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  1. Article ; Online: Reduced theta-band neural oscillatory activity during affective cognitive control in bipolar I disorder.

    Andrews, Carolyn M / Menkes, Margo W / Suzuki, Takakuni / Lasagna, Carly A / Chun, Jinsoo / O'Donnell, Lisa / Grove, Tyler / McInnis, Melvin G / Deldin, Patricia J / Tso, Ivy F

    Journal of psychiatric research

    2022  Volume 158, Page(s) 27–35

    Abstract: Individuals with bipolar I disorder (BD) have difficulty inhibiting context-inappropriate responses. However, neural mechanisms of impaired cognitive control over impulsive behaviors, especially in response to emotion, are unclear. Theta-band neural ... ...

    Abstract Individuals with bipolar I disorder (BD) have difficulty inhibiting context-inappropriate responses. However, neural mechanisms of impaired cognitive control over impulsive behaviors, especially in response to emotion, are unclear. Theta-band neural oscillatory activity over midfrontal areas is thought to reflect cognitive control. The current study examined behavioral performance and theta-band activity during inhibition to affective stimuli in BD, relative to healthy control participants (HC). Sixty-seven participants with BD and 48 HC completed a Go/No-Go task with emotional face stimuli during electroencephalography (EEG) recording. Behavior was measured with reaction time, discriminability (d') and response bias (β). Time-frequency decomposition of EEG data was used to extract event-related theta-band (4-7 Hz) neural oscillatory power and inter-trial phase consistency (ITPC) over midline fronto-central areas. Behavior and theta-band activity were compared between groups, while covarying for age. Participants with BD exhibited slower response execution times on correct Go trials and reduced behavioral discrimination of emotional versus neutral faces, compared to HC. Theta-band power and ITPC were reduced in BD relative to HC. Theta-band power was higher on No-Go trials than Go trials. The magnitude of differences in theta-band activity between Go/No-Go trial types did not differ between groups. Increased theta-band power was associated with faster response execution times, greater discrimination of differing facial expressions, and stronger tendency to respond both across the full sample and within the BD group. Attenuated midline fronto-central theta-band activity may contribute to reduced cognitive control and maladaptive behavioral responding to emotional cues in individuals with BD.
    MeSH term(s) Humans ; Bipolar Disorder/psychology ; Electroencephalography ; Emotions/physiology ; Reaction Time ; Cognition ; Theta Rhythm/physiology
    Language English
    Publishing date 2022-12-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2022.12.012
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  2. Article ; Online: Event-related potential correlates of affective response inhibition in bipolar I disorder: Comparison with schizophrenia.

    Menkes, Margo W / Andrews, Carolyn M / Suzuki, Takakuni / Chun, Jinsoo / O'Donnell, Lisa / Grove, Tyler / Deng, Wisteria / McInnis, Melvin G / Deldin, Patricia J / Tso, Ivy F

    Journal of affective disorders

    2022  Volume 309, Page(s) 131–140

    Abstract: Background: Individuals with bipolar I disorder (BD) have difficulty inhibiting context-inappropriate responses. The neural mechanisms contributing to these difficulties, especially in emotional contexts, are little understood. This study aimed to ... ...

    Abstract Background: Individuals with bipolar I disorder (BD) have difficulty inhibiting context-inappropriate responses. The neural mechanisms contributing to these difficulties, especially in emotional contexts, are little understood. This study aimed to inform mechanisms of impaired impulsivity control in response to emotion in BD, and whether response inhibition indices are altered to a similar degree in schizophrenia spectrum disorders (SZ). We examined alterations to behavioral performance and event-related potentials (ERPs) during inhibition to affective stimuli in BD, relative to healthy control participants (HC) and SZ.
    Methods: Sixty-six participants with BD, 32 participants with SZ, and 48 HC completed a Go/No-Go task with emotional face stimuli while electroencephalography was recorded. Behavioral signal detection metrics (perceptual sensitivity, response bias) and ERPs (N200, P300) were compared across groups.
    Results: Relative to HC, participants with BD showed reduced (1) discrimination of Go vs. No-Go stimuli (i.e., emotional vs. neutral faces), and (2) P300 amplitudes elicited by emotional faces. Results similarly extended to SZ: BD and SZ groups did not differ on behavioral performance nor ERP amplitudes.
    Limitations: Aspects of the Go/No-Go task design may have limited findings, and medication effects on ERP amplitudes in patient samples cannot be fully ruled out.
    Conclusions: Findings suggest the difficulty participants with BD and SZ experienced on the current affective response inhibition task lied largely in discriminating between facial expressions. Difficulties with discriminating emotional from neutral expressions may contribute to difficulties with appropriate behavioral responding in social-affective contexts for individuals with BD and SZ.
    MeSH term(s) Bipolar Disorder/psychology ; Emotions/physiology ; Evoked Potentials/physiology ; Facial Expression ; Humans ; Schizophrenia/diagnosis
    Language English
    Publishing date 2022-04-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2022.04.118
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  3. Article ; Online: Corrigendum to "Event-related potential correlates of affective response inhibition in bipolar I disorder: Comparison with schizophrenia". [J. Affect. Disord. 309 (2022) 131-140].

