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Article ; Online: The use of a standard-length conical tapered stem in hip revision arthroplasty to address Paprosky type I-II femoral defects: a prospective study of 87 patients.

Innocenti, Matteo / Smulders, Katrijn / Andreotti, Mattia / Willems, Jore H / Van Hellemondt, Gijs / Nijhof, Marc W

Archives of orthopaedic and trauma surgery

2023 Volume 143, Issue 9, Page(s) 5945–5955

Abstract: Introduction: Low-grade femoral defects in revision total hip arthroplasty (rTHA) might be preferably treated with a primary implant. Almost no previous study reported the use of standard-length conical tapered (SLCT) stems in these cases. We analyzed a ...

Abstract	Introduction: Low-grade femoral defects in revision total hip arthroplasty (rTHA) might be preferably treated with a primary implant. Almost no previous study reported the use of standard-length conical tapered (SLCT) stems in these cases. We analyzed a series of cases using a SLCT stem in rTHA with Paprosky type I-II femoral defects. The purpose of the study was to determine clinical and radiographic outcomes in this series of rTHA. Materials and methods: We prospectively followed 87 patients undergoing a femoral component rTHA: 53 Paprosky type I and 34 type II femoral defects. Patient-reported measures (Oxford Hip Score, EQ-5D, VAS pain during rest and activity) were administered at baseline, 1 and 2 years post-operatively. Radiographic subsidence overtime was scored. Kaplan-Meier curves were used to evaluate the subsidence over time, the complication-free survival, and the implant survivorship with reoperation and stem revision as endpoints. Results: The mean follow-up was 72.5 (SD ± 23.9) months. All PROMs significatively improved over time. The average subsidence was 2.8 (SD ± 3.2), 3.6 (SD ± 4.4), and 4.0 (SD ± 4.9) mm at 4, 12, and 24 months respectively. 6 stems had subsidence > 10 mm. The survival without complication was 0.85 (95% CI 0.94-0.77), while the implant survival without reoperation was 0.83 (95% CI 0.95-0.72). The overall stem survival rate was 93.7% (95% CI 0.91-0.97) at 2 years. Conclusion: The use of a SLCT stem in rTHA with Paprosky type I-II femoral defects demonstrated good survival with low subsidence rates during the first 2 years after surgery. Surgeons should consider the use of this primary prosthesis as a potential treatment during stem revision in cases with limited femoral bone loss.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Hip ; Hip Prosthesis ; Prospective Studies ; Prosthesis Design ; Retrospective Studies ; Reoperation ; Femur/surgery ; Prosthesis Failure ; Treatment Outcome
Language	English
Publishing date	2023-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-023-04797-y
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Book ; Online: Die Struktur der modernen Literatur

Andreotti, Mario

neue Formen und Techniken des Schreibens: Erzählprosa und Lyrik ; mit einem Glossar zu literarischen, linguistischen und philosophischen Grundbegriffen

(UTB ; 1127 ; utb-studi-e-book)

2014

Abstract: Ich habe in diesem Buch mehr gefunden, als ich gesucht habe. Mein Eindruck: ein Buch von unendlicher Brauchbarkeit.Martin WalserWer moderne Erzählungen, moderne Gedichte, etwa einen Roman von Franz Kafka oder ein Gedicht von Paul Celan, liest, ist ... ...

Author's details	Mario Andreotti
Series title	UTB ; 1127 utb-studi-e-book
Abstract	"Ich habe in diesem Buch mehr gefunden, als ich gesucht habe. Mein Eindruck: ein Buch von unendlicher Brauchbarkeit.Martin WalserWer moderne Erzählungen, moderne Gedichte, etwa einen Roman von Franz Kafka oder ein Gedicht von Paul Celan, liest, ist häufig ratlos, weil ihm der Zugang zu solch künstlerisch neuartigen Texten fehlt. Hier setzt der vorliegende Band an, indem er literarische Kategorien aufzeigt, mit denen sich das wirklich Neue moderner Texte adäquat beschreiben lässt. Der Band berücksichtigt über die klassische Moderne hinaus auch die jüngsten Entwicklungen innerhalb der Post- und der Spätmoderne: von den subkulturellen Formen der Literatur (Pop, Beat, Rap, Slam Poetry) bis zur digitalen Literatur (Hypertext, Handy-Roman). Andreottis Buch wendet sich, schon seiner leserfreundlichen Darstellung und vielen Textbeispiele wegen, an ein breites literarisch interessiertes Publikum, aber auch an Autorinnen und Autoren, die nach neuen Formen des Schreibens suchen.
Keywords	Lyrik ; Textanalyse ; Deutsch ; Epik
Language	German
Size	Online-Ressource (488 S.)
Edition	5., stark erw. und aktualisierte Aufl.
Publisher	Haupt
Publishing place	Bern
Document type	Book ; Online
ISBN	9783825240776 ; 9783838540771 ; 3825240770 ; 3838540778
Database	Former special subject collection: coastal and deep sea fishing

