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  1. AU="Anika Nier"
  2. AU="Bar, Adi"
  3. AU="Alvarado Pinedo, María F."
  4. AU="Scarlett, Garry"
  5. AU="Carlos G. Vanoye"
  6. AU=Lohrmann Jens
  7. AU="Petersen, Moritz"
  8. AU="Giovanni, L."
  9. AU="Liu, Xingzheng"
  10. AU="Głód, Mateusz"
  11. AU=Teo Kelvin Yi Chong
  12. AU="Khatmi, Aysan"
  13. AU="Erculiani, M"
  14. AU="Olivier Lortholary"
  15. AU="Lisnic, Vanda Juranic"
  16. AU="Seabloom, Eric W"
  17. AU="Odvina, Clarita V"
  18. AU="Singh, Inderbir"
  19. AU="Wonoh Lee"
  20. AU="Nelson, Warrick"
  21. AU="Douglas, David N"
  22. AU="King, Gary"
  23. AU="Barbera, Lauren"
  24. AU="Carlino, Antonio"
  25. AU="Shan, Qing-Hua"
  26. AU="Starko, S"
  27. AU="Lievre, Loïc"
  28. AU=Cammack N
  29. AU="Xia, Qin"
  30. AU="Ong, Ju Lynn"
  31. AU="Cullin, Christophe"
  32. AU="Georg K.S. Andersson"
  33. AU="Jeannel, Gaël-François"
  34. AU="Stuart Woods"
  35. AU="Shchegolev, A."
  36. AU="Nadeau, Pierre-Louis"
  37. AU="Gordon, David E A"
  38. AU="Shahid Mahmood"
  39. AU="Rosenblatt, Karin"
  40. AU="Dasgupta, Suvankar"
  41. AU=Nguyen Sylvain AU=Nguyen Sylvain

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  1. Artikel ; Online: Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease

    Anika Nier / Anna Janina Engstler / Ina Barbara Maier / Ina Bergheim

    PLoS ONE, Vol 12, Iss 9, p e

    Studies in children.

    2017  Band 0183282

    Abstract: BACKGROUND & AIMS:Recent studies have shown that patients with manifest non-alcoholic fatty liver disease (NAFLD), e.g. steatosis grade 3 or steatohepatitis with or without beginning fibrosis frequently show altered fecal microbiota composition and ... ...

    Abstract BACKGROUND & AIMS:Recent studies have shown that patients with manifest non-alcoholic fatty liver disease (NAFLD), e.g. steatosis grade 3 or steatohepatitis with or without beginning fibrosis frequently show altered fecal microbiota composition and elevated bacterial endotoxin levels. However, if these alterations are signs of a progressing disease or are already found in initial disease stages has not yet been clarified. METHODS:Twenty children with simple steatosis (grade 1) diagnosed by ultrasound and 29 normal weight healthy control children (age <10 years) were included in the study (mean age 7.6 ± 1.1 years). Metabolic parameters, markers of intestinal barrier function and inflammation were determined. RESULTS:Activity of alanine aminotransferase, concentrations of some markers of inflammation and insulin resistance were significantly higher in plasma of NAFLD children than in controls. When compared to controls, plasma bacterial endotoxin and lipopolysaccharide-binding protein (LBP) levels were significantly higher in NAFLD children (+50% and +24%, respectively), while soluble CD14 serum and D-lactate plasma levels as well as the prevalence of small intestinal bacterial overgrowth did not differ between groups. Plasma endotoxin and LBP levels were positive associated with proinflammatory markers like plasminogen activator inhibitor-1, c-reactive protein, interleukin-6 and leptin while no associations with markers of insulin resistance were found. CONCLUSIONS:Taken together, our results indicate that even in juvenile patients with early stages of NAFLD e.g. simple steatosis grade 1, plasma endotoxin concentrations are already elevated further suggesting that intestinal barrier dysfunction might be present already in the initial phases of the disease.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Impairments of intestinal arginine and NO metabolisms trigger aging-associated intestinal barrier dysfunction and ‘inflammaging'

