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  1. Article ; Online: The ESMO-EURACAN-GENTURIS-ERNPaedCan Clinical Practice Guidelines for bone sarcomas - the challenges of the fight against rare cancers.

    Andreou, D

    Annals of oncology : official journal of the European Society for Medical Oncology

    2021  Volume 32, Issue 12, Page(s) 1470–1471

    MeSH term(s) Humans ; Osteosarcoma ; Sarcoma/diagnosis ; Sarcoma/epidemiology ; Sarcoma/therapy
    Language English
    Publishing date 2021-09-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2021.09.013
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: CORR Insights®: What Proportion of Patients With Musculoskeletal Sarcomas Demonstrate Symptoms of Depression or Anxiety?

    Andreou, Dimosthenis

    Clinical orthopaedics and related research

    2022  Volume 480, Issue 11, Page(s) 2161–2162

    MeSH term(s) Anxiety/diagnosis ; Depression/diagnosis ; Depression/epidemiology ; Humans ; Musculoskeletal System ; Sarcoma/diagnosis ; Soft Tissue Neoplasms/diagnosis
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002356
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Artificial intelligence large language model ChatGPT: is it a trustworthy and reliable source of information for sarcoma patients?

    Valentini, Marisa / Szkandera, Joanna / Smolle, Maria / Scheipl, Susanne / Leithner, Andreas / Andreou, Dimosthenis

    Frontiers in public health

    2024  Volume 12, Page(s) 1303319

    Abstract: Introduction: Since its introduction in November 2022, the artificial intelligence large language model ChatGPT has taken the world by storm. Among other applications it can be used by patients as a source of information on diseases and their treatments. ...

    Abstract Introduction: Since its introduction in November 2022, the artificial intelligence large language model ChatGPT has taken the world by storm. Among other applications it can be used by patients as a source of information on diseases and their treatments. However, little is known about the quality of the sarcoma-related information ChatGPT provides. We therefore aimed at analyzing how sarcoma experts evaluate the quality of ChatGPT's responses on sarcoma-related inquiries and assess the bot's answers in specific evaluation metrics.
    Methods: The ChatGPT responses to a sample of 25 sarcoma-related questions (5 definitions, 9 general questions, and 11 treatment-related inquiries) were evaluated by 3 independent sarcoma experts. Each response was compared with authoritative resources and international guidelines and graded on 5 different metrics using a 5-point Likert scale: completeness, misleadingness, accuracy, being up-to-date, and appropriateness. This resulted in maximum 25 and minimum 5 points per answer, with higher scores indicating a higher response quality. Scores ≥21 points were rated as very good, between 16 and 20 as good, while scores ≤15 points were classified as poor (11-15) and very poor (≤10).
    Results: The median score that ChatGPT's answers achieved was 18.3 points (IQR, i.e., Inter-Quartile Range, 12.3-20.3 points). Six answers were classified as very good, 9 as good, while 5 answers each were rated as poor and very poor. The best scores were documented in the evaluation of how appropriate the response was for patients (median, 3.7 points; IQR, 2.5-4.2 points), which were significantly higher compared to the accuracy scores (median, 3.3 points; IQR, 2.0-4.2 points;
    Discussion: The answers ChatGPT provided on a rare disease, such as sarcoma, were found to be of very inconsistent quality, with some answers being classified as very good and others as very poor. Sarcoma physicians should be aware of the risks of misinformation that ChatGPT poses and advise their patients accordingly.
    MeSH term(s) Humans ; Artificial Intelligence ; Language ; Sarcoma ; Awareness ; Information Sources
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1303319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Extraordinarily Rare Ciliate Legendrea loyezae Fauré-Fremiet, 1908 (Haptoria, Ciliophora).

