate an abstract and a structured article, suggestions for a title and bibliographical references. In conclusion, despite the knowledge demonstrated by this tool, the scientific accuracy and reliability on specific topics is insufficient for the automatic generation of scientifically rigorous articles. In addition, scientists should be aware of the possible ethical and legal implications of these tools.
    MeSH term(s) Ophthalmology ; Artificial Intelligence ; Silicone Oils/adverse effects ; Vitreoretinal Surgery/adverse effects ; Reproducibility of Results ; Language
    Chemical Substances Silicone Oils
    Language English
    Publishing date 2023-04-22
    Publishing country Spain
    Document type Case Reports
    ISSN 2173-5794
    ISSN (online) 2173-5794
    DOI 10.1016/j.oftale.2023.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Visualization and Identification of Silicone Oil Emulsification Using Dynamic Infrared Confocal Scanning Laser Ophthalmoscopy.

    Valentín-Bravo, Francisco Javier / Stanga, Paulo Eduardo / Martínez-Tapia, Sebastián Alfonso / Mejía-Freire, Santiago / Stanga, Sebastian Eduardo Francis / Usategui-Martín, Ricardo / Andrés-Iglesias, Cristina / Pastor-Idoate, Salvador

    Case reports in ophthalmology

    2024  Volume 15, Issue 1, Page(s) 36–40

    Abstract: Introduction: Silicone oil (SO) is a crucial agent used as an intraocular tamponade in the treatment of complex vitreoretinal diseases. Despite its effectiveness, SO is prone to emulsification, which can lead to significant and sometimes irreversible ... ...

    Abstract Introduction: Silicone oil (SO) is a crucial agent used as an intraocular tamponade in the treatment of complex vitreoretinal diseases. Despite its effectiveness, SO is prone to emulsification, which can lead to significant and sometimes irreversible complications in both the anterior and posterior segments of the eye. The detection and monitoring of SO emulsification are therefore of paramount importance. Traditional imaging modalities have limitations in visualizing SO, leading to the exploration of more advanced imaging techniques. This study introduces the application of dynamic infrared confocal scanning laser ophthalmoscopy (IRcSLO) for this purpose and evaluates its effectiveness.
    Case presentation: We report on 2 patients who underwent pars plana vitrectomy with subsequent SO injection for the management of retinal detachment. Postsurgery, both patients were imaged using the Heidelberg Retina Tomography Spectralis IRcSLO. The focus was on the visualization of the SO status, including the presence and distribution of emulsified SO droplets. The IRcSLO imaging technique demonstrated its capability to effectively visualize emulsified SO droplets. Interestingly, this was also true for cases where the SO had been removed. The emulsified droplets were observed as micron-sized, spherical entities with a nonuniform distribution throughout the vitreous cavity.
    Conclusion: Dynamic IRcSLO has proven to be an effective imaging modality for visualizing the emulsification of SO, offering a novel perspective into the characterization of SO droplets. It facilitates the analysis of droplet count, motility, and precise localization within the vitreous cavity. The findings from the case presentations underscore the variability of SO emulsification patterns and the sensitivity of IRcSLO in detecting even minuscule emulsified droplets. This imaging technique has significant potential for future research, particularly in understanding the timing of emulsification, the factors contributing to it, and the development of possible preventive strategies. Additionally, it allows for a more in-depth analysis of the behavior of emulsified SO droplets across different SO viscosities, which could be instrumental in optimizing patient outcomes.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2577666-6
    ISSN 1663-2699
    ISSN 1663-2699
    DOI 10.1159/000535746
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  8. Article ; Online: Ex-Vivo Method to Quantifiably Evaluate the Staining Effectiveness of Anterior Lens Capsule Dyes.

    Fernandez-Bueno, Ivan / Usategui-Martín, Ricardo / Pastor, José Carlos / Andrés-Iglesias, Cristina

    Translational vision science & technology

    2021  Volume 10, Issue 14, Page(s) 17

    Abstract: Purpose: High frequency of cataracts and the requirements of new European Union regulations for medical devices require the availability of preclinical models to adequately evaluate anterior lens capsule dyes before their use in patients. Herein, we ... ...

