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Article ; Online: Healthcare-associated infections point prevalence survey and antimicrobials use in acute care hospitals (PPS 2016–2017) and long-term care facilities (HALT-3)

Giancarlo Ripabelli / Angelo Salzo / Andrea Mariano / Michela L. Sammarco / Manuela Tamburro

Journal of Infection and Public Health, Vol 12, Iss 4, Pp 509-

a comprehensive report of the first experience in Molise Region, Central Italy, and targeted intervention strategies

2019 Volume 515

Abstract: Background: Healthcare associated infections (HAIs) are a major public health concern both in acute hospitals and long-term care facilities (LTCFs), considering the clinical presentations and related costs. The study describes the first regional ... ...

Abstract	Background: Healthcare associated infections (HAIs) are a major public health concern both in acute hospitals and long-term care facilities (LTCFs), considering the clinical presentations and related costs. The study describes the first regional experience on HAIs and antimicrobials consumption obtained through point prevalence survey (PPS) 2016–2017 in the “Antonio Cardarelli” acute hospital, and in the LTCF of Larino municipality (Healthcare-associated infections and Antimicrobial use in European Long-Term care facilities, HALT-3) of Molise Region, Central Italy, both coordinated by the European Center for Disease Control (ECDC). Methods: PPS was carried out during 24–26 November 2016, while HALT-3 on 29 June 2017. Standardized protocols and software provided by ECDC were used to collect facilities information, patients/residents, HAIs and antibiotic consumption data. Results: An active HAI was found in 16 (7.1%) of 224 admitted patients in the acute hospital, and 50% occurred in a clinical specialty ward. Bundles, checklist for HAIs prevention and antimicrobial stewardship were lacking. Among 29 LTCF residents the HAIs prevalence was 3.4%. Surveillance programs for HAIs and antimicrobial stewardship strategy were not available. Conclusion: The overall results identified the need and types of interventions to be implemented in both settings, either at organizational or individual level, to improve antibiotic prescription practice and limit risk factors involved in potentially preventable infections. Keywords: Healthcare-associated infections, Antibiotic use, Surveillance, Point prevalence survey, Italy
Keywords	Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aero-Medical Evacuation during SARS-CoV-2 Pandemic

Domenico Benvenuto / Tommaso Ascoli Bartoli / Ambrogio Curtolo / Claudia Palazzolo / Serena Vita / Andrea Mariano / Laura Scorzolini / Giuseppe Ippolito / Luisa Marchioni / Federico Cerini / Gianpiero D’Offizi / Francesco Vaia / Emanuele Nicastri

Journal of Clinical Medicine, Vol 12, Iss 1, p

Extraordinary Measure or Emerging Treatment Option?

2022 Volume 133

Abstract: Aero-medical evacuation has been considered as a feasible and safe treatment option during COVID pandemic, particularly when the needs of affected patients exceed what local clinics and hospitals are supposed to provide. In this article, we analyzed the ... ...

Abstract	Aero-medical evacuation has been considered as a feasible and safe treatment option during COVID pandemic, particularly when the needs of affected patients exceed what local clinics and hospitals are supposed to provide. In this article, we analyzed the clinical course of 17 patients medically evacuated to the “L. Spallanzani” Institute in Rome, Italy from foreign countries, mainly Africa and Eastern Europe, who had COVID-19 pneumonia with, or without, coinfections such as malaria, HIV, tuberculosis and microbiologically confirmed sepsis syndrome. The aero-medical evacuation of patients with infectious diseases has become one of the greatest medical achievements we have reached during this pandemic; in fact, only two patients with life threatening coinfections have died. Although logistically difficult and cost consuming, medical evacuation should be considered as a treatment option more than a single extraordinary measure, especially among complex cases that require specific technical and human resources.
Keywords	medical evacuation ; COVID-19 ; infectious diseases ; Medicine ; R
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Systematic analysis of direct antiglobulin test results in post-artesunate delayed haemolysis

Tommaso Ascoli Bartoli / Luciana Lepore / Alessandra D’Abramo / Giovanna Adamo / Angela Corpolongo / Laura Scorzolini / Maria Letizia Giancola / Nazario Bevilacqua / Claudia Palazzolo / Andrea Mariano / Giuseppe Ippolito / Pierre Buffet / Emanuele Nicastri

Malaria Journal, Vol 20, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract Background Post-artesunate delayed haemolysis (PADH) is common after severe malaria episodes. PADH is related to the “pitting” phenomenon and the synchronous delayed clearance of once-infected erythrocytes, initially spared during treatment. ... ...

