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  1. Article ; Online: Plasmodium falciparum infection and disease in infancy associated with increased risk of malaria and anaemia in childhood.

    Andronescu, Liana R / Buchwald, Andrea G / Sharma, Ankur / Bauleni, Andy / Mawindo, Patricia / Liang, Yuanyuan / Gutman, Julie R / Mathanga, Don P / Chinkhumba, Jobiba / Laufer, Miriam K

    Malaria journal

    2023  Volume 22, Issue 1, Page(s) 217

    Abstract: Background: Infants under 6 months of age are often excluded from malaria surveillance and observational studies. The impact of malaria during early infancy on health later in childhood remains unknown.: Methods: Infants from two birth cohorts in ... ...

    Abstract Background: Infants under 6 months of age are often excluded from malaria surveillance and observational studies. The impact of malaria during early infancy on health later in childhood remains unknown.
    Methods: Infants from two birth cohorts in Malawi were monitored at quarterly intervals and whenever they were ill from birth through 24 months for Plasmodium falciparum infections and clinical malaria. Poisson regression and linear mixed effects models measured the effect of exposure to malaria in infancy on subsequent malaria incidence, weight-for-age z-scores (WAZ), and haemoglobin concentrations after 6 months.
    Results: Infants with at least one P. falciparum infection during their first 6 months had increased incidence ratio (IRR) of P. falciparum infection (IRR = 1.27, 95% CI, 1.06-1.52) and clinical malaria (IRR = 2.37, 95% CI, 2.02-2.80) compared to infants without infection. Infants with clinical malaria had increased risk of P. falciparum infection incidence between 6 and 24 months (IRR = 1.64, 95% CI, 1.38-1.94) and clinical malaria (IRR = 1.85, 95% CI, 1.48-2.32). Exposure to malaria was associated with lower WAZ over time (p = 0.02) and lower haemoglobin levels than unexposed infants at every time interval (p = 0.02).
    Conclusions: Infants experiencing malaria infection or clinical malaria are at increased risk of subsequent infection and disease, have poorer growth, and lower haemoglobin concentrations.
    MeSH term(s) Humans ; Infant ; Plasmodium falciparum ; Malaria, Falciparum/complications ; Malaria, Falciparum/epidemiology ; Malaria/complications ; Anemia/epidemiology ; Anemia/complications ; Hemoglobins
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-023-04646-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clostridium difficile Colonization of Nursing Home Residents.

    Roghmann, Mary-Claire / Andronescu, Liana R / Stucke, Emily M / Johnson, J Kristie

    Infection control and hospital epidemiology

    2017  Volume 38, Issue 10, Page(s) 1267–1268

    MeSH term(s) Clostridium Infections/epidemiology ; Clostridium difficile/isolation & purification ; Humans ; Nursing Homes/statistics & numerical data ; Skin/microbiology ; United States/epidemiology
    Language English
    Publishing date 2017-08-22
    Publishing country United States
    Document type Letter ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2017.172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1714: Show issues Location:
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  3. Article ; Online: Repertoire of Naturally Acquired Maternal Antibodies Transferred to Infants for Protection Against Shigellosis.

    Ndungo, Esther / Andronescu, Liana R / Buchwald, Andrea G / Lemme-Dumit, Jose M / Mawindo, Patricia / Kapoor, Neeraj / Fairman, Jeff / Laufer, Miriam K / Pasetti, Marcela F

    Frontiers in immunology

    2021  Volume 12, Page(s) 725129

    Abstract: ... ...

    Abstract Shigella
    MeSH term(s) Adolescent ; Adult ; Antibodies, Bacterial/blood ; Cohort Studies ; Dysentery, Bacillary/immunology ; Dysentery, Bacillary/prevention & control ; Female ; Humans ; Immunity, Maternally-Acquired ; Immunoglobulin G/blood ; Immunoglobulin G/classification ; Infant ; Infant, Newborn ; Malawi ; Male ; Pregnancy ; Shigella Vaccines/immunology ; Shigella flexneri/immunology ; Young Adult
    Chemical Substances Antibodies, Bacterial ; Immunoglobulin G ; Shigella Vaccines
    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.725129
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  4. Article ; Online: The Effect of Intermittent Preventive Treatment of Malaria During Pregnancy and Placental Malaria on Infant Risk of Malaria.

