LIVIVO - Search results -

Search results

Result 1 - 10 of total 13

Search options

Article ; Online: Postnatal maternal depressive symptoms and behavioural outcomes in term-born and preterm-born toddlers

Andrew Pickles / Serena Counsell / Ira Kleine / David Edwards / George Vamvakas / Alexandra Lautarescu / Chiara Nosarti / Shona Falconer / Andrew Chew

BMJ Open, Vol 12, Iss

a longitudinal UK community cohort study

2022 Volume 9

Abstract: Objectives To examine the association between maternal depressive symptoms in the immediate postnatal period and offspring’s behavioural outcomes in a large cohort of term-born and preterm-born toddlers.Design and participants Data were drawn from the ... ...

Abstract	Objectives To examine the association between maternal depressive symptoms in the immediate postnatal period and offspring’s behavioural outcomes in a large cohort of term-born and preterm-born toddlers.Design and participants Data were drawn from the Developing Human Connectome Project. Maternal postnatal depressive symptoms were assessed at term-equivalent age, and children’s outcomes were evaluated at a median corrected age of 18.4 months (range 17.3–24.3).Exposure and outcomes Preterm birth was defined as <37 weeks completed gestation. Maternal depressive symptoms were assessed with the Edinburgh Postnatal Depression Scale (EPDS). Toddlers’ outcome measures were parent-rated Child Behaviour Checklist 11/2–5 Total (CBCL) and Quantitative Checklist for Autism in Toddlers (Q-CHAT) scores. Toddlers’ cognition was assessed with the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III).Results Higher maternal EPDS scores were associated with toddlers’ higher CBCL (B=0.93, 95% CI 0.43 to 1.44, p<0.001, f2=0.05) and Q-CHAT scores (B=0.27, 95% CI 0.03 to 0.52, p=0.031, f2=0.01). Maternal EPDS, toddlers’ CBCL and Q-CHAT scores did not differ between preterm (n=97; 19.1% of the total sample) and term participants. Maternal EPDS score did not disproportionately affect preterm children with respect to CBCL or Q-CHAT scores.Conclusions Our findings indicate that children whose mothers reported increased depressive symptoms in the early postnatal period, including subclinical symptoms, exhibit more parent-reported behavioural problems in toddlerhood. These associations were independent of gestational age. Further research is needed to confirm the clinical significance of these findings.
Keywords	Medicine ; R
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Attosecond science based on high harmonic generation from gases and solids

Jie Li / Jian Lu / Andrew Chew / Seunghwoi Han / Jialin Li / Yi Wu / He Wang / Shambhu Ghimire / Zenghu Chang

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 13

Abstract: Different methods are demonstrated in recent years to produce attosecond pulses. Here, the authors discuss recent development and future prospects of the generation of such pulses from gases and solids and their potential applications in spectroscopy and ...

Abstract	Different methods are demonstrated in recent years to produce attosecond pulses. Here, the authors discuss recent development and future prospects of the generation of such pulses from gases and solids and their potential applications in spectroscopy and ultrafast dynamics in atoms, molecules and other complex systems.
Keywords	Science ; Q
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Attosecond science based on high harmonic generation from gases and solids

Jie Li / Jian Lu / Andrew Chew / Seunghwoi Han / Jialin Li / Yi Wu / He Wang / Shambhu Ghimire / Zenghu Chang

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 13

Abstract	Different methods are demonstrated in recent years to produce attosecond pulses. Here, the authors discuss recent development and future prospects of the generation of such pulses from gases and solids and their potential applications in spectroscopy and ultrafast dynamics in atoms, molecules and other complex systems.
Keywords	Science ; Q
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Incidental findings on brain MR imaging of asymptomatic term neonates in the Developing Human Connectome Project

Olivia Carney / Emer Hughes / Nora Tusor / Ralica Dimitrova / Sophie Arulkumaran / Kelly Pegoretti Baruteau / Alexia Egloff Collado / Lucilio Cordero-Grande / Andrew Chew / Shona Falconer / Joanna M. Allsop / Daniel Rueckert / Joseph Hajnal / A. David Edwards / Mary Rutherford

EClinicalMedicine, Vol 38, Iss , Pp 100984- (2021)

2021

Abstract: Background: Interpretation of incidental findings on term neonatal MRI brain imaging can be challenging as there is a paucity of published normative data on asymptomatic term neonates. Reporting radiologists and clinicians need to be familiar with these ... ...

