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  1. Article ; Online: Exploration the homeostasis of signaling molecules in monocotyledonous crops with different CuO nanoparticle tolerance

    Barbara Kacziba / Ádám Szierer / Enikő Mészáros / Andrea Rónavári / Zoltán Kónya / Gábor Feigl

    Plant Stress, Vol 7, Iss , Pp 100145- (2023)

    2023  

    Abstract: Copper is an essential microelement that is indispensable for plant growth and development. The use of copper oxide nanoparticles (CuO NPs) in industry and agriculture has also increased because of their beneficial properties. However, excess amounts of ... ...

    Abstract Copper is an essential microelement that is indispensable for plant growth and development. The use of copper oxide nanoparticles (CuO NPs) in industry and agriculture has also increased because of their beneficial properties. However, excess amounts of CuO NPs may negatively affect the growth of monocotyledonous plant species, primarily through the generation of reactive oxygen species, which results in oxidative stress. Despite their increasingly widespread use, little is known regarding the signaling processes responsible for the effects of CuO NPs on the growth of monocotyledonous crops, or their impact on the homeostasis of reactive nitrogen species, hydrogen sulfide, and protein tyrosine nitration.In this study, the concentration of CuO NP that inhibits 50% of root growth was determined using sorghum, wheat, rye, and triticale as model plant species, and the NP-induced stress response and the balance of reactive molecules were assessed. Based on the effective concentration of CuO NP, wheat, rye, and triticale were more tolerant compared with sorghum, and entirely different response mechanisms in the homeostasis of reactive oxygen, nitrogen and sulfur species were observed. For the sensitive sorghum roots, the amount of reactive molecules was not significantly altered, whereas a significant increase in protein tyrosine nitration indicated a severely stressful state caused by CuO NPs. In contrast, the amount of reactive molecules increased significantly in the roots of the relatively tolerant species, and while the appearance of lipid peroxidation indicated oxidative stress, different changes in protein tyrosine nitration was associated with tolerance. The significant CuO NP-induced rise of endogenous H2S content in the root tips may be partly responsible for the relative tolerance of wheat, rye, and triticale compared with sorghum. CuO NP stress induced distinct modifications in the root tip cell walls of the examined species, where lignification was observed in the relatively sensitive sorghum, while in ...
    Keywords Copper oxide nanoparticles ; Monocotyledonous crops ; Sorghum ; Wheat ; Rye ; Triticale ; Plant ecology ; QK900-989
    Subject code 580
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Conversion Study on the Formation of Mechanochemically Synthesized BaTiO 3

    Gábor Kozma / Kata Lipták / Cora Deák / Andrea Rónavári / Ákos Kukovecz / Zoltán Kónya

    Chemistry, Vol 4, Iss 42, Pp 592-

    2022  Volume 602

    Abstract: Mechanochemistry is a method that can cover the energy demand of reaction pathways between solid materials. This requires enough energy to maintain the reactions between the starting materials. This is called “high-energy milling”. In our case, a ... ...

    Abstract Mechanochemistry is a method that can cover the energy demand of reaction pathways between solid materials. This requires enough energy to maintain the reactions between the starting materials. This is called “high-energy milling”. In our case, a planetary ball mill provided the required energy. Using the Burgio-equation, the required energy is determinable; the energy released during a single impact of a milling ball (E b ), as well as during the whole milling process (E cum ). The aim of this work was the one-step production of BaTiO 3 from BaO and TiO 2 starting materials. Whereas during mechanochemical reactions it is possible to produce nanoparticles of up to 10 nm, the essence of this study is to develop the preparation of BaTiO 3 with a perovskite structure even without subsequent heat treatment, since sintering at high temperatures is associated with a rapid increase in the size of the particles. By describing the synthesis parameters and their energy values (E b and E cum ), it is possible to transpose experimental conditions, so that in the case of other types of planetary ball mills or grinding vessel made of other materials, the results can be used. In this study, the mechanical treatment was carried out with a Fritsch Pulverisette-6 planetary ball mill and the transformation of the starting materials was investigated by X-ray diffractometric, Raman and Energy-dispersive X-ray spectroscopic, and transmission electron microscopic measurements.
    Keywords mechanochemistry ; perovskite ; BaTiO 3 ; ball-milling ; nanoparticles ; Chemistry ; QD1-999
    Subject code 670
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Polyvinyl-Pyrrolidone-Coated Silver Nanoparticles—The Colloidal, Chemical, and Biological Consequences of Steric Stabilization under Biorelevant Conditions

    Andrea Rónavári / Péter Bélteky / Eszter Boka / Dalma Zakupszky / Nóra Igaz / Bettina Szerencsés / Ilona Pfeiffer / Zoltán Kónya / Mónika Kiricsi

    International Journal of Molecular Sciences, Vol 22, Iss 8673, p

    2021  Volume 8673

    Abstract: 1) Background: Several properties of silver nanoparticles (AgNPs), such as cytotoxic, anticancer, and antimicrobial activities, have been subjects of intense research; however, important aspects such as nanoparticle aggregation are generally neglected, ... ...

