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  1. Article ; Online: Evolution of Detecting Early Onset of Alzheimer's Disease: From Neuroimaging to Optical Immunoassays.

    Hsiao, Wesley Wei-Wen / Angela, Stefanny / Le, Trong-Nghia / Ku, Chia-Chi / Hu, Po-Sheng / Chiang, Wei-Hung

    Journal of Alzheimer's disease : JAD

    2023  Volume 93, Issue 3, Page(s) 821–845

    Abstract: Alzheimer's disease (AD) is a pathological disorder defined by the symptoms of memory loss and deterioration of cognitive abilities over time. Although the etiology is complex, it is mainly associated with the accumulation of toxic amyloid-β peptide (Aβ) ...

    Abstract Alzheimer's disease (AD) is a pathological disorder defined by the symptoms of memory loss and deterioration of cognitive abilities over time. Although the etiology is complex, it is mainly associated with the accumulation of toxic amyloid-β peptide (Aβ) aggregates and tau protein-induced neurofibrillary tangles (NFTs). Even now, creating non-invasive, sensitive, specific, and cost-effective diagnostic methods for AD remains challenging. Over the past few decades, polymers, and nanomaterials (e.g., nanodiamonds, nanogold, quantum dots) have become attractive and practical tools in nanomedicine for diagnosis and treatment. This review focuses on current developments in sensing methods such as enzyme-linked immunosorbent assay (ELISA) and surface-enhanced Raman scattering (SERS) to boost the sensitivity in detecting related biomarkers for AD. In addition, optical analysis platforms such as ELISA and SERS have found increasing popularity among researchers due to their excellent sensitivity and specificity, which may go as low as the femtomolar range. While ELISA offers easy technological usage and high throughput, SERS has the advantages of improved mobility, simple electrical equipment integration, and lower cost. Both portable optical sensing techniques are highly superior in terms of sensitivity, specificity, human application, and practicality, enabling the early identification of AD biomarkers.
    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; tau Proteins ; Amyloid beta-Peptides ; Enzyme-Linked Immunosorbent Assay ; Neuroimaging ; Biomarkers
    Chemical Substances tau Proteins ; Amyloid beta-Peptides ; Biomarkers
    Language English
    Publishing date 2023-04-30
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-221202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nanomaterial-based biosensors for avian influenza virus: A new way forward

    Wei-Wen Hsiao, Wesley / Fadhilah, Gianna / Li, Zhengzhong / Endo, Ryu / Lin, Yu-Jou / Angela, Stefanny / Ku, Chia-Chi / Chang, Huan-Cheng / Chiang, Wei-Hung

    Talanta. 2023 Dec., v. 265 p.124892-

    2023  

    Abstract: Avian influenza virus (AIV) is a zoonotic virus that can be transmitted from animals to humans. Although human infections are rare, the virus has a high mortality rate when contracted. Appropriate detection methods are thus crucial for combatting this ... ...

    Abstract Avian influenza virus (AIV) is a zoonotic virus that can be transmitted from animals to humans. Although human infections are rare, the virus has a high mortality rate when contracted. Appropriate detection methods are thus crucial for combatting this pathogen. There is a growing demand for rapid, selective, and accurate methods of identifying the virus. Numerous biosensors have been designed and commercialized to detect AIV. However, they all have considerable shortcomings. Nanotechnology offers a new way forward. Nanomaterials produce more eco-friendly, rapid, and portable diagnostic systems. They also exhibit high sensitivity and selectivity while achieving a low detection limit (LOD). This paper reviews state-of-the-art nanomaterial-based biosensors for AIV detection, such as those composed of quantum dots, gold, silver, carbon, silica, nanodiamond, and other nanoparticles. It also offers insight into potential trial protocols for creating more effective methods of identifying AIV and discusses key issues associated with developing nanomaterial-based biosensors.
    Keywords Influenza A virus ; biosensors ; carbon ; detection limit ; gold ; humans ; mortality ; nanodiamonds ; nanoparticles ; pathogens ; silica ; silver ; viruses ; Avian influenza virus ; Biomarker ; Biosensor ; Nanomaterial ; Point-of-care testing
    Language English
    Dates of publication 2023-12
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.124892
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Nanomaterial-based biosensors for avian influenza virus: A new way forward.

