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Article ; Online: O27 Eliminating hepatitis C in the prisons

Andrew Lloyd

Journal of Virus Eradication, Vol 3, Iss , Pp 10- (2017)

achievable?

2017

Keywords	Microbiology ; QR1-502 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2017-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Estimating health state utilities in hemophagocytic lymphohistiocytosis

Beenish Nafees / Andrew Lloyd / Sarah Dewilde

Journal of Patient-Reported Outcomes, Vol 5, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract Background Hemophagocyti.c lymphohistiocytosis (HLH) is a rare and severe disorder characterized by abnormal activation of the immune system. Primary HLH causes prolonged fever, spleen and liver enlargement, and organ dysfunction, usually in ... ...

Abstract	Abstract Background Hemophagocyti.c lymphohistiocytosis (HLH) is a rare and severe disorder characterized by abnormal activation of the immune system. Primary HLH causes prolonged fever, spleen and liver enlargement, and organ dysfunction, usually in infancy and early childhood and is fatal if left untreated. As effective treatment options emerge, such as emapalumab-lzsg, Health Technology Assessment bodies around the world will assess them in terms of cost-effectiveness. This study was designed to estimate quality of life weights (utilities) for such analyses. Methods Vignettes were developed describing HLH treatment related health states. Health states included active HLH, HLH plus neurological symptoms, receiving chemotherapy, undergoing stem cell transplant (SCT), graft versus host disease (GVHD), cure and end of life care. The vignettes were based on information from in depth interviews with clinical specialists; and qualitative research with four parents of children with primary HLH aged between 1 and 18 years old. The vignettes were then assessed in time trade off (TTO) interviews with members of the UK general public in one on one face to face interviews with trained, experienced interviewers. Preference data were analysed using the generalised estimating equations framework. Results Detailed qualitative data captured the substantial burden of this disease for young children. One hundred participants completed the TTO interviews. The utility score for Active HLH was estimated as 0.32 (95% CI, 0.24 to 0.39). Values for other states were HLH plus neurological symptoms (0.27, 95%CI 0.18–0.35), receiving chemotherapy (0.26, 95%CI 0.17–0.34), undergoing SCT (0.18, 95%CI 0.07–0.28), GVHD (0.07, 95%CI -0.04-0.17), cure (0.72, 95%CI 0.67–0.77) and end of life care (− 0.17, 95%CI -0.27- -0.07). Conclusions This study has estimated utility weights for seven different HLH related states which are based on detailed input from carers and physicians and have good face validity. There are few other options for ...
Keywords	Hemophagocytic lymphohistiocytosis ; Ultra-orphan drugs ; Health state utilities ; Quality of life ; Cost-effectiveness analysis ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: How does the EQ-5D-Y Proxy version 1 perform in 3, 4 and 5-year-old children?

Janine Verstraete / Andrew Lloyd / Des Scott / Jennifer Jelsma

Health and Quality of Life Outcomes, Vol 18, Iss 1, Pp 1-

2020 Volume 10

Abstract: Abstract Background The EQ-5D-Y Proxy is currently recommended for Health Related Quality of Life (HRQoL) measurement in children aged 4–8 years of age. However, it has only been validated in children over six years of age. The aim of this study was to ... ...

