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  1. Article ; Online: SPONTANEOUS CLOSURE OF A LARGE STAGE III MACULAR HOLE AFTER PANRETINAL PHOTOCOAGULATION IN A PATIENT WITH SEVERE PROLIFERATIVE DIABETIC RETINOPATHY.

    Kolomeyer, Anton M / Anetakis, Alexander J

    Retinal cases & brief reports

    2017  Volume 11, Issue 2, Page(s) 104–107

    Abstract: Purpose: To report spontaneous closure of a tractional Stage III macular hole (MH) in a patient with proliferative diabetic retinopathy (PDR) after panretinal photocoagulation (PRP).: Methods: Case report of a 43-year-old man with poorly controlled ... ...

    Abstract Purpose: To report spontaneous closure of a tractional Stage III macular hole (MH) in a patient with proliferative diabetic retinopathy (PDR) after panretinal photocoagulation (PRP).
    Methods: Case report of a 43-year-old man with poorly controlled Type I diabetes and bilateral severe proliferative diabetic retinopathy.
    Results: On presentation, visual acuity was 20/400 and fundus examination was significant for a Stage III tractional MH in the left eye. Vision in the right eye was light perception from neovascular glaucoma. Fluorescein angiography showed extremely severe macular and peripheral ischemia, disk neovascularization, and macular traction from fibroglial tissue. After 5 panretinal photocoagulation sessions over 3 months, the MH spontaneously closed; however, vision remained 20/400. Fluorescein angiography showed regressed disk neovascularization and mild diffuse macular leakage. After a 13-month loss to follow-up, he presented with 20/300 vision, and, despite extensive macular traction from fibroglial tissue, the MH remained closed. Owing to progressive traction from the fibroglial tissue, macular retinal detachment occurred and vision decreased to hand motions. The patient underwent pars plana vitrectomy, scar tissue removal, silicone oil tamponade, and laser. Postoperatively, visual acuity decreased to no light perception because of neovascular glaucoma complications and lack of proper follow-up.
    Conclusion: Spontaneous closure of a Stage III MH may occur in patients with PDR after PRP; however, it may not result in long-term visual improvement.
    MeSH term(s) Adult ; Diabetic Retinopathy/therapy ; Humans ; Light Coagulation ; Male ; Remission, Spontaneous ; Retinal Detachment/therapy ; Retinal Perforations/therapy
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000000300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coagulase-negative staphylococcal endophthalmitis: clinical severity and outcomes based on speciation.

    Adeghate, Jennifer O / Yadav, Sanya / Kowalski, Regis P / Juhász, Emese / Kristóf, Katalin / Olsen, Karl R / Bergren, Robert L / Knickelbein, Jared E / Chhablani, Jay / Martel, Joseph N / Anetakis, Alexander / Dansingani, Kunal K / Rosin, Boris / Gallagher, Denise S / Prensky, Colin / Eller, Andrew W / Friberg, Thomas / Sahel, José-Alain / Errera, Marie-Hélène

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2023  

    Abstract: Objective: To identify characteristics and visual outcomes of coagulase-negative staphylococcal (CoNS) endophthalmitis in the era after the Endophthalmitis Vitrectomy Study.: Design: Single-centre retrospective analysis.: Participants: Forty-two ... ...

    Abstract Objective: To identify characteristics and visual outcomes of coagulase-negative staphylococcal (CoNS) endophthalmitis in the era after the Endophthalmitis Vitrectomy Study.
    Design: Single-centre retrospective analysis.
    Participants: Forty-two samples from 40 patients with documented CoNS endophthalmitis.
    Methods: Visual acuity outcomes of CoNS endophthalmitis were assessed in relation to species and type of treatment instituted (i.e., pars plana vitrectomy [PPV] versus vitreous tap and injection of intravitreal antibiotics [T&I]) on 42 samples from 40 patients.
    Results: Staphylococcus epidermidis was the most prevalent CoNS in our study. Cataract surgery and intravitreal injections were the most common sources for acute CoNS endophthalmitis. Eyes presenting with hand motion or better vision had similar mean final vision after either intravitreal antibiotics or PPV, whereas those with light perception or worse vision at onset had better outcomes after PPV only. Subanalysis showed that patients with S. epidermidis endophthalmitis (n = 39 eyes) had similar visual outcomes with either intravitreal injections or PPV regardless of visual acuity. Hypopyon and vitritis are not always present.
    Conclusions: Patients with S. epidermidis endophthalmitis may benefit similarly from either early vitrectomy or intravitreal antibiotic injections regardless of visual acuity. This finding may be a supplement to the complements the management standards set forth by the Endophthalmitis Vitrectomy Study.
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2023.05.014
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  3. Article ; Online: RELATIVE QUIESCENCE OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION AFTER RESOLUTION OF POSTINJECTION ENDOPHTHALMITIS.

