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  1. Book ; Online: Liquid Biopsy as a Tool for Precision Oncology: New Challenges to Assess Clinical Response

    Ravegnini, Gloria / Del Re, Marzia / Grolla, Ambra A. / van Schaik, Ron H. N. / Angelini, Sabrina

    2020  

    Keywords Science: general issues ; Pharmacology ; liquid biopsy ; precision oncology ; ctDNA (circulating tumor DNA) ; Circulating molecular marker ; personalized medicine
    Size 1 electronic resource (78 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230400
    ISBN 9782889662029 ; 2889662020
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Antimutagenicity and Antioxidant Activity of

    Gasperini, Sofia / Greco, Giulia / Angelini, Sabrina / Hrelia, Patrizia / Fimognari, Carmela / Lenzi, Monia

    Pharmaceutics

    2023  Volume 15, Issue 10

    Abstract: ... Castanea ... ...

    Abstract Castanea sativa
    Language English
    Publishing date 2023-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15102465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical prognostic value of the SMYD2/3 as new epigenetic biomarkers in solid cancer patients: a systematic review and meta-analysis.

    Razmi, Mahdieh / Yazdanpanah, Ayna / Etemad-Moghadam, Shahroo / Alaeddini, Mojgan / Angelini, Sabrina / Eini, Leila

    Expert review of molecular diagnostics

    2022  , Page(s) 1–15

    Abstract: Background: SET and MYND domain-containing protein (SMYD) family with methyltransferase activity is involved in cancer progression. This novel meta-analysis aimed to evaluate the association of SMYD family with the clinical and survival outcomes in ... ...

    Abstract Background: SET and MYND domain-containing protein (SMYD) family with methyltransferase activity is involved in cancer progression. This novel meta-analysis aimed to evaluate the association of SMYD family with the clinical and survival outcomes in solid cancer patients.
    Methods: We systematically searched Embase, PubMed, Scopus and Web of Science to select relevant articles. Hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals were extracted. Heterogeneity was evaluated by chi-square-based Q and I
    Results: Thirty-two articles (4,826 patients) met inclusion criteria. SMYD2/3 overexpression was statistically associated with poor overall survival (HR = 1.794,
    Conclusion: Enhanced SMYD2/3 expression may be an unfavorable clinical prognostic factor in different solid cancer types.
    Language English
    Publishing date 2022-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1080/14737159.2022.2144235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6073: Show issues Location:
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  4. Article ; Online: The Unfolded Protein Response in a Murine Model of Alzheimer's Disease: Looking for Predictors.

    Sita, Giulia / Graziosi, Agnese / Corrieri, Camilla / Ghelli, Luca / Angelini, Sabrina / Cortelli, Pietro / Hrelia, Patrizia / Morroni, Fabiana

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: Alzheimer's disease (AD) represents the most frequent type of dementia worldwide, and aging is the most important risk factor for the sporadic form of the pathology. The endoplasmic reticulum (ER), the main cellular actor involved in proteostasis, ... ...

    Abstract Alzheimer's disease (AD) represents the most frequent type of dementia worldwide, and aging is the most important risk factor for the sporadic form of the pathology. The endoplasmic reticulum (ER), the main cellular actor involved in proteostasis, appears significantly compromised in AD due to the accumulation of the β-amyloid (Aβ) protein and the phosphorylated Tau protein. Increasing protein misfolding activates a specific cellular response known as Unfolded Protein Response (UPR), which orchestrates the recovery of ER function. The aim of the present study was to investigate the role of UPR in a murine model of AD induced by intracerebroventricular (i.c.v.) injection of Aβ
    MeSH term(s) Mice ; Animals ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Endoribonucleases/metabolism ; Disease Models, Animal ; Phosphatidylinositol 3-Kinases/metabolism ; Unfolded Protein Response ; Endoplasmic Reticulum Stress/genetics
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2023-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Somatic pharmacogenomics of gastrointestinal stromal tumor.

    Ravegnini, Gloria / Hrelia, Patrizia / Angelini, Sabrina

    Cancer drug resistance (Alhambra, Calif.)