Abstract	Abstract Background The EQ-5D-Y Proxy is currently recommended for Health Related Quality of Life (HRQoL) measurement in children aged 4–8 years of age. However, it has only been validated in children over six years of age. The aim of this study was to investigate the performance of the EQ-5D-Y proxy version 1 in children between the ages of 3–6 years. Methods A sample of 328 children between 3 and 6 years of age were recruited which included children who were either acutely-ill (AI), chronically-ill (CI) or from the general school going population (GP). The EQ-5D-Y Proxy Version 1 and the PedsQL questionnaires were administered at baseline. The EQ-5D-Y Proxy was administered telephonically 24 h later to children with chronic illnesses to establish test-retest reliability. The distribution of dimensions and summary scores, Cohen’s kappa, the intraclass correlation coefficient, Pearson’s correlation and Analysis of variance were used to explore the reliability, and validity of the EQ-5D-Y for each age group. A single index score was estimated using Latent scores and Adult EQ-5D-3 L values (Dolan). Results The groups included 3-year olds (n = 105), 4-year olds (n = 98) and 5-years olds (n = 118). The dimension Looking after Myself had the greatest variability between age groups and had the highest rate of problems reported. Worried, Sad or Unhappy and Pain or Discomfort were not stable across time in test-retest analysis. The Visual Analogue Scale (VAS), and single index scores estimated using the latent values and Dolan tariff had good test retest (except for the latent value scores in a small number of 4-year olds). EQ-5D-Y scores for all ages had small to moderate correlations with PedsQL total score. The EQ-5D-Y discriminated well between children with a health condition and the general population for all age groups. Caregivers reported difficulty completing the Looking after Myself dimension due to age-related difficulties with washing and dressing. Conclusion The dimension of Looking after Myself is problematic for these young children but most notably so in the 3 year old group. If one considers the summary scores of the EQ-5D-Y Proxy version 1 it appears to work well. Known group validity was demonstrated. Concurrent validity was demonstrated on a composite level but not for individual dimensions of Usual Activities or Worried, Sad or Unhappy. The observable dimensions demonstrated stability over time, with the inferred dimensions (Pain or Discomfort and Worried, Sad or Unhappy) less so, which is to be expected. Further work is needed in exploring either the adaptation of the dimensions in the younger age groups.
Keywords	Health Related Quality of Life ; HRQoL ; Proxy ; EQ-5D-Y ; child ; pre-school ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	360
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The COVID-19 pandemic and health-related quality of life across 13 high- and low-middle-income countries

Mara Violato / Jack Pollard / Andrew Lloyd / Laurence S J Roope / Raymond Duch / Matias Fuentes Becerra / Philip M Clarke

PLoS Medicine, Vol 20, Iss 4, p e

A cross-sectional analysis.

2023 Volume 1004146

Abstract: Background Most research on the Coronavirus Disease 2019 (COVID-19) health burden has focused on confirmed cases and deaths, rather than consequences for the general population's health-related quality of life (HRQoL). It is also important to consider ... ...

Abstract	Background Most research on the Coronavirus Disease 2019 (COVID-19) health burden has focused on confirmed cases and deaths, rather than consequences for the general population's health-related quality of life (HRQoL). It is also important to consider HRQoL to better understand the potential multifaceted implications of the COVID-19 pandemic in various international contexts. This study aimed to assess the association between the COVID-19 pandemic and changes in HRQoL in 13 diverse countries. Methods and findings Adults (18+ years) were surveyed online (24 November to 17 December 2020) in 13 countries spanning 6 continents. Our cross-sectional study used descriptive and regression-based analyses (age adjusted and stratified by gender) to assess the association between the pandemic and changes in the general population's HRQoL, measured by the EQ-5D-5L instrument and its domains (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), and how overall health deterioration was associated with individual-level (socioeconomic, clinical, and experiences of COVID-19) and national-level (pandemic severity, government responsiveness, and effectiveness) factors. We also produced country-level quality-adjusted life years (QALYs) associated to COVID-19 pandemic-related morbidity. We found that overall health deteriorated, on average across countries, for more than one-third of the 15,480 participants, mostly in the anxiety/depression health domain, especially for younger people (<35 years old) and females/other gender. This translated overall into a 0.066 mean "loss" (95% CI: -0.075, -0.057; p-value < 0.001) in the EQ-5D-5L index, representing a reduction of 8% in overall HRQoL. QALYs lost associated with morbidity were 5 to 11 times greater than QALYs lost based on COVID-19 premature mortality. A limitation of the study is that participants were asked to complete the prepandemic health questionnaire retrospectively, meaning responses may be subject to recall bias. Conclusions In this study, ...
Keywords	Medicine ; R
Subject code	360
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The COVID-19 pandemic and health-related quality of life across 13 high- and low-middle-income countries

Mara Violato / Jack Pollard / Andrew Lloyd / Laurence S. J. Roope / Raymond Duch / Matias Fuentes Becerra / Philip M. Clarke

PLoS Medicine, Vol 20, Iss

A cross-sectional analysis

2023 Volume 4

Abstract: Background Most research on the Coronavirus Disease 2019 (COVID-19) health burden has focused on confirmed cases and deaths, rather than consequences for the general population’s health-related quality of life (HRQoL). It is also important to consider ... ...