Abstract	Background: Interpretation of incidental findings on term neonatal MRI brain imaging can be challenging as there is a paucity of published normative data on asymptomatic term neonates. Reporting radiologists and clinicians need to be familiar with these incidental findings to avoid over-investigation and misinterpretation particularly in relation to neurodevelopmental outcome. This study aimed to determine the prevalence of incidental findings in a large group of asymptomatic term neonates participating in the Developing Human Connectome Project (dHCP) who were invited for neurodevelopmental assessment at 18 months. Methods: We retrospectively reviewed MRI brain scans performed on 500 term neonates enrolled in the dHCP study between 2015 and 2019 with normal clinical examination. We reviewed the results of the Bayley Scales of Infant and Toddler Development (Bayley III) applied to participants who attended for neurodevelopmental follow-up at 18 months. Scores considered “delayed” if <70 on language, cognitive or motor scales. Findings: Incidental findings were observed in 47% of term infants. Acute cerebral infarcts were incidentally noted in five neonates (1%). More common incidental findings included punctate white matter lesions (PWMLs) (12%) and caudothalamic subependymal cysts (10%). The most frequent incidental finding was intracranial haemorrhage (25%), particularly subdural haemorrhage (SDH). SDH and PWMLs were more common in infants delivered with ventouse-assistance versus other delivery methods.Neurodevelopmental results were available on 386/500 (77%). 14 infants had a language score < 70 (2 SD below the mean). Of the 386 infants with neurodevelopmental follow up at 18 months, group differences in motor and language scores between infants with and without incidental findings were not significant (p = 0·17 and p = 0·97 respectively). Group differences in cognitive scores at 18 months between infants with (median (interquartile range) -100 (95–105)) and without (100 (95–110)) incidental findings ...
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Neonatal frontal-limbic connectivity is associated with externalizing behaviours in toddlers with Congenital Heart Disease

Alexandra F. Bonthrone / Andrew Chew / Megan Ní Bhroin / Francesca Morassutti Rech / Christopher J. Kelly / Daan Christiaens / Maximilian Pietsch / J-Donald Tournier / Lucilio Cordero-Grande / Anthony Price / Alexia Egloff / Joseph V. Hajnal / Kuberan Pushparajah / John Simpson / A. David Edwards / Mary A. Rutherford / Chiara Nosarti / Dafnis Batalle / Serena J. Counsell

NeuroImage: Clinical, Vol 36, Iss , Pp 103153- (2022)

2022

Abstract: Children with Congenital Heart Disease (CHD) are at increased risk of neurodevelopmental impairments. The neonatal antecedents of impaired behavioural development are unknown. 43 infants with CHD underwent presurgical brain diffusion-weighted MRI [ ... ...

Abstract	Children with Congenital Heart Disease (CHD) are at increased risk of neurodevelopmental impairments. The neonatal antecedents of impaired behavioural development are unknown. 43 infants with CHD underwent presurgical brain diffusion-weighted MRI [postmenstrual age at scan median (IQR) = 39.29 (38.71–39.71) weeks] and a follow-up assessment at median age of 22.1 (IQR 22.0–22.7) months in which parents reported internalizing and externalizing problem scores on the Child Behaviour Checklist. We constructed structural brain networks from diffusion-weighted MRI and calculated edge-wise structural connectivity as well as global and local brain network features. We also calculated presurgical cerebral oxygen delivery, and extracted perioperative variables, socioeconomic status at birth and a measure of cognitively stimulating parenting. Lower degree in the right inferior frontal gyrus (partial ρ = −0.687, p < 0.001) and reduced connectivity in a frontal-limbic sub-network including the right inferior frontal gyrus were associated with higher externalizing problem scores. Externalizing problem scores were unrelated to neonatal clinical course or home environment. However, higher internalizing problem scores were associated with earlier surgery in the neonatal period (partial ρ = −0.538, p = 0.014). Our results highlight the importance of frontal-limbic networks to the development of externalizing behaviours and provide new insights into early antecedents of behavioural impairments in CHD.
Keywords	Congenital Heart Disease ; Neonatal ; Diffusion-weighted MRI ; Graph theory ; Externalizing ; Internalizing ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Generation of octave-spanning mid-infrared pulses from cascaded second-order nonlinear processes in a single crystal

