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  1. Article ; Online: Nanomedicines for brain diseases: where we are and where we are going.

    Tosi, Giovanni / Thomas Duskey, Jason / Angela Vandelli, Maria / Ruozi, Barbara

    Therapeutic delivery

    2021  Volume 12, Issue 9, Page(s) 631–635

    Abstract: Graphical abstract [Formula: see text]. ...

    Abstract Graphical abstract [Formula: see text].
    MeSH term(s) Blood-Brain Barrier ; Brain Diseases ; Drug Delivery Systems ; Humans ; Nanomedicine
    Language English
    Publishing date 2021-08-06
    Publishing country England
    Document type Editorial
    ISSN 2041-6008
    ISSN (online) 2041-6008
    DOI 10.4155/tde-2021-0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Enantioseparation of chiral phytocannabinoids in medicinal cannabis.

    Russo, Fabiana / Tolomeo, Francesco / Angela Vandelli, Maria / Biagini, Giuseppe / Laganà, Aldo / Laura Capriotti, Anna / Cerrato, Andrea / Carbone, Luigi / Perrone, Elisabetta / Cavazzini, Alberto / Maiorano, Vincenzo / Gigli, Giuseppe / Cannazza, Giuseppe / Citti, Cinzia

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2023  Volume 1221, Page(s) 123682

    Abstract: The evaluation of the chiral composition of phytocannabinoids in the cannabis plant is particularly important as the pharmacological effects of the (+) and (-) enantiomers of these compounds are completely different. Chromatographic attempts to assess ... ...

    Abstract The evaluation of the chiral composition of phytocannabinoids in the cannabis plant is particularly important as the pharmacological effects of the (+) and (-) enantiomers of these compounds are completely different. Chromatographic attempts to assess the presence of the minor (+) enantiomers of the main phytocannabinoids, cannabidiolic acid (CBDA) and trans-Δ
    MeSH term(s) Medical Marijuana ; Dronabinol/analysis ; Cannabinoids/analysis ; Cannabis/chemistry ; Cannabidiol/analysis
    Chemical Substances Medical Marijuana ; Dronabinol (7J8897W37S) ; cannabidiolic acid (FJX8O3OJCD) ; Cannabinoids ; Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2023-03-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2023.123682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: ROS-responsive "smart" polymeric conjugate: Synthesis, characterization and proof-of-concept study.

    Oddone, Natalia / Pederzoli, Francesca / Duskey, Jason T / De Benedictis, Chiara A / Grabrucker, Andreas M / Forni, Flavio / Angela Vandelli, Maria / Ruozi, Barbara / Tosi, Giovanni

    International journal of pharmaceutics

    2019  Volume 570, Page(s) 118655

    Abstract: New approaches integrating stimuli-responsive linkers into prodrugs are currently emerging. These "smart" prodrugs can enhance the effectivity of conventional prodrugs with promising clinical applicability. Oxidative stress is central to several diseases, ...

    Abstract New approaches integrating stimuli-responsive linkers into prodrugs are currently emerging. These "smart" prodrugs can enhance the effectivity of conventional prodrugs with promising clinical applicability. Oxidative stress is central to several diseases, including cancer. Therefore, the design of prodrugs that respond to ROS stimulus, allowing a selective drug release in this condition, is fairly encouraging. Aiming to investigate the ROS-responsiveness of prodrugs containing the ROS-cleavable moiety, Thioketal (TK), we performed proof-of-concept studies by synthesizing ROS-responsive conjugate, namely mPEG-TK-Cy5, through exploiting Cy5 fluorescent dye. We demonstrated that, differently to non-ROS-responsive control conjugate (mPEG-Cy5), mPEG-TK-Cy5 shows a selective release of Cy5 in response to ROS in both, ROS-simulated conditions and in vitro on glioblastoma cells. Our results confirm the applicability of TK-technology in the design of ROS-responsive prodrugs, which constitutes a promising approach in cancer treatment. The translatability of this technology for other diseases treatment makes this a highly relevant and promising approach.
    MeSH term(s) Animals ; Cell Line, Tumor ; Drug Liberation/drug effects ; Glioblastoma/drug therapy ; Humans ; Polyethylene Glycols/chemistry ; Polymers/chemistry ; Prodrugs/chemistry ; Prodrugs/pharmacology ; Rats ; Reactive Oxygen Species/metabolism
    Chemical Substances Polymers ; Prodrugs ; Reactive Oxygen Species ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2019-08-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2019.118655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: Ketorolac tromethamine liposomes: encapsulation and release studies.

    Ruozi, Barbara / Tosi, Giovanni / Forni, Flavio / Angela Vandelli, Maria

    Journal of liposome research

    2005  Volume 15, Issue 3-4, Page(s) 175–185

    Abstract: Liposomes loaded with ketorolac tromethamine salt were prepared by using a thin layer evaporation method. The physical properties of liposomes were studied by using atomic force microscopy (AFM) and transmission electron microscopy (TEM). The ... ...

    Abstract Liposomes loaded with ketorolac tromethamine salt were prepared by using a thin layer evaporation method. The physical properties of liposomes were studied by using atomic force microscopy (AFM) and transmission electron microscopy (TEM). The relationship between lipid composition, encapsulation efficiency, vesicle size, and the release of ketorolac tromethamine-loaded liposomes was studied. The drug content was found to be dependent on the lipidic composition used in the preparations and, in particular, vesicles containing both cationic lipids (dimethyldioctadecylammonium bromide and N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride), and phosphatidylcholine had a higher entrapped efficiency than liposomes with phosphatidylcholine alone or in the presence of cholesterol. Finally, the cationic liposomes appear to be useful as carriers for ketorolac tromethamine to control its in vitro release.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Cyclooxygenase Inhibitors/chemistry ; Drug Compounding ; Humans ; Ketorolac Tromethamine/chemistry ; Liposomes/chemistry ; Microscopy, Atomic Force ; Microscopy, Electron, Transmission ; Particle Size
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Cyclooxygenase Inhibitors ; Liposomes ; Ketorolac Tromethamine (4EVE5946BQ)
    Language English
    Publishing date 2005-12-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 645173-1
    ISSN 0898-2104
    ISSN 0898-2104
    DOI 10.1080/08982100500364214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2539: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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