LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 48

Search options

  1. Article: Discussion of the French and British conundrums

    Andrews , Dan

    Productivity puzzles across Europe , p. 174-186

    2016  , Page(s) 174–186

    Author's details Dan Andrews
    Language Undetermined
    Publisher Oxford University Press
    Publishing place Oxford
    Document type Article
    ISBN 978-0-19-878616-0 ; 0-19-878616-6
    Database ECONomics Information System

    More links

    Kategorien

  2. Article ; Online: StabilitySort: assessment of protein stability changes on a genome-wide scale to prioritize potentially pathogenic genetic variation.

    Chuah, Aaron / Li, Sean / Do, Andrea / Field, Matt / Andrews, Dan

    Bioinformatics (Oxford, England)

    2022  Volume 38, Issue 17, Page(s) 4220–4222

    Abstract: Summary: Missense mutations that change protein stability are strongly associated with human genetic disease. With the recent availability of predicted structures for all human proteins generated using the AlphaFold2 prediction model, genome-wide ... ...

    Abstract Summary: Missense mutations that change protein stability are strongly associated with human genetic disease. With the recent availability of predicted structures for all human proteins generated using the AlphaFold2 prediction model, genome-wide assessment of the stability effects of genetic variation can, for the first time, be easily performed. This facilitates the interrogation of personal genetic variation for potentially pathogenic effects through the application of stability metrics. Here, we present a novel tool to prioritize variants predicted to cause strong instability in essential proteins. We show that by filtering by ΔΔG values and then prioritizing by StabilitySort Z-scores, we are able to more accurately discriminate pathogenic, protein-destabilizing mutations from population variation, compared with other mutation effect predictors.
    Availability and implementation: StabilitySort is available as a web service (https://www.stabilitysort.org), as a data download for integration with other tools (https://www.stabilitysort.org/download) or can be deployed as a standalone system from source code (https://gitlab.com/baaron/StabilitySort).
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Humans ; Genome ; Software ; Proteins/genetics ; Protein Stability ; Mutation ; Genetic Variation
    Chemical Substances Proteins
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btac465
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Misallocation, big time: why (and how) structural reform can revive productivity growth in Europe

    Andrews, Dan

    Intereconomics : review of European economic policy Vol. 50, No. 5 , p. 266-273

    2015  Volume 50, Issue 5, Page(s) 266–273

    Author's details Dan Andrews
    Language English
    Size Online-Ressource, graph. Darst.
    Publisher Springer
    Publishing place Berlin ; Heidelberg [u.a.]
    Document type Article ; Online
    ZDB-ID 2066476X ; 2066476-X
    ISSN 1613-964X ; 0020-5346
    ISSN (online) 1613-964X
    ISSN 0020-5346
    DOI 10.1007/s10272-015-0550-2
    Database ECONomics Information System

    More links

    Kategorien

  4. Book ; Article ; Online: Productivity-enhancing labour reallocation in Australia

    Andrews, Dan / Hansell, David

    2019  

    Abstract: International evidence suggests that aggregate productivity growth is driven by the within-industry reallocation of inputs away from less productive firms and towards more productive firms, but little is known about this process in Australia. Accordingly, ...

    Abstract International evidence suggests that aggregate productivity growth is driven by the within-industry reallocation of inputs away from less productive firms and towards more productive firms, but little is known about this process in Australia. Accordingly, this paper exploits firm-level data to explore the nature of productivity-enhancing labour reallocation in Australia over the period 2002-2016. We first show that more productive firms on average account for a higher share of industry employment, particularly in sectors more exposed to competitive pressure via trade, and that this contributes positively to the aggregate level of productivity in Australia. Moreover, we show that the Australian economy is more successful at reallocating resources to high productivity firms than many other OECD countries, which is consistent with Australia's relatively sound structural policy environment that promotes economic flexibility. We then explore the extent to which labour is moving in the right direction over time. While high-productivity firms are more likely to expand and low-productivity firms are more likely to contract (or exit), the extent to which this is true has diminished over time. Counterfactual analysis shows that the weakening responsiveness of employment growth to firm productivity this decade is a significant drag on aggregate labour productivity growth, which motivates further analysis of structural policies that affect competition and labour mobility.
    Keywords ddc:330 ; C23 ; C55 ; D22 ; D30 ; E23 ; E24 ; productivity ; dispersion ; firm-level ; BLADE
    Subject code 381
    Language English
    Publisher Canberra: The Australian Government, The Treasury
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Book ; Article ; Online: Breaking the shackles

    Andrews, Dan / Petroulakis, Filippos

    Zombie firms, weak banks and depressed restructuring in Europe

    2019  

    Abstract: This paper explores the connection between "zombie" firms (firms that would typically exit in a competitive market) and bank health and the consequences for aggregate productivity in 11 European countries. Controlling for cyclical effects, the results ... ...

