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  1. Book ; Online: Antimicrobial Therapy in Intensive Care Unit

    Paramythiotou, Elizabeth / Routsi, Christina / Andremont, Antoine

    2023  

    Keywords Medicine ; Acinetobacter ; pandrug-resistant ; antimicrobial combinations ; synergy ; renal replacement therapy ; Monte Carlo simulation ; antibiotics ; pharmacokinetics ; pharmacodynamics ; microbiome ; probiotics ; intensive care unit ; dysbiosis ; ventilator-associated pneumonia ; extracorporeal membrane oxygenation ; ECMO ; critical illness ; antibiotic choices ; HAP ; VAP ; colonization ; antibiotic pressure ; bloodstream infection ; bacteraemia ; sepsis ; septic shock ; empirical ; probabilistic antibiotics ; source control ; de-escalation ; ICU ; intensive care ; antimicrobial stewardship ; COVID-19 ; procalcitonin ; C-reactive protein ; presepsin ; infection ; biomarker ; guided antimicrobial therapy ; APACHE II score ; bacteremia ; broth microdilution ; colistin ; colistin-resistant ; Gram-negative ; mortality ; SOFA score ; candidemia ; incidence ; epidemiology ; Candida species ; non-albicans Candida species ; fluconazole resistance ; critically ill ; beta-lactam antibiotics ; Acinetobacter baumannii ; antibiotic optimisation ; antibiotic stewardship (AMS) ; aspiration pneumonia ; hospital-acquired pneumonia (HAP) ; multidrug-resistance (MDR) ; non-fermentative Gram-negative bacilli (GNB) ; polymicrobial ; pneumonia resolution ; ventilator-associated pneumonia (VAP) ; carbapenem-resistant A. baumannii (CRAb) ; infection control ; antimicrobial agents ; carbapenems ; antibiotic resistance ; clinical pharmacy services ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; salvage treatment ; double carbapenem ; newer β-lactam-β-lactamase inhibitors ; cefiderocol ; eravacycline ; SARS-CoV-2 infection ; mechanical ventilation ; risk factors ; blood stream infection ; defined daily dose ; antibiotics utilization ; empiric ; n/a
    Language English
    Size 1 electronic resource (260 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376507
    ISBN 9783036567686 ; 3036567682
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Combating Antimicrobial Resistance - A One Health Approach

    Matar, Ghassan M. / Andremont, Antoine

    2020  

    Keywords Science: general issues ; Infectious & contagious diseases ; resistance mechanisms ; combination therapy ; Novel antibiotics ; Natural Products ; mode of action ; Therapeutics ; antimicrobials ; inhibitors
    Size 1 electronic resource (326 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230496
    ISBN 9782889635153 ; 2889635155
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Too Early to Recommend Early Fecal Microbiota Transplantation in Patients With Severe Clostridium difficile Infection, or Not Too Early?

    Andremont, Antoine

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2017  Volume 66, Issue 5, Page(s) 651–652

    MeSH term(s) Clostridium Infections ; Enterocolitis, Pseudomembranous ; Fecal Microbiota Transplantation ; Humans
    Language English
    Publishing date 2017-10-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cix763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 480: Show issues

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  4. Article ; Online: Editorial: Combating Antimicrobial Resistance - A One Health Approach.

    Matar, Ghassan M / Andremont, Antoine / Bazzi, Wael

    Frontiers in cellular and infection microbiology

    2020  Volume 9, Page(s) 458

    MeSH term(s) Animal Husbandry/methods ; Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Bacterial Infections/prevention & control ; Drug Resistance, Bacterial ; Global Health ; Health Policy ; Humans ; One Health
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-01-22
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2019.00458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Unraveling the Diversity of Co-Colonization by CPE

    Levi, Gabrielle / Lurie-Weinberger, Mor / Keren-Paz, Alona / Andremont, Antoine O. / Schwartz, David / Carmeli, Yehuda

    Microorganisms. 2022 June 25, v. 10, no. 7

    2022  

    Abstract: Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency ...