    Annette Brandt / Anja Baumann / Angélica Hernández-Arriaga / Finn Jung / Anika Nier / Raphaela Staltner / Dragana Rajcic / Christian Schmeer / Otto W. Witte / Barbara Wessner / Bernhard Franzke / Karl-Heinz Wagner / Amélia Camarinha-Silva / Ina Bergheim

    Redox Biology, Vol 58, Iss , Pp 102528- (2022)

    2022  

    Abstract: Aging is considered a state of low grade inflammation, occurring in the absence of any overt infection often referred to as ‘inflammaging'. Maintaining intestinal homeostasis may be a target to extend a healthier status in older adults. Here, we report ... ...

    Abstract Aging is considered a state of low grade inflammation, occurring in the absence of any overt infection often referred to as ‘inflammaging'. Maintaining intestinal homeostasis may be a target to extend a healthier status in older adults. Here, we report that even in healthy older men low grade bacterial endotoxemia is prevalent. In addition, employing multiple mouse models, we also show that while intestinal microbiota composition changes significantly during aging, fecal microbiota transplantation to old mice does not protect against aging-associated intestinal barrier dysfunction in small intestine. Rather, intestinal NO homeostasis and arginine metabolism mediated through arginase and NO synthesis is altered in small intestine of aging mice. Treatment with the arginase inhibitor norNOHA prevented aging-associated intestinal barrier dysfunction, low grade endotoxemia and delayed the onset of senescence in peripheral tissue e.g., liver. Intestinal arginine and NO metabolisms could be a target in the prevention of aging-associated intestinal barrier dysfunction and subsequently decline and ‘inflammaging'.
    Schlagwörter Aging ; Endotoxin ; Nitric oxide ; Intestinal permeability ; Microbiota ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Exchanging dietary fat source with extra virgin olive oil does not prevent progression of diet-induced non-alcoholic fatty liver disease and insulin resistance.

    Dragana Rajcic / Annette Brandt / Cheng Jun Jin / Victor Sánchez / Anna Janina Engstler / Finn Jung / Anika Nier / Anja Baumann / Ina Bergheim

    PLoS ONE, Vol 15, Iss 9, p e

    2020  Band 0237946

    Abstract: Dietary fat is discussed to be critical in the development of non-alcoholic fatty liver disease. Here, we assess the effect of exchanging dietary fat source from butterfat to extra virgin olive oil on the progression of an already existing diet-induced ... ...

    Abstract Dietary fat is discussed to be critical in the development of non-alcoholic fatty liver disease. Here, we assess the effect of exchanging dietary fat source from butterfat to extra virgin olive oil on the progression of an already existing diet-induced non-alcoholic fatty liver disease in mice. Female C57BL/6J mice were fed a liquid butterfat-, fructose- and cholesterol-rich diet (BFC, 25E% from butterfat) or control diet (C, 12%E from soybean oil) for 13 weeks. In week 9, fat sources of some BFC- and C-fed mice were switched either to 25E% or 12E% olive oil (OFC and CO). Glucose and insulin tolerance tests were performed, and markers of liver damage and glucose metabolism were assessed. After 6 weeks of feeding, BFC-fed mice had developed marked signs of insulin resistance, which progressed to week 12 being not affected by the exchange of fat sources. Liver damage was similar between BFC- and OFC-fed mice. Markers of lipid metabolism and lipid peroxidation in liver and of insulin signaling in liver and muscle were also similarly altered in BFC- and OFC-fed mice. Taken together, our data suggest that exchanging butterfat with extra virgin olive oil has no effect on the progression of non-alcoholic fatty liver disease and glucose tolerance in mice.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease

    Anja Baumann / Anika Nier / Angélica Hernández-Arriaga / Annette Brandt / Maria J. Lorenzo Pisarello / Cheng J. Jin / Esther Pilar / Amélia Camarinha-Silva / Jörn M. Schattenberg / Ina Bergheim

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 15

    Abstract: Abstract Toll-like receptors (TLRs) in the liver compartment have repeatedly been attributed to the development of non-alcoholic fatty liver disease (NAFLD). Knowledge on TLR expression in blood cells and their relation to intestinal microbiota and NAFLD ...

