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  1. AU="Andreas von Deimling"
  2. AU="Erik MeersauthorLaboratory of Analytical and Applied Ecochemistry, Faculty of Bioscience Engineering, University of Ghent, Coupure Links 653, 9000 Ghent, Belgium"
  3. AU="Thakkar, Nitya"
  4. AU="Hongtao Tie"
  5. AU="Bhati, Saurabh Kumar"
  6. AU="Choi, Hyunho"
  7. AU="Jayaprakash, Balamuralikrishna"
  8. AU="Lee, Brian H"
  9. AU="May, Susann"
  10. AU="Remondes-Costa, Sónia"
  11. AU="Lauren Sauer"
  12. AU="G Saiz, Paula"
  13. AU="Stoica, George"
  14. AU=Odorizzi Pamela M.
  15. AU=Pollaers Katherine
  16. AU="Stefanova, Veselina"
  17. AU="Geraldine M. O’Connor"
  18. AU="Jim E. Banta"
  19. AU="Marti-Bonmati, Luis"
  20. AU="Doris Kampner"
  21. AU="Luca Soraci"

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Treffer 1 - 10 von insgesamt 32

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  1. Artikel ; Online: Intrathecal activation of CD8+ memory T cells in IgG4‐related disease of the brain parenchyma

    Mirco Friedrich / Niklas Kehl / Niko Engelke / Josephine Kraus / Katharina Lindner / Philipp Münch / Iris Mildenberger / Christoph Groden / Achim Gass / Nima Etminan / Marc Fatar / Andreas vonDeimling / David Reuss / Michael Platten / Lukas Bunse

    EMBO Molecular Medicine, Vol 13, Iss 8, Pp n/a-n/a (2021)

    2021  

    Abstract: Abstract IgG4‐related disease (IgG4‐RD) is a fibroinflammatory disorder signified by aberrant infiltration of IgG4‐restricted plasma cells into a variety of organs. Clinical presentation is heterogeneous, and pathophysiological mechanisms of IgG4‐RD ... ...

    Abstract Abstract IgG4‐related disease (IgG4‐RD) is a fibroinflammatory disorder signified by aberrant infiltration of IgG4‐restricted plasma cells into a variety of organs. Clinical presentation is heterogeneous, and pathophysiological mechanisms of IgG4‐RD remain elusive. There are very few cases of IgG4‐RD with isolated central nervous system manifestation. By leveraging single‐cell sequencing of the cerebrospinal fluid (CSF) of a patient with an inflammatory intracranial pseudotumor, we provide novel insights into the immunopathophysiology of IgG4‐RD. Our data illustrate an IgG4‐RD‐associated polyclonal T‐cell response in the CSF and an oligoclonal T‐cell response in the parenchymal lesions, the latter being the result of a multifaceted cell–cell interaction between immune cell subsets and pathogenic B cells. We demonstrate that CD8+ T effector memory cells might drive and sustain autoimmunity via macrophage migration inhibitory factor (MIF)‐CD74 signaling to immature B cells and CC‐chemokine ligand 5 (CCL5)‐mediated recruitment of cytotoxic CD4+ T cells. These findings highlight the central role of T cells in sustaining IgG4‐RD and open novel avenues for targeted therapies.
    Schlagwörter CSF single‐cell sequencing ; cytotoxic T helper cell ; IgG4‐related disease ; inflammatory pseudotumor ; pathogenic B‐cell ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Spatial probabilistic mapping of metabolite ensembles in mass spectrometry imaging

    Denis Abu Sammour / James L. Cairns / Tobias Boskamp / Christian Marsching / Tobias Kessler / Carina Ramallo Guevara / Verena Panitz / Ahmed Sadik / Jonas Cordes / Stefan Schmidt / Shad A. Mohammed / Miriam F. Rittel / Mirco Friedrich / Michael Platten / Ivo Wolf / Andreas von Deimling / Christiane A. Opitz / Wolfgang Wick / Carsten Hopf

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 15

    Abstract: Spatial visualization of metabolites in tissues via mass spectrometry imaging can be prone to user perception bias. Here, the authors report the computational framework moleculaR that introduces probabilistic data-dependent molecular mapping of nonrandom ...

