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Article ; Online: Relative Humidity and Its Impact on the Immune System and Infections

Gabriella Guarnieri / Bianca Olivieri / Gianenrico Senna / Andrea Vianello

International Journal of Molecular Sciences, Vol 24, Iss 9456, p

2023 Volume 9456

Abstract: Relative humidity (RH) represents an underestimated outdoor and indoor environmental parameter. Conditions below and above the optimal range could facilitate infectious transmission as well as the exacerbation of respiratory diseases. The aim of this ... ...

Abstract	Relative humidity (RH) represents an underestimated outdoor and indoor environmental parameter. Conditions below and above the optimal range could facilitate infectious transmission as well as the exacerbation of respiratory diseases. The aim of this review is to outline the consequences for health of suboptimal RH in the environment and how to limit this negative impact. RH primarily affects the rheological properties of the mucus, modifying its osmolarity and thus the mucociliary clearance. The integrity of the physical barrier, maintained by mucus and tight junctions, is critical for protection from pathogens or irritants. Moreover, the control of RH seems to be a strategy to prevent and control the spread of viruses and bacteria. However, the imbalance of RH in the outdoor and indoor environments is frequently associated with the presence of other irritants, allergens, and pathogens, and therefore the burden of a single risk factor is not clearly defined in different situations. Nonetheless, RHmay have a synergistic negative effect with these risk factors, and its normalization, if possible, may have a positive impact on a healthier environment.
Keywords	molecular mechanisms ; prevention ; asthma ; allergic rhinitis ; infection ; respiratory diseases ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	306
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Publishing Eurac Research data on the GEOSS Platform

Roberto Roncella / Bartolomeo Ventura / Andrea Vianello / Enrico Boldrini / Mattia Santoro / Paolo Mazzetti / Stefano Nativi

Big Earth Data, Vol 7, Iss 2, Pp 428-

2023 Volume 450

Abstract: ABSTRACTThis paper is the third of a series that introduces some of the main dataset resources presently shared through the GEOSS Platform. The GEOSS Platform is a brokering infrastructure that brokers more than 190 autonomous information systems and ... ...

Abstract	ABSTRACTThis paper is the third of a series that introduces some of the main dataset resources presently shared through the GEOSS Platform. The GEOSS Platform is a brokering infrastructure that brokers more than 190 autonomous information systems and data catalogs; it was created to provide the technological tool to implement the Global Earth Observation System of Systems (GEOSS). This manuscript focuses on the analysis of Eurac Research datasets and illustrates the data publishing process to enroll the Eurac Research Data Provider to the GEOSS Platform through the administrative and technical registrations. The study provides an analysis of the GEOSS user searches for Eurac Research data in order to understand the main use of datasets of an important Data Provider.
Keywords	GEOSS ; data interoperability ; data sharing ; Eurac Research ; Earth observation ; Geography. Anthropology. Recreation ; G ; Geology ; QE1-996.5
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: AlpConv Atlas

Stefano Della Chiesa / Andrea Vianello / Simone Tritini / Aureliano Piva

Research Ideas and Outcomes, Vol 7, Iss , Pp 1-

The Geospatial Content Management System of the Alpine Convention

2021 Volume 5

Abstract: The Alpine Convention (AC) promotes research, cooperation and monitoring activities in the Alpine region. In this framework, the AC Atlas is the official content management system for geographical data published by the Alpine Convention. The AC Atlas' ... ...

Abstract	The Alpine Convention (AC) promotes research, cooperation and monitoring activities in the Alpine region. In this framework, the AC Atlas is the official content management system for geographical data published by the Alpine Convention. The AC Atlas' final goal is to promote, collect, organize, and disseminate the results of research activities carried out by the Alpine Convention, its Working Groups and by European projects in the Alpine region.The system is based on the open-source GeoNode platform supporting standard OGC services. Hence, the AlpConv Atlas allows for browsing, searching, editing documents, layers, maps, and related metadata by an intuitive web-based graphical user interface. The AC Atlas is finally a collaborative platform for managing various geographical data and the related documentation, which can be of great interest to several stakeholders.
Keywords	Science ; Q
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Severe Asthma, Telemedicine, and Self-Administered Therapy

Gabriella Guarnieri / Marco Caminati / Alessia Achille / Rachele Vaia / Fulvia Chieco Bianchi / Gianenrico Senna / Andrea Vianello

Journal of Clinical Medicine, Vol 11, Iss 960, p

Listening First to the Patient

2022 Volume 960

Abstract: Severe asthma patients are at an increased risk of major complications and they need to be monitored regularly. The COVID-19 pandemic has notably impacted on the health care resources. The telemedicine approach applied to the follow-up of asthmatic ... ...

