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  1. Article ; Online: Paraesophageal Hiatal Hernia Repair With Urinary Bladder Matrix Graft.

    Howell, Raelina S / Fazzari, Melissa / Petrone, Patrizio / Barkan, Alexander / Hall, Keneth / Servide, María José / Anduaga, María Fernanda / Brathwaite, Collin E M

    JSLS : Journal of the Society of Laparoendoscopic Surgeons

    2018  Volume 22, Issue 2

    Abstract: Background and objectives: Paraesophageal hiatal hernia repair can be performed with or without mesh reinforcement. The use, technique, and mesh type remain controversial because of mixed reports on mesh-related complications. Short-term outcomes have ... ...

    Abstract Background and objectives: Paraesophageal hiatal hernia repair can be performed with or without mesh reinforcement. The use, technique, and mesh type remain controversial because of mixed reports on mesh-related complications. Short-term outcomes have become important in all forms of surgery.
    Methods: From January 2012 through April 2017, all patients who underwent isolated hiatal hernia repair in our center were reviewed. Concomitant bariatric surgery cases were excluded. Repairs reinforced by porcine urinary bladder matrix (UBM) graft were compared to non-UBM repairs. Statistical comparison was based on a Wilcoxon 2-sample test or Fisher's exact test.
    Results: We reviewed 239 charts; 110 bariatric cases and 8 cases with non-UBM reinforcement were excluded. We identified 121 patients: 56 UBM-reinforced (46.3%) versus 65 non-UBM (53.7%). Sixteen (28.6%) UBM cases were male versus 23 (35.4%) non-UBM cases. The UBM patients were significantly older (63.9 versus 54.3;
    Conclusions: Hiatal hernia repair with UBM reinforcement can be performed safely with no increase in postoperative complications.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Animals ; Female ; Hernia, Hiatal/surgery ; Herniorrhaphy/methods ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Surgical Mesh ; Swine ; Transplantation, Heterologous ; Treatment Outcome ; Urinary Bladder/transplantation
    Language English
    Publishing date 2018-05-23
    Publishing country United States
    Document type Case Reports ; Journal Article ; Observational Study
    ZDB-ID 2011211-7
    ISSN 1938-3797 ; 1086-8089
    ISSN (online) 1938-3797
    ISSN 1086-8089
    DOI 10.4293/JSLS.2017.00100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 310: Show issues

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  2. Article ; Online: Short-Term Outcomes in Patients Undergoing Paraesophageal Hiatal Hernia Repair.

    Howell, Raelina S / Liu, Helen H / Petrone, Patrizio / Anduaga, María Fernanda / Servide, María José / Hall, Keneth / Barkan, Alexander / Islam, Shahidul / Brathwaite, Collin E M

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 7366

    Abstract: Many patients with hiatal hernias (HH) are asymptomatic; however, symptoms may include heartburn, regurgitation, dysphagia, nausea, or vague epigastric pain depending on the hernia type and severity. The ideal technique and timing of repair remains ... ...

    Abstract Many patients with hiatal hernias (HH) are asymptomatic; however, symptoms may include heartburn, regurgitation, dysphagia, nausea, or vague epigastric pain depending on the hernia type and severity. The ideal technique and timing of repair remains controversial. This report describes short-term outcomes and readmissions of patients undergoing HH repair at our institution. All patients who underwent HH repair from January 2012 through April 2017 were reviewed. Patients undergoing concomitant bariatric surgery were excluded. 239 patients were identified and 128 were included. Eighty-eight were female (69%) and 40 were male (31%) with a mean age of 59 years (range 20-91 years) and a mean BMI of 29.2 kg/m
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Fundoplication/methods ; Gastroesophageal Reflux/surgery ; Hernia, Hiatal/surgery ; Herniorrhaphy ; Humans ; Laparoscopy ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-61566-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spatio-temporal tumor heterogeneity in metastatic CRC tumors: a mutational-based approach.

    Del Carmen, Sofía / Sayagués, José María / Bengoechea, Oscar / Anduaga, María Fernanda / Alcazar, Jose Antonio / Gervas, Ruth / García, Jacinto / Orfao, Alberto / Bellvis, Luis Muñoz / Sarasquete, María Eugenia / Del Mar Abad, María

    Oncotarget

    2018  Volume 9, Issue 76, Page(s) 34279–34288

    Abstract: It is well known that activating mutations in ... ...

    Abstract It is well known that activating mutations in the
    Language English
    Publishing date 2018-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Combined assessment of the TNM stage and

    Sayagués, José María / Del Carmen, Sofía / Del Mar Abad, María / Corchete, Luís Antonio / Bengoechea, Oscar / Anduaga, María Fernanda / Baldeón, María Jesús / Cruz, Juan Jesús / Alcazar, Jose Antonio / Angoso, María / González, Marcos / García, Jacinto / Muñoz-Bellvis, Luís / Orfao, Alberto / Sarasquete, María Eugenia

    Oncotarget

    2018  Volume 9, Issue 35, Page(s) 24081–24096

    Abstract: The prognostic impact ... ...

