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Article ; Online: Virtual Reality Augmented Feedback Rehabilitation Associated to Action Observation Therapy in Buccofacial Apraxia

Daniele Emedoli / Maddalena Arosio / Andrea Tettamanti / Sandro Iannaccone

Clinical Medicine Insights: Case Reports, Vol

Case Report

2021 Volume 14

Abstract: Background: Buccofacial Apraxia is defined as the inability to perform voluntary movements of the larynx, pharynx, mandible, tongue, lips and cheeks, while automatic or reflexive control of these structures is preserved. Buccofacial Apraxia frequently co- ...

Abstract	Background: Buccofacial Apraxia is defined as the inability to perform voluntary movements of the larynx, pharynx, mandible, tongue, lips and cheeks, while automatic or reflexive control of these structures is preserved. Buccofacial Apraxia frequently co-occurs with aphasia and apraxia of speech and it has been reported as almost exclusively resulting from a lesion of the left hemisphere. Recent studies have demonstrated the benefit of treating apraxia using motor training principles such as Augmented Feedback or Action Observation Therapy. In light of this, the study describes the treatment based on immersive Action Observation Therapy and Virtual Reality Augmented Feedback in a case of Buccofacial Apraxia. Participant and Methods: The participant is a right-handed 58-years-old male. He underwent a neurosurgery intervention of craniotomy and exeresis of infra axial expansive lesion in the frontoparietal convexity compatible with an atypical meningioma. Buccofacial Apraxia was diagnosed by a neurologist and evaluated by the Upper and Lower Face Apraxia Test. Buccofacial Apraxia was quantified also by a specific camera, with an appropriately developed software, able to detect the range of motion of automatic face movements and the range of the same movements on voluntary requests. In order to improve voluntary movements, the participant completed fifteen 1-hour rehabilitation sessions, composed of a 20-minutes immersive Action Observation Therapy followed by a 40-minutes Virtual Reality Augmented Feedback sessions, 5 days a week, for 3 consecutive weeks. Results: After treatment, participant achieved great improvements in quality and range of facial movements, performing most of the facial expressions (eg, kiss, smile, lateral angle of mouth displacement) without unsolicited movement. Furthermore, the Upper and Lower Face Apraxia Test showed an improvement of 118% for the Upper Face movements and of 200% for the Lower Face movements. Conclusion: Performing voluntary movement in a Virtual Reality environment with ...
Keywords	Medicine (General) ; R5-920
Subject code	796 ; 629
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Validation of a graphic test to quantitatively assess the dominant hand dexterity

Alessandra Angelucci / Andrea Tettamanti / Elisabetta Sarasso / Massimo Filippi / Andrea Aliverti / Marina Scarlato

PLoS ONE, Vol 17, Iss

2022 Volume 8

Abstract: Dexterity dysfunction is a key feature of disability in many neurological and non-neurological diseases. The Nine-Hole Peg Test (NHPT) is the most used test to assess hand dexterity in clinical practice but presents limitations. A new graphic test to ... ...

Abstract	Dexterity dysfunction is a key feature of disability in many neurological and non-neurological diseases. The Nine-Hole Peg Test (NHPT) is the most used test to assess hand dexterity in clinical practice but presents limitations. A new graphic test to enhance objective evaluation of the of the dominant hand dexterity is proposed. The task consists in drawing a continuous line in paths composed by a part with multiple orthogonal changes of direction (‘meander’), and a second part derived from the Archimedean spiral (‘spiral’). The test was validated in 200 healthy controls and 93 neurological patients. 48 patients performed also the NHPT. Several parameters were analyzed, among which total time, total length, number of touches and number of crossings. Healthy subjects display statistically significant differences with respect to pathological subjects in the case of total time, number of touches, and number of crossings (p<0.001), but not in the case of total length (p = 0.27) needed to complete the second sheet. Moreover, healthy controls display a learning effect, the time needed to complete the second sheet was significantly lower than for the first sheet (p<0.001), and an inverse correlation with age was observed (r = 0.56, p<0.001). The comparison between the NHPT and the new test showed a strong positive correlation (r = 0.71, p<0.001) whereas touches and crossing a weak positive one (r = 0.35, p = 0.01). The new test distinguishes between a slow but precise performance and a fast but imprecise performance, thus providing additional information with respect to NHPT.
Keywords	Medicine ; R ; Science ; Q
Subject code	150
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Validation of a graphic test to quantitatively assess the dominant hand dexterity.