    Weiss, James / Andreou, Demetra / Esteban, Genoveva F

    Protist

    2022  Volume 173, Issue 6, Page(s) 125912

    Abstract: Diverse and dynamic communities of ciliates and other microbes thrive in the natural environment, driving the functioning of aquatic ecosystems. Many microbes are present in very low numbers or are dormant in the 'seedbank', escaping detection in ... ...

    Abstract Diverse and dynamic communities of ciliates and other microbes thrive in the natural environment, driving the functioning of aquatic ecosystems. Many microbes are present in very low numbers or are dormant in the 'seedbank', escaping detection in environmental surveys and, consequently, remaining underexplored. Here, we report an extraordinarily rare ciliate that was discovered after persistent exploration of freshwater anoxic sediments - Legendrea loyezae Fauré-Fremiet, 1908, a member of the Family Spathidiidae, Order Haptorida. In this study, we present the sixth account of the ciliate since 1908 and reveal its phylogenetic position with the first 18S rRNA data for the genus. We explain the key morphological features of the species, describing a remarkable behaviour in which the ciliate "shapeshifts'' due to its ability of controlled full extension and retraction of its tube-like tentacles. Our results shed light on the similarity of L. loyezae to another ciliate that was first described as Legendrea bellerophon, later moved under a new genus and named Thysanomorpha bellerophon. We question the validity of this taxonomic decision and, based on morphological characters and tentacle movement, we propose moving T. bellerophon back under Legendrea. This study demonstrates how continued and persistent exploration of natural habitats lead to the discovery of microbial communities and species.
    MeSH term(s) Phylogeny ; Ecosystem ; DNA, Protozoan/genetics ; Ciliophora/genetics ; RNA, Ribosomal, 18S/genetics
    Chemical Substances DNA, Protozoan ; RNA, Ribosomal, 18S
    Language English
    Publishing date 2022-09-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2036014-9
    ISSN 1618-0941 ; 1434-4610
    ISSN (online) 1618-0941
    ISSN 1434-4610
    DOI 10.1016/j.protis.2022.125912
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  5. Article: Behavioural thermoregulation in cold-water freshwater fish: Innate resilience to climate warming?

    Amat-Trigo, Fatima / Andreou, Demetra / Gillingham, Phillipa K / Britton, J Robert

    Fish and fisheries (Oxford, England)

    2022  Volume 24, Issue 1, Page(s) 187–195

    Abstract: Behavioural thermoregulation enables ectotherms to access habitats providing conditions within their temperature optima, especially in periods of extreme thermal conditions, through adjustments to their behaviours that provide a "whole-body" response to ... ...

    Abstract Behavioural thermoregulation enables ectotherms to access habitats providing conditions within their temperature optima, especially in periods of extreme thermal conditions, through adjustments to their behaviours that provide a "whole-body" response to temperature changes. Although freshwater fish have been detected as moving in response to temperature changes to access habitats that provide their thermal optima, there is a lack of integrative studies synthesising the extent to which this is driven by behaviour across different species and spatial scales. A quantitative global synthesis of behavioural thermoregulation in freshwater fish revealed that across 77 studies, behavioural thermoregulatory movements by fish were detected both vertically and horizontally, and from warm to cool waters and, occasionally, the converse. When fish moved from warm to cooler habitats, the extent of the temperature difference between these habitats decreased with increasing latitude, with juvenile and non-migratory fishes tolerating greater temperature differences than adult and anadromous individuals. With most studies focused on assessing movements of cold-water salmonids during summer periods, there remains an outstanding need for work on climatically vulnerable, non-salmonid fishes to understand how these innate thermoregulatory behaviours could facilitate population persistence in warming conditions.
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2024569-5
    ISSN 1467-2979 ; 1467-2960
    ISSN (online) 1467-2979
    ISSN 1467-2960
    DOI 10.1111/faf.12720
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  6. Article ; Online: Parasite infection but not chronic microplastic exposure reduces the feeding rate in a freshwater fish.