Abstract	Background Most research on the Coronavirus Disease 2019 (COVID-19) health burden has focused on confirmed cases and deaths, rather than consequences for the general population’s health-related quality of life (HRQoL). It is also important to consider HRQoL to better understand the potential multifaceted implications of the COVID-19 pandemic in various international contexts. This study aimed to assess the association between the COVID-19 pandemic and changes in HRQoL in 13 diverse countries. Methods and findings Adults (18+ years) were surveyed online (24 November to 17 December 2020) in 13 countries spanning 6 continents. Our cross-sectional study used descriptive and regression-based analyses (age adjusted and stratified by gender) to assess the association between the pandemic and changes in the general population’s HRQoL, measured by the EQ-5D-5L instrument and its domains (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), and how overall health deterioration was associated with individual-level (socioeconomic, clinical, and experiences of COVID-19) and national-level (pandemic severity, government responsiveness, and effectiveness) factors. We also produced country-level quality-adjusted life years (QALYs) associated to COVID-19 pandemic-related morbidity. We found that overall health deteriorated, on average across countries, for more than one-third of the 15,480 participants, mostly in the anxiety/depression health domain, especially for younger people (<35 years old) and females/other gender. This translated overall into a 0.066 mean “loss” (95% CI: −0.075, −0.057; p-value < 0.001) in the EQ-5D-5L index, representing a reduction of 8% in overall HRQoL. QALYs lost associated with morbidity were 5 to 11 times greater than QALYs lost based on COVID-19 premature mortality. A limitation of the study is that participants were asked to complete the prepandemic health questionnaire retrospectively, meaning responses may be subject to recall bias. Conclusions In this study, ...
Keywords	Medicine ; R
Subject code	300 ; 360
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New developments in the GDIS simulation package: Integration of VASP and USPEX.

Okadome Valencia, Hubert / Wang, Busheng / Frapper, Gilles / Rohl, Andrew Lloyd

Journal of computational chemistry

2021 Volume 42, Issue 22, Page(s) 1602–1626

Abstract: A popular first principles simulation code, the Vienna Ab initio Simulation Package (VASP), and a crystal structure prediction (CSP) package, the Universal Structure Predictor: Evolutionary Xtallography (USPEX) have been integrated into the GDIS ... ...

Abstract	A popular first principles simulation code, the Vienna Ab initio Simulation Package (VASP), and a crystal structure prediction (CSP) package, the Universal Structure Predictor: Evolutionary Xtallography (USPEX) have been integrated into the GDIS visualization software. The aim of this integration is to provide users with a unique and simple interface through which most of the steps of a typical crystal optimization or prediction work. This involved, for the latter, not only setting up a CSP calculation with complete support for the latest version of USPEX, but also displaying the many structure results by linking each structure geometry and its energy via interactive graphics. For the optimization part, any structure displayed by GDIS can now be the starting point for VASP calculations, with support for its most commonly used parameters. Atomic and electronic structures can be displayed as well as dynamic properties such as total energy, force, volume, and pressure for each ionic step. It is not only possible to start calculations from the GDIS visualization software, using an in-place task manager, but a running calculation can also be followed, allowing a greater control of the simulation process. The GDIS software is available under the GNU public license in its second version.
Language	English
Publishing date	2021-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1479181-X
ISSN	1096-987X ; 0192-8651
ISSN (online)	1096-987X
ISSN	0192-8651
DOI	10.1002/jcc.26697
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The ostomy leak impact tool

Beenish Nafees / Zenia M. Størling / Charlotte Hindsberger / Andrew Lloyd

Health and Quality of Life Outcomes, Vol 16, Iss 1, Pp 1-

development and validation of a new patient-reported tool to measure the burden of leakage in ostomy device users

2018 Volume 12

Abstract: Abstract Background Leakage is a major concern for people who use a stoma, but people’s experience and its impact is not well understood. This study aimed to establish a definition of leakage through clinical and user input. This information was used to ... ...

Abstract	Abstract Background Leakage is a major concern for people who use a stoma, but people’s experience and its impact is not well understood. This study aimed to establish a definition of leakage through clinical and user input. This information was used to develop and validate a new measurement tool to understand the impact of leakage for people using a stoma appliance, in the UK, US, France, and Denmark. Methods Participants were recruited from a panel of users, hosted by Coloplast, that includes people who currently use Coloplast products. Six clinicians and 41 users took part in concept elicitation interviews. The qualitative findings were used to draft items. A panel of clinical experts was organized to develop and validate items (N = 6). Cognitive debrief interviews were conducted with five users in each country, which resulted in removing some items and revising the measure. A psychometric validation was conducted with 340 people in four countries whereby participants were asked to complete a series of measures online. Full psychometric analyses including validity and reliability were conducted. Results A final tool was established consisting of three domains related to the burden of leakage: “Emotional impact,” “Usual and social activities,” and “Coping and control.” Convergent validity was evaluated by benchmarking to existing health-related quality of life instruments (domains of SF-36 and Ostomy-Q). This showed high correlation between domains of the leakage tool and other measures, in particular for the Emotional impact domain when compared with SF-36 Emotional well-being and Ostomy-Q Confidence domain (p < 0.001). Coping and control correlated moderately well with most PROs tested for except the physical functioning domains, which showed only modest correlation (p < 0.001). Usual and social activities correlated equally well with all domains. Internal consistency was high for Emotional impact and Usual and social activities (> 0.92). Conclusion The study highlights how users define leakage and ...
Keywords	Leakage ; Stoma ; Quality of life ; Measure ; Ostomy ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	306
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Vegetated Habitats Trophically Support Early Development Stages of a Marine Migrant Fish in a Coastal Lagoon