Alessandra Angelucci / Andrea Tettamanti / Elisabetta Sarasso / Massimo Filippi / Andrea Aliverti / Marina Scarlato

PLoS ONE, Vol 17, Iss 8, p e

2022 Volume 0271889

Abstract	Dexterity dysfunction is a key feature of disability in many neurological and non-neurological diseases. The Nine-Hole Peg Test (NHPT) is the most used test to assess hand dexterity in clinical practice but presents limitations. A new graphic test to enhance objective evaluation of the of the dominant hand dexterity is proposed. The task consists in drawing a continuous line in paths composed by a part with multiple orthogonal changes of direction ('meander'), and a second part derived from the Archimedean spiral ('spiral'). The test was validated in 200 healthy controls and 93 neurological patients. 48 patients performed also the NHPT. Several parameters were analyzed, among which total time, total length, number of touches and number of crossings. Healthy subjects display statistically significant differences with respect to pathological subjects in the case of total time, number of touches, and number of crossings (p<0.001), but not in the case of total length (p = 0.27) needed to complete the second sheet. Moreover, healthy controls display a learning effect, the time needed to complete the second sheet was significantly lower than for the first sheet (p<0.001), and an inverse correlation with age was observed (r = 0.56, p<0.001). The comparison between the NHPT and the new test showed a strong positive correlation (r = 0.71, p<0.001) whereas touches and crossing a weak positive one (r = 0.35, p = 0.01). The new test distinguishes between a slow but precise performance and a fast but imprecise performance, thus providing additional information with respect to NHPT.
Keywords	Medicine ; R ; Science ; Q
Subject code	150
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Continuity of care for patients with dementia during COVID-19 pandemic

Daniele Emedoli / Elise Houdayer / Pasquale Anthony Della Rosa / Alice Zito / Luigia Brugliera / Paolo Cimino / Jeffrey David Padul / Andrea Tettamanti / Sandro Iannaccone / Federica Alemanno

Frontiers in Public Health, Vol

flexibility and integration between in-person and remote visits

2024 Volume 11

Abstract: IntroductionDuring the pandemic, the Cognitive Disorders Unit of San Raffaele Hospital (Milan, Italy) offered patients the opportunity to undergo neuropsychological evaluations and cognitive training through telemedicine.MethodWe conducted an ... ...

Abstract	IntroductionDuring the pandemic, the Cognitive Disorders Unit of San Raffaele Hospital (Milan, Italy) offered patients the opportunity to undergo neuropsychological evaluations and cognitive training through telemedicine.MethodWe conducted an investigation to assess how patients responded to this option and to determine if telemedicine could ensure continuity of care.ResultsBetween October 2019 and May 2022, a total of 5,768 telemedicine appointments and 8,190 in-person outpatient appointments were conducted, resulting in an increase in the rate of telemedicine activity from 16.81% in January 2020 to 23.21% in May 2022. Peaks in telemedicine activity reached 85.64% in May 2020 and 83.65% in February 2021, both representing a significant portion of the total activity. Interestingly, there was a notable positive correlation between telemedicine activity and the worsening of the Italian pandemic (r = 0.433, p = 0.027).DiscussionDuring the peaks of contagion, the total number of visits remained stable, highlighting that telemedicine effectively served as a valuable and efficient tool to ensure continuity of care for vulnerable patients. This was evident from the integration of remote visits with in-person appointments.
Keywords	telemedicine ; telerehabilitation ; cognitive disorders ; cognitive training ; neuropsychology ; COVID-19 ; Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sarcopenia is a Frequent Disease in Sars-Cov-2 Infection

Sandro Iannaccone / Luigia Brugliera / Alfio Spina / Gianluca Nocera / Andrea Tettamanti / Alessandra Giordani / Sara Angelone / Paola Castellazzi / Paolo Cimino / Jeffrey D. Padul / Elise Houdayer / Federica Alemanno

Journal of Rehabilitation Medicine - Clinical Communications, Vol

2023 Volume 6

Abstract: Objective: We aimed to investigate the clinical symptoms and specific care requirements of SARSCoV-2 patients who were admitted to a COVID-19 Rehabilitation Unit while still infectious for SARSCoV-2 and in the subacute phase of the disease. Methods: ... ...

