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  1. Article ; Online: New Perspectives and Strategies for the Management of Hypertension.

    Angeli, Fabio

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 8

    Abstract: Hypertension is the leading preventable risk factor for cardiovascular disease and all-cause mortality worldwide [ ... ]. ...

    Abstract Hypertension is the leading preventable risk factor for cardiovascular disease and all-cause mortality worldwide [...].
    Language English
    Publishing date 2023-08-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10080346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The lowest well tolerated blood pressure: A personalized target for all?

    Verdecchia, Paolo / Angeli, Fabio / Reboldi, Gianpaolo

    European journal of internal medicine

    2024  

    Abstract: The optimal blood pressure (BP) target for prevention of cardiovascular complications of hypertension remains uncertain. Most Guidelines suggest different targets depending on age, comorbidities and treatment tolerability, but the underlying evidence is ... ...

    Abstract The optimal blood pressure (BP) target for prevention of cardiovascular complications of hypertension remains uncertain. Most Guidelines suggest different targets depending on age, comorbidities and treatment tolerability, but the underlying evidence is not strong. Results of randomized strategy trials comparing lower (i.e., more intensive) versus higher (i.e., less intensive) BP targets should drive the definition. However, these trials tested different BP targets based on systolic BP, diastolic BP or combined systolic and diastolic BP goals. Overall, the more intensive treatment targets reduced the risk of major cardiovascular complications of hypertension when compared with the less intensive targets, despite a higher incidence of unwanted effects including, but not limited to, hypotension, electrolyte abnormalities and renal dysfunction. Consequently, some Guidelines defined low BP thresholds (i.e., 120/70 mmHg) not to exceed downward because of the expectation that unwanted effects may outweigh the outcome benefits. The present review discusses the evidence underlying the choice of BP targets, which remains an important step in the management of hypertensive patients. We conclude that, on the ground of the heterogeneity of available data in support to fixed BP targets, their definition should be personalized in all patients and based on best trade-off between efficacy and safety, i.e., the lowest well tolerated BP.
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2024.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Prognostic impact of hypertension grading.

    Angeli, Fabio / Verdecchia, Paolo / Reboldi, Gianpaolo

    European journal of internal medicine

    2024  

    Abstract: Background: Most Hypertension Guidelines grade hypertension according to various cut-off values. We sought to investigate the prognostic impact of Grades 1 (140-159 and/or 90-99 mmHg), 2 (160-179 and/or 100-109 mmHg) and 3 (≥180 and/or ≥110 mmHg).: ... ...

    Abstract Background: Most Hypertension Guidelines grade hypertension according to various cut-off values. We sought to investigate the prognostic impact of Grades 1 (140-159 and/or 90-99 mmHg), 2 (160-179 and/or 100-109 mmHg) and 3 (≥180 and/or ≥110 mmHg).
    Methods: We followed for an average of 10 years a cohort of 3,150 initially untreated hypertensive patients (mean age 50 years, 44 % women) with no previous cardiovascular disease at entry. All patients underwent diagnostic tests including 24-hour ambulatory blood pressure (BP) monitoring.
    Results: At entry, average clinic BP was 156/97 mmHg and average 24-hour BP was 137/87 mmHg. During follow-up, 314 patients experienced a first major cardiovascular event (composite of non-fatal myocardial infarction or stroke, cardiovascular death, or hospitalization for heart failure). Event rate was not formally dissimilar between Grade 1 and Grade 2 (0.73 vs 0.95 per 100 patient-years, respectively; p = 0.06). It was higher in Grade 3 (1.93 per 100 patient-years; p < 0.01 vs Grade 1 and Grade 2). After adjustment for a robust set of covariables, the hazard ratio was not dissimilar between Grade 1 and Grade 2 (p = 0.27), and higher in Grade 3 than in Grade 1 (p < 0.01), but the excess risk in Grade 3 was no longer significant (hazard ratio: 1.25, 95 % CI 0.87-1.78; p = 0.22) after adjustment for 24-hour ambulatory systolic BP.
    Conclusions: We were unable to find a significant difference in the relative hazard of cardiovascular events tied to hypertension Grades 1 and 2. Conversely, Grade 3 (clinic BP ≥180/110 mmHg) portends a higher cardiovascular risk, which is associated with higher levels of 24-hour ambulatory BP.
    Language English
    Publishing date 2024-04-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2024.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Rethinking the Role of the Renin-Angiotensin System in the Pandemic Era of SARS-CoV-2.

