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  1. Article ; Online: Laser renal denervation: A comprehensive evaluation of microstructural renal artery lesions.

    Vakhrushev, Aleksandr D / Condori Leandro, Heber Ivan / Goncharova, Natalia S / Korobchenko, Lev E / Mitrofanova, Lubov B / Makarov, Igor A / Andreeva, Elizaveta M / Lebedev, Dmitry S / Mikhaylov, Evgeny N

    Anatomical record (Hoboken, N.J. : 2007)

    2022  Volume 306, Issue 9, Page(s) 2378–2387

    Abstract: Renal artery denervation (RDN) has been proposed for resistant arterial hypertension. Beyond conventional radiofrequency (RF) ablation, there are emerging RDN technologies, including laser catheter ablation. We aimed at evaluamting the local effects of ... ...

    Abstract Renal artery denervation (RDN) has been proposed for resistant arterial hypertension. Beyond conventional radiofrequency (RF) ablation, there are emerging RDN technologies, including laser catheter ablation. We aimed at evaluamting the local effects of laser ablation on the renal artery and perivascular nerve injury in comparison with radiofrequency ablation. Thirteen pigs (mean weight 36.7 ± 4.7 kg, age 3 months) were divided into three groups: (1) laser ablation in normotensive pigs (LA; n = 3), (2) bipolar RF ablation in normotensive pigs (RF; n = 7), and (3) a sham group (SHAM; n = 3). Transcatheter laser and RF ablations were performed under general anesthesia. After euthanasia, pathology and immunohistochemical studies were performed. Artery wall and perivascular nerve lesions were found in the LA and RF groups. A lower rate of intimal microdissections was evaluated after laser ablation when compared with RF ablation (0 vs. 1.5 [1;2.75] per artery; p < .05). There was a numerical prevalence of nerves with tyrosine hydroxylase expression loss after laser RDN when compared with RF ablation (16.7 [4; 18] vs. 9.1 [0;18] per specimen). Laser ablation is noninferior to RF ablation regarding perivascular nerve injury and is associated with less intimal layer damage.
    MeSH term(s) Swine ; Animals ; Renal Artery/surgery ; Sympathectomy ; Kidney/metabolism ; Hypertension ; Lasers ; Denervation
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.25068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An Ovine Model for Percutaneous Pulmonary Artery Laser Denervation: Perivascular Innervation and Ablation Lesion Characteristics.

    Condori Leandro, Heber Ivan / Koshevaya, Elena G / Mitrofanova, Lubov B / Vakhrushev, Aleksandr D / Goncharova, Natalia S / Korobchenko, Lev E / Andreeva, Elizaveta M / Lebedev, Dmitry S / Mikhaylov, Evgeny N

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: Background: Pulmonary artery denervation (PADN) is an evolving interventional procedure capable to reduce pulmonary artery (PA) pressure. We aimed to compare PA nerve distribution in different specimens and assess the feasibility of an ovine model for a ...

    Abstract Background: Pulmonary artery denervation (PADN) is an evolving interventional procedure capable to reduce pulmonary artery (PA) pressure. We aimed to compare PA nerve distribution in different specimens and assess the feasibility of an ovine model for a denervation procedure and evaluate the acute changes induced by laser energy.
    Methods: The experiment was divided into two phases: (1) the analysis of PA nerve distribution in sheep, pigs, and humans using histological and immunochemical methods; (2) fiberoptic PADN in sheep and postmortem laser lesion characteristics.
    Results: PA nerve density and distribution in sheep differ from humans, although pigs and sheep share similar characteristics, nerve fibers are observed in the media layer, adventitia, and perivascular tissue in sheep. Necrosis of the intima and focal hemorrhages within the media, adventitia, and perivascular adipose tissue were evidenced post laser PADN. Among the identified lesions, 40% reached adventitia and could be classified as effective for PADN. The use of 20 W ablation energy was safer and 30 W-ablation led to collateral organ damage.
    Conclusions: An ovine model is suitable for PADN procedures; however, nerve distribution in the PA bifurcation and main branches differ from human PA innervation. Laser ablation can be safely used for PADN procedures.
    MeSH term(s) Aged ; Animals ; Denervation ; Disease Models, Animal ; Feasibility Studies ; Female ; Humans ; Hypertension, Pulmonary/surgery ; Laser Therapy/methods ; Middle Aged ; Pulmonary Artery/innervation ; Pulmonary Artery/surgery ; Radiation Dosage ; Sheep ; Swine
    Language English
    Publishing date 2021-08-16
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transcatheter radiofrequency pulmonary artery denervation in swine: the evaluation of lesion degree, hemodynamics and pulmonary hypertension inducibility.