    Andronescu, Liana R / Sharma, Ankur / Peterson, Ingrid / Kachingwe, Martin / Kachepa, Witness / Liang, Yuanyuan / Gutman, Julie R / Mathanga, Don P / Chinkhumba, Jobiba / Laufer, Miriam K

    The Journal of infectious diseases

    2021  Volume 225, Issue 2, Page(s) 248–256

    Abstract: Background: Intermittent preventive treatment of malaria during pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) provides greater protection from placental malaria than sulfadoxine-pyrimethamine (SP). Some studies suggest placental malaria ... ...

    Abstract Background: Intermittent preventive treatment of malaria during pregnancy (IPTp) with dihydroartemisinin-piperaquine (DP) provides greater protection from placental malaria than sulfadoxine-pyrimethamine (SP). Some studies suggest placental malaria alters risk of malaria infection in infants, but few have quantified the effect of IPTp on infant susceptibility to malaria.
    Methods: Infants born to women enrolled in a randomized clinical trial comparing IPTp-SP and IPTp-DP in Malawi were followed from birth to 24 months to assess effect of IPTp and placental malaria on time to first malaria episode and Plasmodium falciparum incidence.
    Results: In total, 192 infants born to mothers randomized to IPTp-SP and 195 randomized to IPTp-DP were enrolled. Infants in IPTp exposure groups did not differ significantly regarding incidence of clinical malaria (incidence rate ratio [IRR], 1.03; 95% confidence interval [CI], .58-1.86) or incidence of infection (IRR, 1.18; 95% CI, .92-1.55). Placental malaria exposure was not associated with incidence of clinical malaria (IRR, 1.03; 95% CI, .66-1.59) or infection (IRR, 1.15; 95% CI, .88-1.50). Infant sex, season of birth, and maternal gravidity did not confound results.
    Conclusions: We did not find evidence that IPTp regimen or placental malaria exposure influenced risk of malaria during infancy in this population. Clinical Trials Registration. NCT03009526.
    MeSH term(s) Adult ; Antimalarials/therapeutic use ; Artemisinins/therapeutic use ; Drug Combinations ; Female ; Humans ; Infant ; Malaria/drug therapy ; Malaria/epidemiology ; Malaria/prevention & control ; Malawi/epidemiology ; Parasitemia/prevention & control ; Piperazines/therapeutic use ; Placenta/parasitology ; Pregnancy ; Pregnancy Complications, Parasitic/drug therapy ; Pregnancy Complications, Parasitic/epidemiology ; Pregnancy Complications, Parasitic/prevention & control ; Pyrimethamine/therapeutic use ; Quinolines/therapeutic use ; Sulfadoxine/therapeutic use ; Treatment Outcome
    Chemical Substances Antimalarials ; Artemisinins ; Drug Combinations ; Piperazines ; Quinolines ; fanasil, pyrimethamine drug combination (37338-39-9) ; artenimol (6A9O50735X) ; Sulfadoxine (88463U4SM5) ; piperaquine (A0HV2Q956Y) ; Pyrimethamine (Z3614QOX8W)
    Language English
    Publishing date 2021-07-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab351
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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

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  5. Article ; Online: Evaluating SARS-CoV-2 Saliva and Dried Blood Spot Surveillance Strategies in a Congregate Population.

    Andronescu, Liana R / Richard, Stephanie A / Laing, Eric D / Pisanic, Nora / Coggins, Si'Ana A / Rivera, Magdielis Gregory / Kruczynski, Kate / Saperstein, Adam K / Modi, Jitendrakumar / Fraser, Jamie A / Shaikh, Saira / Broder, Christopher C / Burgess, Timothy H / Heaney, Christopher D / Pollett, Simon D / Millar, Eugene / Coles, Christian L / Simons, Mark P

    Emerging infectious diseases

    2023  Volume 29, Issue 9, Page(s) 1925–1928

    Abstract: The optimal approach to COVID-19 surveillance in congregate populations remains unclear. Our study at the US Naval Academy in Annapolis, Maryland, USA, assessed the concordance of antibody prevalence in longitudinally collected dried blood spots and ... ...

    Abstract The optimal approach to COVID-19 surveillance in congregate populations remains unclear. Our study at the US Naval Academy in Annapolis, Maryland, USA, assessed the concordance of antibody prevalence in longitudinally collected dried blood spots and saliva in a setting of frequent PCR-based testing. Our findings highlight the utility of salivary-based surveillance.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; COVID-19/epidemiology ; Saliva ; COVID-19 Testing ; Clinical Laboratory Techniques
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2909.230417
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: SARS-CoV-2 infection is associated with self-reported post-acute neuropsychological symptoms within six months of follow-up.