Abstract	Severe asthma patients are at an increased risk of major complications and they need to be monitored regularly. The COVID-19 pandemic has notably impacted on the health care resources. The telemedicine approach applied to the follow-up of asthmatic patients has been proven to be effective in monitoring their disease and their adherence to the therapy. The aim of our study was to investigate the satisfaction of severe asthma patients before the activation of a telemedicine management, as well as their current experience with self-administration of injection therapy. An ad hoc questionnaire was developed and sent by e-mail to 180 severe asthma patients. Most of subjects, 82%, were confident with the idea of doing self-measurements and self-managing their disease. Further, 77% of subjects favoured to carry out virtual visits and telemedicine. Regarding the home treatment, 93% of patients considered the self-injection therapy easy, 94% of subjects felt safe, and 93% were not worried while self-administering. Only mild adverse events were reported in 22% of patients after self-administration. Our results showed an agreement between what is considered necessary and practicable by healthcare personnel and what is perceived by the severe asthma patients in terms of treatment and monitoring of the disease with Telehealth. Biologics have a safety profile and can be easily self-administred at home.
Keywords	patient empowerment ; home-administration ; patient preferences ; adherence ; biologics ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical response to biologicals for severe asthma

Roberto Benoni / Silvia Panunzi / Veronica Batani / Francesca Moretti / Stefano Fuggini / Mattia Todesco / Gianenrico Senna / Albino Poli / Andrea Vianello / Marco Caminati

ERJ Open Research, Vol 8, Iss

any relevance for sex in different age ranges?

2022 Volume 3

Abstract: Background Whether sex can influence the clinical response to biological treatment in patients with severe asthma has not been fully addressed. Aims and methods The aim of this study was to investigate in patients with severe asthma undergoing biological ...

Abstract	Background Whether sex can influence the clinical response to biological treatment in patients with severe asthma has not been fully addressed. Aims and methods The aim of this study was to investigate in patients with severe asthma undergoing biological treatment the individual evolution of lung function measurements and patient-reported asthma control scores over a 12-month follow-up period, in relation to patients’ sex, in different age ranges. Second, the change in the administered dose of oral corticosteroids (OCS) before and after 12 months of treatment was investigated. Results 64 patients (58% female and 42% male) with a median age of 52 years were enrolled in the study. There were no relevant differences between sexes in terms of lung function, patient-reported asthma control, exacerbation rate and daily OCS dose within the study timeframe. A separate sub-analysis by biological treatment confirmed the same finding. Stratifying individuals by age, we showed that older men had lower lung function parameter values (forced expiratory volume in 1 s (FEV1) % predicted and FEV1/forced vital capacity index) than older women, whereas an opposite trend was observed in terms of Asthma Control Test score. No other relevant differences were detected after age stratification. Conclusion According to our findings, sex does not act as a determinant of treatment response to biologicals in people with severe asthma. Although to be confirmed in larger studies, our data suggest that neither sex nor age should limit biological treatment prescription, once the eligibility criteria for that therapy are satisfied.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	European Respiratory Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Benralizumab Efficacy in Late Non-Responders to Mepolizumab and Variables Associated with Occurrence of Switching

Marco Caminati / Alessandro Marcon / Gabriella Guarnieri / Jessica Miotti / Diego Bagnasco / Giovanna Elisiana Carpagnano / Girolamo Pelaia / Rachele Vaia / Matteo Maule / Andrea Vianello / Gianenrico Senna

Journal of Clinical Medicine, Vol 12, Iss 1836, p

A Real-Word Perspective

2023 Volume 1836

Abstract: Overlapping eligibility to different biologics for severe asthma is still challenging, especially when addressing the same target. We aimed to characterize severe eosinophilic asthma patients according to their maintained or reduced response to ... ...

