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  1. Article: Editorial: Diagnostic accuracy of sepsis: clinical scores combination and serum biomarkers for rapid diagnosis and prognosis.

    Spoto, Silvia / Bustos, César / Angeletti, Silvia

    Frontiers in medicine

    2023  Volume 10, Page(s) 1252213

    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1252213
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  2. Article ; Online: Matrix assisted laser desorption time of flight mass spectrometry (MALDI-TOF MS) in clinical microbiology.

    Angeletti, Silvia

    Journal of microbiological methods

    2017  Volume 138, Page(s) 20–29

    Abstract: The microbiological management of patients with suspected bacterial infection includes the identification of the pathogen and the determination of the antibiotic susceptibility. These traditional approaches, based on the pure culture of the microorganism, ...

    Abstract The microbiological management of patients with suspected bacterial infection includes the identification of the pathogen and the determination of the antibiotic susceptibility. These traditional approaches, based on the pure culture of the microorganism, require at least 36-48h. A new method, Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS), has been recently developed to profile bacterial proteins from whole cell extracts and obtain a bacterial fingerprint able to discriminate microorganisms from different genera and species. By whole cell-mass spectrometry, microbial identification can be achieved within minutes from cultured isolate, rather than traditional phenotypic or genotypic characterizations. From the year 2009 an explosion of applications of this technology has been observed with promising results. Several studies have been performed and showed that MALDI-TOF represents a reliable alternative method for rapid bacteria and fungi identification in clinical setting. A future area of expansion is represented by the application of MALDI-TOF technology to the antibiotic susceptibility test. In conclusion, the revision of the literature available up to date demonstrated that MALDI-TOF MS represents an innovative technology for the rapid and accurate identification of bacterial and fungal isolates in clinical settings. By an earlier microbiological diagnosis, MALDI-TOF MS contributes to a reduced mortality and hospitalization time of the patients and consequently has a significant impact on cost savings and public health.
    MeSH term(s) Bacteria/classification ; Bacteria/drug effects ; Bacteria/genetics ; Bacterial Infections/diagnosis ; Fungi/classification ; Fungi/drug effects ; Fungi/genetics ; Humans ; Microbial Sensitivity Tests/methods ; Microbiological Techniques/methods ; Molecular Typing ; Mycological Typing Techniques ; Mycoses/diagnosis ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
    Language English
    Publishing date 2017-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2016.09.003
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  3. Article ; Online: The influence of gut microbiome on periprosthetic joint infections: State-of-the art.

    Longo, Umile Giuseppe / Lalli, Alberto / Bandini, Benedetta / Angeletti, Silvia / Lustig, Sebastien / Budhiparama, Nicolaas Cyrillus

    Journal of ISAKOS : joint disorders & orthopaedic sports medicine

    2024  

    Abstract: Early periprosthetic joint infection constitutes one of the most frightening complications of joint replacement. Recently, some evidence has highlighted the potential link between dysregulation of the gut microbiota and degenerative diseases of joints. ... ...

    Abstract Early periprosthetic joint infection constitutes one of the most frightening complications of joint replacement. Recently, some evidence has highlighted the potential link between dysregulation of the gut microbiota and degenerative diseases of joints. It has been hypothesized that microbiome dysbiosis may increase the risk of periprosthetic joint infection by facilitating bacterial translocation from these sites to the bloodstream or by impairing local or systemic immune responses. Although the processes tying the gut microbiome to infection susceptibility are still unknown, new research suggests that the presurgical gut microbiota-a previously unconsidered component-may influence the patient's ability to resist infection. Exploring the potential impact of the microbiome on periprosthetic joint infections may therefore bring new insights into the pathogenesis and therapy of these disorders. For a successful therapy, a proper surgical procedure in conjunction with an antibacterial concept is essential. As per the surgical approach, different treatment strategies include surgical irrigation, debridement, antibiotic therapy, and implant retention with or without polyethylene exchange. Other alternatives could be one-stage or two-stage revisions surgery. Interventions that either directly target gut microbes as well as interventions that modify the composition and/or function of the commensal microbes represent an innovative and potentially successful field to be explored. In recent times, innovative therapeutic methods have arisen in the realm of microbiome restoration and the management of gut-related ailments. These progressive approaches offer fresh perspectives on tackling intricate microbial imbalances in the gastrointestinal tract. These emerging therapies signify a shift towards more precise and individualized approaches to microbiome restoration and the management of gut-related disorders. Once a more advanced knowledge of the pathways linking the gut microbiota to musculoskeletal tissues is gained, relevant microbiome-based therapies can be developed. If dysbiosis is proven to be a significant contributor, developing treatments for dysbiosis may represent a new frontier in the prevention of periprosthetic joint infections.
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2059-7762
    ISSN (online) 2059-7762
    DOI 10.1016/j.jisako.2024.01.011
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  4. Article: Matrix assisted laser desorption time of flight mass spectrometry (MALDI-TOF MS) in clinical microbiology

    Angeletti, Silvia

    Journal of microbiological methods. 2017 July, v. 138

    2017  

    Abstract: The microbiological management of patients with suspected bacterial infection includes the identification of the pathogen and the determination of the antibiotic susceptibility. These traditional approaches, based on the pure culture of the microorganism, ...

    Abstract The microbiological management of patients with suspected bacterial infection includes the identification of the pathogen and the determination of the antibiotic susceptibility. These traditional approaches, based on the pure culture of the microorganism, require at least 36–48h.A new method, Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS), has been recently developed to profile bacterial proteins from whole cell extracts and obtain a bacterial fingerprint able to discriminate microorganisms from different genera and species. By whole cell-mass spectrometry, microbial identification can be achieved within minutes from cultured isolate, rather than traditional phenotypic or genotypic characterizations. From the year 2009 an explosion of applications of this technology has been observed with promising results. Several studies have been performed and showed that MALDI-TOF represents a reliable alternative method for rapid bacteria and fungi identification in clinical setting. A future area of expansion is represented by the application of MALDI-TOF technology to the antibiotic susceptibility test.In conclusion, the revision of the literature available up to date demonstrated that MALDI-TOF MS represents an innovative technology for the rapid and accurate identification of bacterial and fungal isolates in clinical settings. By an earlier microbiological diagnosis, MALDI-TOF MS contributes to a reduced mortality and hospitalization time of the patients and consequently has a significant impact on cost savings and public health.
    Keywords antibiotic resistance ; bacteria ; bacterial infections ; bacterial proteins ; desorption ; fungi ; matrix-assisted laser desorption-ionization mass spectrometry ; mortality ; pathogens ; patients ; phenotype
    Language English
    Dates of publication 2017-07
    Size p. 20-29.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2016.09.003
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  5. Article ; Online: Laboratory breakpoints for assessing high level gentamicin resistance in Streptococcus agalactiae: it is the time for a consensus.

    Creti, Roberta / Imperi, Monica / Berardi, Alberto / Angeletti, Silvia / Gherardi, Giovanni

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 28, Issue 8, Page(s) 1050–1052

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Consensus ; Gentamicins/pharmacology ; Humans ; Microbial Sensitivity Tests ; Streptococcal Infections/diagnosis ; Streptococcal Infections/microbiology ; Streptococcus agalactiae
    Chemical Substances Anti-Bacterial Agents ; Gentamicins
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.04.011
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  6. Article ; Online: Response to Carletti et al, "About the origin of the first two SARS-CoV-2 infections in Italy: Inference not supported by appropriate sequence analysis".

    Ciccozzi, Massimo / Giovanetti, Marta / Benvenuto, Domenico / Angeletti, Silvia

    Journal of medical virology

    2020  Volume 92, Issue 9, Page(s) 1406–1407

    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Sequence Analysis
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25823
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  7. Article ; Online: Bringing phylogeny and clinical microbiology together.

    Ciotti, Marco / Angeletti, Silvia / Ciccozzi, Massimo

    Future microbiology

    2020  Volume 15, Page(s) 5–7

    MeSH term(s) Bacteria/classification ; Drug Resistance, Microbial/genetics ; Humans ; Microbiological Techniques ; Molecular Typing ; Phylogeny ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; beta-Lactamases/genetics
    Chemical Substances beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2020-02-11
    Publishing country England
    Document type Editorial
    ISSN 1746-0921
    ISSN (online) 1746-0921
    DOI 10.2217/fmb-2019-0264
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  8. Article ; Online: A doubt of multiple introduction of SARS-CoV-2 in Italy: A preliminary overview.

    Giovanetti, Marta / Angeletti, Silvia / Benvenuto, Domenico / Ciccozzi, Massimo

    Journal of medical virology

    2020  Volume 92, Issue 9, Page(s) 1634–1636

    Abstract: The emergence of the novel betacoronavirus, recently renamed as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised serious concerns due to the virus's rapid dissemination worldwide. Nevertheless, there is limited information about ... ...

    Abstract The emergence of the novel betacoronavirus, recently renamed as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised serious concerns due to the virus's rapid dissemination worldwide. Nevertheless, there is limited information about the genomic epidemiology of SARS-CoV-2 circulating in Italy from surveillance studies. The shortage of complete genomic sequences available impairs our understanding of the SARS-CoV-2 introduction and establishment in the country. To better understand its dynamics in Italy, we analyzed complete genomes of SARS-CoV-2 isolates, obtained directly from clinical samples. Our phylogenetic reconstructions suggest possible multiple introduction of SARS-CoV-2. Continued genomic surveillance strategies are needed to improve monitoring and understanding of the current SARS-CoV-2 epidemics, which might help to attenuate public health impact of infectious diseases.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/virology ; Computational Biology ; Genome, Viral ; Genomics/methods ; Genotype ; High-Throughput Nucleotide Sequencing ; Humans ; Italy/epidemiology ; Pandemics ; Phylogeny ; Public Health Surveillance ; SARS-CoV-2/classification ; SARS-CoV-2/genetics
    Keywords covid19
    Language English
    Publishing date 2020-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25773
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  9. Article ; Online: The first two cases of 2019-nCoV in Italy: Where they come from?