    Abstract Spatial visualization of metabolites in tissues via mass spectrometry imaging can be prone to user perception bias. Here, the authors report the computational framework moleculaR that introduces probabilistic data-dependent molecular mapping of nonrandom spatial patterns of metabolite signals.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

    Erik Jung / Matthias Osswald / Miriam Ratliff / Helin Dogan / Ruifan Xie / Sophie Weil / Dirk C. Hoffmann / Felix T. Kurz / Tobias Kessler / Sabine Heiland / Andreas von Deimling / Felix Sahm / Wolfgang Wick / Frank Winkler

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 16

    Abstract: Whether the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have a different role in glioblastoma progression and resistance to therapies is currently unclear. Here, the authors, by long-term tracking of ...

    Abstract Whether the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have a different role in glioblastoma progression and resistance to therapies is currently unclear. Here, the authors, by long-term tracking of individual glioma, demonstrate that both niches can partially compensate for each other and that glioma cells localized in both niches are resistant to radio- and chemotherapy.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Frame-based stereotactic biopsies using an intraoperative MR-scanner are as safe and effective as conventional stereotactic procedures.

    Jan-Oliver Neumann / Benito Campos / Bilal Younes / Martin Jakobs / Christine Jungk / Christopher Beynon / Andreas von Deimling / Andreas Unterberg / Karl Kiening

    PLoS ONE, Vol 13, Iss 10, p e

    2018  Band 0205772

    Abstract: BACKGROUND:Frame-based stereotactic biopsy (FBSB) is a minimally-invasive and effective procedure for the diagnosis of brain lesions and will likely gain clinical importance. Since FBSB procedures comprise a variety of imaging and sampling methods, it is ...

    Abstract BACKGROUND:Frame-based stereotactic biopsy (FBSB) is a minimally-invasive and effective procedure for the diagnosis of brain lesions and will likely gain clinical importance. Since FBSB procedures comprise a variety of imaging and sampling methods, it is necessary to compare the safety and effectiveness of individual techniques. OBJECTIVE:To assess the safety and effectiveness of FBSB using 1.5T iMRI as a one-stop procedure under general anesthesia without intraoperative histological examination. METHODS:In this single-center, retrospective analysis, 500 consecutive FBSBs using iMRI were compared to a historic control of 100 biopsies with traditional workflows (computed tomography (CT) with MRI image fusion). All procedures were performed under general anesthesia. Data on surgical procedures, pre- and postoperative neurologic patient status, complications and diagnostic yield were extracted from clinical records. RESULTS:Complication rates and diagnostic yield showed no significant differences between both groups. Mortality was 0.6%, 95% CI = [0.12%, 1.74%], in the iMRI and 0.0% [0.00%, 3.62%], in the control group with a morbidity of 5.4% [3.6%, 7.8%] and 6.0% [2.2%, 12.6%] and a diagnostic yield of 96.8% [94.9%, 98.2%] and 96.0% [90.1%, 98.9%]. Mean procedure duration was 124 [121, 127] minutes using iMRI and 112 [106, 118] minutes in the control group. CONCLUSION:FBSB using 1.5T iMRI under general anesthesia is a safe and effective procedure and is equivalent to traditional stereotactic workflows with respect to complication rate and diagnostic yield.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma

    Anastasia Makarevic / Carmen Rapp / Steffen Dettling / David Reuss / Christine Jungk / Amir Abdollahi / Andreas von Deimling / Andreas Unterberg / Christel Herold-Mende / Rolf Warta

    International Journal of Molecular Sciences, Vol 21, Iss 7801, p

    2020  Band 7801

    Abstract: Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and, ... ...

