Article ; Online: Acetate sensing by GPR43 alarms neutrophils and protects from severe sepsis
Communications Biology, Vol 4, Iss 1, Pp 1-
2021 Volume 11
Abstract: Katja Schlatterer et al. use mouse models to show that elevated serum acetate concentrations prime human neutrophils in a GPR43-dependent fashion, and rescue mice from severe sepsis. These results suggest microbiome-, diet-, or pathogen-derived short- ... ...
Abstract | Katja Schlatterer et al. use mouse models to show that elevated serum acetate concentrations prime human neutrophils in a GPR43-dependent fashion, and rescue mice from severe sepsis. These results suggest microbiome-, diet-, or pathogen-derived short-chain fatty acids govern the defense capacities of immune cells, potentially hinting at the therapeutic potential of GPR43 in treating sepsis. |
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Keywords | Biology (General) ; QH301-705.5 |
Language | English |
Publishing date | 2021-07-01T00:00:00Z |
Publisher | Nature Portfolio |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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