Yanchun Yin / Xiaoming Ren / Andrew Chew / Jie Li / Yang Wang / Fengjiang Zhuang / Yi Wu / Zenghu Chang

Scientific Reports, Vol 7, Iss 1, Pp 1-

2017 Volume 7

Abstract: Abstract We report on experimental generation of a 6.8 μJ laser pulse spanning from 1.8 to 4.2 μm from cascaded second-order nonlinear processes in a 0.4-mm BiB3O6 (BIBO) crystal. The nonlinear processes are initiated by intra-pulse difference frequency ... ...

Abstract	Abstract We report on experimental generation of a 6.8 μJ laser pulse spanning from 1.8 to 4.2 μm from cascaded second-order nonlinear processes in a 0.4-mm BiB3O6 (BIBO) crystal. The nonlinear processes are initiated by intra-pulse difference frequency generation (DFG) using spectrally broadened Ti:Sapphire spectrum, followed by optical parametric amplification (OPA) of the DFG pulse. The highest energy, 12.6 μJ, is achieved in a 0.8-mm BIBO crystal with a spectrum spanning from 1.8 to 3.5 μm. Such cascaded nonlinear processes are enabled by the broadband pump and the coincident phase matching angle of DFG and OPA. The spectrum is initiated from the DFG process and is thus expected to have passive stable carrier-envelope phase, which can be used to seed either a chirped pulse amplifier (CPA) or an optical parametric chirped pulse amplifier (OPCPA) for achieving high-energy few-cycle mid-infrared pulses. Such cascaded second-order nonlinear processes can be found in many other crystals such as KTA, which can extend wavelengths further into mid-infrared. We achieved a 0.8 μJ laser pulse spanning from 2.2 to 5.0 μm in KTA.
Keywords	Medicine ; R ; Science ; Q
Subject code	535
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Parental age effects on neonatal white matter development

Oliver Gale-Grant / Daan Christiaens / Lucilio Cordero-Grande / Andrew Chew / Shona Falconer / Antonios Makropoulos / Nicholas Harper / Anthony N Price / Jana Hutter / Emer Hughes / Suresh Victor / Serena J Counsell / Daniel Rueckert / Joseph V Hajnal / A David Edwards / Jonathan O'Muircheartaigh / Dafnis Batalle

NeuroImage: Clinical, Vol 27, Iss , Pp 102283- (2020)

2020

Abstract: Objective: Advanced paternal age is associated with poor offspring developmental outcome. Though an increase in paternal age-related germline mutations may affect offspring white matter development, outcome differences could also be due to psychosocial ... ...

Abstract	Objective: Advanced paternal age is associated with poor offspring developmental outcome. Though an increase in paternal age-related germline mutations may affect offspring white matter development, outcome differences could also be due to psychosocial factors. Here we investigate possible cerebral changes prior to strong environmental influences using brain MRI in a cohort of healthy term-born neonates. Methods: We used structural and diffusion MRI images acquired soon after birth from a cohort (n = 275) of healthy term-born neonates. Images were analysed using a customised tract based spatial statistics (TBSS) processing pipeline. Neurodevelopmental assessment using the Bayley-III scales was offered to all participants at age 18 months. For statistical analysis neonates were compared in two groups, representing the upper quartile (paternal age ≥38 years) and lower three quartiles. The same method was used to assess associations with maternal age. Results: In infants with older fathers (≥38 years), fractional anisotropy, a marker of white matter organisation, was significantly reduced in three early maturing anatomical locations (the corticospinal tract, the corpus callosum, and the optic radiation). Fractional anisotropy in these locations correlated positively with Bayley-III cognitive composite score at 18 months in the advanced paternal age group. A small but significant reduction in total brain volume was also observed in in the infants of older fathers. No significant associations were found between advanced maternal age and neonatal imaging. Conclusions: The epidemiological association between advanced paternal age and offspring outcome is extremely robust. We have for the first time demonstrated a neuroimaging phenotype of advanced paternal age before sustained parental interaction that correlates with later outcome.
Keywords	Paternal age ; Brain development ; Diffusion MRI ; Newborn ; Bayley ; White matter ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	610 ; 616
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Exploring the multiple-hit hypothesis of preterm white matter damage using diffusion MRI

