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Article ; Online: Estimated glomerular filtration rate in clinical practice: Consensus positioning of the Brazilian Society of Nephrology (SBN) and Brazilian Society of Clinical Pathology and Laboratory Medicine (SBPC/ML).

Kirsztajn, Gianna Mastroianni / Silva Junior, Geraldo Bezerra da / Silva, Artur Quintiliano Bezerra da / Abensur, Hugo / Romão Junior, João Egídio / Bastos, Marcus Gomes / Calice-Silva, Viviane / Carmo, Lilian Pires de Freitas do / Sandes-Freitas, Tainá Veras de / Abreu, Patrícia Ferreira / Andreguetto, Bruna Dolci / Cortes, Luiz Gustavo Ferreira / Oliveira, Maria Gabriela de Lucca / Vieira, Luisane Maria Falci / Moura-Neto, José A / Andriolo, Adagmar

Jornal brasileiro de nefrologia

2024 Volume 46, Issue 3, Page(s) e20230193

Abstract: Chronic kidney disease (CKD) represents one of today's main public health problems. Serum creatinine measurement and estimation of the glomerular filtration rate (GFR) are the main tools for evaluating renal function. There are several equations to ... ...

Abstract	Chronic kidney disease (CKD) represents one of today's main public health problems. Serum creatinine measurement and estimation of the glomerular filtration rate (GFR) are the main tools for evaluating renal function. There are several equations to estimate GFR, and CKD-EPI equation (Chronic Kidney Disease - Epidemiology) is the most recommended one. There are still some controversies regarding serum creatinine measurement and GFR estimation, since several factors can interfere in this process. An important recent change was the removal of the correction for race from the equations for estimating GFR, which overestimated kidney function, and consequently delayed the implementation of treatments such as dialysis and kidney transplantation. In this consensus document from the Brazilian Societies of Nephrology and Clinical Pathology and Laboratory Medicine, the main concepts related to the assessment of renal function are reviewed, as well as possible existing controversies and recommendations for estimating GFR in clinical practice.
MeSH term(s)	Humans ; Glomerular Filtration Rate ; Nephrology ; Creatinine ; Brazil ; Consensus ; Renal Dialysis ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy ; Pathology, Clinical
Chemical Substances	Creatinine (AYI8EX34EU)
Language	Portuguese
Publishing date	2024-04-05
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2057873-8
ISSN	2175-8239 ; 2175-8239
ISSN (online)	2175-8239
ISSN	2175-8239
DOI	10.1590/2175-8239-JBN-2023-0193en
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association of the immature platelet fraction with sepsis diagnosis and severity.

Enz Hubert, Rodolfo Monteiro / Rodrigues, Melina Veiga / Andreguetto, Bruna Dolci / Santos, Thiago M / de Fátima Pereira Gilberti, Maria / de Castro, Vagner / Annichino-Bizzacchi, Joyce M / Dragosavac, Desanka / Carvalho-Filho, Marco Antonio / De Paula, Erich Vinicius

Scientific reports

2015 Volume 5, Page(s) 8019

Abstract: Management of Sepsis would greatly benefit from the incorporation of simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate infected from non-infected patients, provide information about prognosis and ... ...

Abstract	Management of Sepsis would greatly benefit from the incorporation of simple and informative new biomarkers in clinical practice. Ideally, a sepsis biomarker should segregate infected from non-infected patients, provide information about prognosis and organ-specific damage, and be accessible to most healthcare services. The immature platelet fraction (IPF) and immature reticulocyte fraction (IRF) are new analytical parameters of the complete blood count, that have been studied as biomarkers of several inflammatory conditions. Recently, a study performed in critically-ill patients suggested that IPF could be a more accurate sepsis biomarker than C-reactive protein (CRP) and procalcitonin. In this retrospective study we evaluated the performance of IPF and IRF as biomarkers of sepsis diagnosis and severity. 41 patients admitted to two intensive care units were evaluated, 12 of which with severe sepsis or septic shock, and 11 with non-complicated sepsis. Significantly higher IPF levels were observed in patients with severe sepsis/septic shock. IPF correlated with sepsis severity scores and presented the highest diagnostic accuracy for the presence of sepsis of all studied clinical and laboratory parameters. No significant differences were observed in IRF levels. Our results suggest that IPF levels could be used as a biomarker of sepsis diagnosis and severity.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Blood Platelets ; C-Reactive Protein ; Female ; Humans ; Male ; Middle Aged ; Platelet Count ; Prognosis ; Reticulocyte Count ; Reticulocytes/pathology ; Sepsis/blood ; Sepsis/pathology
Chemical Substances	Biomarkers ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2015-01-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep08019
Database	MEDical Literature Analysis and Retrieval System OnLINE