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  1. Book: Resilienz und Pandemie

    Karsten, Andreas H. / Voßschmidt, Stefan

    Handlungsempfehlungen anhand von Erfahrungen mit COVID-19

    2022  

    Author's details Andreas H. Karsten, Stefan Voßschmidt (Hrsg.)
    Keywords Epidemie ; Maßnahmenplanung ; Pandemie ; Deutschland ; COVID-19 ; Gesellschaft ; Resilienz ; Krisenmanagement ; Katastrophenschutz ; Gesundheitsrecht ; Katastrophenmedizin ; Zivilschutz
    Subject Bevölkerungsschutz ; Ziviler Bevölkerungsschutz ; Notfallschutz ; Widerstandsfähigkeit ; Psychische Widerstandsfähigkeit ; Psychische Widerstandskraft ; Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion ; Gesundheitswesen
    Language German
    Size 227 Seiten, Illustrationen, Karten
    Edition 1. Auflage
    Publisher Verlag W. Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT021607515
    ISBN 978-3-17-039930-3 ; 9783170399327 ; 9783170399334 ; 3-17-039930-6 ; 3170399322 ; 3170399330
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 A 15 available for loan (reading room) Lesesaal EG

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  2. Book ; Online ; E-Book: Resilienz und kritische Infrastrukturen

    Karsten, Andreas H. / Voßschmidt, Stefan

    Aufrechterhaltung von Versorgungstrukturen im Krisenfall

    2019  

    Author's details Andreas H. Karsten, Stefan Voßschmidt (Hrsg.)
    Language German
    Size 1 Online-Ressource (369 Seiten)
    Edition 1. Auflage
    Publisher Verlag W. Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020397843
    ISBN 978-3-17-035435-7 ; 9783170354333 ; 3-17-035435-3 ; 3170354337
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Methodological aspects of evaluating the nutritive value of feed ingredients in fish

    Sutter, David Andreas Hermann

    a study on Nile tilapia (Oreochromis niloticus)

    2018  

    Author's details von M.Sc. David Andreas Hermann Sutter
    Language English
    Size XII, 172 Blätter, Illustrationen, 30 cm
    Publisher Humboldt-Universität zu Berlin
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Humboldt-Universität zu Berlin, 2018
    HBZ-ID HT020164528
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    194/414 available for loan (reading room) Freihandmagazin (U1)

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  4. Book ; Thesis: Die "Aktion T4" und die Rolle der Heil- und Pflegeanstalt Günzburg

    Görgl, Andreas Hermann

    2008  

    Author's details Andreas Hermann Görgl
    Language German
    Size III, 108 S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Diss., 2008
    HBZ-ID HT016142517
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 D 1223 on loan 0 Vormerkungen

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  5. Article ; Online: Amyotrophic Lateral Sclerosis

    Matthias Boentert / Andreas Hermann / Julian Großkreutz

    Journal of Clinical Medicine, Vol 12, Iss 5055, p

    Advances and Prospects

    2023  Volume 5055

    Abstract: The JCM Topical Collection “Amyotrophic Lateral Sclerosis: Latest Advances and Prospects” started in 2020 and currently includes 11 publications reflecting a broad range of clinical research areas in the ALS field [.] ...

    Abstract The JCM Topical Collection “Amyotrophic Lateral Sclerosis: Latest Advances and Prospects” started in 2020 and currently includes 11 publications reflecting a broad range of clinical research areas in the ALS field [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Caregivers’ View of Socio-Medical Care in the Terminal Phase of Amyotrophic Lateral Sclerosis—How Can We Improve Holistic Care in ALS?

    Katharina Linse / Elisa Aust / René Günther / Andreas Hermann

    Journal of Clinical Medicine, Vol 11, Iss 254, p

    2022  Volume 254

    Abstract: Multidimensional socio-medical care with an early integration of palliative principles is strongly recommended in amyotrophic lateral sclerosis (ALS), but provided inconsistently. We conducted telephone interviews with 49 former caregivers of deceased ... ...