    Goncharova, Natalia S / Condori Leandro, Heber Ivan / Vakhrushev, Aleksandr D / Koshevaya, Elena G / Skorik, Yury A / Mitrofanova, Lubov B / Murashova, Lada A / Korobchenko, Lev E / Andreeva, Elizaveta M / Lebedev, Dmitry S / Moiseeva, Olga M / Mikhaylov, Evgeny N

    BMC pulmonary medicine

    2021  Volume 21, Issue 1, Page(s) 418

    Abstract: Background: Mechanisms of positive effects of pulmonary artery (PA) denervation (PADN) remain poorly understood. The study aimed to evaluate pulmonary hemodynamic changes after PADN and their association with the extent of PA wall damage in an acute ... ...

    Abstract Background: Mechanisms of positive effects of pulmonary artery (PA) denervation (PADN) remain poorly understood. The study aimed to evaluate pulmonary hemodynamic changes after PADN and their association with the extent of PA wall damage in an acute thromboxane A2 (TXA2)-induced pulmonary hypertension (PH) model in swine.
    Methods: In this experimental sham-controlled study, 17 normotensive male white Landrace pigs (the mean weight 36.2 ± 4.5 kg) were included and randomly assigned to group I (n = 9)-PH modeling before and after PADN, group II (n = 4)-PADN only, or group III (n = 4)-PH modeling before and after a sham procedure. Radiofrequency (RF) PADN was performed in the PA trunk and at the proximal parts of the right and left PAs. PA wall lesions were characterized at the autopsy study using histological and the immunohistochemical examination.
    Results: In groups I and II, no statistically significant changes in the mean pulmonary arterial pressure nor systemic blood pressure were found after PADN (-0.8 ± 3.4 vs 4.3 ± 8.6 mmHg, P = 0.47; and 6.0 ± 15.9 vs -8.3 ± 7.5 mmHg, P = 0.1; correspondingly). There was a trend towards a lower diastolic pulmonary arterial pressure after PADN in group I when compared with group III during repeat PH induction (34.4 ± 2.9 vs 38.0 ± 0.8; P = 0.06). Despite the presence of severe PA wall damage at the RF application sites, S100 expression was preserved in the majority of PA specimens. The presence of high-grade PA lesions was associated with HR acceleration after PADN (ρ = 0.68, p = 0.03). No significant correlation was found between the grade of PA lesion severity and PA pressure after PADN with or without PH induction.
    Conclusions: Extended PADN does not affect PH induction using TXA2. Significant PA adventitia damage is associated with HR acceleration after PADN. Possible delayed effects of PADN on perivascular nerves and pulmonary hemodynamics require further research in chronic experiments.
    MeSH term(s) Animals ; Blood Pressure ; Catheter Ablation/methods ; Denervation/methods ; Disease Models, Animal ; Hemodynamics ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/surgery ; Male ; Pulmonary Artery/physiopathology ; Pulmonary Artery/surgery ; Swine
    Language English
    Publishing date 2021-12-18
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-021-01786-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pulmonary and Systemic Hemodynamics following Multielectrode Radiofrequency Catheter Renal Denervation in Acutely Induced Pulmonary Arterial Hypertension in Swine.

    Vakhrushev, Aleksandr D / Сondori Leonardo, Heber Ivan / Goncharova, Natalia S / Korobchenko, Lev E / Mitrofanova, Lubov B / Andreeva, Elizaveta M / Koshevaya, Elena G / Lebedev, Dmitry S / Mikhaylov, Evgeny N

    BioMed research international

    2021  Volume 2021, Page(s) 4248111

    Abstract: Objective: We aimed to assess the effects of renal denervation (RDN) on systemic and pulmonary hemodynamics in a swine model of thromboxane A2- (TXA2-) induced pulmonary arterial hypertension (PAH).: Methods: The study protocol comprised two PAH ... ...