    Menkes, Margo W / Andrews, Carolyn M / Suzuki, Takakuni / Chun, Jinsoo / O'Donnell, Lisa / Grove, Tyler / Deng, Wisteria / McInnis, Melvin G / Deldin, Patricia J / Tso, Ivy F

    Journal of affective disorders

    2022  Volume 315, Page(s) 298

    Language English
    Publishing date 2022-08-11
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2022.07.064
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  4. Article ; Online: Preliminary Evidence for Sociotropy and Autonomy in Relation to Antidepressant Treatment Outcome.

    Cardinale, Ryan / Menkes, Margo W / Andrews, Carolyn M / Webb, Christian A / Jha, Manish K / Trombello, Joseph M / Trivedi, Madhukar H / McInnis, Melvin G / Deldin, Patricia J

    The Psychiatric quarterly

    2021  Volume 92, Issue 3, Page(s) 1069–1077

    Abstract: Sociotropy and autonomy are cognitive-personality styles that have been hypothesized to confer vulnerability to different presentations of major depressive disorder (MDD), which may respond differentially to treatment. Specifically, the profile of low ... ...

    Abstract Sociotropy and autonomy are cognitive-personality styles that have been hypothesized to confer vulnerability to different presentations of major depressive disorder (MDD), which may respond differentially to treatment. Specifically, the profile of low sociotropy and high autonomy is hypothesized to indicate a positive response to antidepressant medication. The current study examines sociotropy and autonomy in relation to sertraline treatment response in individuals with MDD. As part of an ancillary study to the larger Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) project, individuals with MDD participated in an 8-week trial of sertraline and completed a self-report questionnaire of sociotropy and autonomy. Discriminant function analyses were used to examine whether sociotropy and autonomy scores could distinguish antidepressant treatment responders (determined by a 50% or greater reduction in depressive symptoms) from non-responders. The sociotropy scale successfully discriminated sertraline treatment responders from non-responders. Further, lower sociotropy was associated with greater improvements in depressive symptomology following sertraline treatment. The current findings suggest individuals with MDD characterized by low sociotropy are more likely to benefit from sertraline. Given the promising results of the Sociotropy-Autonomy Scale in discriminating treatment responders from non-responders, the low resources necessary for administration, and the ease of translation into routine clinical care, the scale warrants further research attention.
    MeSH term(s) Antidepressive Agents/therapeutic use ; Depressive Disorder, Major/drug therapy ; Humans ; Personal Autonomy ; Personality ; Treatment Outcome
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207521-0
    ISSN 1573-6709 ; 0033-2720
    ISSN (online) 1573-6709
    ISSN 0033-2720
    DOI 10.1007/s11126-021-09891-1
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  5. Article ; Online: Sleep quality and neuropsychological functioning in bipolar I disorder.

    Menkes, Margo W / Andrews, Carolyn M / Burgess, Helen J / Carley, Isabel / Marshall, David F / Langenecker, Scott A / McInnis, Melvin G / Deldin, Patricia J / Ryan, Kelly A

    Journal of affective disorders

    2021  Volume 293, Page(s) 133–140

    Abstract: Background: Individuals with bipolar I disorder (BD-I) experience both poor sleep and neuropsychological dysfunction relative to non-psychiatric populations, which limits functional recovery. Poor sleep adversely affects learning, memory, and executive ... ...

    Abstract Background: Individuals with bipolar I disorder (BD-I) experience both poor sleep and neuropsychological dysfunction relative to non-psychiatric populations, which limits functional recovery. Poor sleep adversely affects learning, memory, and executive functioning in healthy individuals; however, little is known about the role of poor sleep in neuropsychological functioning in BD-I. We tested whether sleep disturbance was greater in BD-I than healthy control participants (HC), and compared the effect of sleep quality on learning, memory, and executive functioning between BD-I and HC.
    Methods: Participants with BD-I (N=250) and HC (N=206) completed the Pittsburgh Sleep Quality Index, neuropsychological testing, and clinician-administered mood measures as part of a naturalistic study of bipolar disorder. We examined effects of both diagnosis and sleep quality on neuropsychological functioning.
    Results: Relative to HC, BD-I showed poorer sleep quality and neuropsychological functioning in verbal learning, verbal and visual memory, processing speed, psychomotor speed, inhibitory control, and selective attention (7/9 domains). Poor sleep quality was associated with poorer verbal learning, verbal fluency, processing speed, and interference control (4/9). Effects of poor sleep on neuropsychological functioning did not differ between BD-I and HC.
    Limitations: The assessment of sleep quality using a self-report measure and the effects of medications/sleeping aids (given the naturalistic study design) should be considered when interpreting results.
    Conclusions: Those with BD-I experiencing poor sleep may also be more vulnerable to verbal learning and executive functioning impairments. The findings of poor sleep in relation to poorer neuropsychological functioning have implications for assessment and treatment of sleep disturbance in BD-I.
    MeSH term(s) Bipolar Disorder/complications ; Cognition Disorders ; Executive Function ; Humans ; Neuropsychological Tests ; Sleep
    Language English
    Publishing date 2021-06-18
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2021.06.022
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1485: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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