    Abstract Abstract Toll-like receptors (TLRs) in the liver compartment have repeatedly been attributed to the development of non-alcoholic fatty liver disease (NAFLD). Knowledge on TLR expression in blood cells and their relation to intestinal microbiota and NAFLD development is limited. Here, we determined TLR expression patterns in peripheral blood mononuclear cells (PBMCs) of NAFLD patients and controls, their relation to intestinal microbiota and the impact of TLRs found altered in NAFLD development. Markers of intestinal permeability in blood and TLR mRNA expression in PBMCs were determined in 37 NAFLD patients and 15 age-matched healthy controls. Fecal microbiota composition was evaluated in 21 NAFLD patients and 9 controls using 16S rRNA gene amplicon sequencing. Furthermore, TLR1 −/− and C57BL/6 mice (n = 5–6/group) were pair-fed a liquid control or a fat-, fructose- and cholesterol-rich diet. Intestinal microbiota composition and markers of intestinal permeability like zonulin and bacterial endotoxin differed significantly between groups with the latter markers being significantly higher in NAFLD patients. Expression of TLR1-8 and 10 mRNA was detectable in PBMCs; however, only TLR1 expression, being higher in NAFLD patients, were significantly positively correlated with the prevalence of Holdemanella genus while negative correlations were found with Gemmiger and Ruminococcus genera. TLR1 −/− mice were significantly protected from the development of diet-induced NAFLD when compared to wild-type mice. While intestinal microbiota composition and permeability differed significantly between NAFLD patients and healthy subjects, in PBMCs, only TLR1 expression differed between groups. Still, targeting these alterations might be a beneficial approach in the treatment of NAFLD in some patients.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Citrulline supplementation attenuates the development of non-alcoholic steatohepatitis in female mice through mechanisms involving intestinal arginase

    Dragana Rajcic / Anja Baumann / Angélica Hernández-Arriaga / Annette Brandt / Anika Nier / Cheng Jun Jin / Victor Sánchez / Finn Jung / Amélia Camarinha-Silva / Ina Bergheim

    Redox Biology, Vol 41, Iss , Pp 101879- (2021)

    2021  

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is by now the most prevalent liver disease worldwide. The non-proteogenic amino acid l-citrulline (L-Cit) has been shown to protect mice from the development of NAFLD. Here, we aimed to further assess if L-Cit ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is by now the most prevalent liver disease worldwide. The non-proteogenic amino acid l-citrulline (L-Cit) has been shown to protect mice from the development of NAFLD. Here, we aimed to further assess if L-Cit also attenuates the progression of a pre-existing diet-induced NAFLD and to determine molecular mechanisms involved. Female C57BL/6J mice were either fed a liquid fat-, fructose- and cholesterol-rich diet (FFC) or control diet (C) for 8 weeks to induce early stages of NASH followed by 5 more weeks with either FFC-feeding +/- 2.5 g L-Cit/kg bw or C-feeding. In addition, female C57BL/6J mice were either pair-fed a FFC +/- 2.5 g L-Cit/kg bw +/- 0.01 g/kg bw i.p. N(ω)-hydroxy-nor-l-arginine (NOHA) or C diet for 8 weeks.The protective effects of supplementing L-Cit on the progression of a pre-existing NAFLD were associated with an attenuation of 1) the increased translocation of bacterial endotoxin and 2) the loss of tight junction proteins as well as 3) arginase activity in small intestinal tissue, while no marked changes in intestinal microbiota composition were prevalent in small intestine. Treatment of mice with the arginase inhibitor NOHA abolished the protective effects of L-Cit on diet-induced NAFLD. Our results suggest that the protective effects of L-Cit on the development and progression of NAFLD are related to alterations of intestinal arginase activity and intestinal permeability.
    Schlagwörter Arginase ; Bacterial endotoxin ; Hepatic inflammation ; Intestinal permeability ; NO ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Microbiota profiling in aging-associated inflammation and liver degeneration