Abstract	Abstract Background Post-artesunate delayed haemolysis (PADH) is common after severe malaria episodes. PADH is related to the “pitting” phenomenon and the synchronous delayed clearance of once-infected erythrocytes, initially spared during treatment. However, direct antiglobulin test (DAT) positivity has been reported in several PADH cases, suggesting a contribution of immune-mediated erythrocyte clearance. The aim of the present study was to compare clinical features of cases presenting a positive or negative DAT. Methods Articles reporting clinical data of patients diagnosed with PADH, for whom DAT had been performed, were collected from PubMed database. Data retrieved from single patients were extracted and univariate analysis was performed in order to identify features potentially related to DAT results and steroids use. Results Twenty-two studies reporting 39 PADH cases were included: median baseline parasitaemia was 20.8% (IQR: 11.2–30) and DAT was positive in 17 cases (45.5%). Compared to DAT-negative individuals, DAT-positive patients were older (49.5 vs 31; p = 0.01), had a higher baseline parasitaemia (27% vs 17%; p = 0.03) and were more commonly treated with systemic steroids (11 vs 3 patients, p = 0.002). Depth and kinetics of delayed anaemia were not associated with DAT positivity. Conclusions In this case series, almost half of the patients affected by PADH had a positive DAT. An obvious difference between the clinical courses of patients presenting with a positive or negative DAT was lacking. This observation suggests that DAT result may not be indicative of a pathogenic role of anti-erythrocytes antibodies in patients affected by PADH, but it may be rather a marker of immune activation.
Keywords	Malaria ; Artemisinins ; Artesunate ; Hemolytic anemia ; Coombs test ; Drug-related side effects and adverse reactions ; Arctic medicine. Tropical medicine ; RC955-962 ; Infectious and parasitic diseases ; RC109-216
Subject code	616
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Estrategia didáctica para el desarrollo del trabajo independiente de la asignatura Metodología de la Investigación Cualitativa en Salud

German Onelio Márquez Molina / Antonio Obed Tarajano Roselló / Andrea Mariano Mateo / Aldo Scrich Vázquez

Humanidades Médicas, Vol 13, Iss 2, Pp 498-

2013 Volume 525

Abstract: Introducción: La asignatura Metodología de la Investigación Cualitativa en Salud se imparte a los estudiantes de tercer año de la Licenciatura en Enfermería en la modalidad de clase teórico-práctica como forma organizativa de la docencia. Ello recalca la ...

Abstract	Introducción: La asignatura Metodología de la Investigación Cualitativa en Salud se imparte a los estudiantes de tercer año de la Licenciatura en Enfermería en la modalidad de clase teórico-práctica como forma organizativa de la docencia. Ello recalca la importancia del trabajo independiente. Las insuficiencias con relación a éste inciden directamente en la asimilación y apropiación de los conocimientos de la asignatura. Objetivo: Elaborar una estrategia didáctica que contribuya al desarrollo del trabajo independiente correspondiente a la asignatura Metodología de la Investigación Cualitativa en Salud. Material y métodos: Se realizó una investigación de desarrollo, encaminada a perfeccionar el proceso docente educativo en la Facultad de Enfermería, de la Universidad de Ciencias Médicas de Camagüey, durante el curso escolar 2011-2012. Para el diagnóstico inicial se procedió al análisis de documentos: los planes de estudio y el programa de la asignatura. También se aplicaron encuestas a un grupo de estudiantes y al colectivo de profesores que imparten la asignatura. Una vez elaborada la estrategia se evaluó por criterio de expertos. Resultados y discusión: La estrategia pone a disposición de la comunidad académica un software educativo que relaciona los contenidos de la asignatura, lo que permitirá al estudiantado realizar las tareas docentes que se orientan en clases así como asimilar, consolidar y sistematizar los conocimientos con mayor facilidad.
Keywords	estrategia didáctica ; metodología de la investigación cualitativa en salud ; software educativo ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270 ; Social sciences (General) ; H1-99
Language	Spanish
Publishing date	2013-07-01T00:00:00Z
Publisher	Centro para el Desarrollo de las Ciencias Sociales y Humanísticas en Salud
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Imported severe malaria and risk factors for intensive care

Alessandra D'Abramo / Luciana Lepore / Marco Iannetta / Saba Gebremeskel Tekle / Angela Corpolongo / Laura Scorzolini / Nazario Bevilacqua / Andrea Mariano / Maria Letizia Giancola / Antonella Vulcano / Micaela Maritti / Alessandro Agresta / Mario Antonini / Umberto D'Alessandro / Emanuele Nicastri / Spallanzani Group for Malaria Study

PLoS ONE, Vol 14, Iss 11, p e

A single-centre retrospective analysis.