    2019  Volume 2, Issue 1, Page(s) 107–115

    Abstract: Gastrointestinal stromal tumors (GISTs) are rare entities, which, however, represent the most common mesenchymal tumor of the gastrointestinal tract. The discovery of gain of function mutations ... ...

    Abstract Gastrointestinal stromal tumors (GISTs) are rare entities, which, however, represent the most common mesenchymal tumor of the gastrointestinal tract. The discovery of gain of function mutations on
    Language English
    Publishing date 2019-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2019.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Toward Precision Medicine: How Far Is the Goal?

    Ravegnini, Gloria / Angelini, Sabrina

    International journal of molecular sciences

    2016  Volume 17, Issue 2, Page(s) 245

    Abstract: The accomplishment of the Human Genome Project, followed by the availability of high-throughput technologies, has led to an impressive change in biomedical research. ...

    Abstract The accomplishment of the Human Genome Project, followed by the availability of high-throughput technologies, has led to an impressive change in biomedical research.
    MeSH term(s) Genetic Variation ; Genome, Human ; Goals ; Humans ; Precision Medicine
    Language English
    Publishing date 2016-02-17
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms17020245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: GH and IGF System: The Regulatory Role of miRNAs and lncRNAs in Cancer.

    Catellani, Cecilia / Ravegnini, Gloria / Sartori, Chiara / Angelini, Sabrina / Street, Maria E

    Frontiers in endocrinology

    2021  Volume 12, Page(s) 701246

    Abstract: Growth hormone (GH) and the insulin-like growth factor (IGF) system are involved in many biological processes and have growth-promoting actions regulating cell proliferation, differentiation, apoptosis and angiogenesis. A recent chapter in epigenetics is ...

    Abstract Growth hormone (GH) and the insulin-like growth factor (IGF) system are involved in many biological processes and have growth-promoting actions regulating cell proliferation, differentiation, apoptosis and angiogenesis. A recent chapter in epigenetics is represented by microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) which regulate gene expression. Dysregulated miRNAs and lncRNAs have been associated with several diseases including cancer. Herein we report the most recent findings concerning miRNAs and lncRNAs regulating GH and the IGF system in the context of pituitary adenomas, osteosarcoma and colorectal cancer, shedding light on new possible therapeutic targets. Pituitary adenomas are increasingly common intracranial tumors and somatotroph adenomas determine supra-physiological GH secretion and cause acromegaly. Osteosarcoma is the most frequent bone tumor in children and adolescents and was reported in adults who were treated with GH in childhood. Colorectal cancer is the third cancer in the world and has a higher prevalence in acromegalic patients.
    MeSH term(s) Gene Expression Regulation ; Human Growth Hormone/metabolism ; Humans ; Insulin-Like Growth Factor I/metabolism ; MicroRNAs/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; RNA, Long Noncoding/genetics
    Chemical Substances MicroRNAs ; RNA, Long Noncoding ; Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2021-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.701246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: miRNA levels are associated with body mass index in endometrial cancer and may have implications for therapy.

    Ravegnini, Gloria / Gorini, Francesca / Coada, Camelia Alexandra / De Leo, Antonio / de Biase, Dario / Di Costanzo, Stella / De Crescenzo, Eugenia / Coschina, Emma / Monesmith, Sarah / Bernante, Paolo / Garelli, Silvia / Balsamo, Francesca / Hrelia, Patrizia / De Iaco, Pierandrea / Angelini, Sabrina / Perrone, Anna Myriam

    Cancer science

    2024  Volume 115, Issue 3, Page(s) 883–893

    Abstract: Endometrial cancer (EC) is the most prevalent gynecological cancer in high-income countries. Its incidence is skyrocketing due to the increase in risk factors such as obesity, which represents a true pandemic. This study aimed to evaluate microRNA (miRNA) ...