    Arnett, Justin J / Brodowska, Katarzyna / Gallagher, Denise S / Eller, Andrew W / Friberg, Thomas R / Anetakis, Alexander J / Martel, Joseph N

    Retina (Philadelphia, Pa.)

    2019  Volume 40, Issue 9, Page(s) 1719–1723

    Abstract: Purpose: To evaluate alterations in treatment burden and course of exudative age-related macular degeneration in patients who contracted endophthalmitis from intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections.: Methods: ... ...

    Abstract Purpose: To evaluate alterations in treatment burden and course of exudative age-related macular degeneration in patients who contracted endophthalmitis from intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections.
    Methods: Retrospective study at the University of Pittsburgh Medical Center examining frequency of anti-VEGF injections, activity of choroidal neovascularization, and visual acuity before and after endophthalmitis treatment.
    Results: Twenty-one patients meeting inclusion criteria were identified, of whom 7 (33%) patients did not restart anti-VEGF treatment 12 months after endophthalmitis because of quiescence of exudative age-related macular degeneration without significant visual acuity loss (P > 0.05). Patients who resumed anti-VEGF treatment exhibited 32% and 38% decreases in injection frequency by 12 and 24 months after endophthalmitis, respectively (P < 0.05). On first optical coherence tomography follow-up, 10 patients exhibited quiescence of choroidal neovascularization activity, although there were no measurable changes in macular thickness (P > 0.05). No differences in post-endophthalmitis exudative age-related macular degeneration progression or treatment burden were observed when factoring adjuvant intravitreal steroid therapy, culture results, nor choroidal neovascularization subtypes.
    Conclusion: Endophthalmitis resolution is associated with a decrease in choroidal neovascularization activity and a reduction of anti-VEGF treatment burden in patients with exudative age-related macular degeneration.
    MeSH term(s) Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Bevacizumab/therapeutic use ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/physiopathology ; Endophthalmitis/drug therapy ; Endophthalmitis/etiology ; Exudates and Transudates ; Eye Infections, Bacterial/drug therapy ; Eye Infections, Bacterial/etiology ; Female ; Fluorescein Angiography ; Humans ; Intravitreal Injections/adverse effects ; Male ; Middle Aged ; Ranibizumab/therapeutic use ; Retrospective Studies ; Tomography, Optical Coherence ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/physiology ; Wet Macular Degeneration/drug therapy ; Wet Macular Degeneration/physiopathology
    Chemical Substances Angiogenesis Inhibitors ; Anti-Bacterial Agents ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V) ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2019-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000002666
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    Zs.A 1724: Show issues Location:
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  4. Article: Challenges in posterior uveitis-tips and tricks for the retina specialist.

    Paez-Escamilla, Manuel / Caplash, Sonny / Kalra, Gagan / Odden, Jamie / Price, Danielle / Marroquin, Oscar C / Koscumb, Stephen / Commiskey, Patrick / Indermill, Chad / Finkelstein, Jerome / Gushchin, Anna G / Coca, Andreea / Friberg, Thomas R / Eller, Andrew W / Gallagher, Denise S / Harwick, Jean C / Waxman, Evan L / Chhablani, Jay / Bonhomme, Gabrielle /
    Prensky, Colin / Anetakis, Alexander J / Martel, Joseph N / Massicotte, Erika / Ores, Raphaelle / Girmens, Jean-Francois / Pearce, Thomas M / Sahel, Jose-Alain / Dansingani, Kunal / Westcott, Mark / Errera, Marie-Helene

    Journal of ophthalmic inflammation and infection

    2023  Volume 13, Issue 1, Page(s) 35

    Abstract: Purpose: Posterior uveitis is a common chorioretinal pathology affecting all ages worldwide and is a frequent reason for referral to the retina clinic. The spectrum of etiologies for uveitis is very broad and includes infectious and auto-immune diseases. ...