    Abstract Purpose: High frequency of cataracts and the requirements of new European Union regulations for medical devices require the availability of preclinical models to adequately evaluate anterior lens capsule dyes before their use in patients. Herein, we describe an ex vivo method to quantifiably evaluate the macroscopic and microscopic staining effectiveness of anterior lens capsule dyes using porcine eyes.
    Methods: Commercially available trypan blue-based products or physiological saline solution (negative control) was injected into porcine eyes. Anterior pole and lens (after extraction) were macroscopically photographed, and the images were quantitatively analyzed. Lenses were histologically processed, and the staining intensity microscopically was semiquantified.
    Results: Macroscopic evaluation of the anterior pole revealed bluish staining of the anterior capsule; however, this coloring cannot be macroscopically discerned after lens extraction. Quantitative image analyses showed significant (P < 0.01) staining of the lens capsule compared to the negative control, but not significant (P > 0.05) between the products tested. Quantitative analysis of dying on lens images could not be performed. Microscopic semiquantification of the capsule staining intensity allows us to appreciate differences between products.
    Conclusions: The described method is a quick and useful tool for macroscopic evaluation by surgeons to choose an anterior capsule staining for use during everyday surgeries, and a more specific microscopic evaluation also allows us to determine the effectiveness and usefulness of these products.
    Translational relevance: This method satisfies preclinical effectiveness evaluations required by European Union regulations and complements the safety and toxicity evaluations that new products must guarantee before they enter the market and are used in clinical practice.
    MeSH term(s) Animals ; Anterior Capsule of the Lens/diagnostic imaging ; Coloring Agents ; Humans ; Lens Capsule, Crystalline ; Staining and Labeling ; Swine ; Trypan Blue
    Chemical Substances Coloring Agents ; Trypan Blue (I2ZWO3LS3M)
    Language English
    Publishing date 2021-12-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.10.14.17
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  9. Article ; Online: Production of molecular weight fractionated hemicelluloses hydrolyzates from spent coffee grounds combining hydrothermal extraction and a multistep ultrafiltration/diafiltration.

    Ramos-Andrés, Marta / Andrés-Iglesias, Cristina / García-Serna, Juan

    Bioresource technology

    2019  Volume 292, Page(s) 121940

    Abstract: Spent coffee grounds are a huge residual stream from instant coffee makers. The production of spent coffee oil and molecular weight fractionated hemicellulose hydrolysates via supercritical ... ...

    Abstract Spent coffee grounds are a huge residual stream from instant coffee makers. The production of spent coffee oil and molecular weight fractionated hemicellulose hydrolysates via supercritical CO
    MeSH term(s) Coffee ; Molecular Weight ; Polysaccharides ; Ultrafiltration
    Chemical Substances Coffee ; Polysaccharides ; hemicellulose (8024-50-8)
    Language English
    Publishing date 2019-08-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2019.121940
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    In stock of ZB MED Bonn / Germany

    Z 3258: Show issues

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  10. Article: Safety, biocompatibility, and potential functionality of a new accommodative intraocular lens: An experimental study in rabbits.

    Fernandez-Bueno, Ivan / Olcina, Luis Ignacio / Andrés-Iglesias, Cristina / Puertas-Neyra, Kevin / Fernández-Martínez, Itziar / Usategui-Martín, Ricardo / Maldonado-López, Miguel José

    Heliyon

    2023  Volume 9, Issue 9, Page(s) e19604

    Abstract: This study aims to evaluate the safety, biocompatibility, and functionality of a new accommodative intraocular lens (IOL) (LUZ, patent PCT/ES2016/070,813) after implantation in rabbit eyes. LUZ (Study) and EyeCee® plus a capsular ring (Control) were ... ...

    Abstract This study aims to evaluate the safety, biocompatibility, and functionality of a new accommodative intraocular lens (IOL) (LUZ, patent PCT/ES2016/070,813) after implantation in rabbit eyes. LUZ (Study) and EyeCee® plus a capsular ring (Control) were implanted in rabbits (
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e19604
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