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  1. AU="Anil K. Mantha"
  2. AU="Artzner, Christoph"
  3. AU=Diana Giovanni
  4. AU="Kinloch, Sabine"
  5. AU="Nuertey, David"
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  1. Article ; Online: Essential Oils and Their Constituents as Anticancer Agents

    Nandini Gautam / Anil K. Mantha / Sunil Mittal

    BioMed Research International, Vol

    A Mechanistic View

    2014  Volume 2014

    Abstract: Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and ...

    Abstract Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitro and in vivo studies for EOs and their constituents. This review also highlights in-depth various mechanisms of action of different EOs and their constituents reported in the treatment strategies for different types of cancer. The current review indicates that EOs and their constituents act by multiple pathways and mechanisms involving apoptosis, cell cycle arrest, antimetastatic and antiangiogenic, increased levels of reactive oxygen and nitrogen species (ROS/RNS), DNA repair modulation, and others to demonstrate their antiproliferative activity in the cancer cell. The effect of EOs and their constituents on tumour suppressor proteins (p53 and Akt), transcription factors (NF-κB and AP-1), MAPK-pathway, and detoxification enzymes like SOD, catalase, glutathione peroxidase, and glutathione reductase has also been discussed.
    Keywords Medicine ; R
    Subject code 333
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Inflammatory response of gliadin protein isolated from various wheat varieties on human intestinal cell line

    Gupta, Kunj Bihari / Shishir Upadhyay / Ram Gopal Saini / Anil K. Mantha / Monisha Dhiman

    Journal of cereal science. 2018 May, v. 81

    2018  

    Abstract: Wheat protein contributes a significant part in human diet, apart from its well-known nutritional values, wheat gluten/gliadin proteins are also responsible for the many allergic/inflammatory diseases and chronic inflammation in the small intestine may ... ...

    Abstract Wheat protein contributes a significant part in human diet, apart from its well-known nutritional values, wheat gluten/gliadin proteins are also responsible for the many allergic/inflammatory diseases and chronic inflammation in the small intestine may cause diarrhea and malabsorption, in a specific population of individuals. In the present study, the antigenic characteristics of twelve wheat varieties of diverse origin namely C273, C281, C286, C306, C518, C591, Agra Local, 9D, 8A, Raj4229, HD3027, NP824 released during 1920–2012 were evaluated. Gliadin proteins from these varieties were tested on human colon cancer cell line HCT116 to assess their effect on inflammation, oxidative and nitrosative stress, pro-inflammatory cytokines. The results show that these wheat varieties induced high levels of ROS/RNS and MPO activity which was further supported by the increase in the mRNA levels of a cytokine such as IL-1β and IL-15. It can be concluded that gliadin from these wheat varieties is suggested to act as a potential antigen by enhancing the level of inflammation irrespective of their year of release and origin which if not controlled may lead to the initiation of celiac disease in genetically susceptible individuals or may be responsible for other wheat protein intolerance associated diseases.
    Keywords antigens ; celiac disease ; colorectal neoplasms ; diarrhea ; gliadin ; human cell lines ; human nutrition ; humans ; inflammation ; interleukin-15 ; interleukin-1beta ; messenger RNA ; neoplasm cells ; nutritive value ; small intestine ; wheat ; wheat gluten ; wheat protein
    Language English
    Dates of publication 2018-05
    Size p. 91-98.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 408468-8
    ISSN 0733-5210
    ISSN 0733-5210
    DOI 10.1016/j.jcs.2018.03.012
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3775: Show issues

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  3. Article: Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies

    Mittal, Sunil / Anil K. Mantha / Hardeep Kaur / Nandini Gautam

    Biosensors & bioelectronics. 2017 Feb. 15, v. 88

    2017  

    Abstract: Breast cancer is highly prevalent in females and accounts for second highest number of deaths, worldwide. Cumbersome, expensive and time consuming detection techniques presently available for detection of breast cancer potentiates the need for ... ...

    Abstract Breast cancer is highly prevalent in females and accounts for second highest number of deaths, worldwide. Cumbersome, expensive and time consuming detection techniques presently available for detection of breast cancer potentiates the need for development of novel, specific and ultrasensitive devices. Biosensors are the promising and selective detection devices which hold immense potential as point of care (POC) tools. Present review comprehensively scrutinizes various breast cancer biosensors developed so far and their technical evaluation with respect to efficiency and potency of selected bioreceptors and biotransducers. Use of glycoproteins, DNA biomarkers, micro-RNA, circulatory tumor cells (CTC) and some potential biomarkers are introduced briefly. The review also discusses various strategies used in signal amplification such as nanomaterials, redox mediators, p19 protein, duplex specific nucleases (DSN) and redox cycling.
    Keywords biomarkers ; biosensors ; breast neoplasms ; DNA ; females ; glycoproteins ; microRNA ; nanomaterials ; neoplasm cells ; nucleases
    Language English
    Dates of publication 2017-0215
    Size p. 217-231.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2016.08.028
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Pharmacophore Pattern Identification of Tachykinin Receptor Selective Peptide Agonists

    Anjali Dike / Indu R. Chandrashekaran / Anil K. Mantha / Najma Z. Baquer / Sudha M. Cowsik

    American Journal of Biochemistry and Biotechnology, Vol 3, Iss 4, Pp 180-

    Implications in Receptor Selectivity

    2007  Volume 186

    Abstract: The mammalian tachykinin (TK) peptides and their three Neurokinin (NK1, NK2 and NK3) receptors represent an effector system with wide-ranging actions on neuronal, airway smooth muscle, mucosal, endothelial, immune, inflammatory and remodeling cell ... ...

    Abstract The mammalian tachykinin (TK) peptides and their three Neurokinin (NK1, NK2 and NK3) receptors represent an effector system with wide-ranging actions on neuronal, airway smooth muscle, mucosal, endothelial, immune, inflammatory and remodeling cell function. Recent clinical and preclinical data suggests the pathophysiological role of TKs in various diseases including asthma, emesis and depression. The TK-NK receptor interactions and overlapping functions mediated by each NK receptor indicate added therapeutic benefit of using multiple NK receptor blockade. In the absence of structural data on neurokinin receptors, the membrane-induced structure of tachykinins play an important role as a first step towards understanding structure-activity relationship. A comparison of the conformational features of different NK1, NK2 and NK3 receptor agonists highlights several features which might be responsible for determining selectivity for the particular receptor subtype. An attempt has been made to correlate the observed conformational differences to the binding ability and biological activity of various NK1, NK2 and NK3 receptor agonists. The membrane bound conformations of tachykinins have been used as a starting point, leading to useful pharmacophore patterns that can be used for identifying lead structures with novel scaffolds.
    Keywords </keyword><keyword>Tachykinin ; Neuropeptide ; Neurokinin receptor ; Pharmacophore pattern ; Solution conformation ; Biochemistry ; QD415-436 ; Organic chemistry ; QD241-441 ; Chemistry ; QD1-999 ; Science ; Q ; DOAJ:Biochemistry ; DOAJ:Life Sciences ; DOAJ:Biology and Life Sciences ; Biotechnology ; TP248.13-248.65 ; Chemical technology ; TP1-1185 ; Technology ; T ; DOAJ:Biotechnology
    Subject code 540
    Language English
    Publishing date 2007-01-01T00:00:00Z
    Publisher Science Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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