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Book: Die Struktur der modernen Literatur

Andreotti, Mario

neue Formen und Techniken des Schreibens: Erzählprosa und Lyrik ; mit einem Glossar zu literarischen, linguistischen und philosophischen Grundbegriffen

(UTB ; 1127)

2014

Author's details	Mario Andreotti
Series title	UTB ; 1127
Keywords	Lyrik ; Textanalyse ; Deutsch ; Epik
Language	German
Size	488 S., Ill., graph. Darst., 185 mm x 120 mm
Edition	5., stark erw. und aktualisierte Aufl.
Publisher	Haupt
Publishing place	Bern
Document type	Book
ISBN	9783825240776 ; 3825240770
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: A 12-month Prospective Study of HIV-infected and HIV-uninfected Women and Their Infants in Malawi: Comparative Analysis of Clinical Events and Infant Growth.

Floridia, Marco / Orlando, Stefano / Andreotti, Mauro / Mphwere, Robert / Kavalo, Thom / Ciccacci, Fausto / Scarcella, Paola / Marazzi, Maria Cristina / Giuliano, Marina

The American journal of tropical medicine and hygiene

2022 Volume 108, Issue 2, Page(s) 394–402

Abstract: Few studies have compared clinical outcomes in HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) infants in the current scenario of universal and lifelong maternal antiretroviral therapy (ART). HIV-uninfected and HIV-infected Malawian women ...

Abstract	Few studies have compared clinical outcomes in HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) infants in the current scenario of universal and lifelong maternal antiretroviral therapy (ART). HIV-uninfected and HIV-infected Malawian women receiving ART and their breastfed infants were followed for 12 months postpartum, analyzing the rates of infectious and noninfectious events and assessing infant growth at 6 weeks, 6 months, and 12 months. The cohorts included 227 mothers (70 HIV-negative, 157 HIV-positive) and 235 infants (72 HUU, 163 HEU). No maternal or infant deaths occurred during follow-up. HIV-negative women were less likely to complete follow-up (48.6% versus 91.1%). Mothers with and without HIV had similar rates of both infectious and noninfectious events per person-month. Infants who were HEU, compared with HUU, had higher rates of events of any type, lower respiratory tract infections (LRTI), and noninfectious events. HEU had lower body mass index (BMI) at 6 weeks but did not differ from HUU in all anthropometric measures at 6 and 12 months; in growth between 6 weeks and 12 months; and in occurrence of stunting, underweight, and wasting at 6 weeks, 6 months, and 12 months. During the first year of life, infants who were HEU, compared with HUU, showed a transiently lower BMI and an increased risk of LRTI.
MeSH term(s)	Infant ; Humans ; Female ; Prospective Studies ; Malawi/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Breast Feeding ; Communicable Diseases ; Respiratory Tract Infections
Language	English
Publishing date	2022-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.22-0482
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Article ; Online: Maternal retention and early infant HIV diagnosis in a prospective cohort study of HIV-positive women and their children in Malawi.

Giuliano, Marina / Orlando, Stefano / Andreotti, Mauro / Mthiko, Bryan / Mphwere, Robert / Kavalo, Thom / Ciccacci, Fausto / Marazzi, Maria Cristina / Floridia, Marco

International journal of STD & AIDS

2022 Volume 34, Issue 1, Page(s) 54–61

Abstract: Background: Post-partum loss to follow-up and lack of early HIV infant diagnosis (EID) can significantly affect the efficiency of programs for the prevention of mother-to-child transmission.: Methods: In a prospective observational study 167 women ... ...

Abstract	Background: Post-partum loss to follow-up and lack of early HIV infant diagnosis (EID) can significantly affect the efficiency of programs for the prevention of mother-to-child transmission. Methods: In a prospective observational study 167 women were enrolled at week 36 of gestation and followed with their infants up to one year after delivery. Retention was defined as the proportion of women who attended the 12 months visit and EID as an HIV PCR test performed within 2 months. Determinants for retention and EID were assessed in univariate analyses and in multivariable logistic regression models. Results: Women lost to follow-up (24/167 or 14.4%) had a shorter duration of antiretroviral therapy (ART) at enrolment in comparison to women retained in care ( Conclusions: Longer duration of ART at enrolment significantly predicted a better post-partum retention, suggesting that specific counselling interventions should be targeted to recent ART initiators. A low proportion of infants did not receive an EID, but predictive factors were difficult to identify.
MeSH term(s)	Infant ; Female ; Humans ; Pregnancy ; Prospective Studies ; Malawi/epidemiology ; Infectious Disease Transmission, Vertical/prevention & control ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Early Diagnosis ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Infectious/epidemiology
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624221136647
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Article: Children with Kawasaki disease or Kawasaki-like syndrome (MIS-C/PIMS) at the time of COVID-19: are they all the same? Case series and literature review.