Abstract	Objective: We aimed to investigate the clinical symptoms and specific care requirements of SARSCoV-2 patients who were admitted to a COVID-19 Rehabilitation Unit while still infectious for SARSCoV-2 and in the subacute phase of the disease. Methods: Patients admitted to our COVID-19 Rehabilitation Unit from March 2020 to December 2020 were evaluated for sarcopenia, and they also completed the following assessments: functional independence measure, short physical performance battery and Hamilton Rating Scale for Depression. Age and body mass index and symptoms of dysosmia or dysgeusia were also recorded. Results: A total of 126 patients were enrolled (50 women, median age 72 years, 18.7 years), of whom 82% of patients presented with low grip strength. Sarcopenia was diagnosed in 52 patients. Sarcopenic patients were older than nonsarcopenic ones (median age 73.4 years, IQR 13.2 vs 63.9 years, IQR 14.5, respectively, p = 0.014). Sarcopenia was associated with the presence of depression (p = 0.008), was more common in women (p = 0.023) and was associated with greater functional deficits (functional independence measure and short physical performance battery analyses, p < 0.05). Sarcopenic patients also had a lower body mass index than other patients (p < 0.01). Conclusion: More than 40% of our patients suffered from sarcopenia, which was associated with ageing, depression, low body mass index, reduction in functional autonomy and being a woman. Such data provide evidence for the need to assist hospitalized COVID-19 patients by means of a multidisciplinary specialist team. LAY ABSTRACT Many COVID-19 patients who require hospitalization in the first phase of the disease benefit from respiratory, motor or cognitive rehabilitation before being dismissed from the hospital. During this rehabilitative phase, these patients are still positive for SARS-CoV-2 and potentially infectious, although their symptoms might differ from the symptoms they encountered in the first days. The objective of this study was to examine ...
Keywords	SARS-CoV-2 ; sarcopenia ; rehabilitation ; COVID-19 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Medical Journals Sweden
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rehabilitation of COVID-19 patients

Luigia Brugliera / Alfio Spina / Paola Castellazzi / Paolo Cimino / Andrea Tettamanti / Elise Houdayer / Pietro Arcuri / Federica Alemanno / Pietro Mortini / Sandro Iannaccone

Journal of Rehabilitation Medicine, Vol 52, Iss 4, p jrm

2020 Volume 00046

Keywords	Therapeutics. Pharmacology ; RM1-950 ; covid19
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Foundation for Rehabilitation Information
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rehabilitation of COVID-19 patients

Luigia Brugliera / Alfio Spina / Paola Castellazzi / Paolo Cimino / Andrea Tettamanti / Elise Houdayer / Pietro Arcuri / Federica Alemanno / Pietro Mortini / Sandro Iannaccone

2020

Abstract: ... n/ ... ...

Abstract	n/a
Keywords	COVID-19 ; Physical Therapy ; Sports Therapy and Rehabilitation ; Rehabilitation ; General Medicine ; covid19
Language	English
Publishing date	2020-04-01
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 cognitive deficits after respiratory assistance in the subacute phase

Federica Alemanno / Elise Houdayer / Anna Parma / Alfio Spina / Alessandra Del Forno / Alessandra Scatolini / Sara Angelone / Luigia Brugliera / Andrea Tettamanti / Luigi Beretta / Sandro Iannaccone

PLoS ONE, Vol 16, Iss 2, p e

A COVID-rehabilitation unit experience.

2021 Volume 0246590

Abstract: Introduction COVID-19 complications can include neurological, psychiatric, psychological, and psychosocial impairments. Little is known on the consequences of SARS-COV-2 on cognitive functions of patients in the sub-acute phase of the disease. We aimed ... ...

Abstract	Introduction COVID-19 complications can include neurological, psychiatric, psychological, and psychosocial impairments. Little is known on the consequences of SARS-COV-2 on cognitive functions of patients in the sub-acute phase of the disease. We aimed to investigate the impact of COVID-19 on cognitive functions of patients admitted to the COVID-19 Rehabilitation Unit of the San Raffaele Hospital (Milan, Italy). Material and methods 87 patients admitted to the COVID-19 Rehabilitation Unit from March 27th to June 20th 2020 were included. Patients underwent Mini Mental State Evaluation (MMSE), Montreal Cognitive Assessment (MoCA), Hamilton Rating Scale for Depression, and Functional Independence Measure (FIM). Data were divided in 4 groups according to the respiratory assistance in the acute phase: Group1 (orotracheal intubation), Group2 (non-invasive ventilation using Biphasic Positive Airway Pressure), Group3 (Venturi Masks), Group4 (no oxygen therapy). Follow-ups were performed at one month after home-discharge. Results Out of the 87 patients (62 Male, mean age 67.23 ± 12.89 years), 80% had neuropsychological deficits (MoCA and MMSE) and 40% showed mild-to-moderate depression. Group1 had higher scores than Group3 for visuospatial/executive functions (p = 0.016), naming (p = 0.024), short- and long-term memory (p = 0.010, p = 0.005), abstraction (p = 0.024), and orientation (p = 0.034). Group1 was younger than Groups2 and 3. Cognitive impairments correlated with patients' age. Only 18 patients presented with anosmia. Their data did not differ from the other patients. FIM (<100) did not differ between groups. Patients partly recovered at one-month follow-up and 43% showed signs of post-traumatic stress disorder. Conclusion Patients with severe functional impairments had important cognitive and emotional deficits which might have been influenced by the choice of ventilatory therapy, but mostly appeared to be related to aging, independently of FIM scores. These findings should be integrated for correct ...
Keywords	Medicine ; R ; Science ; Q
Subject code	150
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effectiveness of treatments for acute and sub-acute mechanical non-specific low back pain