    Abstract Endometrial cancer (EC) is the most prevalent gynecological cancer in high-income countries. Its incidence is skyrocketing due to the increase in risk factors such as obesity, which represents a true pandemic. This study aimed to evaluate microRNA (miRNA) expression in obesity-related EC to identify potential associations between this specific cancer type and obesity. miRNA levels were analyzed in 84 EC patients stratified based on body mass index (BMI; ≥30 or <30) and nine noncancer women with obesity. The data were further tested in The Cancer Genome Atlas (TCGA) cohort, including 384 EC patients, 235 with BMI ≥30 and 149 with BMI <30. Prediction of miRNA targets and analysis of their expression were also performed to identify the potential epigenetic networks involved in obesity modulation. In the EC cohort, BMI ≥30 was significantly associated with 11 deregulated miRNAs. The topmost deregulated miRNAs were first analyzed in 84 EC samples by single miRNA assay and then tested in the TCGA dataset. This independent validation provided further confirmation about the significant difference of three miRNAs (miR-199a-5p, miR-449a, miR-449b-5p) in normal-weight EC patients versus EC patients with obesity, resulting significantly higher expressed in the latter. Moreover, the three miRNAs were significantly correlated with grade, histological type, and overall survival. Analysis of their target genes revealed that these miRNAs may regulate obesity-related pathways. In conclusion, we identified specific miRNAs associated with BMI that are potentially involved in modulating obesity-related pathways and that may provide novel implications for the clinical management of obese EC patients.
    MeSH term(s) Humans ; Female ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Body Mass Index ; Gene Expression Profiling/methods ; Endometrial Neoplasms/genetics ; Obesity/complications ; Obesity/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.15977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Editorial: Liquid Biopsy as a Tool for Precision Oncology: New Challenges to Assess Clinical Response.

    Ravegnini, Gloria / Del Re, Marzia / Grolla, Ambra A / van Schaik, Ron H N / Angelini, Sabrina

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 598261

    Language English
    Publishing date 2020-10-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.598261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: New insights into irritable bowel syndrome pathophysiological mechanisms: contribution of epigenetics.

    Dothel, Giovanni / Barbaro, Maria Raffaella / Di Vito, Aldo / Ravegnini, Gloria / Gorini, Francesca / Monesmith, Sarah / Coschina, Emma / Benuzzi, Eva / Fuschi, Daniele / Palombo, Marta / Bonomini, Francesca / Morroni, Fabiana / Hrelia, Patrizia / Barbara, Giovanni / Angelini, Sabrina

    Journal of gastroenterology

    2023  Volume 58, Issue 7, Page(s) 605–621

    Abstract: Irritable bowel syndrome (IBS) is a complex multifactorial condition including alterations of the gut-brain axis, intestinal permeability, mucosal neuro-immune interactions, and microbiota imbalance. Recent advances proposed epigenetic factors as ... ...

    Abstract Irritable bowel syndrome (IBS) is a complex multifactorial condition including alterations of the gut-brain axis, intestinal permeability, mucosal neuro-immune interactions, and microbiota imbalance. Recent advances proposed epigenetic factors as possible regulators of several mechanisms involved in IBS pathophysiology. These epigenetic factors include biomolecular mechanisms inducing chromosome-related and heritable changes in gene expression regardless of DNA coding sequence. Accordingly, altered gut microbiota may increase the production of metabolites such as sodium butyrate, a prominent inhibitor of histone deacetylases. Patients with IBS showed an increased amount of butyrate-producing microbial phila as well as an altered profile of methylated genes and micro-RNAs (miRNAs). Importantly, gene acetylation as well as specific miRNA profiles are involved in different IBS mechanisms and may be applied for future diagnostic purposes, especially to detect increased gut permeability and visceromotor dysfunctions. In this review, we summarize current knowledge of the role of epigenetics in IBS pathophysiology.
    MeSH term(s) Humans ; Irritable Bowel Syndrome/genetics ; Gastrointestinal Microbiome/physiology ; Microbiota ; Epigenesis, Genetic ; Permeability
    Language English
    Publishing date 2023-05-09
    Publishing country Japan
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-023-01997-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
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