Madeleine L. Barnett / Nora Tusor / Gareth Ball / Andrew Chew / Shona Falconer / Paul Aljabar / Jessica A. Kimpton / Nigel Kennea / Mary Rutherford / A. David Edwards / Serena J. Counsell

NeuroImage: Clinical, Vol 17, Iss , Pp 596-

2018 Volume 606

Abstract: Background: Preterm infants are at high risk of diffuse white matter injury and adverse neurodevelopmental outcome. The multiple hit hypothesis suggests that the risk of white matter injury increases with cumulative exposure to multiple perinatal risk ... ...

Abstract	Background: Preterm infants are at high risk of diffuse white matter injury and adverse neurodevelopmental outcome. The multiple hit hypothesis suggests that the risk of white matter injury increases with cumulative exposure to multiple perinatal risk factors. Our aim was to test this hypothesis in a large cohort of preterm infants using diffusion weighted magnetic resonance imaging (dMRI). Methods: We studied 491 infants (52% male) without focal destructive brain lesions born at <34weeks, who underwent structural and dMRI at a specialist Neonatal Imaging Centre. The median (range) gestational age (GA) at birth was 30+1 (23+2–33+5) weeks and median postmenstrual age at scan was 42+1 (38–45) weeks. dMRI data were analyzed using tract based spatial statistics and the relationship between dMRI measures in white matter and individual perinatal risk factors was assessed. We tested the hypothesis that increased exposure to perinatal risk factors was associated with lower fractional anisotropy (FA), and higher radial, axial and mean diffusivity (RD, AD, MD) in white matter. Neurodevelopmental performance was investigated using the Bayley Scales of Infant and Toddler Development, Third Edition (BSITD-III) in a subset of 381 infants at 20months corrected age. We tested the hypothesis that lower FA and higher RD, AD and MD in white matter were associated with poorer neurodevelopmental performance. Results: Identified risk factors for diffuse white matter injury were lower GA at birth, fetal growth restriction, increased number of days requiring ventilation and parenteral nutrition, necrotizing enterocolitis and male sex. Clinical chorioamnionitis and patent ductus arteriosus were not associated with white matter injury. Multivariate analysis demonstrated that fetal growth restriction, increased number of days requiring ventilation and parenteral nutrition were independently associated with lower FA values. Exposure to cumulative risk factors was associated with reduced white matter FA and FA values at term equivalent ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: 53-attosecond X-ray pulses reach the carbon K-edge

Jie Li / Xiaoming Ren / Yanchun Yin / Kun Zhao / Andrew Chew / Yan Cheng / Eric Cunningham / Yang Wang / Shuyuan Hu / Yi Wu / Michael Chini / Zenghu Chang

Nature Communications, Vol 8, Iss 1, Pp 1-

2017 Volume 5

Abstract: Isolated attosecond pulses are produced using high harmonic generation and sources of these pulses often suffer from low photon flux in soft X-ray regime. Here the authors demonstrate efficient generation and characterization of 53 as pulses with photon ... ...

Abstract	Isolated attosecond pulses are produced using high harmonic generation and sources of these pulses often suffer from low photon flux in soft X-ray regime. Here the authors demonstrate efficient generation and characterization of 53 as pulses with photon energy near the water window.
Keywords	Science ; Q
Language	English
Publishing date	2017-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: High-harmonic generation in amorphous solids

Yong Sing You / Yanchun Yin / Yi Wu / Andrew Chew / Xiaoming Ren / Fengjiang Zhuang / Shima Gholam-Mirzaei / Michael Chini / Zenghu Chang / Shambhu Ghimire

Nature Communications, Vol 8, Iss 1, Pp 1-

2017 Volume 5

Abstract: Although higher harmonic generation from solids has become of interest in many fields, its observation is typically limited to crystalline solids. Here, the authors demonstrate that higher harmonics can be generated from amorphous solids. ...

Abstract	Although higher harmonic generation from solids has become of interest in many fields, its observation is typically limited to crystalline solids. Here, the authors demonstrate that higher harmonics can be generated from amorphous solids.
Keywords	Science ; Q
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED