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Book ; Online: Why Icebergs Float

Andrew Morris

Exploring Science in Everyday Life

2016

Abstract: ... than follow the path of a syllabus or textbook, Andrew Morris takes examples from the science we see every day ...

Abstract	From paintings and food to illness and icebergs, science is happening everywhere. Rather than follow the path of a syllabus or textbook, Andrew Morris takes examples from the science we see every day and uses them as entry points to explain a number of fundamental scientific concepts – from understanding colour to the nature of hormones – in ways that anyone can grasp. While each chapter offers a separate story, they are linked together by their fascinating relevance to our daily lives.
Keywords	atoms ; substances ; science ; compounds ; popular science ; PDZ
Language	English
Publisher	UCL Press
Publishing country	nl
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Perceived Safety Benefits of Aftermarket Driver Support Systems

Ruth Welsh / Andrew Morris

Safety, Vol 4, Iss 4, p

Results from a Large Scale European Field Operational Test (FOT)

2018 Volume 54

Abstract: A field operational test (FOT) is a technique used within traffic safety to evaluate the overall value of in-vehicle information systems (IVISs) under normal operating conditions. In this study, a pan-European FOT was used to evaluate Navigation, Speed ... ...

Abstract	A field operational test (FOT) is a technique used within traffic safety to evaluate the overall value of in-vehicle information systems (IVISs) under normal operating conditions. In this study, a pan-European FOT was used to evaluate Navigation, Speed Information/Alert, Traffic Information, and Green Driving Support functions together with participants’ perceptions of safety’ before, during, and after using the functions. Through utilization and adherence to the FOT methodology, data were collected over a period ranging from 8 to 16 months in five European countries in order to assess the driver pre-conceived ideas and subsequent subjective and objective experiences with the IVIS functions. Several analyses of data were conducted, and this paper describes the results relating to the ‘user-experience’ as evaluated through subjective responses. The study showed that before the FOTs started, overall participants expected a higher safety benefit through using Speed Alert compared to the other functions. This function was also perceived to offer the highest safety benefit after the FOT had been completed. Perceptions of safety were found to be lowest for the green-driving function. The results offer insights into public expectations of IVIS functions and how these change with experience and overall; they suggest that, in some cases, the perception to safety benefits could be somewhat misplaced.
Keywords	field operational test ; perceptions ; safety ; Navigation ; Traffic Information ; Speed Alert ; Green Driving Support ; Industrial safety. Industrial accident prevention ; T55-55.3 ; Medicine (General) ; R5-920
Subject code	380
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Understanding the role of patient and public involvement in renal dietetic research

Andrew Morris / Deborah Biggerstaff / Nithya Krishnan / Deborah Lycett

Patient Experience Journal (2017)

2017

Abstract: The objective was to consult patients on a proposed recruitment strategy to a patient and public involvement exercise. We wanted to explore the reasoning and willingness of patients to become co-researchers within a grant application. Eighteen people ... ...

Abstract	The objective was to consult patients on a proposed recruitment strategy to a patient and public involvement exercise. We wanted to explore the reasoning and willingness of patients to become co-researchers within a grant application. Eighteen people using the renal health service informed the consultation by action research so that their experiences could be used to guide the overall methodology. Twelve people took part in semi-structured interviews. NVIVO 10 and Framework Analysis were used to interpret emerging themes from the data. The recruitment strategy, informed by research expertise, became an experience-based expert design. The design took into account the limitations of attendance, the informational and physical needs of these service users. Service users wanted to share their experiences with people who would listen and were in a position to help make the changes. This gave them a sense of purpose and autonomy in their treatment and helped them cope with living with renal disease in society. However, feelings of doubt as to whether they could personally ‘make a difference’ as a co-researcher, were common. Consulting service users enabled the research team to recruit more people to interviews to explore motivation considering the unique personal and social needs of this service user group. Service users may need additional and continued support if they are to successfully take part in a clinical study research advisory group.
Keywords	patient involvement ; public consultation ; patient co-researchers ; renal ; dietetics ; service users ; qualitative health ; action research ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
Subject code	020
Language	English
Publishing date	2017-07-01T00:00:00Z
Publisher	The Beryl Institute
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR

Ningyu Zhu / Chengxian Zhang / Atish Prakash / Zheng Hou / Wei Liu / Weifeng She / Andrew Morris / Kwang Sik Kim

EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)

2021

Abstract: Abstract Group B Streptococcus (GBS) remains the most common Gram‐positive bacterium causing neonatal meningitis and GBS meningitis continues to be an important cause of mortality and morbidity. In this study, we showed that GBS penetration into the ... ...

Abstract	Abstract Group B Streptococcus (GBS) remains the most common Gram‐positive bacterium causing neonatal meningitis and GBS meningitis continues to be an important cause of mortality and morbidity. In this study, we showed that GBS penetration into the brain occurred initially in the meningeal and cortex capillaries, and exploits a defined host cell signaling network comprised of S1P2, EGFR, and CysLT1. GBS exploitation of such network in penetration of the blood–brain barrier was demonstrated by targeting S1P2, EGFR, and CysLT1 using pharmacological inhibition, gene knockout and knockdown cells, and gene knockout animals, as well as interrogation of the network (up‐ and downstream of each other). More importantly, counteracting such targets as a therapeutic adjunct to antibiotic therapy was beneficial in improving the outcome of animals with GBS meningitis. These findings indicate that investigating GBS penetration of the blood–brain barrier provides a novel approach for therapeutic development of GBS meningitis.
Keywords	blood–brain barrier ; CysLTs ; EGFR ; GBS meningitis ; S1P ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
Subject code	616
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ecological connectivity in fragmented agricultural landscapes and the importance of scattered trees and small patches

Darrel Chin Fung Tiang / Andrew Morris / Mathew Bell / Christopher N. Gibbins / Badrul Azhar / Alex M. Lechner

Ecological Processes, Vol 10, Iss 1, Pp 1-

2021 Volume 16

Abstract: Abstract Background Fragmentation and habitat loss can restrict species movement and reduce connectivity, negatively impacting biodiversity. Characterising the overall connectivity of an area can inform better management of human modified landscapes. ... ...

Abstract	Abstract Background Fragmentation and habitat loss can restrict species movement and reduce connectivity, negatively impacting biodiversity. Characterising the overall connectivity of an area can inform better management of human modified landscapes. Contemporary connectivity modelling methods seldom incorporate fine-scale movement patterns associated with movement between fine-scaled structural connectivity elements such as scattered trees, roadside corridors and small patches of habitat. This study aims to characterise connectivity within the Karuah-Myall catchments, a typical woodland ecosystem that is fragmented by agriculture, using least-cost path analysis and a graph-theoretic approach; it focuses on how fine-scaled vegetation such as scattered trees support connectivity. We mapped scattered (and paddock) trees within this agricultural landscape where the main human modified land use was pasture. We modelled connectivity for a general representative woodland species using an interpatch dispersal distance and gap crossing threshold, and resistance from different land cover types. The gap crossing distance threshold was used to model movement between fine-scaled vegetation features. We compared the least-cost paths modelled with and without scattered trees. Results Our results show that by excluding scattered trees, least-cost paths across the cleared pasture landscape did not reflect the types of movement patterns typically observed from field studies, such as those associated with a foray-search strategy used by small and medium mammals and birds. The modelling also shows that the Karuah-Myall catchments are well connected and provide value to biodiversity beyond the catchment borders, by connecting coastal vegetation to the Great Eastern Ranges national wildlife corridor initiative. Conclusion Connectivity models that exclude fine-scale landscape features such as scattered trees and small, linear patches risk misrepresenting connectivity patterns. Models of regional-scale connectivity can be influenced ...
Keywords	Scattered trees ; Landscape connectivity ; Gap crossing ; Fragmentation ; Agricultural landscape ; Ecology ; QH540-549.5
Subject code	580
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Barriers and facilitators to the uptake of an antimicrobial stewardship program in primary care

Lianne Jeffs / Warren McIsaac / Michelle Zahradnik / Arrani Senthinathan / Linda Dresser / Mark McIntyre / David Tannenbaum / Chaim Bell / Andrew Morris

PLoS ONE, Vol 15, Iss 3, p e

A qualitative study.

2020 Volume 0223822

Abstract: The overuse of antimicrobials in primary care can be linked to an increased risk of antimicrobial-resistant bacteria for individual patients. Although there are promising signs of the benefits associated with Antimicrobial Stewardship Programs (ASPs) in ... ...

Abstract	The overuse of antimicrobials in primary care can be linked to an increased risk of antimicrobial-resistant bacteria for individual patients. Although there are promising signs of the benefits associated with Antimicrobial Stewardship Programs (ASPs) in hospitals and long-term care settings, there is limited knowledge in primary care settings and how to implement ASPs in these settings is unclear. In this context, a qualitative study was undertaken to explore the perceptions of primary care prescribers of the usefulness, feasibility, and experiences associated with the implementation of a pilot community-focused ASP intervention in three primary care clinics. Qualitative interviews were conducted with primary care clinicians, including local ASP champions, prescribers, and other primary health care team members, while they participated in an ASP initiative within one of three primary care clinics. An iterative conventional content analyses approach was used to analyze the transcribed interviews. Themes emerged around the key enablers and barriers associated with ASP implementation. Study findings point to key insights relevant to the scalability of community ASP activities with primary care providers.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Industry Partnership

Matt Mowlem / Alexander Beaton / Robin Pascal / Allison Schaap / Socratis Loucaides / Sam Monk / Andrew Morris / Christopher L. Cardwell / Sara E. Fowell / Matthew D. Patey / Patricia López-García

Frontiers in Marine Science, Vol

Lab on Chip Chemical Sensor Technology for Ocean Observing

2021 Volume 8

Abstract: We introduce for the first time a new product line able to make high accuracy measurements of a number of water chemistry parameters in situ: i.e., submerged in the environment including in the deep sea (to 6,000 m). This product is based on the ... ...

Abstract	We introduce for the first time a new product line able to make high accuracy measurements of a number of water chemistry parameters in situ: i.e., submerged in the environment including in the deep sea (to 6,000 m). This product is based on the developments of in situ lab on chip technology at the National Oceanography Centre (NOC), and the University of Southampton and is produced under license by Clearwater Sensors Ltd., a start-up and industrial partner in bringing this technology to global availability and further developing its potential. The technology has already been deployed by the NOC, and with their partners worldwide over 200 times including to depths of ∼4,800 m, in turbid estuaries and rivers, and for up to a year in seasonally ice-covered regions of the arctic. The technology is capable of making accurate determinations of chemical and biological parameters that require reagents and which produce an electrical, absorbance, fluorescence, or luminescence signal. As such it is suitable for a wide range of environmental measurements. Whilst further parameters are in development across this partnership, Nitrate, Nitrite, Phosphate, Silicate, Iron, and pH sensors are currently available commercially. Theses sensors use microfluidics and optics combined in an optofluidic chip with electromechanical valves and pumps mounted upon it to mix water samples with reagents and measure the optical response. An overview of the sensors and the underlying components and technologies is given together with examples of deployments and integrations with observing platforms such as gliders, autonomous underwater vehicles and moorings.
Keywords	submersible ; autonomous ; in situ ; lab on chip ; microfluidics ; analytical chemistry ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	620
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Case Report

Bill Ayach / Aadil Dhansay / Andrew Morris / James W. Tam / Davinder S. Jassal

POCUS Journal, Vol 2, Iss

Type 1 aortic dissection presenting as acute pericarditis: the roles of POCUS and transthoracic echocardiography

2017 Volume 3

Abstract: Clinical Presentation: A 59 year old male presented with a 1 day history of non-exertional chest pain that was pleuritic in nature and aggravated by lying flat. His chest pain symptoms were preceded by a one week history of “flu-like” symptoms. Physical ... ...

Abstract	Clinical Presentation: A 59 year old male presented with a 1 day history of non-exertional chest pain that was pleuritic in nature and aggravated by lying flat. His chest pain symptoms were preceded by a one week history of “flu-like” symptoms. Physical exam demonstrated a blood pressure of 114/55 mmHg, heart rate of 75 bpm, and a normal oxygen saturation on room air. Cardiac examination revealed a biphasic pericardial rub vs. to-and-fro murmur. EKG demonstrated diffused ST-elevation and PR depression consistent with acute pericarditis. Laboratory findings revealed a normal WBC of 11.2×109/L and hsTnT of 78 ng/L. Imaging Findings: A point of care ultrasound (POCUS) assessment demonstrated mild aortic insufficiency with a dilated ascending aorta with no pericardial effusion or wall motion abnormalities. An expedited transthoracic echocardiography (TTE) confirmed a bicuspid aortic valve with moderate aortic insufficiency. The aortic root and ascending aorta were dilated at 50 and 52 mm, respectively. There was evidence of an aortic dissection flap prolapsing across the left ventricular outflow tract. A dissection flap was also visualized within the abdominal aorta consistent with a Type 1 aortic dissection. Computed tomography of the aorta confirmed the Type 1 aortic dissection and the patient underwent an urgent valve-sparing aortic root replacement procedure. Discussion Points: Despite a typical clinical presentation for acute pericarditis, any unexpected physical exam or laboratory findings should lead to a POCUS assessment. This case demonstrates a rare presentation of aortic dissection which could have been easily missed without a POCUS assessment. Here we propose an algorithm for a POCUS examination in setting of pleuritic chest pain consistent with pericarditis.
Keywords	Internal medicine ; RC31-1245 ; Medical technology ; R855-855.5
Subject code	610
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	CINQUILL Medical Publishers Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: An unusual culprit: Klebsiella pneumoniae causing septicaemia outbreaks in neonatal pigs?

Bowring, Bethany G / Alison M. Collins / Andrew Morris / V. Anthony Fahy

Elsevier B.V. Veterinary microbiology. 2017 May, v. 203

2017

Abstract: This study investigated the cause of recent outbreaks of septicaemia in neonatal pigs in Australia (Victoria and Queensland). Septicaemia in neonatal pigs is commonly caused by enterotoxigenic E. coli, extraintestinal pathogenic E. coli and beta- ... ...

Abstract	This study investigated the cause of recent outbreaks of septicaemia in neonatal pigs in Australia (Victoria and Queensland). Septicaemia in neonatal pigs is commonly caused by enterotoxigenic E. coli, extraintestinal pathogenic E. coli and beta-haemolytic streptococci. Infrequent causes of septicaemia are Actinobacillus suis and Citrobacter freundii. Therefore, it was quite unexpected when Klebsiella pneumoniae was isolated in predominant growth from multiple organs of pigs dying of septicaemia from six days of age. Two cases in Victoria were associated with multilocus sequence type 25 (ST25), whereas the cases on a single farm in Queensland were associated with two different sequence types (ST278 and ST1978). Similar outbreaks of septicaemia have also occurred in England, but all were associated with K. pneumoniae ST25. The K. pneumoniae sequence types did not cluster phylogenetically into groups of isolates from the same geographical location or into groups which caused either septicaemia or pneumonia. Antibiotic resistance also varied between isolates and showed neomycin resistance in Queensland. These results suggest that several sequence types of K. pneumoniae are involved in causing outbreaks of septicaemia in neonatal pigs, in addition to its previously recognised role in pneumonia and mastitis.
Keywords	Actinobacillus suis ; antibiotic resistance ; Citrobacter freundii ; enterotoxigenic Escherichia coli ; farms ; Klebsiella pneumoniae ; mastitis ; neomycin ; phylogeny ; pneumonia ; septicemia ; Streptococcus ; swine ; England ; Queensland
Language	English
Dates of publication	2017-05
Size	p. 267-270.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2017.03.018
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Prospective data linkage to facilitate COVID-19 trials – A call to action

P Alison Paprica, Professor / Matthew Sydes, Professor / Kimberlyn McGrail, Professor / Andrew Morris, Professor / Michael J Schull, Professor / Rhoswyn Walker, Dr.

International Journal of Population Data Science, Vol 5, Iss

2020 Volume 2

Abstract: Many countries around the world are creating COVID-19 trial datasets and databases of COVID-19-related data such as test results that cover entire populations. It is our strong recommendation, and sincere hope, that these data assets will be brought ... ...

Abstract	Many countries around the world are creating COVID-19 trial datasets and databases of COVID-19-related data such as test results that cover entire populations. It is our strong recommendation, and sincere hope, that these data assets will be brought together through record linkage so that their scientific value and impact for society can be amplified. We call on trialists, data stewards and research funders to work together so that prospective linkage of trial data to medical databases becomes the norm, starting with COVID-19 trials.
Keywords	data linkage ; covid-19 ; clinical trials ; administrative data ; electronic medical records ; registry data ; Demography. Population. Vital events ; HB848-3697 ; covid19
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Swansea University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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