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Article ; Online: In the Right Place at the Right Time

Ulises Ahumada-Castro / Galdo Bustos / Eduardo Silva-Pavez / Andrea Puebla-Huerta / Alenka Lovy / César Cárdenas

Frontiers in Cell and Developmental Biology, Vol

Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes

2021  Volume 9

Abstract: In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)- ...

Abstract In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+ communication on organelle function as well as catabolism and anabolism, particularly in cancer.
Keywords IP3Rs ; calcium ; endoplasmic reticulum ; mitochondria ; lysosome ; metabolism ; Biology (General) ; QH301-705.5
Language English
Publishing date 2021-03-01T00:00:00Z
Publisher Frontiers Media S.A.
Document type Article ; Online
Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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