2019 Volume 0225135

Abstract: OBJECTIVES:This study aims to identify the risk factors for intensive care (IC) in severe malaria patients admitted to the "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy. METHODS:All patients with confirmed severe malaria ... ...

Abstract	OBJECTIVES:This study aims to identify the risk factors for intensive care (IC) in severe malaria patients admitted to the "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy. METHODS:All patients with confirmed severe malaria and hospitalized between 2007 and 2015 were included in the analysis and stratified into two groups: those requiring IC and those who did not. Five prognostic malaria scores were estimated; clinical severity at IC unit admission was assessed using the Sequential Organ Failure Assessment and the quick-Sequential Organ Failure Assessment scores. Univariate and multivariate analysis were performed to assess factors independently associated to IC. RESULTS:A total of 98 severe malaria patients were included; 10 of them required IC. There were no deaths or sequelae. Patients requiring IC had higher severity scores. At the multivariate analysis, only the number of World Health Organization criteria and the aspartate aminotransferase value were independently associated with the need of IC. CONCLUSIONS:An early and accurate assessment of the severity score is essential for the management of severe malaria patients.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Invasive candidiasis due to Candida norvegensis in a liver transplant patient

Maria Musso / Maddalena Giannella / Mario Antonini / Eugenio Bordi / Giuseppe Maria Ettorre / Loretta Tessitore / Andrea Mariano / Alessandro Capone

Infectious Disease Reports, Vol 6, Iss

case report and literature review

2014 Volume 2

Abstract: Candida norvegensis is an emerging fluconazole-resistant pathogen isolated in most cases from skin and mucous membranes of immunocompromized patients. Documented invasive candidiasis (IC) due to C. norvegensis has been rarely reported, thus the clinical ... ...

Abstract	Candida norvegensis is an emerging fluconazole-resistant pathogen isolated in most cases from skin and mucous membranes of immunocompromized patients. Documented invasive candidiasis (IC) due to C. norvegensis has been rarely reported, thus the clinical features of patients at risk for this pathogen are poorly defined. We report a liver transplant patient who developed IC due to C. norvegensis and review other cases of C. norvegensis IC published in the literature.
Keywords	transplantation ; infection ; azole ; resistant ; fungal ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hepatitis A, Italy

Raffaele D'Amelio / Alfonso Mele / Andrea Mariano / Luisa Romanò / Roberto Biselli / Florigio Lista / Alessandro Zanetti / Tommaso Stroffolini

Emerging Infectious Diseases, Vol 11, Iss 7, Pp 1155-

2005 Volume 1156

Keywords	HAV ; Italy ; Seroprevalence ; Epidemiology ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2005-07-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy

Fabrizio Albarello / Elisa Pianura / Federica Di Stefano / Massimo Cristofaro / Ada Petrone / Luisa Marchioni / Claudia Palazzolo / Vincenzo Schininà / Emanuele Nicastri / Nicola Petrosillo / Paolo Campioni / Petersen Eskild / Alimuddin Zumla / Giuseppe Ippolito / Maria Alessandra Abbonizio / Chiara Agrati / Gioia Amadei / Alessandra Amendola / Mario Antonini /

Raffaella Barbaro / Barbara Bartolini / Martina Benigni / Nazario Bevilacqua / Licia Bordi / Veronica Bordoni / Marta Branca / Maria Rosaria Capobianchi / Cinzia Caporale / Ilaria Caravella / Fabrizio Carletti / Concetta Castilletti / Roberta Chiappini / Carmine Ciaralli / Francesca Colavita / Angela Corpolongo / Salvatore Curiale / Alessandra D’Abramo / Cristina Dantimi / Alessia De Angelis / Giada De Angelis / Rachele Di Lorenzo / Federica Ferraro / Lorena Fiorentini / Andrea Frustaci / Paola Gallì / Gabriele Garotto / Maria Letizia Giancola / Filippo Giansante / Emanuela Giombini / Maria Cristina Greci / Eleonora Lalle / Simone Lanini / Daniele Lapa / Luciana Lepore / Andrea Lucia / Franco Lufrani / Manuela Macchione / Alessandra Marani / Andrea Mariano / Maria Cristina Marini / Micaela Maritti / Giulia Matusali / Silvia Meschi / Francesco Messina Chiara Montaldo / Silvia Murachelli / Roberto Noto / Emanuele Pallini / Virgilio Passeri / Federico Pelliccioni / Antonella Petrecchia / Maria Pisciotta / Silvia Pittalis / Costanza Proietti / Vincenzo Puro / Gabriele Rinonapoli / Martina Rueca / Alessandra Sacchi / Francesco Sanasi / Carmen Santagata / Silvana Scarcia / Paola Scognamiglio / Laura Scorzolini / Giulia Stazi / Francesco Vaia / Francesco Vairo / Maria Beatrice Valli

