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Book: Radiotherapy for head and neck cancers

Ang, K. Kian / Garden, Adam S.

indications and techniques

2012

Author's details	K. Kian Ang ; Adam Garden
Keywords	Head and Neck Neoplasms / radiotherapy ; Radiotherapy / methods
Language	English
Size	VI, 292 S. : zahlr. Ill., graph. Darst., 28 cm
Edition	4. ed.
Publisher	Wolters Kluwer, Lippincott Williams & Wilkins
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
Note	Includes bibliographical references and index
Accompanying material	Zugang zu paralleler Internetausgabe über Code
HBZ-ID	HT017008900
ISBN	978-1-608-31686-1 ; 1-608-31686-6
Database	Catalogue ZB MED Medicine, Health

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Book: Radiation oncology

Cox, James D. / Ang, Kie Kian

rationale, technique and results

(Expert consult)

2010

Author's details	James D. Cox ; K. Kian Ang
Series title	Expert consult
Keywords	Neoplasms / radiotherapy ; Cancer--Radiotherapy
Subject code	616.9940642
Language	English
Size	XII, 1072 S. : Ill., graph. Darst., 29 cm
Edition	9. ed.
Publisher	Mosby Elsevier
Publishing place	Philadelphia, Pa
Publishing country	United States
Document type	Book
Accompanying material	Zugang zur Internetausgabe über Code
HBZ-ID	HT016141017
ISBN	978-0-323-04971-9 ; 0-323-04971-0
Database	Catalogue ZB MED Medicine, Health

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2009 A 5820	order for loan	Magazin
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Book ; Online: Radiotherapy for head and neck cancers

Ang, K. K. / Garden, Adam S.

indications and techniques

2006

Author's details	K. Kian Ang, Adam S. Garden
Keywords	Head and neck neoplasms - radiotherapy ; Radiotherapy - methods
Language	English
Size	1 Online-Ressource (xi, 212 Seiten), Illustrationen
Edition	3rd ed.
Publisher	Lippincott Williams & Wilkins
Publishing place	Philadelphia
Document type	Book ; Online
Note	Includes bibliographical references and index
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	978-0-7817-6093-5 ; 0-7817-6093-3
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Radiotherapy for head and neck cancers

Ang, Kie Kian / Garden, Adam S.

indications and techniques

2006

Author's details	K. Kian Ang ; Adam S. Garden
Keywords	Head and Neck Neoplasms / radiotherapy ; Radiotherapy / methods ; Head/Cancer/Radiotherapy ; Neck/Cancer/Radiotherapy
Subject code	616.994910642
Language	English
Size	XI, 212 S. : zahlr. Ill.
Edition	3. ed.
Publisher	Lippincott Williams & Wilkins
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
Note	Includes bibliographical references and index. - Previous ed.: 2001
HBZ-ID	HT014532823
ISBN	0-7817-6093-3 ; 978-0-7817-6093-5
Database	Catalogue ZB MED Medicine, Health

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2005 A 5141	order for loan	Magazin

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Article: A case report of acquired Haemophilia A: A rare medical emergency.

Ang, K T / Joyce Gan, M Y / Syed, E S

The Medical journal of Malaysia

2022 Volume 77, Issue 3, Page(s) 388–392

Abstract: Acquired Haemophilia A (AHA) is a rare potentially lifethreatening bleeding disorder caused by the presence of autoantibodies against coagulation factors. It is usually characterised by severe spontaneous haemorrhage, which can lead to high morbidity and ...

Abstract	Acquired Haemophilia A (AHA) is a rare potentially lifethreatening bleeding disorder caused by the presence of autoantibodies against coagulation factors. It is usually characterised by severe spontaneous haemorrhage, which can lead to high morbidity and mortality. The diagnosis is often challenging. Treatment requires vigilant and accurate laboratory investigations, control of bleeding episodes, and eradication of inhibitors using bypassing agents and/or immunosuppressive agents. Hereby, we present a case report of unusual bleeding episodes with isolated raised activated partial thromboplastin time (APTT).
MeSH term(s)	Autoantibodies ; Hemophilia A/complications ; Hemophilia A/diagnosis ; Hemorrhage/diagnosis ; Hemorrhage/etiology ; Humans ; Partial Thromboplastin Time
Chemical Substances	Autoantibodies
Language	English
Publishing date	2022-05-31
Publishing country	Malaysia
Document type	Case Reports ; Journal Article
ZDB-ID	604286-7
ISSN	0300-5283
ISSN	0300-5283
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Article: Association of Triglyceride Glucose Index with Prevalence and Incidence of Diabetic Retinopathy in a Singaporean Population.

Neelam, Kumari / Aung, Khin Chaw Yu / Ang, Keven / Tavintharan, Subramaniam / Sum, Chee Fang / Lim, Su Chi

Clinical ophthalmology (Auckland, N.Z.)

2023 Volume 17, Page(s) 445–454

Abstract: Objective: To examine the association of triglyceride glucose (TyG) index (product of fasting triglyceride and glucose) with prevalence and incidence of diabetic retinopathy (DR) in type 2 diabetes.: Methods: 1339 patients from an ongoing Singapore ... ...

Abstract	Objective: To examine the association of triglyceride glucose (TyG) index (product of fasting triglyceride and glucose) with prevalence and incidence of diabetic retinopathy (DR) in type 2 diabetes. Methods: 1339 patients from an ongoing Singapore Study of Macro-angiopathy and Micro-Vascular Reactivity in Type 2 Diabetes (SMART2D) were included in this study. Fasting triglyceride and glucose levels were quantified and color fundus photographs were assessed for DR presence and severity. Logistic regression models were used to evaluate associations of TyG index with DR prevalence and incidence (median follow-up period = 3.2 years). Results: Mean TyG index was higher in patients with DR than no DR (9.24±0.7 versus 9.04± 0.6, p<0.001). TyG index was significantly associated with DR prevalence (OR=1.4, CI 1.1-1.7, p=0.002) and incidence (OR=1.8, CI 1.04-2.9, p=0.03), after adjusting for confounders. In a stratified analysis, the association between TyG index and DR prevalence reached significance only in the subgroup with HbA1c levels < 7.0% (OR=2, CI 1.1-3.8, p=0.03). TyG index significantly predicted DR prevalence and incidence with area under receiver operating curve as 0.77 (CI 0.74-0.80, p <0.001) and 0.66 (CI 0.57-0.76, p value <0.01), respectively. Conclusion: TyG index is a good predictor for DR prevalence and incidence. It can also be a secondary treatment target for patients with optimally controlled levels of HbA1c.
Language	English
Publishing date	2023-02-02
Publishing country	New Zealand
Document type	Journal Article
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S382336
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Article ; Online: Exploring the Use of Digital Interventions by People with Severe Mental Illness to Support Their Physical Health: A Mixed Methods Study.

Gillis, Cathy / Williams, Julie / Gillett, George / McGrath, Ray / Ang, Karen / Bakolis, Ioannis / Arias de La Torre, Jorge / Tredget, Gracie / Gaughran, Fiona / Cross, Sean / Stepan, Natalia / Sevdalis, Nick / Khadjesari, Zarnie

Issues in mental health nursing

2024 Volume 45, Issue 1, Page(s) 9–26

Abstract: People with severe mental illness (SMI) are more likely to experience physical health conditions than the general population. Little is known about the experience of people with SMI using digital health interventions (DHIs) to support their physical ... ...

