LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Andreas Große"
  2. AU="Xiang, Fei"

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: The Wilms Tumor Gene wt1a Contributes to Blood-Cerebrospinal Fluid Barrier Function in Zebrafish

    Vera L. Hopfenmüller / Birgit Perner / Hanna Reuter / Thomas J. D. Bates / Andreas Große / Christoph Englert

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 9

    Abstract: The Wilms tumor suppressor gene Wt1 encodes a zinc finger transcription factor, which is highly conserved among vertebrates. It is a key regulator of urogenital development and homeostasis but also plays a role in other organs including the spleen and ... ...

    Abstract The Wilms tumor suppressor gene Wt1 encodes a zinc finger transcription factor, which is highly conserved among vertebrates. It is a key regulator of urogenital development and homeostasis but also plays a role in other organs including the spleen and the heart. More recently additional functions for Wt1 in the mammalian central nervous system have been described. In contrast to mammals, bony fish possess two paralogous Wt1 genes, namely wt1a and wt1b. By performing detailed in situ hybridization analyses during zebrafish development, we discovered new expression domains for wt1a in the dorsal hindbrain, the caudal medulla and the spinal cord. Marker analysis identified wt1a expressing cells of the dorsal hindbrain as ependymal cells of the choroid plexus in the myelencephalic ventricle. The choroid plexus acts as a blood-cerebrospinal fluid barrier and thus is crucial for brain homeostasis. By employing wt1a mutant larvae and a dye accumulation assay with fluorescent tracers we demonstrate that Wt1a is required for proper choroid plexus formation and function. Thus, Wt1a contributes to the barrier properties of the choroid plexus in zebrafish, revealing an unexpected role for Wt1 in the zebrafish brain.
    Keywords Wilms tumor protein ; zebrafish ; choroid plexus ; CRISPR/cas9 ; dye accumulation assay ; fluorescent tracer ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Thesis: Gustav Blumröder

    Große Kracht, Andreas

    (1802 - 1985) ; Studien zu Leben und Werk unter besonderer Berücksichtigung seiner anthropologischen Psychiatrie

    1997  

    Author's details vorgelegt von Andreas Große Kracht
    Language German
    Size 115 Bl.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Univ., Diss., 1998
    HBZ-ID HT009333877
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    98 E 2890 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Myosin VI regulates the spatial organisation of mammalian transcription initiation

    Yukti Hari-Gupta / Natalia Fili / Ália dos Santos / Alexander W. Cook / Rosemarie E. Gough / Hannah C. W. Reed / Lin Wang / Jesse Aaron / Tomas Venit / Eric Wait / Andreas Grosse-Berkenbusch / J. Christof M. Gebhardt / Piergiorgio Percipalle / Teng-Leong Chew / Marisa Martin-Fernandez / Christopher P. Toseland

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 18

    Abstract: The actin-based molecular motors, myosins, have also been linked to transcription, but their precise role has remained elusive. Here the authors show RNA polymerase II (RNAPII) is lost from chromatin upon myosin perturbation and that myosin acts as a ... ...

    Abstract The actin-based molecular motors, myosins, have also been linked to transcription, but their precise role has remained elusive. Here the authors show RNA polymerase II (RNAPII) is lost from chromatin upon myosin perturbation and that myosin acts as a molecular anchor to maintain RNAPII spatial organisation.
    Keywords Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish

    Andrés Sanz-Morejón / Ana B. García-Redondo / Hanna Reuter / Inês J. Marques / Thomas Bates / María Galardi-Castilla / Andreas Große / Steffi Manig / Xavier Langa / Alexander Ernst / Indre Piragyte / Marius-Alexandru Botos / Juan Manuel González-Rosa / Marta Ruiz-Ortega / Ana M. Briones / Mercedes Salaices / Christoph Englert / Nadia Mercader

    Cell Reports, Vol 28, Iss 5, Pp 1296-1306.e

    2019  Volume 6

    Abstract: Summary: Organ regeneration is preceded by the recruitment of innate immune cells, which play an active role during repair and regrowth. Here, we studied macrophage subtypes during organ regeneration in the zebrafish, an animal model with a high ... ...

    Abstract Summary: Organ regeneration is preceded by the recruitment of innate immune cells, which play an active role during repair and regrowth. Here, we studied macrophage subtypes during organ regeneration in the zebrafish, an animal model with a high regenerative capacity. We identified a macrophage subpopulation expressing Wilms tumor 1b (wt1b), which accumulates within regenerating tissues. This wt1b+ macrophage population exhibited an overall pro-regenerative gene expression profile and different migratory behavior compared to the remainder of the macrophages. Functional studies showed that wt1b regulates macrophage migration and retention at the injury area. Furthermore, wt1b-null mutant zebrafish presented signs of impaired macrophage differentiation, delayed fin growth upon caudal fin amputation, and reduced cardiomyocyte proliferation following cardiac injury that correlated with altered macrophage recruitment to the regenerating areas. We describe a pro-regenerative macrophage subtype in the zebrafish and a role for wt1b in organ regeneration. : Sanz-Morejón et al. identify Wilms tumor 1b (Wt1b)+ macrophages with a pro-regenerative gene signature in injured fins and hearts in the zebrafish. They show that Wt1b controls macrophage migration and differentiation. Regeneration is impaired in wt1b mutants, supporting a role for this gene, likely within macrophages, in organ regeneration. Keywords: heart regeneration, zebrafish, macrophages, Wilms tumor 1b, fin regeneration
    Keywords Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2019-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top