    Abstract Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. In this paper, we present three cases that illustrate the underlying mechanisms of co-colonization, focusing on horizontal gene transfer (HGT) and patient-to-patient transmission. We also demonstrate the diversity of CPE species and discuss the potential consequences of co-colonization.
    Keywords antibiotic resistance ; beta-lactamase ; horizontal gene transfer
    Language English
    Dates of publication 2022-0625
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10071292
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Spare and repair the gut microbiota from antibiotic-induced dysbiosis: state-of-the-art.

    Andremont, Antoine / Cervesi, Julie / Bandinelli, Pierre-Alain / Vitry, Fabien / de Gunzburg, Jean

    Drug discovery today

    2021  Volume 26, Issue 9, Page(s) 2159–2163

    Abstract: Homeostasis of the intestinal microbiota is currently recognized as a major contributor to human health. Furthermore, intestinal dysbiosis is associated with a multitude of consequences, including intestinal colonization by antibiotic-resistant or ... ...

    Abstract Homeostasis of the intestinal microbiota is currently recognized as a major contributor to human health. Furthermore, intestinal dysbiosis is associated with a multitude of consequences, including intestinal colonization by antibiotic-resistant or pathogenic bacteria, such as Clostridioides difficile, and reduced efficacy of promising anticancer immunotherapies. By far, the most immediate and drastic exposure leading to dysbiosis is antibiotic treatment. Many attempts have been made to prevent or repair antibiotic-associated dysbiosis. Here, we review these innovations and the difficulties associated with their development.
    MeSH term(s) Animals ; Anti-Bacterial Agents/adverse effects ; Dysbiosis/chemically induced ; Dysbiosis/prevention & control ; Gastrointestinal Microbiome/drug effects ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-02-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2021.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 4725: Show issues Location:
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  7. Article: Isolation in small populations of Wayampi Amerindians promotes endemicity and homogenisation of their faecal virome, but its distribution is not entirely random

    Pérez-Brocal, Vicente / Andremont, Antoine / Moya, Andrés

    FEMS microbiology ecology. 2018 Feb. 01, v. 94, no. 2

    2018  

    Abstract: The isolated community of the Wayampi Amerindians has been extensively studied for the presence of beta lactamase-producing enterobacteria and their gut microbiota. However, no information about their virome was available. This study tries to establish ... ...

    Abstract The isolated community of the Wayampi Amerindians has been extensively studied for the presence of beta lactamase-producing enterobacteria and their gut microbiota. However, no information about their virome was available. This study tries to establish potential associations between the virome and diverse epidemiological data, through the metagenomic study of the faecal prophages and DNA viruses from 31 samples collected in 2010. Taxonomic assignments, composition, abundance and diversity analyses were obtained to characterise the virome and were compared between groups according to several demographic, environmental and medical data. Prophages outnumbered viruses. Composition and abundance of virome indicated relatively low variability. Diversity within samples showed no significant differences, regardless of the group comparison. Significant differences were observed in the beta diversity among samples according to hospitalisation and gender, but not by extended spectrum β-lactamase carriage, antibiotic intake or possession of pets, although some viruses differed in some cases (e.g. immunodeficiency-associated stool virus associated with antibiotic intake). The faecal virome of adult Wayampi is more homogeneous than that from western populations. Not a single factor analysed can explain alone the observed distribution of the virome, but differences by gender (fewer variability in females than males) may reflect differences in life habits and work.
    Keywords American Indians ; DNA viruses ; adults ; antibiotics ; beta-lactamase ; feces ; females ; indigenous species ; intestinal microorganisms ; males ; metagenomics ; pets ; species diversity ; viruses
    Language English
    Dates of publication 2018-0201
    Publishing place Oxford University Press
    Document type Article
    ZDB-ID 283722-5
    ISSN 1574-6941 ; 0168-6496
    ISSN (online) 1574-6941
    ISSN 0168-6496
    DOI 10.1093/femsec/fix184
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 2967: Show issues Location:
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  8. Article ; Online: Isolation in small populations of Wayampi Amerindians promotes endemicity and homogenisation of their faecal virome, but its distribution is not entirely random.