International Journal of Infectious Diseases, Vol 93, Iss , Pp 192-

An uncommon radiological presentation

2020 Volume 197

Abstract: Introduction: Several recent case reports have described common early chest imaging findings of lung pathology caused by 2019 novel Coronavirus (SARS-COV2) which appear to be similar to those seen previously in SARS-CoV and MERS-CoV infected patients. ... ...

Abstract	Introduction: Several recent case reports have described common early chest imaging findings of lung pathology caused by 2019 novel Coronavirus (SARS-COV2) which appear to be similar to those seen previously in SARS-CoV and MERS-CoV infected patients. Objective: We present some remarkable imaging findings of the first two patients identified in Italy with COVID-19 infection travelling from Wuhan, China. The follow-up with chest X-Rays and CT scans was also included, showing a progressive adult respiratory distress syndrome (ARDS). Results: Moderate to severe progression of the lung infiltrates, with increasing percentage of high-density infiltrates sustained by a bilateral and multi-segmental extension of lung opacities, were seen. During the follow-up, apart from pleural effusions, a tubular and enlarged appearance of pulmonary vessels with a sudden caliber reduction was seen, mainly found in the dichotomic tracts, where the center of a new insurgent pulmonary lesion was seen. It could be an early alert radiological sign to predict initial lung deterioration. Another uncommon element was the presence of mediastinal lymphadenopathy with short-axis oval nodes. Conclusions: Although only two patients have been studied, these findings are consistent with the radiological pattern described in literature. Finally, the pulmonary vessels enlargement in areas where new lung infiltrates develop in the follow-up CT scan, could describe an early predictor radiological sign of lung impairment. Keywords: COVID-19, SARS-COV2, CT-scan, Ground glass opacities, Crazy-paving, Enlarged pulmonary vessels
Keywords	Infectious and parasitic diseases ; RC109-216 ; covid19
Subject code	610
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Estrategia didáctica para el desarrollo del trabajo independiente de la asignatura Metodología de la Investigación Cualitativa en Salud

German Onelio Márquez Molina / Antonio Obed Tarajano Roselló / Andrea Mariano Mateo / Aldo Scrich Vázquez

Humanidades Médicas, Vol 13, Iss 2, Pp 498-525

Abstract	Introducción: La asignatura Metodología de la Investigación Cualitativa en Salud se imparte a los estudiantes de tercer año de la Licenciatura en Enfermería en la modalidad de clase teórico-práctica como forma organizativa de la docencia. Ello recalca la importancia del trabajo independiente. Las insuficiencias con relación a éste inciden directamente en la asimilación y apropiación de los conocimientos de la asignatura. Objetivo: Elaborar una estrategia didáctica que contribuya al desarrollo del trabajo independiente correspondiente a la asignatura Metodología de la Investigación Cualitativa en Salud.Material y métodos: Se realizó una investigación de desarrollo, encaminada a perfeccionar el proceso docente educativo en la Facultad de Enfermería, de la Universidad de Ciencias Médicas de Camagüey, durante el curso escolar 2011-2012. Para el diagnóstico inicial se procedió al análisis de documentos: los planes de estudio y el programa de la asignatura. También se aplicaron encuestas a un grupo de estudiantes y al colectivo de profesores que imparten la asignatura. Una vez elaborada la estrategia se evaluó por criterio de expertos. Resultados y discusión: La estrategia pone a disposición de la comunidad académica un software educativo que relaciona los contenidos de la asignatura, lo que permitirá al estudiantado realizar las tareas docentes que se orientan en clases así como asimilar, consolidar y sistematizar los conocimientos con mayor facilidad.
Keywords	estrategia didáctica ; metodología de la investigación cualitativa en salud ; software educativo ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270 ; Social sciences (General) ; H1-99
Language	Spanish
Publisher	Centro para el Desarrollo de las Ciencias Sociales y Humanísticas en Salud
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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