Abstract	People with severe mental illness (SMI) are more likely to experience physical health conditions than the general population. Little is known about the experience of people with SMI using digital health interventions (DHIs) to support their physical health. We explored how people with SMI use DHIs to support their physical health, the acceptability, factors affecting use, and impact on physical health. This was a three-stage mixed methods study (1) online survey of people with SMI; (2) interviews with a subsample of participants from Stage 1; (3) stakeholder workshops. Participants were generally satisfied with the DHIs they used. The most popular DHIs were targeted at diet, exercise, and weight management. Factors that encouraged use included simplicity and data-linkage. Concerns included costs, data security, and reliability of information. Positive impacts included accountability and tangible physical health benefits. Mental health impacted engagement with DHIs. DHIs were seen as a useful tool to monitor physical health but could not replace contact with clinical services. DHIs were considered useful and acceptable by people with SMI and may be used as an extension of clinical care. The specific needs and priorities of people with SMI should be considered both in developing and recommending interventions.
MeSH term(s)	Humans ; Reproducibility of Results ; Mental Disorders/psychology ; Mental Health ; Telemedicine ; Digital Health
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	603180-8
ISSN	1096-4673 ; 0161-2840
ISSN (online)	1096-4673
ISSN	0161-2840
DOI	10.1080/01612840.2023.2279207
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Zs.B 2562: Show issues

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Article ; Online: Reduced skeletal muscle mass to visceral fat area ratio is independently associated with reduced cognitive function in type 2 diabetes mellitus.

Low, Serena / Ng, Tze Pin / Goh, Kiat Sern / Moh, Angela / Khoo, Jonathon / Ang, Keven / Yap, Philip / Cheong, Chin Yee / Tang, Wern Ee / Lim, Ziliang / Subramaniam, Tavintharan / Sum, Chee Fang / Lim, Su Chi

Journal of diabetes and its complications

2024 Volume 38, Issue 2, Page(s) 108672

Abstract: Aim: Skeletal muscle mass to visceral fat area ratio (SVR) has been recognised as an index of sarcopenic obesity. SVR is associated with type 2 diabetes mellitus (T2DM), metabolic syndrome and arterial stiffness which are known risk factors for ... ...

Abstract	Aim: Skeletal muscle mass to visceral fat area ratio (SVR) has been recognised as an index of sarcopenic obesity. SVR is associated with type 2 diabetes mellitus (T2DM), metabolic syndrome and arterial stiffness which are known risk factors for cognitive dysfunction. We aimed to investigate association between SVR and cognitive function in patients with T2DM. Methods: This was a cross-sectional study of 1326 patients with T2DM and mean age 61.3 ± 8.0 years. SVR was assessed based on bioelectrical impedance measurements of muscle mass and visceral fat area (VFA). Cognitive function was assessed using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Linear regression was used to examine the association between SVR in quartiles and RBANS score, adjusting for demographics, education, presence of depressive symptoms, clinical covariates and medications. Results: The lower SVR quartiles were negatively associated with RBANS total score in the unadjusted analysis. The corresponding coefficients for Quartiles 1 and 2 SVR were -3.79 (95 % CI -5.39 to -2.19; p < 0.001) and -1.47 (95 % CI -2.86 to -0.07; p = 0.039) in fully adjusted analysis. The negative association between Quartile 1 SVR and RBANS score was evident in immediate memory, delayed memory, visuo-spatial construction, language and attention domains. Muscle mass and VFA alone had weaker associations with RBANS scores. Conclusion: Our study demonstrated, for the first time, an independent association between reduced SVR and lower cognitive function. This is evident in global and multiple cognitive domains. The synergistic effects of reduced muscle mass and visceral obesity may be more pronounced than their independent effects on cognitive function.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Diabetes Mellitus, Type 2/diagnosis ; Intra-Abdominal Fat ; Cross-Sectional Studies ; Cognition ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/epidemiology ; Muscle, Skeletal
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2023.108672
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Zs.A 2225: Show issues

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Article ; Online: Association between Plasma LRG1 and Lower Cognitive Function in Asians with Type 2 Diabetes Mellitus.

Low, Serena / Moh, Angela / Pandian, Bhuvaneswari / Tan, Xin Li / Pek, Sharon / Zheng, Huili / Ang, Keven / Tang, Wern Ee / Lim, Ziliang / Subramaniam, Tavintharan / Sum, Chee Fang / Lim, Su Chi

The Journal of clinical endocrinology and metabolism

2024

Abstract: Context: Leucine-rich α-2-glycoprotein 1 (LRG1) has been implicated in the pathogenesis of diabetic complications, but its association with cognitive function remains unclear.: Objective: Our primary objective is to investigate the longitudinal ... ...