Abstract	Overlapping eligibility to different biologics for severe asthma is still challenging, especially when addressing the same target. We aimed to characterize severe eosinophilic asthma patients according to their maintained or reduced response to mepolizumab over time and to explore baseline variables significantly associated with the occurrence of switching to benralizumab. We performed a multicentre retrospective observational study evaluating OCS reduction, exacerbation rate, lung function, exhaled nitric oxide levels (FeNO), Asthma control test (ACT), and blood eosinophil concentrations at baseline and before and after switching occurrence among 43 female and 25 male patients with severe asthma aged 23 to 84 years. Younger age, higher OCS daily dose and lower blood eosinophils at baseline were associated with a significantly higher risk (odds) for switching occurrence. All the patients showed an optimal response to mepolizumab, up to six months. The need for switching, according to the above-mentioned criterion, occurred for 30 out of 68 patients after a median time of 21 months (Q1–Q3: 12–24) from mepolizumab initiation. At the follow-up time-point after the switch (median time: 31 months, Q–Q3: 22–35), all the outcomes substantially improved and no cases of poor clinical response to benralizumab were detected. Although the small sample size and the retrospective design represent major limitations, to our knowledge, our study provides the first real-word focus on clinical variables potentially predicting a better response to anti IL-5r in patients fully eligible for both mepolizumab and benralizumab and suggests that in late non responder patients to mepolizumab, more robustly targeting the IL-5 axis may be effective.
Keywords	severe eosinophilic asthma ; benralizumab ; mepolizumab ; switch ; clinical response ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hidden Comorbidities in Asthma

Matteo Maule / Bianca Olivieri / Gabriella Guarnieri / Lucia De Franceschi / Nicola Martinelli / Rachele Vaia / Giuseppe Argentino / Andrea Vianello / Gianenrico Senna / Marco Caminati

Journal of Clinical Medicine, Vol 12, Iss 2294, p

A Perspective for a Personalized Approach

2023 Volume 2294

Abstract: Bronchial asthma is the most frequent inflammatory non-communicable condition affecting the airways worldwide. It is commonly associated with concomitant conditions, which substantially contribute to its burden, whether they involve the lung or other ... ...

Abstract	Bronchial asthma is the most frequent inflammatory non-communicable condition affecting the airways worldwide. It is commonly associated with concomitant conditions, which substantially contribute to its burden, whether they involve the lung or other districts. The present review aims at providing an overview of the recent acquisitions in terms of asthma concomitant systemic conditions, besides the commonly known respiratory comorbidities. The most recent research has highlighted a number of pathobiological interactions between asthma and other organs in the view of a shared immunological background underling different diseases. A bi-univocal relationship between asthma and common conditions, including cardiovascular, metabolic or neurodegenerative diseases, as well as rare disorders such as sickle cell disease, α1-Antitrypsin deficiency and immunologic conditions with hyper-eosinophilia, should be considered and explored, in terms of diagnostic work-up and long-term assessment of asthma patients. The relevance of that acquisition is of utmost importance in the management of asthma patients and paves the way to a new approach in the light of a personalized medicine perspective, besides targeted therapies.
Keywords	asthma ; eosinophils ; wheezing ; α1-Antitrypsin deficiency ; immunodeficiencies ; sickle cell disease ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High-Flow Tracheal Oxygen for Tracheostomy Tube Removal in Lung Transplant Recipients

Federico Lionello / Gabriella Guarnieri / Giovanna Arcaro / Leonardo Bertagna De Marchi / Beatrice Molena / Cristina Contessa / Annalisa Boscolo / Federico Rea / Paolo Navalesi / Andrea Vianello

Journal of Clinical Medicine, Vol 12, Iss 24, p

2023 Volume 7566

Abstract: 1) Background: Because of a complicated intraoperative course and/or poor recovery of graft function, approximately 15% of lung transplant (LT) recipients require prolonged mechanical ventilation (PMV) and receive a tracheostomy. This prospective study ... ...

Abstract	(1) Background: Because of a complicated intraoperative course and/or poor recovery of graft function, approximately 15% of lung transplant (LT) recipients require prolonged mechanical ventilation (PMV) and receive a tracheostomy. This prospective study aimed to assess the effect of High-Flow Tracheal Oxygen (HFTO) on tracheostomy tube removal in LT recipients receiving PMV postoperatively. (2) Methods: The clinical course of 14 LT recipients receiving HFTO was prospectively evaluated and compared to that of 13 comparable controls receiving conventional oxygen therapy (COT) via tracheostomy. The study’s primary endpoint was the number of patients whose tracheostomy tube was removed at discharge from an Intermediate Respiratory Care Unit (IRCU). (3) Results: Setting up HFTO proved easy, and it was well tolerated by all the patients. The number of patients whose tracheostomy tube was removed was significantly higher in the HFOT group compared to the COT group [13/14 vs. 6/13 ( p = 0.0128)]. (4) Conclusions: HFTO is an effective, safe therapy that facilitates tracheostomy tube removal in LT recipients after weaning from PMV.
Keywords	lung transplant ; tracheostomy ; high-flow oxygen ; mechanical ventilation ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlation between α1-Antitrypsin Deficiency and SARS-CoV-2 Infection

Andrea Vianello / Gabriella Guarnieri / Fausto Braccioni / Beatrice Molena / Sara Lococo / Alessia Achille / Federico Lionello / Leonardo Salviati / Marco Caminati / Gianenrico Senna

Journal of Clinical Medicine, Vol 10, Iss 4493, p

Epidemiological Data and Pathogenetic Hypotheses

2021 Volume 4493

Abstract: The most common hereditary disorder in adults, α1-antitrypsin deficiency (AATD), is characterized by reduced plasma levels or the abnormal functioning of α1-antitrypsin (AAT), a major human blood serine protease inhibitor, which is encoded by the SERine ... ...

Abstract	The most common hereditary disorder in adults, α1-antitrypsin deficiency (AATD), is characterized by reduced plasma levels or the abnormal functioning of α1-antitrypsin (AAT), a major human blood serine protease inhibitor, which is encoded by the SERine Protein INhibitor-A1 ( SERPINA1 ) gene and produced in the liver. Recently, it has been hypothesized that the geographic differences in COVID-19 infection and fatality rates may be partially explained by ethnic differences in SERPINA1 allele frequencies. In our review, we examined epidemiological data on the correlation between the distribution of AATD, SARS-CoV-2 infection, and COVID-19 mortality rates. Moreover, we described shared pathogenetic pathways that may provide a theoretical basis for our epidemiological findings. We also considered the potential use of AAT augmentation therapy in patients with COVID-19.
Keywords	α1-antitrypsin deficiency ; COVID-19 ; SARS-CoV-2 ; genetics ; Medicine ; R
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 Vaccination in Patients with Severe Asthma on Biologic Treatment

Marco Caminati / Gabriella Guarnieri / Veronica Batani / Elena Scarpieri / Anita Finocchiaro / Fulvia Chieco-Bianchi / Gianenrico Senna / Andrea Vianello

Vaccines, Vol 9, Iss 853, p

Safety, Tolerability, and Impact on Disease Control

2021 Volume 853

Abstract: Background: COVID-19 vaccination has been recommended for severe asthmatics. We aimed to evaluate the safety, tolerability, and impact on disease control and patient’s quality of life of the mRNA SARS-CoV-2/COVID-19 vaccine in severe asthma patients ... ...

Abstract	Background: COVID-19 vaccination has been recommended for severe asthmatics. We aimed to evaluate the safety, tolerability, and impact on disease control and patient’s quality of life of the mRNA SARS-CoV-2/COVID-19 vaccine in severe asthma patients regarding biologic treatment. Methods: Severe asthmatic patients regularly managed by two big allergy and respiratory referral centers were offered to undergo Pfizer COVID 19 vaccination at the hospital site. Patients filled in an adverse events questionnaire after the first and second dose, as well as the Asthma Control Test (ACT) and Asthma Quality of Life Questionnaire (AQLQ). Results: Overall, 253 patients were vaccinated; only 16 patients refused. No serious events were detected. Less than 20% of patients reported side effects, most of which were classified as very common side effects. No differences were reported according to the ongoing biologic drug. A significant improvement in both ACT and AQLQ was observed between the first and the second dose administration. Conclusions: Our data confirm the optimal safety and tolerability profile of mRNA SARS- CoV-2/COVID-19 in severe asthma patients on biologic treatment, as well as their positive attitude towards COVID-19 vaccination. The negligible proportion of patients reporting side effects and the absence of asthma exacerbations are relevant to support the COVID-19 vaccination campaign in severe asthma patients worldwide.
Keywords	Pfizer mRNA SARS-CoV-2/COVID 19 vaccine ; severe asthma ; biologics ; safety ; tolerability ; quality of life ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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