    Abstract Purpose: Posterior uveitis is a common chorioretinal pathology affecting all ages worldwide and is a frequent reason for referral to the retina clinic. The spectrum of etiologies for uveitis is very broad and includes infectious and auto-immune diseases. Inflammation can be confined to the eye or may be a part of systemic disease. A useful outline is therefore proposed to aid in the correct diagnosis of these challenging entities. The situation is further complicated by the fact that many neoplastic conditions resemble features of posterior uveitis; they are known as "masqueraders of uveitis". Here, we summarize different posterior uveitides that present with rare findings, along with masqueraders that can be difficult to distinguish. These conditions pose a diagnostic dilemma resulting in delay in treatment because of diagnostic uncertainty.
    Methods: An extensive literature search was performed on the MEDLINE/PUBMED, EBSCO and Cochrane CENTRAL databases from January 1985 to January 2022 for original studies and reviews of predetermined diagnoses that include posterior uveitic entities, panuveitis and masquerade syndromes.
    Results: We described conditions that can present as mimickers of posterior uveitis (i.e., immune check-points inhibitors and Vogt-Koyanagi-Harada-like uveitis; leukemia and lymphoma associated posterior uveitis), inflammatory conditions that present as mimickers of retinal diseases (i.e., Purtscher-like retinopathy as a presentation of systemic lupus erythematosus; central serous chorioretinopathy masquerading inflammatory exudative retinal detachment), and uveitic conditions with rare and diagnostically challenging etiologies (i.e., paradoxical inflammatory effects of anti-TNF-α; post vaccination uveitis; ocular inflammation after intravitreal injection of antiangiogenic drugs).
    Conclusion: This review of unique posterior uveitis cases highlights the overlapping features of posterior uveitis (paradoxical inflammatory effects of anti -TNF α and uveitis; Purtscher-like retinopathy as a presentation of systemic lupus erythematosus, …) and the nature of retinal conditions (ischemic ocular syndrome, or central retinal vein occlusion, amyloidosis, inherited conditions like retinitis pigmentosa, autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), etc.…) that may mimic them is represented. Careful review of past uveitis history, current medications and recent vaccinations, detailed examination of signs of past or present inflammation, eventually genetic testing and/ or multimodal retinal imaging (like fluorescein angiography, EDI-OCT, OCT-angiography for lupus Purtscher-like retinopathy evaluation, or ICG for central serous retinopathy, or retinal amyloid angiopathy) may aid in correct diagnosis.
    Language English
    Publishing date 2023-08-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2592309-2
    ISSN 1869-5760
    ISSN 1869-5760
    DOI 10.1186/s12348-023-00342-5
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  5. Article ; Online: Review of the Current Literature and Our Experience on the Value of OCT-angiography in White Dot Syndromes.

    Mebsout-Pallado, Céline / Orès, Raphaëlle / Terrada, Céline / Dansingani, Kunal K / Chhablani, Jay / Eller, Andrew W / Martel, Joseph N / Anetakis, Alexander / Harwick, Jean C / Waxman, Evan L / Gallagher, Denise S / Prensky, Colin / Indermill, Chad / Sedira, Neila / Héron, Emmanuel / Paques, Michel / Brignole-Baudouin, Françoise / Bodaghi, Bahram / Sahel, José-Alain /
    Gaudric, Alain / Mrejen, Sarah / Errera, Marie-Hélène

    Ocular immunology and inflammation

    2021  Volume 30, Issue 2, Page(s) 364–378

    Abstract: Purpose: To describe the application of OCT-A in various posterior uveitis disorders in our experience and to compare it with the available literature.: Methods: Eighteen eyes with the diagnoses of multifocal choroiditis (MFC), multifocal placoid ... ...

    Abstract Purpose: To describe the application of OCT-A in various posterior uveitis disorders in our experience and to compare it with the available literature.
    Methods: Eighteen eyes with the diagnoses of multifocal choroiditis (MFC), multifocal placoid pigment epitheliopathy (APMPPE), multiple evanescent white dot syndrome (MEWDS), tuberculous serpiginous-like choroiditis (SLC), serpiginous choroiditis (SC), and birdshot chorioretinopathy (BSCR) were studied.
    Results: We found flow void of the choriocapillaris in patients with APMPPE, SC, MFC, BSCR, and in SLC. In contrast, perfusion of the choriocapillaris seemed normal in patients with MEWDS.
    Conclusions: We confirmed that OCT-A contributes new information on the physiopathology of white dot syndromes and inflammatory chorioretinopathies, notably on whether or not the choriocapillaris is involved. Comparing the OCT-A features allowed us to suggest that both APMPPE and SLC might be part of the same spectrum of inflammatory disease with primary involvement at the level of the choriocapillaris and secondary RPE damage.
    MeSH term(s) Birdshot Chorioretinopathy ; Choroid ; Choroiditis/diagnosis ; Fluorescein Angiography ; Humans ; Multifocal Choroiditis ; Tomography, Optical Coherence ; White Dot Syndromes
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2020.1837185
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