    Abstract (1) Background: Several properties of silver nanoparticles (AgNPs), such as cytotoxic, anticancer, and antimicrobial activities, have been subjects of intense research; however, important aspects such as nanoparticle aggregation are generally neglected, although a decline in colloidal stability leads to a loss of the desired biological activities. Colloidal stability is affected by pH, ionic strength, or a plethora of biomolecules that interact with AgNPs under biorelevant conditions. (2) Methods: As only a few studies have focused on the relationship between aggregation behavior and the biological properties of AgNPs, here, we have systematically evaluated this issue by completing a thorough analysis of sterically (via polyvinyl-pyrrolidone (PVP)) stabilized AgNPs that were subjected to different circumstances. We assessed ultraviolet–visible light absorption, dynamic light scattering, zeta potential measurements, in vitro cell viability, and microdilution assays to screen both colloidal stability as well as bioactivity. (3) Results: The results revealed that although PVP provided outstanding biorelevant colloidal stability, the chemical stability of AgNPs could not be maintained completely with this capping material. (4) Conclusion: These unexpected findings led to the realization that stabilizing materials have more profound importance in association with biorelevant applications of nanomaterials than just being simple colloidal stabilizers.
    Keywords chemical stability ; steric stabilization ; aggregation behavior ; antimicrobial activity ; cytotoxicity ; anticancer activity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Green Silver and Gold Nanoparticles

    Andrea Rónavári / Nóra Igaz / Dóra I. Adamecz / Bettina Szerencsés / Csaba Molnar / Zoltán Kónya / Ilona Pfeiffer / Monika Kiricsi

    Molecules, Vol 26, Iss 4, p

    Biological Synthesis Approaches and Potentials for Biomedical Applications

    2021  Volume 844

    Abstract: The nanomaterial industry generates gigantic quantities of metal-based nanomaterials for various technological and biomedical applications; however, concomitantly, it places a massive burden on the environment by utilizing toxic chemicals for the ... ...

    Abstract The nanomaterial industry generates gigantic quantities of metal-based nanomaterials for various technological and biomedical applications; however, concomitantly, it places a massive burden on the environment by utilizing toxic chemicals for the production process and leaving hazardous waste materials behind. Moreover, the employed, often unpleasant chemicals can affect the biocompatibility of the generated particles and severely restrict their application possibilities. On these grounds, green synthetic approaches have emerged, offering eco-friendly, sustainable, nature-derived alternative production methods, thus attenuating the ecological footprint of the nanomaterial industry. In the last decade, a plethora of biological materials has been tested to probe their suitability for nanomaterial synthesis. Although most of these approaches were successful, a large body of evidence indicates that the green material or entity used for the production would substantially define the physical and chemical properties and as a consequence, the biological activities of the obtained nanomaterials. The present review provides a comprehensive collection of the most recent green methodologies, surveys the major nanoparticle characterization techniques and screens the effects triggered by the obtained nanomaterials in various living systems to give an impression on the biomedical potential of green synthesized silver and gold nanoparticles.
    Keywords green synthesis ; silver nanoparticle ; gold nanoparticle ; nanoparticle characterization ; antimicrobial activity ; toxicity ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Estradiol-Based Salicylaldehyde (Thio)Semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities

    Tatsiana V. Petrasheuskaya / Ferenc Kovács / Nóra Igaz / Andrea Rónavári / Bálint Hajdu / Laura Bereczki / Nóra V. May / Gabriella Spengler / Béla Gyurcsik / Mónika Kiricsi / Éva Frank / Éva A. Enyedy

    Molecules, Vol 28, Iss 1, p

    2022  Volume 54

    Abstract: A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1 H and ¹³C nuclear magnetic resonance spectroscopy, UV– ... ...

    Abstract A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1 H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% ( v/v ) DMSO/H 2 O. Estradiol-(T)SCs form mono-ligand complexes with Cu(II) ions and exhibit high stability with the exception of estradiol-SC. The Cu(II) complexes of estradiol-TSC and its N,N -dimethyl derivative displayed the highest cytotoxicity among the tested compounds in MCF-7, MCF-7 KCR, DU-145, and A549 cancer cells. The complexes do not damage DNA according to both in vitro cell-free and cellular assays. All the Cu(II)-TSC complexes revealed significant activity against the Gram-positive Staphylococcus aureus bacteria strain. Estradiol-TSCs showed efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not result in significant changes to physico-chemical and biological properties.
    Keywords estradiol hybrids ; (thio)semicarbazones ; cytotoxicity ; solution equilibrium ; EPR spectroscopy ; X-ray crystal structure ; Organic chemistry ; QD241-441
    Subject code 540 ; 500
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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