    Angeli, Fabio / Zappa, Martina / Verdecchia, Paolo

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 1

    Abstract: After assessing the levels of spread and severity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, academic literature focused on the pathophysiology of coronavirus disease 2019 (COVID-19) [ ... ]. ...

    Abstract After assessing the levels of spread and severity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, academic literature focused on the pathophysiology of coronavirus disease 2019 (COVID-19) [...].
    Language English
    Publishing date 2023-01-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10010014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Global burden of new-onset hypertension associated with severe acute respiratory syndrome coronavirus 2 infection.

    Angeli, Fabio / Zappa, Martina / Verdecchia, Paolo

    European journal of internal medicine

    2023  Volume 119, Page(s) 31–33

    Abstract: Several reports documented a specific effect of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on blood pressure (BP), during and after the acute phase of infection. Clinical studies demonstrated that coronavirus disease 2019 (COVID-19) ...

    Abstract Several reports documented a specific effect of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on blood pressure (BP), during and after the acute phase of infection. Clinical studies demonstrated that coronavirus disease 2019 (COVID-19) is associated with an increased risk of a persistent increase in BP requiring a new or intensified anti-hypertensive treatment during hospitalization. The picture is further complicated by the evidence from large databases showing an increased risk of new-onset hypertension in COVID-19 survivors on the long term. To further elucidate the epidemiological burden of this phenomenon, we performed a pooled analysis of 4 studies reporting crude incidence rates of new-onset hypertension among COVID-19 patients and contemporary controls. Overall, COVID-19 was associated with a 65% increased risk of new-onset hypertension when compared with controls (p<0.0001); furthermore, incidence of new-onset hypertension was 9% and 5% among COVID-19 patients and controls, respectively. In both the acute phase and recovery from infection, the interaction between spike proteins of SARS-CoV-2 and angiotensin converting enzyme 2 (ACE
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Peptidyl-Dipeptidase A/metabolism ; Hypertension/epidemiology ; Mutation
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2023-10-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Is the competition between variants the end of severe acute respiratory syndrome coronavirus 2 pandemic? A journey from Wuhan to XBB.1.16.

    Zappa, Martina / Verdecchia, Paolo / Angeli, Fabio

    European journal of internal medicine

    2023  Volume 113, Page(s) 13–15

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Pandemics ; Renin-Angiotensin System ; Peptidyl-Dipeptidase A/metabolism
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2023-04-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.04.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Hypertension and myocarditis following COVID-19 vaccination. Two sides of the coin?

    Angeli, Fabio / Reboldi, Gianpaolo / Zappa, Martina / Verdecchia, Paolo

    European journal of internal medicine

    2023  Volume 113, Page(s) 107–109

    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Myocarditis/etiology ; Renin-Angiotensin System ; Hypertension/etiology ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-04-28
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.04.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Severe acute respiratory syndrome coronavirus 2 evolution: How mutations affect XBB.1.5 variant.

    Zappa, Martina / Verdecchia, Paolo / Angeli, Fabio

    European journal of internal medicine

    2023  Volume 112, Page(s) 128–132

    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Mutation
    Language English
    Publishing date 2023-03-29
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.03.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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  9. Article ; Online: When the responsibility for a crime is shared between several actors. The case of hypertensive heart failure with preserved ejection fraction.

    Coiro, Stefano / Verdecchia, Paolo / Angeli, Fabio

    European journal of internal medicine

    2023  Volume 120, Page(s) 29–31

    MeSH term(s) Humans ; Stroke Volume ; Heart Failure ; Hypertension ; Crime
    Language English
    Publishing date 2023-11-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.11.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: It Is Time to Reconsider the Blood Pressure Targets in Patients With Type 2 Diabetes?

    Verdecchia, Paolo / Reboldi, Gianpaolo / Angeli, Fabio

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 80, Issue 8, Page(s) 1654–1657

    MeSH term(s) Humans ; Blood Pressure/physiology ; Diabetes Mellitus, Type 2 ; Hypertension/drug therapy ; Hypotension/drug therapy ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Cardiovascular Diseases/drug therapy
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.21461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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