Silvia Gianola / Greta Castellini / Anita Andreano / Davide Corbetta / Pamela Frigerio / Valentina Pecoraro / Valentina Redaelli / Andrea Tettamanti / Andrea Turolla / Lorenzo Moja / Maria Grazia Valsecchi

Systematic Reviews, Vol 8, Iss 1, Pp 1-

protocol for a systematic review and network meta-analysis

2019 Volume 8

Abstract: Abstract Background Non-specific low back pain (LBP) is the leading cause of disability worldwide. Acute LBP usually has a good prognosis, with rapid improvement within the first 6 weeks. However, the majority of patients develop chronic LBP and suffer ... ...

Abstract	Abstract Background Non-specific low back pain (LBP) is the leading cause of disability worldwide. Acute LBP usually has a good prognosis, with rapid improvement within the first 6 weeks. However, the majority of patients develop chronic LBP and suffer from recurrences. For clinical management, a plethora of treatments is currently available but evidence of the most effective options is lacking. The objective of this study will be to identify the most effective interventions to relieve pain and reduce disability in acute and sub-acute non-specific LBP. Methods/design We will search electronic databases (MEDLINE, Embase, CENTRAL) from inception onwards. The eligible population will be individuals with non-specific LBP older than 18 years, both males and females, who experience pain less than 6 weeks (acute) or between 6 and 12 weeks (subacute). Eligible interventions and comparators will include all conservative rehabilitation or pharmacological treatments provided by any health professional; the only eligible study design will be a randomized controlled trial. The primary outcomes will be pain intensity and back-specific functional status. Secondary outcomes will be any adverse events. Studies published in languages other than English will also potentially be included. Two reviewers will independently screen the titles and abstracts retrieved from a literature search, as well as potentially relevant full-text articles. General characteristics, potential effect modifiers, and outcome data will be extracted from the included studies, and the risk of bias will be appraised. Conflicts at all levels of screening and abstraction will be resolved through team discussions. After describing the results of the review, if appropriate, a random effects meta-analysis and network meta-analysis will be conducted in a frequentist setting, assuming equal heterogeneity across all treatment comparisons and accounting for correlations induced by multi-arm studies using a multivariate normal model. Discussion Our systematic review ...
Keywords	Medicine ; R
Subject code	650 ; 028
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intra‐arterial transplantation of HLA‐matched donor mesoangioblasts in Duchenne muscular dystrophy

Giulio Cossu / Stefano C Previtali / Sara Napolitano / Maria Pia Cicalese / Francesco Saverio Tedesco / Francesca Nicastro / Maddalena Noviello / Urmas Roostalu / Maria Grazia Natali Sora / Marina Scarlato / Maurizio De Pellegrin / Claudia Godi / Serena Giuliani / Francesca Ciotti / Rossana Tonlorenzi / Isabella Lorenzetti / Cristina Rivellini / Sara Benedetti / Roberto Gatti /

Sarah Marktel / Benedetta Mazzi / Andrea Tettamanti / Martina Ragazzi / Maria Adele Imro / Giuseppina Marano / Alessandro Ambrosi / Rossana Fiori / Maria Pia Sormani / Chiara Bonini / Massimo Venturini / Letterio S Politi / Yvan Torrente / Fabio Ciceri

EMBO Molecular Medicine, Vol 8, Iss 12, Pp 1470-

2016 Volume 1471

Keywords	Medicine (General) ; R5-920 ; Genetics ; QH426-470
Language	English
Publishing date	2016-12-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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