    Parker, Ben / Britton, J Robert / Green, Iain D / Amat-Trigo, Fátima / Andreou, Demetra

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 320, Page(s) 121120

    Abstract: Microplastics (plastics <5 mm) are an environmental contaminant that can negatively impact the behaviour and physiology of aquatic biota. Although parasite infection can also alter the behaviour and physiology of their hosts, few studies have ... ...

    Abstract Microplastics (plastics <5 mm) are an environmental contaminant that can negatively impact the behaviour and physiology of aquatic biota. Although parasite infection can also alter the behaviour and physiology of their hosts, few studies have investigated how microplastic and parasite exposure interact to affect hosts. Accordingly, an interaction experiment tested how exposure to environmentally relevant microplastic concentrations and the trophically transmitted parasite Pomphorhynchus tereticollis affected the parasite load, condition metrics and feeding rate of the freshwater fish final host chub Squalius cephalus. Microplastic exposure was predicted to increase infection susceptibility, resulting in increased parasite loads, whereas parasite and microplastic exposure were expected to synergistically and negatively impact condition indices and feeding rates. Following chronic (≈170 day) dietary microplastic exposure, fish were exposed to a given number of gammarids (4/8/12/16/20), with half of the fish presented with parasite infected individuals, before a comparative functional response experiment tested differences in feeding rates on different live prey densities. Contrary to predictions, dietary microplastic exposure did not affect parasite abundance at different levels of parasite exposure, specific growth rate was the only condition index that was lower for exposed but unexposed fish, with no single or interactive effects of microplastic exposure detected. However, parasite infected fish had significantly lower feeding rates than unexposed fish in the functional response experiment, with exposed but unexposed fish also showing an intermediate decrease in feeding rates. Thus, the effects of parasitism on individuals were considerably stronger than microplastic exposure, with no evidence of interactive effects. Impacts of environmentally relevant microplastic levels might thus be relatively minor versus other stressors, with their interactive effects difficult to predict based on their single effects.
    MeSH term(s) Animals ; Microplastics ; Plastics/toxicity ; Host-Parasite Interactions ; Parasites ; Cyprinidae ; Parasitic Diseases ; Fresh Water/parasitology ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/analysis ; Environmental Monitoring
    Chemical Substances Microplastics ; Plastics ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.121120
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online ; Research data: (with research data) Copulation order, density cues and variance in fertilization success in a cestode.

    Andreou, D / Benesh, D P

    Parasitology

    2014  Volume 141, Issue 7, Page(s) 934–939

    Abstract: Simultaneous hermaphrodites maximize their fitness by optimizing their investment into male or female functions. Allocation of resources to male function (tissues, traits, and/or behaviours increasing paternity) is predicted to increase as density, and ... ...

    Abstract Simultaneous hermaphrodites maximize their fitness by optimizing their investment into male or female functions. Allocation of resources to male function (tissues, traits, and/or behaviours increasing paternity) is predicted to increase as density, and the associated level of sperm competition, increases. We tested whether the simultaneous hermaphroditic cestode Schistocephalus solidus uses cues of potential partner densities in its fish intermediate host to improve its male reproductive success in the final host. We had two worms, one originating from a multiple infection in the fish intermediate host and one from a single infection, sequentially compete to fertilize the eggs of a third worm. The fertilization rates of the two competitors nearly always differed from the 50-50 null expectation, sometimes considerably, implying there was a 'winner' in each experimental competition. However, we did not find a significant effect of density in the fish host (single vs multiple) or mating order on paternity. Additional work will be needed to identify the traits and environmental conditions that explain the high variance in male reproductive success observed in this experiment.
    MeSH term(s) Animals ; Cestoda/physiology ; Copulation/physiology ; Female ; Fertilization/physiology ; Male
    Language English
    Publishing date 2014-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207627-5
    ISSN 1469-8161 ; 0031-1820 ; 0031-1820
    ISSN (online) 1469-8161
    ISSN 0031-1820
    DOI 10.1017/S0031182014000043
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  8. Article: Copulation order, density cues and variance in fertilization success in a cestode

    ANDREOU, D / BENESH, D. P

    Parasitology. 2014 June, v. 141, no. 7

    2014  

    Abstract: Simultaneous hermaphrodites maximize their fitness by optimizing their investment into male or female functions. Allocation of resources to male function (tissues, traits, and/or behaviours increasing paternity) is predicted to increase as density, and ... ...

