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Article ; Online: Kidney Disease Progression in Membranous Nephropathy among Black Participants with High-Risk APOL1 Genotype.

Chen, Dhruti P / Henderson, Candace D / Anguiano, Jaeline / Aiello, Claudia P / Collie, Mary M / Moreno, Vanessa / Hu, Yichun / Hogan, Susan L / Falk, Ronald J

Clinical journal of the American Society of Nephrology : CJASN

2023 Volume 18, Issue 3, Page(s) 337–343

Abstract: Background: Disparity in CKD progression among Black individuals persists in glomerular diseases. Genetic variants in the apolipoprotein L1 ( APOL1 ) gene in the Black population contribute to kidney disease, but the influence in membranous nephropathy ... ...

Abstract	Background: Disparity in CKD progression among Black individuals persists in glomerular diseases. Genetic variants in the apolipoprotein L1 ( APOL1 ) gene in the Black population contribute to kidney disease, but the influence in membranous nephropathy remains unknown. Methods: Longitudinally followed participants enrolled in the Glomerular Disease Collaborative Network or Cure Glomerulonephropathy Network were included if they had DNA or genotyping available for APOL1 (Black participants with membranous nephropathy) or had membranous nephropathy but were not Black. eGFR slopes were estimated using linear mixed-effects models with random effects and adjusting for covariates and interaction terms of covariates. Fisher exact test, Kruskal-Wallis test, and Kaplan-Meier curves with log-rank tests were used to compare groups. Results: Among 118 Black membranous nephropathy participants, 16 (14%) had high-risk APOL1 genotype (two risk alleles) and 102 (86%) had low-risk APOL1 genotype (zero or one risk alleles, n =53 and n =49, respectively). High-risk APOL1 membranous nephropathy participants were notably younger at disease onset than low-risk APOL1 and membranous nephropathy participants that were not Black ( n =572). eGFR at disease onset was not different between groups, although eGFR decline (slope) was steeper in participants with high-risk APOL1 genotype (-16±2 [±SE] ml/min per 1.73 m 2 per year) compared with low-risk APOL1 genotype (-4±0.8 ml/min per 1.73 m 2 per year) or membranous nephropathy participants that did not identify themselves as Black (-2.0±0.4 ml/min per 1.73 m 2 per year) ( P <0.0001). Time to kidney failure was faster in the high-risk APOL1 genotype than low-risk APOL1 genotype or membranous nephropathy participants that were not Black. Conclusions: The prevalence of high-risk APOL1 variant among Black membranous nephropathy participants is comparable with the general Black population (10%-15%), yet the high-risk genotype was associated with worse eGFR decline and faster time to kidney failure compared with low-risk genotype and participants that were not Black.
MeSH term(s)	Humans ; Apolipoprotein L1/genetics ; Apolipoproteins/genetics ; Disease Progression ; Genotype ; Glomerular Filtration Rate/genetics ; Glomerulonephritis, Membranous/genetics ; Kidney ; Renal Insufficiency, Chronic/genetics ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors ; Black People/genetics
Chemical Substances	APOL1 protein, human ; Apolipoprotein L1 ; Apolipoproteins
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.0000000000000070
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Article: Syngas production with CO2 utilization through the oxidative reforming of methane in a new cermet-carbonate packed-bed membrane reactor

Fabián-Anguiano, J.A. / Ramírez-Moreno, M.J. / Balmori-Ramírez, H. / Romero-Serrano, J.A. / Romero-Ibarra, I.C. / Ma, Xiaoli / Ortiz-Landeros, J.

Journal of membrane science. 2021 Nov. 01, v. 637

2021

Abstract: A series of γ-LiAlO₂-Ag cermets was studied to be integrated into a packed-bed membrane reactor with potential application in the selective separation of CO₂ and O₂; and simultaneous syngas production through the coupling of the oxidative CO₂ reforming ... ...

Abstract	A series of γ-LiAlO₂-Ag cermets was studied to be integrated into a packed-bed membrane reactor with potential application in the selective separation of CO₂ and O₂; and simultaneous syngas production through the coupling of the oxidative CO₂ reforming of methane process.The γ-LiAlO₂ was chemically synthesized and incorporated into an Ag matrix, in different amounts, by powder metallurgy using ball milling and uniaxial pressing techniques. The obtained cermets exhibit excellent wettability properties against molten carbonates, facilitating their infiltration and forming dense dual-phase membranes with the molten salts. Moreover, the cermet supports show corrosion resistance against the alkaline molten carbonates and superior thermal stability due to the γ-LiAlO₂ suppresses the sintering of the metallic phase.The membrane's performance was evaluated in the selective gas separation at high temperatures. The membranes exhibit simultaneous CO₂ and O₂ permeation with a flux of 0.78 and 0.43 ml·min⁻¹·cm⁻², at 850 °C, respectively. Besides, during the oxidative reforming process, the membrane reactor shows conversion of about 100 % of CO₂ under the studied separation and reaction conditions. The syngas (H₂+CO) production reaches values of 4.94 ml·min⁻¹·cm⁻² at 825 °C using a 10 % Ni/CeO₂ catalyst.A long-term permeation test was conducted for 225 h, during which the membrane exhibits excellent thermal and chemical stability properties under continuous reaction conditions of syngas production. This fact is attributed to its outstanding chemical inertness against carbonates as well as the observed sinterability properties of the used cermet support.
Keywords	carbon dioxide ; corrosion ; metallurgy ; methane ; permeability ; synthesis gas ; thermal stability ; wettability
Language	English
Dates of publication	2021-1101
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2021.119607
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Article ; Online: Ultrasensitive nanostructure sensor arrays on flexible substrates for multiplexed and simultaneous electrochemical detection of a panel of cardiac biomarkers.

Radha Shanmugam, Nandhinee / Muthukumar, Sriram / Chaudhry, Shajee / Anguiano, Jonathan / Prasad, Shalini

Biosensors & bioelectronics

2017 Volume 89, Issue Pt 2, Page(s) 764–772

Abstract: Multiplexed detection of protein biomarkers offers new opportunities for early diagnosis and efficient treatment of complex diseases. Cardiovascular diseases (CVDs) has the highest mortality risk in USA and Europe with 15-20 million cases being reported ... ...

Abstract	Multiplexed detection of protein biomarkers offers new opportunities for early diagnosis and efficient treatment of complex diseases. Cardiovascular diseases (CVDs) has the highest mortality risk in USA and Europe with 15-20 million cases being reported annually. Cardiac Troponins (T and I) are well established protein biomarkers associated with heart muscle damage and point-of-care monitoring of both these two biomarkers has significant benefits on patient care. A flexible disposable electrochemical biosensor device comprising of vertically oriented zinc oxide (ZnO) nanostructures was developed for rapid and simultaneous screening of cardiac Troponin-I (cTnI) and cardiac-Troponin-T (cTnT) in a point-of-care sensor format. The biosensors were designed by selective hydrothermal growth of ZnO nanostructures onto the working electrodes of polyimide printed circuit board platforms, resulting in the generation of high density nanostructure ZnO arrays based electrodes. The size, density and surface terminations of the nanostructures were leveraged towards achieving surface confinement of the target cTnT and cTnI molecules on to the electrode surface. Multiplexing and simultaneous detection was achieved through sensor platform design comprising of arrays of Troponin functionalized ZnO nanostructure electrodes. The sensitivity and specificity of the biosensor was characterized using two types of electrochemical techniques; electrochemical impedance spectroscopy (EIS) and Mott-Schottky analysis on the same sensor platform to demonstrate multi-configurable modes. Limit of detection of 1pg/mL in human serum was achieved for both cTnI and cTnT. Cross reactivity analysis showed the selectivity of detecting cTnT and cTnI in human serum with wide dynamic range.
MeSH term(s)	Antibodies, Immobilized/chemistry ; Biomarkers/blood ; Biosensing Techniques/instrumentation ; Cardiovascular Diseases/blood ; Electrochemical Techniques/instrumentation ; Equipment Design ; Humans ; Immunoassay/instrumentation ; Limit of Detection ; Nanostructures/chemistry ; Nanostructures/ultrastructure ; Point-of-Care Systems ; Troponin I/blood ; Troponin T/blood ; Zinc Oxide/chemistry
Chemical Substances	Antibodies, Immobilized ; Biomarkers ; Troponin I ; Troponin T ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2017-03-15
Publishing country	England
Document type	Evaluation Studies ; Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2016.10.046
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Article ; Online: Aspergillus infection of the larynx in a solid organ transplant recipient.

Wisniowski-Yáñez, Andrea / Ramírez-Anguiano, Jaqueline / Rosado-Canto, Rodrigo / Valdivia-Cayoja, Adolfo / Pérez-Gutiérrez, Teresa / Cuellar-Rodriguez, Jennifer

Transplant infectious disease : an official journal of the Transplantation Society

2018 Volume 20, Issue 4, Page(s) e12900

Abstract: Primary laryngeal aspergillosis is a rare condition. Only a few cases have been reported in the past years. Most of them have been reported in healthy patients or with a mild immunocompromised state. We report a case of primary laryngeal aspergillosis in ...

Abstract	Primary laryngeal aspergillosis is a rare condition. Only a few cases have been reported in the past years. Most of them have been reported in healthy patients or with a mild immunocompromised state. We report a case of primary laryngeal aspergillosis in a solid organ transplant recipient (SOT), an infection not previously described in this population; we reviewed the published literature in all populations.
MeSH term(s)	Antifungal Agents/therapeutic use ; Aspergillosis/diagnosis ; Aspergillosis/drug therapy ; Aspergillosis/immunology ; Aspergillosis/microbiology ; Aspergillus fumigatus/isolation & purification ; Biopsy ; Graft Rejection/prevention & control ; Humans ; Immunocompromised Host ; Immunosuppression/adverse effects ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Laryngoscopy ; Larynx/diagnostic imaging ; Larynx/microbiology ; Larynx/pathology ; Male ; Middle Aged
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2018-05-07
Publishing country	Denmark
Document type	Case Reports ; Journal Article
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.12900
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Article ; Online: Resistive Part of Impedance as a Possible Indicator of Hepatocellular Carcinoma.

Salazar-Anguiano, Jeny / Chávez-López, María de Guadalupe / Zúñiga-García, Violeta / Camacho, Javier / Elías-Viñas, David

Archives of medical research

2018 Volume 49, Issue 2, Page(s) 89–93

Abstract: Background and aims: In this work, the multi-frequency impedance both in normal and liver cancer tissues was studied. This was to investigate the feasibility to detect liver cancer by a low cost, easy to use, and a relatively non-invasive electrical ... ...

Abstract	Background and aims: In this work, the multi-frequency impedance both in normal and liver cancer tissues was studied. This was to investigate the feasibility to detect liver cancer by a low cost, easy to use, and a relatively non-invasive electrical impedance measure technique, and thus potentially improving liver cancer diagnosis. Methods: Hepatocellular carcinoma (HCC) was induced in male Wistar rats by the administration of diethylnitrosamine (DEN) during 16 weeks. The electrical impedances at a frequency sweep of 10-100 KHz in the whole body and 10-60 KHz in the liver were taken at the end of the treatment. Results: The electrical impedance showed that the real component values of the impedance change in HCC. In addition, we found that the imaginary component was not associated with HCC. Conclusion: Our results suggest that the electrical impedance may be used as a diagnostic HCC tool.
MeSH term(s)	Animals ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/pathology ; Diethylnitrosamine ; Electric Impedance ; Liver/pathology ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology ; Male ; Rats ; Rats, Wistar
Chemical Substances	Diethylnitrosamine (3IQ78TTX1A)
Language	English
Publishing date	2018-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1156844-6
ISSN	1873-5487 ; 0188-4409 ; 0188-0128
ISSN (online)	1873-5487
ISSN	0188-4409 ; 0188-0128
DOI	10.1016/j.arcmed.2018.04.012
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Article ; Online: Motor learning impairment in rats under a high sucrose diet.

Flores-Fuentes, Nayely / Hernandez-Cruz, Carolina / Bermeo, Karina / Barajas-Martinez, Antonio / Hernandez-Serratos, Valeria Nayely / Aceves-Rodriguez, Erick Mauricio / Martinez-Alonso, Eduardo / Castro, Hector / Martinez-Huerta, Maricela Irel / Elias-Viñas, David / Salazar-Anguiano, Jeny / Arenas, Isabel / Garcia, David E

Physiology & behavior

2021 Volume 234, Page(s) 113384

Abstract: Motor learning skills are reliable indicators of behavioral acquisition and cognitive disorders. The ease with which learning skills are measured disparities the complexity of the interpretation concerning neural plasticity. Conversely, a wealth of ... ...

Abstract	Motor learning skills are reliable indicators of behavioral acquisition and cognitive disorders. The ease with which learning skills are measured disparities the complexity of the interpretation concerning neural plasticity. Conversely, a wealth of information regarding metabolic derangements has long been reported with direct connection to high sucrose diets. However, the impact of excessive sucrose consumption on undergoing cognitive processes has been only scarcely addressed up to now. Therefore, the goal of this work was to describe the associative relationship between high sucrose consumption and changes in motor learning skills acquisition. Motor learning impairments conditioned by central alterations are hypothesized. Rotarod, elevated plus-maze and open field trials, along with metabolic and pro-inflammatory biomarkers tests in Wistar rats under a high sucrose treatment, were performed. Motor learning impairment in high sucrose diet-treated rats was found while spontaneous locomotor activity remained unchanged. Even though, no anxiety-like behavior under high sucrose diet-treatment was observed. Consistently, the worst outcome in the glucose tolerance test was developed, the worst motor learning performance was observed. Furthermore, insulin resistance correlated positively with a pro-inflammatory state and a decreased latency to fall in the rotarod test. Indeed, C-reactive protein and tumor necrosis factor-α serum levels, along with the homeostasis model assessment of insulin resistance (HOMA-IR), significantly increased in motor learning impairment. Together, these results support behavioral, metabolic and pro-inflammatory changes associated with deleterious changes in central nervous system likely involving crucial motor learning structures. Underlying pro-inflammatory-triggered processes may explain cognitive disorders in advanced states of metabolic derangements.
MeSH term(s)	Animals ; Anxiety ; Diet ; Glucose Tolerance Test ; Maze Learning ; Rats ; Rats, Wistar ; Sucrose
Chemical Substances	Sucrose (57-50-1)
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2021.113384
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Article: Design and synthesis of (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol.

Das, Bhaskar C / Mahalingam, Sakkarapalayam M / Evans, Todd / Kabalka, George W / Anguiano, J / Hema, K

Chemical communications (Cambridge, England)

2009 , Issue 16, Page(s) 2133–2135

Abstract: A novel strategy for synthesizing (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol has been developed; the allylic alcohol was treated with PPh(3).HBr in methanol followed by ...

Abstract	A novel strategy for synthesizing (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol has been developed; the allylic alcohol was treated with PPh(3).HBr in methanol followed by aldehydes in the presence of a base and furnished the 1,3-dienes in moderate to good yields (79-86%).
MeSH term(s)	Benzene Derivatives/chemical synthesis ; Benzene Derivatives/chemistry ; Cyclohexenes/chemistry ; Magnetic Resonance Spectroscopy ; Mass Spectrometry
Chemical Substances	1-(2,6,6-trimethylcyclohex-1-enyl)ethanol ; Benzene Derivatives ; Cyclohexenes
Language	English
Publishing date	2009-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/b823063c
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Article ; Online: Neuromas mucosos de localización laríngea en una neoplasia endocrina múltiple 2B.