    Abstract Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and, therefore, a major prerequisite for successful immunotherapy in a series of primary ( n = 78) and recurrent ( n = 66) isocitrate dehydrogenase (IDH)-mutant glioma and their changes following treatment with radio- and/or chemotherapy. After multicolor immunofluorescence staining, T cells were counted in entire tumor sections using a software-based setup. Newly diagnosed diffuse IDH-mutant gliomas displayed a median T-cell infiltration of 0.99 T cells/mm 2 (range: 0–48.97 CD3 + T cells/mm 2 ), which was about two-fold increased for CD3 + , helper, and cytotoxic T cells in recurrent glioma. Furthermore, T-cell infiltration of recurrent tumors was associated with the type of adjuvant treatment of the primary tumor. Interestingly, only glioma patients solely receiving radiotherapy presented consistently with increased T-cell infiltration in their recurrent tumors. This was confirmed in a subset of 27 matched pairs. In conclusion, differences in the T-cell infiltration of primary and recurrent gliomas were demonstrated, and evidence was provided for a beneficial long-term effect on T-cell infiltration upon treatment with radiotherapy.
    Schlagwörter lower-grade glioma ; T-cell infiltration ; TissueFAXS ; primary tumors ; recurrent tumors ; radiotherapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Genomic characterization of DICER1-associated neoplasms uncovers molecular classes

    Felix K. F. Kommoss / Anne-Sophie Chong / Anne-Laure Chong / Elke Pfaff / David T. W. Jones / Laura S. Hiemcke-Jiwa / Lennart A. Kester / Uta Flucke / Manfred Gessler / Daniel Schrimpf / Felix Sahm / Blaise A. Clarke / Colin J. R. Stewart / Yemin Wang / C. Blake Gilks / Friedrich Kommoss / David G. Huntsman / Ulrich Schüller / Christian Koelsche /
    W. Glenn McCluggage / Andreas von Deimling / William D. Foulkes

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 13

    Abstract: DICER1 syndrome is associated with a predisposition to multiple tumor types. Here, the authors identify and characterize 3 molecular subgroups of mesenchymal tumors with DICER1 mutations. ...

    Abstract DICER1 syndrome is associated with a predisposition to multiple tumor types. Here, the authors identify and characterize 3 molecular subgroups of mesenchymal tumors with DICER1 mutations.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: mIDH-associated DNA hypermethylation in acute myeloid leukemia reflects differentiation blockage rather than inhibition of TET-mediated demethylation

    Laura Wiehle / Günter Raddatz / Stefan Pusch / Julian Gutekunst / Andreas von Deimling / Manuel Rodríguez-Paredes / Frank Lyko

    Cell Stress, Vol 1, Iss 1, Pp 55-

    2017  Band 67

    Abstract: Isocitrate dehydrogenases 1 and 2 (IDH1/2) are recurrently mutated in acute myeloid leukemia (AML), but their mechanistic role in leukemogenesis is poorly understood. The inhibition of TET enzymes by D-2-hydroxyglutarate (D-2-HG), which is produced by ... ...

    Abstract Isocitrate dehydrogenases 1 and 2 (IDH1/2) are recurrently mutated in acute myeloid leukemia (AML), but their mechanistic role in leukemogenesis is poorly understood. The inhibition of TET enzymes by D-2-hydroxyglutarate (D-2-HG), which is produced by mutant IDH1/2 (mIDH1/2), has been suggested to promote epigenetic deregulation during tumorigenesis. In addition, mIDH also induces a differentiation block in various cell culture and mouse models. Here we analyze the genomic methylation patterns of AML patients with mIDH using Infinium 450K data from a large AML cohort and found that mIDH is associated with pronounced DNA hypermethylation at tens of thousands of CpGs. Interestingly, however, myeloid leukemia cells overexpressing mIDH, cells that were cultured in the presence of D-2-HG or TET2 mutant AML patients did not show similar methylation changes. In further analyses, we also characterized the methylation landscapes of myeloid progenitor cells and analyzed their relationship to mIDH-associated hypermethylation. Our findings identify the differentiation state of myeloid cells, rather than inhibition of TET-mediated DNA demethylation, as a major factor of mIDH-associated hypermethylation in AML. Furthermore, our results are also important for understanding the mode of action of currently developed mIDH inhibitors.
    Schlagwörter mIDH ; DNA methylation ; AML ; TET enzymes ; differentiation ; D-2-hydroxyglutarate ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2017-09-01T00:00:00Z
    Verlag Shared Science Publishers OG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: CIC protein instability contributes to tumorigenesis in glioblastoma

