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  1. Article ; Online: Peptides 2020: A Clear Therapeutic Vision.

    Angell, Yvonne / Holford, Mandë / Moos, Walter H

    Protein and peptide letters

    2019  Volume 25, Issue 12, Page(s) 1042–1043

    MeSH term(s) Drug Discovery ; Humans ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/therapeutic use
    Chemical Substances Peptides
    Language English
    Publishing date 2019-01-31
    Publishing country Netherlands
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1280776-x
    ISSN 1875-5305 ; 0929-8665
    ISSN (online) 1875-5305
    ISSN 0929-8665
    DOI 10.2174/092986652512190118153004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4452: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Building on Success: A Bright Future for Peptide Therapeutics.

    Angell, Yvonne / Holford, Mandë / Moos, Walter H

    Protein and peptide letters

    2018  Volume 25, Issue 12, Page(s) 1044–1050

    Abstract: The primary aim of this review article is to highlight current exciting and future looking areas of research in peptide science as applied to the discovery and development of novel therapeutics. Among the strengths of peptides as drug candidates are ... ...

    Abstract The primary aim of this review article is to highlight current exciting and future looking areas of research in peptide science as applied to the discovery and development of novel therapeutics. Among the strengths of peptides as drug candidates are their high potency, specificity, and good safety profile. These positive attributes of peptides along with advances in drug delivery technologies have generated renewed interest in the discovery, optimization, and development of peptides as therapeutics. The intent of this review is to demonstrate that peptides have broad applicability in many therapeutic areas by examining some of the most compelling indications and targets for peptide therapeutics. For example, target selection for peptide therapeutics is challenging due to the inherent properties of peptides; therefore, identifying a clear differentiation strategy for a new peptide program over a small molecule or antibody program from the outset is critical for successful navigation of drug development hurdles. In this review, some of the latest techniques that accentuate the advantages and overcome the druggability limitations of peptides will be covered. Emerging technologies for enhancing the pharmacokinetics of peptides to achieve sufficient in vivo half-lives will be described and evaluated, as well as novel technologies for getting peptides across cell membranes to reach intracellular targets and across the blood-brain-barrier to reach central nervous system targets.
    MeSH term(s) Animals ; Cell Membrane/chemistry ; Drug Design ; Drug Discovery/methods ; Humans ; Peptides/chemistry ; Peptides/pharmacokinetics ; Peptides/therapeutic use
    Chemical Substances Peptides
    Language English
    Publishing date 2018-11-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1280776-x
    ISSN 1875-5305 ; 0929-8665
    ISSN (online) 1875-5305
    ISSN 0929-8665
    DOI 10.2174/0929866525666181114155542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4452: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Development of a polyvalent assay system for lead identification.

    Lovering, Frank / Angell, Yvonne / Zhang, Yan-Ling / Bridges, Kristie

    Bioorganic & medicinal chemistry letters

    2004  Volume 14, Issue 20, Page(s) 5081–5083

    Abstract: In an effort to identify new approaches to lead discovery a polyvalent assay was developed to allow identification of weak inhibitors. This approach involves the polyvalent display of a protein binder off a Tenta-gel scaffold and the generation of a ... ...

    Abstract In an effort to identify new approaches to lead discovery a polyvalent assay was developed to allow identification of weak inhibitors. This approach involves the polyvalent display of a protein binder off a Tenta-gel scaffold and the generation of a polyvalent display of protein by biotinylation followed by complexation with fluorescently labeled streptavidin. Subsequent exposure of the streptavidin complexed protein to Tenta-gel beads with active protein binders results in fluorescent beads, which are easily viewed under a fluorescent microscope.
    MeSH term(s) Biotinylation ; Drug Design ; Fluorescent Dyes/chemistry ; Ligands ; Microscopy, Fluorescence/methods ; Molecular Mimicry ; Phosphotyrosine/chemistry ; Polystyrenes/chemistry ; Protein Binding ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases/antagonists & inhibitors ; Protein Tyrosine Phosphatases/chemistry ; Streptavidin/chemistry
    Chemical Substances Fluorescent Dyes ; Ligands ; Polystyrenes ; Tentagel resin (136841-34-4) ; Phosphotyrosine (21820-51-9) ; Streptavidin (9013-20-1) ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 (EC 3.1.3.48) ; Protein Tyrosine Phosphatases (EC 3.1.3.48)
    Language English
    Publishing date 2004-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2004.07.078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: High-affinity FGFR2 binding peptides derived from the native epitope of the KGF ligand.

    Pan, Yijun / Angell, Yvonne M / Green, Jennifer M / Wright, Kathy L / Miguel, Joy / Schatz, Peter J / Holmes, Christopher P

    Advances in experimental medicine and biology

    2008  Volume 611, Page(s) 511–512

    MeSH term(s) Amino Acid Sequence ; Binding Sites ; Epitopes/chemistry ; Fibroblast Growth Factor 7/chemistry ; Fibroblast Growth Factor 7/metabolism ; Ligands ; Molecular Sequence Data ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Receptor, Fibroblast Growth Factor, Type 2/chemistry
    Chemical Substances Epitopes ; Ligands ; Peptide Fragments ; Fibroblast Growth Factor 7 (126469-10-1) ; Receptor, Fibroblast Growth Factor, Type 2 (EC 2.7.10.1)
    Language English
    Publishing date 2008-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-0-387-73657-0_222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Methods to Circumvent a Difficult Coupling in the Solid-Phase Synthesis of Cyclosporine Analogues.

    Raman, Prakash / Stokes, Suzanne S. / Angell, Yvonne M. / Flentke, George R. / Rich, Daniel H.

    The Journal of organic chemistry

    1998  Volume 63, Issue 17, Page(s) 5734–5735

    Language English
    Publishing date 1998-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo980889q
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article: Discovery and optimization of a TRAIL R2 agonist for cancer therapy.

    Angell, Yvonne M / Bhandari, Ashok / De Francisco, M Nuria / Frederick, Brian T / Green, Jennifer M / Leu, Karen / Leuther, Kerstin / Sana, Reuben / Schatz, Peter J / Whitehorn, Erik A / Wright, Kathy / Holmes, Christopher P

    Advances in experimental medicine and biology

    2008  Volume 611, Page(s) 101–103

    MeSH term(s) Amino Acid Sequence ; Chromatography, High Pressure Liquid ; Drug Discovery ; Humans ; Mass Spectrometry ; Molecular Mimicry ; Molecular Sequence Data ; Neoplasms/drug therapy ; Receptors, TNF-Related Apoptosis-Inducing Ligand/agonists
    Chemical Substances Receptors, TNF-Related Apoptosis-Inducing Ligand
    Language English
    Publishing date 2008-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-0-387-73657-0_45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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