    Abstract Simultaneous hermaphrodites maximize their fitness by optimizing their investment into male or female functions. Allocation of resources to male function (tissues, traits, and/or behaviours increasing paternity) is predicted to increase as density, and the associated level of sperm competition, increases. We tested whether the simultaneous hermaphroditic cestode Schistocephalus solidus uses cues of potential partner densities in its fish intermediate host to improve its male reproductive success in the final host. We had two worms, one originating from a multiple infection in the fish intermediate host and one from a single infection, sequentially compete to fertilize the eggs of a third worm. The fertilization rates of the two competitors nearly always differed from the 50–50 null expectation, sometimes considerably, implying there was a ‘winner’ in each experimental competition. However, we did not find a significant effect of density in the fish host (single vs multiple) or mating order on paternity. Additional work will be needed to identify the traits and environmental conditions that explain the high variance in male reproductive success observed in this experiment.
    Keywords Schistocephalus ; copulation ; eggs ; environmental factors ; females ; fish ; hermaphroditism ; intermediate hosts ; males ; paternity ; reproductive success ; sperm competition ; variance
    Language English
    Dates of publication 2014-06
    Size p. 934-939.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 207627-5
    ISSN 1469-8161 ; 0031-1820
    ISSN (online) 1469-8161
    ISSN 0031-1820
    DOI 10.1017/S0031182014000043
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  9. Article ; Online: Systemische Therapieoptionen bei lokal fortgeschrittenen und metastasierten myxoiden, dedifferenzierten und pleomorphen Liposarkomen.

    Pink, Daniel / West, Antje / Andreou, Dimosthenis

    Zentralblatt fur Chirurgie

    2020  Volume 145, Issue 2, Page(s) 160–167

    Abstract: Just a few years ago, all patients with metastatic soft tissue sarcoma received the same chemotherapy drugs. However, it is now recognised that the various sarcoma subtypes are different tumours with distinct genetic alterations and different biological ... ...

    Title translation Systemic Therapy Options for Locally Advanced and Metastatic Myxoid, Dedifferentiated and Pleomorphic Liposarcoma.
    Abstract Just a few years ago, all patients with metastatic soft tissue sarcoma received the same chemotherapy drugs. However, it is now recognised that the various sarcoma subtypes are different tumours with distinct genetic alterations and different biological behaviour, so that histology-specific treatment protocols have been increasingly implemented in recent years. This is also the case for the different subtypes of liposarcoma - the myxoid/round cell variant, as well as dedifferentiated and pleomorphic liposarcoma. This article will present published data and the authors' experience with the various systemic treatment options. both in first line and in subsequent lines of treatment, as well as a brief overview of experimental treatment approaches.
    MeSH term(s) Humans ; Liposarcoma ; Sarcoma ; Soft Tissue Neoplasms
    Language German
    Publishing date 2020-04-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200935-3
    ISSN 1438-9592 ; 0044-409X
    ISSN (online) 1438-9592
    ISSN 0044-409X
    DOI 10.1055/a-1117-4143
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  10. Article ; Online: Van Neck-Odelberg Disease.

    Schneider, Kristian Nikolaus / Gosheger, Georg / Andreou, Dimosthenis

    Deutsches Arzteblatt international

    2020  Volume 117, Issue 19, Page(s) 343

    MeSH term(s) Humans ; Osteochondritis
    Language English
    Publishing date 2020-07-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2020.0343
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