    Andronescu, Liana R / Richard, Stephanie A / Scher, Ann I / Lindholm, David A / Mende, Katrin / Ganesan, Anuradha / Huprikar, Nikhil / Lalani, Tahaniyat / Smith, Alfred / Mody, Rupal M / Jones, Milissa U / Bazan, Samantha E / Colombo, Rhonda E / Colombo, Christopher J / Ewers, Evan / Larson, Derek T / Maves, Ryan C / Berjohn, Catherine M / Maldonado, Carlos J /
    English, Caroline / Sanchez Edwards, Margaret / Rozman, Julia S / Rusiecki, Jennifer / Byrne, Celia / Simons, Mark P / Tribble, David / Burgess, Timothy H / Pollett, Simon D / Agan, Brian K

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0297481

    Abstract: Background: Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neuropsychological ... ...

    Abstract Background: Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term neuropsychological impairment, it is important to characterize the frequency and predictors of this post-infection phenotype.
    Methods: The Epidemiology, Immunology, and Clinical Characteristics of Emerging Infectious Diseases with Pandemic Potential (EPICC) study is a longitudinal study assessing the impact of SARS-CoV-2 infection in U.S. Military Healthcare System (MHS) beneficiaries, i.e. those eligible for care in the MHS including active duty servicemembers, dependents, and retirees. Four broad areas of neuropsychological symptoms were assessed cross-sectionally among subjects 1-6 months post-infection/enrollment, including: depression (Patient Health Questionnaire-9), anxiety (General Anxiety Disorder-7), fatigue (PROMIS® Fatigue 7a), and cognitive function (PROMIS® Cognitive Function 8a and PROMIS® Cognitive Function abilities 8a). Multivariable Poisson regression models compared participants with and without SARS-CoV-2 infection history on these measures, adjusting for sex, ethnicity, active-duty status, age, and months post-first positive or enrollment of questionnaire completion (MPFP/E); models for fatigue and cognitive function were also adjusted for depression and anxiety scores.
    Results: The study population included 2383 participants who completed all five instruments within six MPFP/E, of whom 687 (28.8%) had at least one positive SARS-CoV-2 test. Compared to those who had never tested positive for SARS-CoV-2, the positive group was more likely to meet instrument-based criteria for depression (15.4% vs 10.3%, p<0.001), fatigue (20.1% vs 8.0%, p<0.001), impaired cognitive function (15.7% vs 8.6%, p<0.001), and impaired cognitive function abilities (24.3% vs 16.3%, p<0.001). In multivariable models, SARS-CoV-2 positive participants, assessed at an average of 2.7 months after infection, had increased risk of moderate to severe depression (RR: 1.44, 95% CI 1.12-1.84), fatigue (RR: 2.07, 95% CI 1.62-2.65), impaired cognitive function (RR: 1.64, 95% CI 1.27-2.11), and impaired cognitive function abilities (RR: 1.41, 95% CI 1.15-1.71); MPFP/E was not significant.
    Conclusions: Participants with a history of SARS-CoV-2 infection were up to twice as likely to report cognitive impairment and fatigue as the group without prior SARS-CoV-2 infection. These findings underscore the continued importance of preventing SARS-CoV-2 infection and while time since infection/enrollment was not significant through 6 months of follow-up, this highlights the need for additional research into the long-term impacts of COVID-19 to mitigate and reverse these neuropsychological outcomes.
    MeSH term(s) Humans ; Self Report ; COVID-19/complications ; COVID-19/epidemiology ; SARS-CoV-2 ; Follow-Up Studies ; Longitudinal Studies ; Fatigue/epidemiology ; Fatigue/etiology ; Anxiety Disorders
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297481
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  7. Article ; Online: Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi.

    Andronescu, Liana R / Buchwald, Andrea G / Coalson, Jenna E / Cohee, Lauren / Bauleni, Andy / Walldorf, Jenny A / Kandangwe, Chifundo / Mzilahowa, Themba / Taylor, Terrie E / Mathanga, Don P / Laufer, Miriam K

    Malaria journal

    2019  Volume 18, Issue 1, Page(s) 329

    Abstract: Background: Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, ... ...

    Abstract Background: Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi.
    Methods: From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season.
    Results: There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07-2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection.
    Conclusions: Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Insecticide-Treated Bednets ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/prevention & control ; Malawi/epidemiology ; Male ; Mosquito Control/instrumentation ; Plasmodium falciparum ; Prevalence ; Seasons ; Surveys and Questionnaires
    Language English
    Publishing date 2019-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-019-2930-8
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