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  1. Article ; Online: Shigellosis outbreak among persons experiencing homelessness-San Diego County, California, October-December 2021.

    Ohlsen, Elizabeth C / Angel, Kristen / Maroufi, Azarnoush / Kao, Annie / Victorio, Maria J / Cua, Lynnie S / Kimura, Akiko / Vanden Esschert, Kayla / Logan, Naeemah / McMichael, Temet M / Beatty, Mark E / Shah, Seema

    Epidemiology and infection

    2023  Volume 152, Page(s) e61

    Abstract: During October 2021, the County of San Diego Health and Human Services Agency identified five cases of shigellosis among persons experiencing homelessness (PEH). We conducted an outbreak investigation and developed interventions to respond to shigellosis ...

    Abstract During October 2021, the County of San Diego Health and Human Services Agency identified five cases of shigellosis among persons experiencing homelessness (PEH). We conducted an outbreak investigation and developed interventions to respond to shigellosis outbreaks among PEH. Confirmed cases occurred among PEH with stool-cultured
    MeSH term(s) Humans ; Dysentery, Bacillary/epidemiology ; Pandemics ; Disease Outbreaks/prevention & control ; Ill-Housed Persons ; California
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268823001681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Novel Treatment of a Vaccinia Virus Infection from an Occupational Needlestick - San Diego, California, 2019.

    Whitehouse, Erin R / Rao, Agam K / Yu, Yon C / Yu, Patricia A / Griffin, Margaret / Gorman, Susan / Angel, Kristen A / McDonald, Eric C / Manlutac, Anna Liza / de Perio, Marie A / McCollum, Andrea M / Davidson, Whitni / Wilkins, Kimberly / Ortega, Eddy / Satheshkumar, Panayampalli S / Townsend, Michael B / Isakari, Marcia / Petersen, Brett W

    MMWR. Morbidity and mortality weekly report

    2019  Volume 68, Issue 42, Page(s) 943–946

    Abstract: Vaccinia virus (VACV) is an orthopoxvirus used in smallpox vaccines, as a vector for novel cancer treatments, and for experimental vaccine research (1). The Advisory Committee on Immunization Practices (ACIP) recommends smallpox vaccination for ... ...

    Abstract Vaccinia virus (VACV) is an orthopoxvirus used in smallpox vaccines, as a vector for novel cancer treatments, and for experimental vaccine research (1). The Advisory Committee on Immunization Practices (ACIP) recommends smallpox vaccination for laboratory workers who handle replication-competent VACV (1). For bioterrorism preparedness, the U.S. government stockpiles tecovirimat, the first Food and Drug Administration-approved antiviral for treatment of smallpox (caused by variola virus and globally eradicated in 1980*
    MeSH term(s) Adult ; California ; Female ; Humans ; Laboratory Personnel ; Needlestick Injuries/virology ; Occupational Diseases/therapy ; Occupational Injuries/virology ; Vaccinia/therapy
    Language English
    Publishing date 2019-10-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm6842a2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A.

    Ganesan, Shyamala / Unger, Benjamin L / Comstock, Adam T / Angel, Kristen A / Mancuso, Peter / Martinez, Fernando J / Sajjan, Umadevi S

    Thorax

    2012  Volume 68, Issue 2, Page(s) 131–141

    Abstract: Background: Decreased activity of forkhead transcription factor class O (FoxO)3A, a negative regulator of NF-κB-mediated chemokine expression, is implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Previously, we showed that ... ...

    Abstract Background: Decreased activity of forkhead transcription factor class O (FoxO)3A, a negative regulator of NF-κB-mediated chemokine expression, is implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Previously, we showed that quercetin reduces lung inflammation in a murine model of COPD. Here, we examined the mechanisms underlying decreased FoxO3A activation and its modulation by quercetin in COPD human airway epithelial cells and in a COPD mouse model.
    Methods: Primary COPD and normal human airway epithelial cells were treated with quercetin, LY294002 or erlotinib for 2 weeks. IL-8 was measured by ELISA. FoxO3A, Akt, and epidermal growth factor (EGF) receptor (EGFR) phosphorylation and nuclear FoxO3A levels were determined by Western blot analysis. Effects of quercetin on lung chemokine expression, nuclear FoxO3A levels and phosphorylation of EGFR and Akt were determined in COPD mouse model.
    Results: Compared with normal, COPD cells showed significantly increased IL-8, which negatively correlated with nuclear FoxO3A levels. COPD bronchial biopsies also showed reduced nuclear FoxO3A. Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt. Treatment with quercetin partially reversed these changes.
    Conclusions: In COPD airways, aberrant EGFR activity increases PI 3-kinase/Akt-mediated phosphorylation of FoxO3A, thereby decreasing nuclear FoxO3A and increasing chemokine expression. Quercetin restores nuclear FoxO3A and reduces chemokine expression partly by modulating EGFR/PI 3-kinase/Akt activity.
    MeSH term(s) Animals ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Bronchi/drug effects ; Bronchi/metabolism ; Cell Nucleus/chemistry ; Disease Models, Animal ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/pharmacology ; ErbB Receptors/metabolism ; Forkhead Box Protein O3 ; Forkhead Transcription Factors/metabolism ; Humans ; Immunohistochemistry ; Interleukin-8/biosynthesis ; Interleukin-8/metabolism ; Mice ; Mice, Inbred C57BL ; Oncogene Protein v-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Pulmonary Disease, Chronic Obstructive/metabolism ; Quercetin/administration & dosage ; Quercetin/pharmacology ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/metabolism
    Chemical Substances Antioxidants ; Enzyme Inhibitors ; FOXO3 protein, human ; Forkhead Box Protein O3 ; Forkhead Transcription Factors ; FoxO3 protein, mouse ; Interleukin-8 ; Quercetin (9IKM0I5T1E) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Oncogene Protein v-akt (EC 2.7.11.1)
    Language English
    Publishing date 2012-10-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2012-201719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.83: Show issues Location:
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