    Giovanetti, Marta / Benvenuto, Domenico / Angeletti, Silvia / Ciccozzi, Massimo

    Journal of medical virology

    2020  Volume 92, Issue 5, Page(s) 518–521

    Abstract: A novel Coronavirus, 2019-nCoV, has been identified as the causal pathogen of an ongoing epidemic, with the first cases reported in Wuhan, China, last December 2019, and has since spread to other countries worldwide, included Europe and very recently ... ...

    Abstract A novel Coronavirus, 2019-nCoV, has been identified as the causal pathogen of an ongoing epidemic, with the first cases reported in Wuhan, China, last December 2019, and has since spread to other countries worldwide, included Europe and very recently Italy. In this short report, phylogenetic reconstruction was used to better understand the transmission dynamics of the virus from its first introduction in China focusing on the more recent evidence of infection in a couple of Chinese tourists arrived in Italy on 23rd January 2020 and labeled as Coronavirus Italian cases. A maximum clade credibility tree has been built using a dataset of 54 genome sequences of 2019-nCoV plus two closely related bat strains (SARS-like CoV) available in GenBank. Bayesian time-scaled phylogenetic analysis was implemented in BEAST 1.10.4. The Bayesian phylogenetic reconstruction showed that 2019-2020 nCoV firstly introduced in Wuhan on 25 November 2019, started epidemic transmission reaching many countries worldwide, including Europe and Italy where the two strains isolated dated back 19 January 2020, the same that the Chinese tourists arrived in Italy. Strains isolated outside China were intermixed with strains isolated in China as evidence of likely imported cases in Rome, Italy, and Europe, as well. In conclusion, this report suggests that further spread of 2019-nCoV epidemic was supported by human mobility and that quarantine of suspected or diagnosed cases is useful to prevent further transmission. Viral genome phylogenetic analysis represents a useful tool for the evaluation of transmission dynamics and preventive action.
    MeSH term(s) Animals ; Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; COVID-19 ; Chiroptera/virology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Genome, Viral ; Humans ; Interatrial Block ; Italy/epidemiology ; Models, Genetic ; Mutation Rate ; Pandemics ; Phylogeny ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25699
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  10. Article ; Online: Cost-effectiveness analysis of O-Ring wound retractor in elective laparoscopic colorectal surgery.

    Lauricella, Sara / Caricato, Marco / Mascianà, Gianluca / Ciccozzi, Massimo / Angeletti, Silvia / Capolupo, Gabriella Teresa

    Annali italiani di chirurgia

    2022  Volume 92, Page(s) 460–464

    Abstract: Introduction: Surgical site infections (SSIs) are a feared complication following colorectal surgery and have a sizeable economic impact on the healthcare system. The aim of this study is to assess the clinical effectiveness and cost-effectiveness of O- ... ...

    Abstract Introduction: Surgical site infections (SSIs) are a feared complication following colorectal surgery and have a sizeable economic impact on the healthcare system. The aim of this study is to assess the clinical effectiveness and cost-effectiveness of O-Ring wound protector/retractor in elective laparoscopic colorectal surgery.
    Methods: Data were analyzed from a retrospective colorectal database from January 2015 to June 2018. SSI was defined according to the criteria published by the European Centre for Disease Prevention and Control (ECDC). An economic evaluation was conducted comparing the group in which Alexis® device was used during surgery (Group A) with a control group (Group B) in which Alexis® device was not used.
    Results: Two hundred fifty-eight consecutive patients were enrolled in our study. Among them, the intervention group (Group A, 154 patients) was compared with the control group (Group B, 94 patients). A total of 8 (5.2%) and 14 (15%) patients with SSIs were identified in groups A and B, respectively (p = 0.008). The economic evaluation showed that there was no difference in terms of costs and returns on comparing both groups.
    Conclusion: The final costs and profit are similar in both groups, but the use of O-Ring protector reduces SSI rates and may significantly improve patient's quality of life.
    Key words: Colorectal surgery, Cost-effectiveness, Surgical site infection, Length of stay, Wound protector/retractor.
    MeSH term(s) Colorectal Surgery ; Cost-Benefit Analysis ; Humans ; Laparoscopy ; Quality of Life ; Retrospective Studies ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control
    Language English
    Publishing date 2022-05-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 418927-9
    ISSN 2239-253X ; 0003-469X
    ISSN (online) 2239-253X
    ISSN 0003-469X
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