    Anja Baumann / Angélica Hernández-Arriaga / Annette Brandt / Victor Sánchez / Anika Nier / Finn Jung / Richard Kehm / Annika Höhn / Tilman Grune / Christiane Frahm / Otto Wilhelm Witte / Amélia Camarinha-Silva / Ina Bergheim

    International Journal of Medical Microbiology, Vol 311, Iss 4, Pp 151500- (2021)

    2021  

    Abstract: Background: The number of people above the age of 60 years is raising world-wide being associated with an increase in the prevalence of aging-associated impairments and even diseases. Recent studies suggest that aging is associated with alterations in ... ...

    Abstract Background: The number of people above the age of 60 years is raising world-wide being associated with an increase in the prevalence of aging-associated impairments and even diseases. Recent studies suggest that aging is associated with alterations in bacterial endotoxin levels and that these changes may add to low-grade inflammation, the so-called ‘inflammaging’, and aging-associated liver degeneration. However, mechanisms involved, and especially, the interaction of intestinal microbiota and barrier in the development of aging-associated inflammation and liver degeneration have not been fully understood. Objective: The aim of the present study was to determine if intestinal microbiota composition changes with age and if these alterations are associated with changes of markers of intestinal barrier function and the development of inflammation and liver degeneration. Methods: Blood, liver, small and large intestinal tissue of male 2-, 15-, 24- and 30-months old C57BL/6 mice fed standard chow were obtained. Intestinal microbiota composition, expression levels of antimicrobial peptides in small intestine and markers of intestinal barrier function were measured. Furthermore, indices of liver damage, inflammation and expression levels of lipopolysaccharide binding protein (Lbp) as well as of toll-like receptors (Tlr) 1-9 in liver tissue were assessed. Results: Pairwise comparisons of the microbial community in the small intestine showed differences between 2- and 24-, 15- and 24-, as well as 15- and 30-months old animals while Shannon’s diversity, species richness and evenness indexes did not differ in both small and large intestine, respectively, between age groups. Concentrations of nitric oxide were significantly lower in small intestine of 15-, 24- and 30-months old mice compared to 2-months old mice while mRNA expression of the antimicrobial peptides defensin alpha 1 and lysozyme 1 was unchanged. In contrast, in liver tissue, older age of animals was associated with increasing inflammation and the development ...
    Schlagwörter Aging ; Defensins ; Intestinal permeability ; Microbiota ; NOx ; Toll-like receptors ; Microbiology ; QR1-502 ; Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine

    Annette Brandt / Angélica Hernández-Arriaga / Richard Kehm / Victor Sánchez / Cheng Jun Jin / Anika Nier / Anja Baumann / Amélia Camarinha-Silva / Ina Bergheim

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Band 14

    Abstract: Abstract The antidiabetic drug metformin has been proposed to affect non-alcoholic fatty liver disease (NAFLD) through its effects on intestinal microbiota and barrier function. However, so far most studies focused on long-term effects and more ... ...