Marino, A / Varisco, T / Quattrocchi, G / Amoroso, A / Beltrami, D / Venturiello, S / Ripamonti, A / Villa, A / Andreotti, M / Ciuffreda, M / Cimaz, R

Reumatismo

2021 Volume 73, Issue 1, Page(s) 48–53

Abstract: Since the coronavirus disease 2019 (COVID-19) outbreak started, children have been considered marginally involved compared to adults, with a quite significant percentage of asymptomatic carriers. Very recently, an overwhelming inflammatory activation, ... ...

Abstract	Since the coronavirus disease 2019 (COVID-19) outbreak started, children have been considered marginally involved compared to adults, with a quite significant percentage of asymptomatic carriers. Very recently, an overwhelming inflammatory activation, which shares clinical similarities with Kawasaki disease (KD), has been described in children exposed to COVID-19. We report three KD-like cases that occurred during the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a highly affected area of Northern Italy. The clinical presentation was characterized by the presence of unremitting fever, diarrhea and elevated inflammatory markers. Case #1 and Case #2 occurred one week apart and shared other clinical features: laboratory tests confirmed COVID-19 exposure and high inflammatory activation with myocardial involvement. Case #3 followed a more typical pattern for KD. Interestingly, this patient showed lower levels of procalcitonin, C-reactive protein, D-dimers, and ferritin compared to the other two cases, whereas platelet count was higher. We hypothesize that SARS-CoV-2 might act in children as a trigger, either inducing a classical KD phenotype or causing a systemic inflammatory response leading to a severe KD-like phenotype, eventually characterized by myocardial impairment. We think that bringing these cases and their differences to the attention of the rheumatology community during the COVID-19 pandemic will be beneficial in order to highlight the importance of early diagnosis and to increase awareness of this new phenomenon.
MeSH term(s)	COVID-19/complications ; COVID-19/diagnosis ; COVID-19/etiology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Italy ; Male ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/etiology ; Retrospective Studies ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/etiology
Language	English
Publishing date	2021-04-19
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	414816-2
ISSN	2240-2683 ; 0048-7449
ISSN (online)	2240-2683
ISSN	0048-7449
DOI	10.4081/reumatismo.2021.1331
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Article: Autoimmune rhomboencephalitis: A pediatric case report.

Marino, Achille / Canonico, Francesco / Pinzani, Raffaella Maria / Andreotti, Massimo / Varisco, Tiziana / Cappellari, Alberto Maria

Turk pediatri arsivi

2020 Volume 55, Issue 4, Page(s) 449–452

Abstract: Rhomboencephalitis is a potentially life-threatening condition due to inflammation of the hindbrain with an unpredictable outcome depending on the wide spectrum of etiologies and the promptness of diagnosis and treatment. A 23-month-old Caucasian male ... ...

Abstract	Rhomboencephalitis is a potentially life-threatening condition due to inflammation of the hindbrain with an unpredictable outcome depending on the wide spectrum of etiologies and the promptness of diagnosis and treatment. A 23-month-old Caucasian male presented with fever, clouding of consciousness, and trunk ataxia. Three weeks earlier he received active immunization against varicella-zoster virus. Routine laboratory tests were unremarkable. Cerebrospinal fluid showed might elevation of leukocytes. The infection panel was negative. Brain magnetic resonance showed signal hyperintensity in the dorsal portion of the pons, which was consistent with a rhomboencephalitis. Autoimmune pathogenesis was supposed and a high dose of steroids was started. The patient's neurologic status progressively improved till full recovery and complete regression of previous magnetic resonance lesions after 1 year. Nevertheless, longer follow-up is needed in order not to miss any possible signs of an underlying autoimmune neurologic disorder.
Language	English
Publishing date	2020-12-16
Publishing country	Turkey
Document type	Case Reports
ISSN	1306-0015
ISSN	1306-0015
DOI	10.14744/TurkPediatriArs.2020.26576
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Article ; Online: Micronutrient and Nutritional Status of HIV-Exposed and HIV-Unexposed Malawian Infants in the First Year of Life: Assessment of Ferritin, Vitamin A, and D Status and Its Association with Growth.

Floridia, Marco / Galluzzo, Clementina Maria / Orlando, Stefano / Luhanga, Richard / Mphwere, Robert / Kavalo, Thom / Andreotti, Mauro / Amici, Roberta / Ciccacci, Fausto / Marazzi, Maria Cristina / Giuliano, Marina

Nutrients

2023 Volume 15, Issue 14

Abstract: Breastfed Malawian infants from Human Immunodeficiency Virus (HIV)-uninfected and HIV-infected women who received antiretroviral therapy were followed until 12 months of age, allowing us to evaluate plasma levels of ferritin, vitamin A (as retinol- ... ...