Andolina, Cristina / Franzoi, Piero / Jackson, Andrew Lloyd / Mazzola, Antonio / Vizzini, Salvatrice

Estuaries and coasts. 2020 Mar., v. 43, no. 2

2020

Abstract: Understanding the trophic ecology of early developmental stages of commercial fish species migrating between sea and coastal lagoons is crucial to effective management of nursery habitats and resulting resources. While most information on diet shift of ... ...

Abstract	Understanding the trophic ecology of early developmental stages of commercial fish species migrating between sea and coastal lagoons is crucial to effective management of nursery habitats and resulting resources. While most information on diet shift of the gilthead seabream Sparus aurata comes from studies in experimental conditions, here we investigated the trophic niche dynamics of post-larvae, juveniles and sub-adults in natural environment, hypothesising that habitat and resources use of marine and lagoonal sites will exhibit strong relationship with ontogeny of the species. Carbon and nitrogen stable isotopes showed evidence of a clear shift in the trophic niche features, trophic position and trophic pathways supporting S. aurata during growth. Main differences occurred between post-larvae and juveniles/sub-adults, perfectly matching their diet shift from zooplanktivorous to zoobenthivorous habits. The wider trophic niche of juveniles exploiting the variety of resources within the lagoon, compared to the narrower niche of marine post-larvae demonstrates the importance of the trophic role of the lagoon as nursey ground, where aquatic macrophytes (seagrasses and macroalgae) provide the main trophic support as sources of organic matter.
Keywords	carbon ; coastal water ; diet ; early development ; fish ; habitats ; juveniles ; macroalgae ; nitrogen ; ontogeny ; organic matter ; postlarvae ; seagrasses ; Sparus aurata ; stable isotopes ; trophic relationships
Language	English
Dates of publication	2020-03
Size	p. 424-437.
Publishing place	Springer US
Document type	Article
ZDB-ID	2229170-2
ISSN	1559-2731 ; 1559-2723
ISSN (online)	1559-2731
ISSN	1559-2723
DOI	10.1007/s12237-019-00683-2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Reducing MSH4 copy number prevents meiotic crossovers between non-homologous chromosomes in Brassica napus

Adrián Gonzalo / Marie-Odile Lucas / Catherine Charpentier / Greta Sandmann / Andrew Lloyd / Eric Jenczewski

Nature Communications, Vol 10, Iss 1, Pp 1-

2019 Volume 9

Abstract: Non-homologous crossovers impair correct chromosome segregation in allopolyploids. Here the authors show that most non-homologous crossovers in Brassica napus arise from MSH4-dependent recombination and provide evidence that post-polyploidization ... ...

Abstract	Non-homologous crossovers impair correct chromosome segregation in allopolyploids. Here the authors show that most non-homologous crossovers in Brassica napus arise from MSH4-dependent recombination and provide evidence that post-polyploidization reduction of MSH4 duplicate stabilizes meiosis.
Keywords	Science ; Q
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reducing MSH4 copy number prevents meiotic crossovers between non-homologous chromosomes in Brassica napus

Adrián Gonzalo / Marie-Odile Lucas / Catherine Charpentier / Greta Sandmann / Andrew Lloyd / Eric Jenczewski

Nature Communications, Vol 10, Iss 1, Pp 1-

2019 Volume 9

Abstract	Non-homologous crossovers impair correct chromosome segregation in allopolyploids. Here the authors show that most non-homologous crossovers in Brassica napus arise from MSH4-dependent recombination and provide evidence that post-polyploidization reduction of MSH4 duplicate stabilizes meiosis.
Keywords	Science ; Q
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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