Abstract	Context: Leucine-rich α-2-glycoprotein 1 (LRG1) has been implicated in the pathogenesis of diabetic complications, but its association with cognitive function remains unclear. Objective: Our primary objective is to investigate the longitudinal association between LRG1 and cognitive function in patients with type 2 diabetes mellitus (T2DM). Secondarily, we determine the causal relationship using Mendelian Randomization (MR), and the role of arterial stiffness as a potential mediator. Methods: T2DM patients (n = 1039; age = 64.1 ± 6.4 years) were followed-up for 5.3 ± 1.2 years. Plasma LRG1 was measured at baseline using enzyme-linked immunosorbent assay. Baseline and follow-up cognitive function was assessed using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). One-sample MR was performed with rs4806985 as plasma LRG1-associated single-nucleotide polymorphism (SNP). Mediation analysis was performed to examine if pulse wave velocity (PWV), an arterial stiffness index, mediated the association between plasma LRG1 and follow-up cognitive function. Results: Elevated baseline natural log (Ln)-transformed LRG1 was inversely associated with baseline and follow-up RBANS total score with adjusted coefficients -1.38 (95%CI -2.55 to -0.21; p = 0.021) and -1.38 (95%CI -2.70 to -0.07; p = 0.039), respectively. Genetically-predicted higher levels of plasma LRG1 was associated with lower follow-up RBANS total score with coefficient -7.44 (95%CI -14.14 to -0.74; p = 0.030) per unit increase in LnLRG1. Higher PWV accounted for 27.7% of the association between LnLRG1 and follow-up RBANS total score. Conclusions: Baseline plasma LRG1 was associated with lower cognitive function at follow-up in patients with T2DM, mediated by PWV. MR analysis provided evidence of an association between genetically influenced plasma LRG1 and lower cognitive function at follow-up.
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgad768
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Article ; Online: Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes.

Gurung, Resham L / Liu, Sylvia / Liu, Jian-Jun / M, Yiamunaa / Zheng, Huili / Chan, Clara / Ang, Keven / Subramaniam, Tavintharan / Sum, Chee Fang / Lim, Su Chi

Cardiovascular diabetology

2024 Volume 23, Issue 1, Page(s) 70

Abstract: Background: Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular events (MACEs) in patients with ... ...

Abstract	Background: Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular events (MACEs) in patients with type 2 diabetes (T2D). Methods: This prospective study included 1083 T2D individuals recruited from a secondary hospital and a primary care facility. The primary outcome was a composite of four-point MACE (nonfatal myocardial infarction, stroke, unstable angina pectoris leading to hospitalization and cardiovascular death). Circulating angiogenin was measured by a proximity extension assay. Cox regression models were used to evaluate the association of baseline plasma angiogenin with the risk of MACE. Results: During a median follow-up of 9.3 years, 109 (10%) MACE were identified. Plasma angiogenin was significantly higher in participants with MACE than in those without MACE (P < 0.001). Doubling of plasma angiogenin concentration was associated with a 3.10-fold (95% CI 1.84-5.22) increased risk for MACE. The association was only moderately attenuated after adjustment for demographic and cardiometabolic risk factors (adjusted HR 2.38, 95% CI 1.34-4.23) and remained statistically significant after additional adjustment for estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (uACR) (adjusted HR 1.90, 95% CI 1.02-3.53). A consistent outcome was obtained when plasma angiogenin was analysed as a categorical variable in tertiles. Conclusions: Plasma angiogenin was associated with the risk of future cardiovascular events in patients with T2D and may be a promising novel biomarker for identifying high-risk T2D patients for early management.
MeSH term(s)	Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/complications ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Myocardial Infarction/complications ; Prospective Studies ; Ribonuclease, Pancreatic ; Risk Factors
Chemical Substances	angiogenin (EC 3.1.27.-) ; Ribonuclease, Pancreatic (EC 3.1.27.5)
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-024-02156-8
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