    Wei-Wen Hsiao, Wesley / Fadhilah, Gianna / Lee, Cheng-Chung / Endo, Ryu / Lin, Yu-Jou / Angela, Stefanny / Ku, Chia-Chi / Chang, Huan-Cheng / Chiang, Wei-Hung

    Talanta

    2023  Volume 265, Page(s) 124892

    Abstract: Avian influenza virus (AIV) is a zoonotic virus that can be transmitted from animals to humans. Although human infections are rare, the virus has a high mortality rate when contracted. Appropriate detection methods are thus crucial for combatting this ... ...

    Abstract Avian influenza virus (AIV) is a zoonotic virus that can be transmitted from animals to humans. Although human infections are rare, the virus has a high mortality rate when contracted. Appropriate detection methods are thus crucial for combatting this pathogen. There is a growing demand for rapid, selective, and accurate methods of identifying the virus. Numerous biosensors have been designed and commercialized to detect AIV. However, they all have considerable shortcomings. Nanotechnology offers a new way forward. Nanomaterials produce more eco-friendly, rapid, and portable diagnostic systems. They also exhibit high sensitivity and selectivity while achieving a low detection limit (LOD). This paper reviews state-of-the-art nanomaterial-based biosensors for AIV detection, such as those composed of quantum dots, gold, silver, carbon, silica, nanodiamond, and other nanoparticles. It also offers insight into potential trial protocols for creating more effective methods of identifying AIV and discusses key issues associated with developing nanomaterial-based biosensors.
    MeSH term(s) Animals ; Humans ; Influenza in Birds/diagnosis ; Influenza A virus ; Biosensing Techniques/methods ; Nanostructures ; Nanoparticles
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.124892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Facile synthesis of hierarchical porous ZIF-8@TiO2 for simultaneous adsorption and photocatalytic decomposition of crystal violet

    Angela, Stefanny / Bervia Lunardi, Valentino / Kusuma, Karissa / Edi Soetaredjo, Felycia / Nyoo Putro, Jindrayani / Permatasari Santoso, Shella / Elisa Angkawijaya, Artik / Lie, Jenni / Gunarto, Chintya / Kurniawan, Alfin / Ismadji, Suryadi

    Environmental nanotechnology, monitoring & management. 2021 Dec., v. 16

    2021  

    Abstract: In this study, a facile one-pot method was developed to create hierarchical porous M−ZIF−8 by utilizing NaOH as a defecting agent. The as-synthesized material comprising macroporous and mesoporous and exhibits hierarchical porosity. TiO₂ (anatase) with ... ...

    Abstract In this study, a facile one-pot method was developed to create hierarchical porous M−ZIF−8 by utilizing NaOH as a defecting agent. The as-synthesized material comprising macroporous and mesoporous and exhibits hierarchical porosity. TiO₂ (anatase) with different mass ratios (5%, 15%, and 25%) were immobilized into M−ZIF−8 to combine the synergism of adsorption and photocatalytic oxidation. Five percent of TiO₂ immobilized in M−ZIF−8 gave the best adsorption and photocatalytic degradation. The adsorption kinetics and isotherms of CV on M−ZIF−8 were also evaluated to validate the adsorption capability of M−ZIF−8. After four consecutive experiments, the adsorption and photocatalytic performance of M−ZIF−8@TiO₂ to degrade CV slightly decreased.
    Keywords administrative management ; adsorption ; gentian violet ; oxidation ; photocatalysis ; porosity ; porous media ; synergism
    Language English
    Dates of publication 2021-12
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2821777-9
    ISSN 2215-1532
    ISSN 2215-1532
    DOI 10.1016/j.enmm.2021.100598
    Database NAL-Catalogue (AGRICOLA)

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