    Abstract Objective: We aimed to assess the effects of renal denervation (RDN) on systemic and pulmonary hemodynamics in a swine model of thromboxane A2- (TXA2-) induced pulmonary arterial hypertension (PAH).
    Methods: The study protocol comprised two PAH inductions with a target mean pulmonary artery pressure (PAP) of 40 mmHg at baseline and following either the RDN or sham procedure. Ten Landrace pigs underwent the first PAH induction; then, nine animals were randomly allocated in 1 : 1 ratio to RDN or sham procedure; the second PAH induction was performed in eight animals (one animal died of pulmonary embolism during the first PAH induction, and one animal died after RDN). In the RDN group, ablation was performed in all available renal arteries, and balloon inflation within artery branches was performed in controls. An autopsy study of the renal arteries was performed.
    Results: At baseline, the target mean PAP was achieved in all animals with 25.0 [20.1; 25.2] mcg of TXA2. The second PAH induction required the same mean TXA2 dose and infusion time. There was no statistically significant difference in the mean PAP at second PAH induction between the groups (39.0 ± 5.3 vs. 39.75 ± 0.5 mmHg,
    Conclusions: According to our results, RDN does not result in significant acute pulmonary or systemic hemodynamic changes in the TXA2-induced PAH model. The potential chronic effects of RDN on PAH require further research.
    MeSH term(s) Animals ; Arterial Pressure ; Blood Pressure/drug effects ; Catheter Ablation/methods ; Catheters ; Denervation/methods ; Familial Primary Pulmonary Hypertension/pathology ; Hemodynamics/physiology ; Hypertension/physiopathology ; Kidney/physiopathology ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Arterial Hypertension/pathology ; Renal Artery/pathology ; Swine ; Sympathectomy/methods
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2021/4248111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stimulation Mapping of the Pulmonary Artery for Denervation Procedures: an Experimental Study.

    Condori Leandro, Heber Ivan / Vakhrushev, Aleksandr D / Goncharova, Natalia S / Korobchenko, Lev E / Koshevaya, Elena G / Mitrofanova, Lubov B / Andreeva, Elizaveta M / Moiseeva, Olga M / Lebedev, Dmitry S / Mikhaylov, Evgeny N

    Journal of cardiovascular translational research

    2020  Volume 14, Issue 3, Page(s) 546–555

    Abstract: Transcatheter pulmonary artery denervation (PADN) has been developed for the correction of pulmonary hypertension. We investigated pulmonary artery stimulation mapping and its role in PADN procedures. Artery stimulation was performed in 17 Landrace pigs. ...

    Abstract Transcatheter pulmonary artery denervation (PADN) has been developed for the correction of pulmonary hypertension. We investigated pulmonary artery stimulation mapping and its role in PADN procedures. Artery stimulation was performed in 17 Landrace pigs. Low-frequency stimulation defined areas of ventricular and atrial capture. High-frequency stimulation evoked the following responses: sinus rhythm slowing and/or atrial rhythm acceleration in 59% of animals, phrenic nerve capture in 100%, and laryngeal recurrent nerve capture in 23%. The sites with evoked heart rate responses were marked by discrete radiofrequency ablations (RFA). An autopsy showed nerves in the adventitia and perivascular fat under the RFA sites, and the lack of muscarinic-1, tyrosine hydroxylase, and dopamine-5 receptors' expression. During PADN, areas adjacent to the course of phrenic and recurrent laryngeal nerves should be avoided. RFA at points with heart rate responses leads to the non-reproducibility of evoked reactions and the disappearance of neural markers' expression. Graphical abstract.
    MeSH term(s) Animals ; Autonomic Denervation/adverse effects ; Biomarkers/metabolism ; Catheter Ablation/adverse effects ; Electric Stimulation ; Electrocardiography ; Evoked Potentials ; Heart Rate ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/surgery ; Male ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/innervation ; Pulmonary Artery/metabolism ; Sus scrofa
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2422411-X
    ISSN 1937-5395 ; 1937-5387
    ISSN (online) 1937-5395
    ISSN 1937-5387
    DOI 10.1007/s12265-020-10079-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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