    Abstract Multidimensional socio-medical care with an early integration of palliative principles is strongly recommended in amyotrophic lateral sclerosis (ALS), but provided inconsistently. We conducted telephone interviews with 49 former caregivers of deceased ALS patients to examine their experience of care in the terminal phase including caregiver burden. Patients who received specialized palliative care (45% of patients) were more likely to die at home ( p = 0.004) and without burdening symptoms ( p = 0.021). The majority of caregivers (86%) reported deficits in socio-medical care. Most frequently mentioned were problems receiving medical aids (45%) and a lack of caregiver support (35%). A higher level of deficits experienced by caregivers was associated with negative health outcomes on the side of the caregivers (reported by 57% of them; p = 0.002) and stronger caregiver burden ( p = 0.004). To provide good quality of dying to patients and reduce the burden on caregivers, multidimensional—including palliative—care in ALS urgently needs to be strengthened in the healthcare structures.
    Keywords amyotrophic lateral sclerosis ; end-of-life care ; palliative care ; caregiver burden ; informal caregivers ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Impact of Organelle Transport Deficits on Mitophagy and Autophagy in Niemann–Pick Disease Type C

    Maik Liedtke / Christin Völkner / Andreas Hermann / Moritz J. Frech

    Cells, Vol 11, Iss 507, p

    2022  Volume 507

    Abstract: Defective mitochondria are pathophysiological features of a number of neurodegenerative diseases. Here, we investigated mitochondrial dysfunction in the context of the rare lysosomal storage diseases Niemann–Pick disease type C1 and type C2 (NP-C1 and NP- ...

    Abstract Defective mitochondria are pathophysiological features of a number of neurodegenerative diseases. Here, we investigated mitochondrial dysfunction in the context of the rare lysosomal storage diseases Niemann–Pick disease type C1 and type C2 (NP-C1 and NP-C2). Mutations in either the NPC1 or NPC2 gene lead to cholesterol accumulation in late endosomes and lysosomes, resulting in impaired cholesterol homeostasis. The extent to which this may lead to mitochondrial dysfunction has been poorly studied so far. Therefore, we investigated the morphology, function, and transport of mitochondria, as well as their degradation via mitophagy, in a disease-associated human neural cell model of NP-C. By performing live cell imaging, we observed markedly reduced mitochondrial transport, although morphology and function were not appreciably altered. However, we observed a defective mitophagy induction shown by a reduced capability to elevate parkin expression and engulf mitochondria in autophagosomes after treatment with carbonyl cyanide 3-chlorophenylhydrazone (CCCP). This was accompanied by defects in autophagy induction, exhibited by a hampered p62 expression and progression, shown by increased LC3BII levels and a defective fusion of autophagosomes and lysosomes. The latter might have been additionally influenced by the observed reduced lysosomal transport. Hence, we hypothesized that a reduced recycling of mitochondria contributes to the pathophysiology of NP-C.
    Keywords NPC1 ; NPC2 ; mitochondria ; induced pluripotent stem cells ; iPSCs ; lysosomal storage disorder ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons

    Banaja P. Dash / Axel Freischmidt / Jochen H. Weishaupt / Andreas Hermann

    International Journal of Molecular Sciences, Vol 23, Iss 9652, p

    2022  Volume 9652

    Abstract: Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease marked by death of motor neurons (MNs) present in the spinal cord, brain stem and motor cortex. Despite extensive research, the reason for neurodegeneration is still ...

    Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease marked by death of motor neurons (MNs) present in the spinal cord, brain stem and motor cortex. Despite extensive research, the reason for neurodegeneration is still not understood. To generate novel hypotheses of putative underlying molecular mechanisms, we used human induced pluripotent stem cell (hiPSCs)-derived motor neurons (MNs) from SOD1 - and TARDBP (TDP-43 protein)-mutant-ALS patients and healthy controls to perform high-throughput RNA-sequencing (RNA-Seq). An integrated bioinformatics approach was employed to identify differentially expressed genes (DEGs) and key pathways underlying these familial forms of the disease (fALS). In TDP43-ALS, we found dysregulation of transcripts encoding components of the transcriptional machinery and transcripts involved in splicing regulation were particularly affected. In contrast, less is known about the role of SOD1 in RNA metabolism in motor neurons. Here, we found that many transcripts relevant for mitochondrial function were specifically altered in SOD1-ALS, indicating that transcriptional signatures and expression patterns can vary significantly depending on the causal gene that is mutated. Surprisingly, however, we identified a clear downregulation of genes involved in protein translation in SOD1-ALS suggesting that ALS-causing SOD1 mutations shift cellular RNA abundance profiles to cause neural dysfunction. Altogether, we provided here an extensive profiling of mRNA expression in two ALS models at the cellular level, corroborating the major role of RNA metabolism and gene expression as a common pathomechanism in ALS.
    Keywords amyotrophic lateral sclerosis (ALS) ; human induced pluripotent stem cells (iPSC) ; motor neurons (MN) ; RNA sequencing (RNA-Seq) ; differentially expressed genes (DEG) ; protein-protein interaction (PPI) ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Neuroacanthocytosis Syndromes

    Ruth H. Walker / Kevin Peikert / Hans H. Jung / Andreas Hermann / Adrian Danek

    Contact, Vol

    The Clinical Perspective

    2023  Volume 6

    Abstract: The two very rare neurodegenerative diseases historically known as the “neuroacanthocytosis syndromes” are due to mutations of either VPS13A or XK. These are phenotypically similar disorders that affect primarily the basal ganglia and hence result in ... ...

    Abstract The two very rare neurodegenerative diseases historically known as the “neuroacanthocytosis syndromes” are due to mutations of either VPS13A or XK. These are phenotypically similar disorders that affect primarily the basal ganglia and hence result in involuntary abnormal movements as well as neuropsychiatric and cognitive alterations. There are other shared features such as abnormalities of red cell membranes which result in acanthocytes, whose relationship to neurodegeneration is not yet known. Recent insights into the functions of these two proteins suggest dysfunction of lipid processing and trafficking at the subcellular level and may provide a mechanism for neuronal dysfunction and death, and potentially a target for therapeutic interventions.
    Keywords Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: High pressure study of sodium trihydride

    Tomas Marqueño / Mikhail A. Kuzovnikov / Israel Osmond / Phillip Dalladay-Simpson / Andreas Hermann / Ross T. Howie / Miriam Peña-Alvarez

    Frontiers in Chemistry, Vol

    2024  Volume 11

    Abstract: The reactivity between NaH and H2 has been investigated through a series of high-temperature experiments up to pressures of 78 GPa in diamond anvil cells combined with first principles calculations. Powder X-ray diffraction measurements show that heating ...

    Abstract The reactivity between NaH and H2 has been investigated through a series of high-temperature experiments up to pressures of 78 GPa in diamond anvil cells combined with first principles calculations. Powder X-ray diffraction measurements show that heating NaH in an excess of H2 to temperatures around 2000 K above 27 GPa yields sodium trihydride (NaH3), which adopts an orthorhombic structure (space group Cmcm). Raman spectroscopy measurements indicate that NaH3 hosts quasi-molecular hydrogen (H2δ−) within a NaH lattice, with the H2δ− stretching mode downshifted compared to pure H2 (Δν ∼−120 cm−1 at 50 GPa). NaH3 is stable under room temperature compression to at least 78 GPa, and exhibits remarkable P-T stability, decomposing at pressures below 18 GPa. Contrary to previous experimental and theoretical studies, heating NaH (or NaH3) in excess H2 between 27 and 75 GPa does not promote further hydrogenation to form sodium polyhydrides other than NaH3.
    Keywords hydrides ; sodium ; high pressure ; X-ray diffraction ; Raman ; density functional calculations ; Chemistry ; QD1-999
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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