    Abstract Abstract The antidiabetic drug metformin has been proposed to affect non-alcoholic fatty liver disease (NAFLD) through its effects on intestinal microbiota and barrier function. However, so far most studies focused on long-term effects and more progressed disease stages. The aim of this study was to assess in two experimental settings, if the onset of NAFLD is associated with changes of intestinal microbiota and barrier function and to determine effects of metformin herein. C57Bl/6J mice were fed a liquid control diet (C) or fat-, fructose- and cholesterol-rich diet (FFC) for four days or six weeks ±300 mg/kg BW/day metformin (Met). Markers of liver health, intestinal barrier function and microbiota composition were assessed. Metformin treatment markedly attenuated FFC-induced NAFLD in both experiments with markers of inflammation and lipidperoxidation in livers of FFC + Met-fed mice being almost at the level of controls. Metformin treatment attenuated the loss of tight junction proteins in small intestine and the increase of bacterial endotoxin levels in portal plasma. Changes of intestinal microbiota found in FFC-fed mice were also significantly blunted in FFC + Met-fed mice. Taken together, protective effects of metformin on the onset of NAFLD are associated with changes of intestinal microbiota composition and lower translocation of bacterial endotoxins.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Consumption of decaffeinated coffee protects against the development of early non-alcoholic steatohepatitis

    Annette Brandt / Anika Nier / Cheng Jun Jin / Anja Baumann / Finn Jung / Vicent Ribas / Carmen García-Ruiz / Jose C. Fernández-Checa / Ina Bergheim

    Redox Biology, Vol 21, Iss , Pp - (2019)

    Role of intestinal barrier function

    2019  

    Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide lacking universally accepted therapies. Studies suggest that coffee consumption is associated with a reduced risk of NAFLD; however, molecular ... ...

    Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide lacking universally accepted therapies. Studies suggest that coffee consumption is associated with a reduced risk of NAFLD; however, molecular mechanisms and ingredients involved remain to be fully understood. Here, we determined the effects of regular intake of decaffeinated coffee on the development of NAFLD in mice, and molecular mechanisms involved. Methods: Female C57BL/6J mice (n = 6–7/ group) were pair-fed either a liquid control diet (C) or fat-, fructose- and cholesterol-rich diet (FFC) +/- decaffeinated coffee (DeCaf, 6 g/kg BW) for 4 days or 6 weeks. Indices of liver damage, hepatic inflammation and parameters of insulin resistance and intestinal permeability as well as nitric oxide system were determined. Results: Early signs of insulin resistance and non-alcoholic steatohepatitis (NASH) found after 6 weeks of FFC feeding were significantly lower in FFC+DeCaf-fed mice when compared to FFC-fed animals. Moreover, elevation of portal endotoxin levels and loss of tight junction proteins in proximal small intestine found in FFC-fed mice were significantly attenuated in FFC+DeCaf-fed animals. These beneficial effects of DeCaf were associated with a protection against the significant induction of inducible NO-synthase protein levels and 3-nitrotyrosine protein adducts found in proximal small intestine of FFC-fed mice. Similar protective effects of DeCaf were also found in mice fed the FFC diet short-term. Conclusion: Our results suggest that protective effects of DeCaf on the development of NAFLD are at least in part related to maintaining intestinal barrier function. Keywords: Fatty liver, Inflammation, iNOS, Coffee, Intestinal permeability
    Schlagwörter Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-02-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel: Oral arginine supplementation protects female mice from the onset of non-alcoholic steatohepatitis

    Sellmann, Cathrin / Christian Degen / Cheng Jun Jin / Anika Nier / Anna Janina Engstler / Dana Hasan Alkhatib / Jean-Pascal De Bandt / Ina Bergheim

    Amino acids. 2017 July, v. 49, no. 7

    2017  

    Abstract: Dietary arginine (Arg) supplementation has been proposed to have positive effects on the development of liver diseases. In the present study, we investigate if an oral Arg supplementation in diet protects mice fed a fructose, fat and cholesterol enriched ...