    Pérez-Brocal, Vicente / Andremont, Antoine / Moya, Andrés

    FEMS microbiology ecology

    2018  Volume 94, Issue 2

    Abstract: The isolated community of the Wayampi Amerindians has been extensively studied for the presence of beta lactamase-producing enterobacteria and their gut microbiota. However, no information about their virome was available. This study tries to establish ... ...

    Abstract The isolated community of the Wayampi Amerindians has been extensively studied for the presence of beta lactamase-producing enterobacteria and their gut microbiota. However, no information about their virome was available. This study tries to establish potential associations between the virome and diverse epidemiological data, through the metagenomic study of the faecal prophages and DNA viruses from 31 samples collected in 2010. Taxonomic assignments, composition, abundance and diversity analyses were obtained to characterise the virome and were compared between groups according to several demographic, environmental and medical data. Prophages outnumbered viruses. Composition and abundance of virome indicated relatively low variability. Diversity within samples showed no significant differences, regardless of the group comparison. Significant differences were observed in the beta diversity among samples according to hospitalisation and gender, but not by extended spectrum β-lactamase carriage, antibiotic intake or possession of pets, although some viruses differed in some cases (e.g. immunodeficiency-associated stool virus associated with antibiotic intake). The faecal virome of adult Wayampi is more homogeneous than that from western populations. Not a single factor analysed can explain alone the observed distribution of the virome, but differences by gender (fewer variability in females than males) may reflect differences in life habits and work.
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; DNA Viruses/classification ; DNA Viruses/genetics ; DNA Viruses/isolation & purification ; Enterobacteriaceae/genetics ; Enterobacteriaceae/metabolism ; Feces/virology ; Female ; French Guiana ; Gastrointestinal Microbiome/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Metagenomics ; Prophages/classification ; Prophages/genetics ; Prophages/isolation & purification ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2018-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 283722-5
    ISSN 1574-6941 ; 0168-6496
    ISSN (online) 1574-6941
    ISSN 0168-6496
    DOI 10.1093/femsec/fix184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Unraveling the Diversity of Co-Colonization by CPE.

    Levi, Gabrielle / Lurie-Weinberger, Mor / Keren-Paz, Alona / Andremont, Antoine O / Schwartz, David / Carmeli, Yehuda

    Microorganisms

    2022  Volume 10, Issue 7

    Abstract: Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency ...

    Abstract Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. In this paper, we present three cases that illustrate the underlying mechanisms of co-colonization, focusing on horizontal gene transfer (HGT) and patient-to-patient transmission. We also demonstrate the diversity of CPE species and discuss the potential consequences of co-colonization.
    Language English
    Publishing date 2022-06-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10071292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: What to do about resistant bacteria in the food-chain?

    Andremont, Antoine / Fiona Fleck

    Bulletin of the World Health Organization

    2015  Volume 93, Issue 4, Page(s) 217–218

    Abstract: This year's World Health Day is on food safety. The mass use of antibiotics in animal husbandry is contaminating the food supply with resistant bacteria, causing difficult-to-treat infections while reducing the power of antibiotics to cure human ... ...

    Abstract This year's World Health Day is on food safety. The mass use of antibiotics in animal husbandry is contaminating the food supply with resistant bacteria, causing difficult-to-treat infections while reducing the power of antibiotics to cure human infections. Antoine Andremont talks to Fiona Fleck.
    MeSH term(s) Animal Husbandry/methods ; Animals ; Anti-Bacterial Agents/administration & dosage ; Bacteria/drug effects ; Drug Resistance, Bacterial ; Food Microbiology ; Food Safety ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2015-04-01
    Publishing country Switzerland
    Document type Interview
    ZDB-ID 80213-x
    ISSN 1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
    ISSN (online) 1564-0604
    ISSN 0042-9686 ; 0366-4996 ; 0510-8659
    DOI 10.2471/BLT.15.030415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 215: Show issues Location:
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