Abstract	Breastfed Malawian infants from Human Immunodeficiency Virus (HIV)-uninfected and HIV-infected women who received antiretroviral therapy were followed until 12 months of age, allowing us to evaluate plasma levels of ferritin, vitamin A (as retinol-binding protein, RBP), and vitamin D (25(OH)D) at six months, as well as nutritional status and growth between six and 12 months. Ferritin and RBP levels were adjusted for inflammation. The study included 88 infants, 63 of whom were part of a recent cohort (2019-2021) that included 49 HIV-exposed but uninfected (HEU) and 14 HIV-unexposed and uninfected (HUU) infants, as well as 25 infants (all HEU) from an earlier cohort (2008-2011). No differences were observed between HEU and HUU infants regarding micronutrient levels, anthropometric indexes, growth, and rates of stunting, being underweight, or wasting. HEU infants from the earlier cohort, when compared to more recent HEU infants, had significantly worse anthropometric measures at six months and inferior growth between six and twelve months. Overall, ferritin deficiency involved 68.6% of infants, while vitamin A and vitamin D deficiency involved 8% and 1.2% of infants, respectively. Micronutrient deficiencies were not associated with HIV exposure, cohort, stunting, being underweight, or wasting. At six months, stunting, being underweight, and wasting involved 25.0%, 2.7% and 2.8% of infants, respectively, with no differences related to HIV exposure. Ferritin deficiency at six months was associated with inferior subsequent growth. In this small observational study conducted in Malawian infants, no major nutritional gap was observed between HIV-exposed and HIV-unexposed infants, though the study highlighted specific nutritional deficiencies that deserve attention. High rates of stunting and ferritin deficiency were observed in the first year of life in Malawian infants, irrespective of maternal HIV status; a significant association between ferritin deficiency and worse subsequent growth was found. Vitamin A and vitamin D deficiencies were much less frequent. Based on the data observed, nutritional interventions should give priority to the correction of ferritin deficiency and chronic undernutrition.
MeSH term(s)	Humans ; Infant ; Female ; Nutritional Status ; Vitamin A ; HIV ; Ferritins ; Micronutrients ; Thinness/complications ; HIV Infections/complications ; HIV Infections/epidemiology ; Trace Elements ; Growth Disorders/etiology ; Growth Disorders/complications ; Malnutrition/complications ; Cachexia/complications ; Vitamin D Deficiency/complications
Chemical Substances	Vitamin A (11103-57-4) ; Ferritins (9007-73-2) ; Micronutrients ; Trace Elements
Language	English
Publishing date	2023-07-24
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15143282
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Article: SARS-CoV-2-Specific CD8

Ferrantelli, Flavia / Manfredi, Francesco / Chiozzini, Chiara / Leone, Patrizia / Pugliese, Katherina / Spada, Massimo / Di Virgilio, Antonio / Giovannelli, Andrea / Valeri, Mauro / Cara, Andrea / Michelini, Zuleika / Andreotti, Mauro / Federico, Maurizio

Vaccines

2023 Volume 11, Issue 9

Abstract: Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 enters the host by infecting nasal ciliated cells. Then, the virus can spread towards the oropharyngeal cavity and the pulmonary tissues. The antiviral adaptive immunity is promptly induced in ... ...

Abstract	Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 enters the host by infecting nasal ciliated cells. Then, the virus can spread towards the oropharyngeal cavity and the pulmonary tissues. The antiviral adaptive immunity is promptly induced in response to the virus's detection, with virus-specific T-lymphocytes appearing before antiviral antibodies. Both the breadth and potency of antiviral CD8
Language	English
Publishing date	2023-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11091433
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Article ; Online: Antiviral effect of SARS-CoV-2 N-specific CD8

Manfredi, Francesco / Chiozzini, Chiara / Ferrantelli, Flavia / Leone, Patrizia / Pugliese, Katherina / Spada, Massimo / Di Virgilio, Antonio / Giovannelli, Andrea / Valeri, Mauro / Cara, Andrea / Michelini, Zuleika / Andreotti, Mauro / Federico, Maurizio

NPJ vaccines

2023 Volume 8, Issue 1, Page(s) 83

Abstract: Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogenic effects generated by respiratory infectious agents. We recently provided evidence that the generation of endogenous extracellular ...

Abstract	Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogenic effects generated by respiratory infectious agents. We recently provided evidence that the generation of endogenous extracellular vesicles (EVs) engineered for the incorporation of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 Nucleocapsid (N) protein induced immunity in the lungs of K18-hACE2 transgenic mice, which then can survive the lethal virus infection. However, nothing is known about the ability of the N-specific CD8
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-023-00686-y
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