    Abstract This paper explores the connection between "zombie" firms (firms that would typically exit in a competitive market) and bank health and the consequences for aggregate productivity in 11 European countries. Controlling for cyclical effects, the results show that zombie firms are more likely to be connected to weak banks, suggesting that the zombie firm problem in Europe may at least partly stem from bank forbearance. The increasing survival of zombie firms congests markets and constrains the growth of more productive firms, to the detriment of aggregate productivity growth. Our results suggest that around one-third of the impact of zombie congestion on capital misallocation can be directly attributed to bank health and additional analysis suggests that this may partly be due to reduced availability of credit to healthy firms. Finally, improvements in bank health are more likely to be associated with a reduction in the prevalence of zombie firms in countries where insolvency regimes do not unduly inhibit corporate restructuring. Thus, leveraging the important complementarities between bank strengthening efforts and insolvency regime reform would contribute to breaking the shackles on potential growth in Europe.
    Keywords ddc:330 ; D24 ; G21 ; L25 ; O47 ; Zombie Firms ; Factor Reallocation ; Productivity ; Credit Constraints
    Subject code 381
    Language English
    Publisher Frankfurt a. M.: European Central Bank (ECB)
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  6. Book ; Online: Digital technology diffusion

    Andrews, Dan / Nicoletti, Giuseppe / Timiliotis, Christina

    a matter of capabilities, incentives or both?

    (OECD Economics Department working papers ; no. 1476)

    2018  

    Author's details Dan Andrews, Giuseppe Nicoletti, Christina Timiliotis
    Series title OECD Economics Department working papers ; no. 1476
    Language English
    Size 1 Online-Ressource (circa 80 Seiten), Illustrationen
    Document type Book ; Online
    Note Zusammenfassung in französischer Sprache
    Database ECONomics Information System

    More links

    Kategorien

  7. Book ; Online: Design of insolvency regimes across countries

    McGowan, Muge Adalet / Andrews, Dan

    (OECD Economics Department working papers ; no. 1504)

    2018  

    Author's details Muge Adalet McGowan, Dan Andrews
    Series title OECD Economics Department working papers ; no. 1504
    Language English
    Size 1 Online-Ressource (circa 37 Seiten), Illustrationen
    Document type Book ; Online
    Note Zusammenfassung in französischer Sprache
    Database ECONomics Information System

    More links

    Kategorien

  8. Book ; Article ; Online: The career effects of labour market conditions at entry

    Andrews, Dan / Deutscher, Nathan / Hambur, Jonathan / Hansell, David

    2020  

    Abstract: This paper explores the effects of labour market conditions at graduation on an individual's work-life over the following decade. Australians graduating into a state and year with a 5 percentage point higher youth unemployment rate can expect to earn ... ...

    Abstract This paper explores the effects of labour market conditions at graduation on an individual's work-life over the following decade. Australians graduating into a state and year with a 5 percentage point higher youth unemployment rate can expect to earn roughly 8 per cent less in their first year of work and 3½ per cent less after five years, with the effect gradually fading to around zero ten years on. The magnitude of this effect varies according to the characteristics of the individual and the tertiary institution they attend. We then explore the mechanisms behind this scarring. Scarring partly reflects the subsequent evolution of the unemployment rate - the fact that unemployment shocks tend to persist - highlighting the potential for timely and effective macroeconomic stabilisation policies to ameliorate these scarring effects. More generally, job switching to more productive firms emerges as a key channel through which workers recover from adverse shocks that initially disrupt (worker-firm) match quality. We find some evidence that the speed of recovery has slowed since 2000, which is consistent with the decline in labour market dynamism observed in Australia over that period.
    Keywords ddc:330 ; E24 ; J62 ; J64 ; Wages ; job mobility ; job search
    Subject code 331
    Language English
    Publisher Canberra: The Australian Government, The Treasury
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  9. Book ; Online: Confronting the zombies

    Andrews, Dan / McGowan, Muge Adalet / Millot, Valentine

    policies for productivity revival

    (OECD economic policy paper ; no. 21 (December 2017))

    2017  

    Author's details this paper has been prepared by: Dan Andrews, Müge Adalet McGowan, Valentine Millot
    Series title OECD economic policy paper ; no. 21 (December 2017)
    Language English
    Size 1 Online-Ressource (circa 36 Seiten), Illustrationen
    Publisher OECD Publishing
    Publishing place Paris
    Document type Book ; Online
    Note Zusammenfassung in französischer Sprache
    DOI 10.1787/f14fd801-en
    Database ECONomics Information System

    More links

    Kategorien

  10. Book ; Online: Rebalancing Turkey’s growth by improving resource allocation and productivity in manufacturing

    Atabek, Aslıhan / Andrews, Dan / Gönenç, Rauf

    (Working paper / Türkiye Cumhuriyet Merkez Bankası ; no: 17, 04)

    2017  

    Author's details Aslıhan Atabek, Dan Andrews, Rauf Gönenç
    Series title Working paper / Türkiye Cumhuriyet Merkez Bankası ; no: 17, 04
    Keywords Industrie ; Produktivitätsentwicklung ; Wettbewerb ; Strukturwandel ; Institutionelle Infrastruktur ; Türkei
    Language English
    Size 1 Online-Ressource (circa 38 Seiten), Illustrationen
    Document type Book ; Online
    Database ECONomics Information System

    More links

    Kategorien

To top