LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Andrew C. White"
  2. AU="Yu-Cheng Wang"
  3. AU="Post, Robert"
  4. AU="Pemmari, Toini"
  5. AU="Stefanik-Guizlo, Kelsey"
  6. AU=Elsea Sarah H
  7. AU="Barbara Mognetti"
  8. AU="Gibb, Jonathan"
  9. AU="Garg, Priya S"
  10. AU="Van Driessche, Veroniek"
  11. AU="Solianova, Veronika"
  12. AU="Strauss, Sarah"
  13. AU="Messemaker, Tobias C"
  14. AU="Daniel, Maria Urszula"
  15. AU=Edwards Robert J AU=Edwards Robert J
  16. AU="Shriver, Craig D"
  17. AU="Huang, Xiang-Zhong"
  18. AU=Cabanne Eglantine
  19. AU="Bernal, A"
  20. AU="Malorie Perry"
  21. AU="Oppenheim, Alan"
  22. AU="Ozcan, Muhit"
  23. AU="Zhang, Cissy"
  24. AU="Blaize, Justin L"
  25. AU="R, Ram Babu"
  26. AU="Khalili Arash"
  27. AU="Bhatia, Sandeep"
  28. AU="Ticha, Johnson M"
  29. AU="Aranzabal Barrio, N"

Suchergebnis

Treffer 1 - 4 von insgesamt 4

Suchoptionen

  1. Artikel ; Online: New insights into the functions of Cox-2 in skin and esophageal malignancies

    Hyeongsun Moon / Andrew C. White / Alexander D. Borowsky

    Experimental and Molecular Medicine, Vol 52, Iss 4, Pp 538-

    2020  Band 547

    Abstract: Cancer: Inflammatory enzyme linked to skin and esophageal tumors Drugs that block a pro-inflammatory enzyme implicated in cancer initiation and progression could help suppress the development of skin and esophageal cancers that arise from abnormal ... ...

    Abstract Cancer: Inflammatory enzyme linked to skin and esophageal tumors Drugs that block a pro-inflammatory enzyme implicated in cancer initiation and progression could help suppress the development of skin and esophageal cancers that arise from abnormal squamous cells (skin cells and cells lining the respiratory and digestive tracts). In a review article, Hyeongsun Moon from the University of California, Davis, USA, and colleagues discuss experimental evidence from genetically engineered mouse models demonstrating that expression of an enzyme called cyclooxygenase-2 (Cox-2) is critical to the transformation of stem and progenitor cells in the skin and esophagus into cancer cells. Cox-2 is already the target of many drugs approved for treating inflammatory conditions such as arthritis. The preclinical data suggest that the same medications, or agents directed at mediators of Cox-2 signaling, may help tamp down the inflammation that can spur tumor-prone cells into turning malignant.
    Schlagwörter Medicine ; R ; Biochemistry ; QD415-436
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2020-04-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress

    Hyeongsun Moon / Jerry Zhu / Leanne R. Donahue / Eunju Choi / Andrew C. White

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 10

    Abstract: Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population. ...

    Abstract Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel ; Online: Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress

    Hyeongsun Moon / Jerry Zhu / Leanne R. Donahue / Eunju Choi / Andrew C. White

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 10

    Abstract: Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population. ...

    Abstract Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice

    Darline Garibay / Jon Lou / Seon A. Lee / Karolina E. Zaborska / Margot H. Weissman / Erica Sloma / Leanne Donahue / Andrew D. Miller / Andrew C. White / M. Dodson Michael / Kyle W. Sloop / Bethany P. Cummings

    Cell Reports, Vol 23, Iss 4, Pp 967-

    2018  Band 973

    Abstract: Summary: Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes high rates of type 2 diabetes remission and remarkable increases in postprandial glucagon-like peptide-1 (GLP-1) secretion. GLP-1 plays a critical role in islet function by ... ...

    Abstract Summary: Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes high rates of type 2 diabetes remission and remarkable increases in postprandial glucagon-like peptide-1 (GLP-1) secretion. GLP-1 plays a critical role in islet function by potentiating glucose-stimulated insulin secretion; however, the mechanisms remain incompletely defined. Therefore, we applied a murine VSG model to an inducible β cell-specific GLP-1 receptor (GLP-1R) knockout mouse model to investigate the role of the β cell GLP-1R in islet function. Our data show that loss of β cell GLP-1R signaling decreases α cell GLP-1 expression after VSG. Furthermore, we find a β cell GLP-1R-dependent increase in α cell expression of the prohormone convertase required for the production of GLP-1 after VSG. Together, the findings herein reveal two concepts. First, our data support a paracrine role for α cell-derived GLP-1 in the metabolic benefits observed after VSG. Second, we have identified a role for the β cell GLP-1R as a regulator of α cell proglucagon processing. : The mechanisms by which GLP-1 enhances insulin secretion remain incompletely defined. Garibay et al. show that β cell GLP-1R signaling regulates α cell PC1/3 expression and GLP-1 production, pointing to an intra-islet paracrine positive feedback loop by which GLP-1-potentiated insulin secretion is amplified. Keywords: GLP-1, prohormone convertase 1/3, vertical sleeve gastrectomy, β cell
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2018-04-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang