Article: Cortico-thalamic development and disease: From cells, to circuits, to schizophrenia.
2023 Volume 17, Page(s) 1130797
Abstract: The human brain is the most complex structure generated during development. Unveiling the ontogenesis and the intrinsic organization of specific neural networks may represent a key to understanding the physio-pathological aspects of different brain areas. ...
| Abstract | The human brain is the most complex structure generated during development. Unveiling the ontogenesis and the intrinsic organization of specific neural networks may represent a key to understanding the physio-pathological aspects of different brain areas. The cortico-thalamic and thalamo-cortical (CT-TC) circuits process and modulate essential tasks such as wakefulness, sleep and memory, and their alterations may result in neurodevelopmental and psychiatric disorders. These pathologies are reported to affect specific neural populations but may also broadly alter physiological connections and thus dysregulate brain network generation, communication, and function. More specifically, the CT-TC system is reported to be severely affected in disorders impacting superior brain functions, such as schizophrenia (SCZ), bipolar disorder, autism spectrum disorders or epilepsy. In this review, the focus will be on CT development, and the models exploited to uncover and comprehend its molecular and cellular mechanisms. In parallel to animal models, still fundamental to unveil human neural network establishment, advanced |
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| Language | English |
| Publishing date | 2023-03-02 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2452969-2 |
| ISSN | 1662-5129 |
| ISSN | 1662-5129 |
| DOI | 10.3389/fnana.2023.1130797 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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