    Abstract The prognostic impact of
    Language English
    Publishing date 2018-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.25300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors.

    Gutiérrez, María Laura / Corchete, Luis Antonio / Sarasquete, María Eugenia / Del Mar Abad, María / Bengoechea, Oscar / Fermiñán, Encarna / Anduaga, María Fernanda / Del Carmen, Sofía / Iglesias, Manuel / Esteban, Carmen / Angoso, María / Alcazar, Jose Antonio / García, Jacinto / Orfao, Alberto / Muñoz-Bellvís, Luis / Sayagués, José María

    Oncotarget

    2017  Volume 8, Issue 64, Page(s) 107685–107700

    Abstract: Despite significant advances have been achieved in the genetic characterization of sporadic colorectal cancer (sCRC), the precise genetic events leading to the development of distant metastasis remain poorly understood. Thus, accurate prediction of ... ...

    Abstract Despite significant advances have been achieved in the genetic characterization of sporadic colorectal cancer (sCRC), the precise genetic events leading to the development of distant metastasis remain poorly understood. Thus, accurate prediction of metastatic disease in newly-diagnosed sCRC patients remains a challenge. Here, we evaluated the specific genes and molecular pathways associated with the invasive potential of colorectal tumor cells, through the assessment of the gene expression profile (GEP) of coding and non-coding genes in metastatic (MTX) vs. non-metastatic (non-MTX) primary sCRC tumors followed for >5 years. Overall, MTX tumors showed up-regulation of genes associated with tumor progression and metastatic potential while non-MTX cases displayed GEP associated with higher cell proliferation, activation of DNA repair and anti-tumoral immune/inflammatory responses. Based on only 19 genes a specific GEP that classifies sCRC tumors into two MTX-like and non-MTX-like molecular subgroups was defined which shows an independent prognostic impact on patient overall survival, particularly when it is combined with the lymph node status at diagnosis. In summary, we show an association between the global GEP of primary sCRC cells and their metastatic potential and defined a GEP-based classifier that provides the basis for further prognostic stratification of sCRC patients who are at risk of distant metastases.
    Language English
    Publishing date 2017-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.22591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genomic characterization of liver metastases from colorectal cancer patients.

    Sayagués, José María / Corchete, Luís Antonio / Gutiérrez, María Laura / Sarasquete, Maria Eugenia / Del Mar Abad, María / Bengoechea, Oscar / Fermiñán, Encarna / Anduaga, María Fernanda / Del Carmen, Sofia / Iglesias, Manuel / Esteban, Carmen / Angoso, María / Alcazar, Jose Antonio / García, Jacinto / Orfao, Alberto / Muñoz-Bellvis, Luís

    Oncotarget

    2016  Volume 7, Issue 45, Page(s) 72908–72922

    Abstract: Metastatic dissemination is the most frequent cause of death of sporadic colorectal cancer (sCRC) patients. Genomic abnormalities which are potentially characteristic of such advanced stages of the disease are complex and so far, they have been poorly ... ...

    Abstract Metastatic dissemination is the most frequent cause of death of sporadic colorectal cancer (sCRC) patients. Genomic abnormalities which are potentially characteristic of such advanced stages of the disease are complex and so far, they have been poorly described and only partially understood. We evaluated the molecular heterogeneity of sCRC tumors based on simultaneous assessment of the overall GEP of both coding mRNA and non-coding RNA genes in primary sCRC tumor samples from 23 consecutive patients and their paired liver metastases. Liver metastases from the sCRC patients analyzed, systematically showed deregulated transcripts of those genes identified as also deregulated in their paired primary colorectal carcinomas. However, some transcripts were found to be specifically deregulated in liver metastases (vs. non-tumoral colorectal tissues) while expressed at normal levels in their primary tumors, reflecting either an increased genomic instability of metastatic cells or theiradaption to the liver microenvironment. Newly deregulated metastatic transcripts included overexpression of APOA1, HRG, UGT2B4, RBP4 and ADH4 mRNAS and the miR-3180-3p, miR-3197, miR-3178, miR-4793 and miR-4440 miRNAs, together with decreased expression of the IGKV1-39, IGKC, IGKV1-27, FABP4 and MYLK mRNAS and the miR-363, miR-1, miR-143, miR-27b and miR-28-5p miRNAs. Canonical pathways found to be specifically deregulated in liver metastatic samples included multiple genes related with intercellular adhesion and the metastatic processes (e.g., IGF1R, PIK3CA, PTEN and EGFR), endocytosis (e.g., the PDGFRA, SMAD2, ERBB3, PML and FGFR2), and the cell cycle (e.g., SMAD2, CCND2, E2F5 and MYC). Our results also highlighted the activation of genes associated with the TGFβ signaling pathway, -e.g. RHOA, SMAD2, SMAD4, SMAD5, SMAD6, BMPR1A, SMAD7 and MYC-, which thereby emerge as candidate genes to play an important role in CRC tumor metastasis.
    Language English
    Publishing date 2016-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 1949-2553
    ISSN (online) 1949-2553
    DOI 10.18632/oncotarget.12140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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