    Abstract Dietary arginine (Arg) supplementation has been proposed to have positive effects on the development of liver diseases. In the present study, we investigate if an oral Arg supplementation in diet protects mice fed a fructose, fat and cholesterol enriched Western-style diet (WSD) from the development of non-alcoholic steatohepatitis (NASH). Female C57BL/6J mice were fed a liquid control diet or a liquid WSD ± Arg (2.49 g/kg body weight/day) for 6 weeks. Indices of liver injury, glucose metabolism and intestinal permeability were determined. While Arg supplementation had no effects on body weight gain, fasting blood glucose levels were significantly lower in WSD+Arg-fed mice than in C+Arg-fed animals. WSD-fed mice developed liver steatosis accompanied with inflammation, both being significantly attenuated in WSD+Arg-fed mice. These effects of Arg supplementation went along with a protection against WSD-induced decreased tight junction protein levels in the upper parts of the small intestine, increased levels of bacterial endotoxin in portal plasma as well as increased hepatic toll-like receptor-4 mRNA and 4-hydroxynonenal protein adduct levels. In conclusion, Arg supplementation may protect mice from the development of NASH.
    Schlagwörter Toll-like receptor 4 ; Western diets ; arginine ; blood glucose ; body weight changes ; cholesterol ; endotoxins ; fatty liver ; females ; fructose ; glucose ; inflammation ; liver ; messenger RNA ; metabolism ; mice ; permeability ; small intestine ; tight junctions
    Sprache Englisch
    Erscheinungsverlauf 2017-07
    Umfang p. 1215-1225.
    Erscheinungsort Springer Vienna
    Dokumenttyp Artikel
    ZDB-ID 1121341-3
    ISSN 1438-2199 ; 0939-4451
    ISSN (online) 1438-2199
    ISSN 0939-4451
    DOI 10.1007/s00726-017-2423-4
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome

    Annick V. Hartstra / Valentina Schüppel / Sultan Imangaliyev / Anouk Schrantee / Andrei Prodan / Didier Collard / Evgeni Levin / Geesje Dallinga-Thie / Mariette T. Ackermans / Maaike Winkelmeijer / Stefan R. Havik / Amira Metwaly / Ilias Lagkouvardos / Anika Nier / Ina Bergheim / Mathias Heikenwalder / Andreas Dunkel / Aart J. Nederveen / Gerhard Liebisch /
    Giulia Mancano / Sandrine P. Claus / Alfonso Benítez-Páez / Susanne E. la Fleur / Jacques J. Bergman / Victor Gerdes / Yolanda Sanz / Jan Booij / Elles Kemper / Albert K. Groen / Mireille J. Serlie / Dirk Haller / Max Nieuwdorp

    Molecular Metabolism, Vol 42, Iss , Pp 101076- (2020)

    2020  

    Abstract: Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the ... ...

    Abstract Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown. Methods: We compared the effect of fecal microbiota transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral butyrate supplementation on (123I-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin transporter (SERT) binding as well as stable isotope-determined insulin sensitivity at baseline and after 4 weeks in 24 male and female treatment-naïve metabolic syndrome subjects. Plasma metabolites and fecal microbiota were also determined at these time points. Results: We observed an increase in brain DAT after donor FMT compared to oral butyrate that reduced this binding. However, no effect on body weight and insulin sensitivity was demonstrated after post-RYGB donor feces transfer in humans with metabolic syndrome. Increases in fecal levels of Bacteroides uniformis were significantly associated with an increase in DAT, whereas increases in Prevotella spp. showed an inverse association. Changes in the plasma metabolites glycine, betaine, methionine, and lysine (associated with the S-adenosylmethionine cycle) were also associated with altered striatal DAT expression. Conclusions: Although more and larger studies are needed, our data suggest a potential gut microbiota-driven modulation of brain dopamine and serotonin transporters in human subjects with obese metabolic syndrome. These data also suggest the presence of a gut-brain axis in humans that can be modulated. NTR registration: 4488.
    Schlagwörter Obesity ; Gutmicrobiota ; Gut-brain axis ; Metabolites ; Internal medicine ; RC31-1245
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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