Soroa-Ruiz, Francisco / Lara-Sánchez, Hugo / Ramírez Anguiano, Jaqueline / Córdova-Ramón, Juan Carlos

Acta otorrinolaringologica espanola

2014 Volume 65, Issue 3, Page(s) 197–199

Title translation	Multiple mucosal neuromas in the larynx as part of a multiple endocrine neoplasia type 2B.
MeSH term(s)	Adult ; Female ; Humans ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/surgery ; Multiple Endocrine Neoplasia Type 2b/pathology ; Multiple Endocrine Neoplasia Type 2b/surgery ; Neoplasms, Multiple Primary/pathology ; Neoplasms, Multiple Primary/surgery ; Neuroma/pathology ; Neuroma/surgery ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery
Language	Spanish
Publishing date	2014-05
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	730022-0
ISSN	1988-3013 ; 0001-6519
ISSN (online)	1988-3013
ISSN	0001-6519
DOI	10.1016/j.otorri.2012.09.008
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Article ; Online: Cumulative disease activity predicts incidental hearing impairment in patients with rheumatoid arthritis (RA).

Pascual-Ramos, Virginia / Contreras-Yáñez, Irazú / Rivera-Hoyos, Paula / Enríquez, Lorena / Ramírez-Anguiano, Jaqueline

Clinical rheumatology

2014 Volume 33, Issue 3, Page(s) 315–321

Abstract: We previously reported that 24% of 113 rheumatoid arthritis (RA) patients had hearing impairment (HI). We investigated if disease activity was a predictor of incidental HI. One hundred and four patients completed three consecutive 6 months-apart ... ...

Abstract	We previously reported that 24% of 113 rheumatoid arthritis (RA) patients had hearing impairment (HI). We investigated if disease activity was a predictor of incidental HI. One hundred and four patients completed three consecutive 6 months-apart rheumatic evaluations and concomitant audiometric evaluations which included at least an interview, an otoscopic evaluation, and a pure tone audiometry. HI was defined if the average thresholds for at least one of low-, mid-, or high-frequency ranges were ≥25 decibels (dB) hearing level in one or both ears. Appropriated statistics was used. Internal review board approval was obtained. Patients were most frequently middle-aged (43.4 ± 13.3 years), female (89.4%), and had median disease duration of 5 years and low disease activity. All were receiving RA treatment. At inclusion, 24 patients had HI which was sensorineural in 91.7% of them. Among the 80 patients without HI at baseline, 10 (12.5%) developed incidental HI, and they had more disease activity either at baseline ([median, range] disease activity score-28 joints evaluated-C-reactive protein [DAS28-CRP], 3.9 [1.6-7.3] vs. 2.1 [1-8.7], p = 0.006) or cumulative previous incidental HI (3.4 [1.8-4.8] vs. 2 [1-6.2], p = 0.007) and were more frequently on combined methotrexate and sulfasalazine (20 vs. 1.4%, p = 0.05) than their counterparts. In the adjusted Cox proportional model, cumulative DAS28-CRP was the only variable to predict incidental HI (odds ratio, 1.8; 95% confidence interval, 1.1-2.7; p = 0.01). Almost 13% of RA patients with short disease duration and low disease activity developed incidental HI during 1 year. Cumulative disease activity predicted incidental HI.
MeSH term(s)	Adult ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Audiometry, Pure-Tone ; Female ; Hearing Loss/etiology ; Humans ; Male ; Middle Aged ; Severity of Illness Index
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2014-01-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-014-2485-6
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Article: Divertículo de Meckel inusual.

Martínez-Jiménez, M A / Torres-Anguiano, J R / Aguilar-García, J

Revista de gastroenterologia de Mexico

2011 Volume 76, Issue 1, Page(s) 46–47

Title translation	Unusual Meckel's diverticulum.
MeSH term(s)	Humans ; Male ; Meckel Diverticulum/pathology ; Meckel Diverticulum/surgery ; Middle Aged
Language	Spanish
Publishing date	2011-01
Publishing country	Mexico
Document type	Case Reports ; Journal Article
ZDB-ID	732082-6
ISSN	0375-0906
ISSN	0375-0906
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