    Severa Bunda / Pardeep Heir / Julie Metcalf / Annie Si Cong Li / Sameer Agnihotri / Stefan Pusch / Mamatjan Yasin / Mira Li / Kelly Burrell / Sheila Mansouri / Olivia Singh / Mark Wilson / Amir Alamsahebpour / Romina Nejad / Bethany Choi / David Kim / Andreas von Deimling / Gelareh Zadeh / Kenneth Aldape

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 17

    Abstract: Capicua (CIC) is a tumour suppressor in oligodendroglioma. Here, the authors show that ERK activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant form of CIC enhances efficacy of ERK inhibition in ... ...

    Abstract Capicua (CIC) is a tumour suppressor in oligodendroglioma. Here, the authors show that ERK activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant form of CIC enhances efficacy of ERK inhibition in glioblastoma.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-02-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: CIC protein instability contributes to tumorigenesis in glioblastoma

    Severa Bunda / Pardeep Heir / Julie Metcalf / Annie Si Cong Li / Sameer Agnihotri / Stefan Pusch / Mamatjan Yasin / Mira Li / Kelly Burrell / Sheila Mansouri / Olivia Singh / Mark Wilson / Amir Alamsahebpour / Romina Nejad / Bethany Choi / David Kim / Andreas von Deimling / Gelareh Zadeh / Kenneth Aldape

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 17

    Abstract: Capicua (CIC) is a tumour suppressor in oligodendroglioma. Here, the authors show that ERK activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant form of CIC enhances efficacy of ERK inhibition in ... ...

    Abstract Capicua (CIC) is a tumour suppressor in oligodendroglioma. Here, the authors show that ERK activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant form of CIC enhances efficacy of ERK inhibition in glioblastoma.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Loss of Mpdz impairs ependymal cell integrity leading to perinatal‐onset hydrocephalus in mice

    Anja Feldner / M Gordian Adam / Fabian Tetzlaff / Iris Moll / Dorde Komljenovic / Felix Sahm / Tobias Bäuerle / Hiroshi Ishikawa / Horst Schroten / Thomas Korff / Ilse Hofmann / Hartwig Wolburg / Andreas vonDeimling / Andreas Fischer

    EMBO Molecular Medicine, Vol 9, Iss 7, Pp 890-

    2017  Band 905

    Abstract: Abstract Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ (MUPP1) are the only known human gene loci associated with non‐syndromic hydrocephalus. To investigate functions of the tight junction‐associated protein Mpdz, we generated mouse ... ...

    Abstract Abstract Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ (MUPP1) are the only known human gene loci associated with non‐syndromic hydrocephalus. To investigate functions of the tight junction‐associated protein Mpdz, we generated mouse models. Global Mpdz gene deletion or conditional inactivation in Nestin‐positive cells led to formation of supratentorial hydrocephalus in the early postnatal period. Blood vessels, epithelial cells of the choroid plexus, and cilia on ependymal cells, which line the ventricular system, remained morphologically intact in Mpdz‐deficient brains. However, flow of cerebrospinal fluid through the cerebral aqueduct was blocked from postnatal day 3 onward. Silencing of Mpdz expression in cultured epithelial cells impaired barrier integrity, and loss of Mpdz in astrocytes increased RhoA activity. In Mpdz‐deficient mice, ependymal cells had morphologically normal tight junctions, but expression of the interacting planar cell polarity protein Pals1 was diminished and barrier integrity got progressively lost. Ependymal denudation was accompanied by reactive astrogliosis leading to aqueductal stenosis. This work provides a relevant hydrocephalus mouse model and demonstrates that Mpdz is essential to maintain integrity of the ependyma.
    Schlagwörter aqueductal stenosis ; cerebrospinal fluid ; ependymal cells ; hydrocephalus ; tight junction ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Sprache Englisch
    Erscheinungsdatum 2017-07-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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