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  1. Book: Adding lamivudine to zidovudine containing regimens

    Anis, Aslam H.

    the CAESAR study

    (PharmacoEconomics ; 15, Suppl. 1)

    1999  

    Author's details guest ed. Aslam H. Anis
    Series title PharmacoEconomics ; 15, Suppl. 1
    Collection
    Language English
    Size 76 S. : graph. Darst.
    Publisher Adis
    Publishing place Auckland u.a.
    Publishing country New Zealand
    Document type Book
    HBZ-ID HT010405326
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3579 -15,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: The impact of changing the reference countries on the list prices for patented medicines in Canada: A policy analysis.

    Zhang, Wei / Guh, Daphne P / Grootendorst, Paul / Hollis, Aidan / Anis, Aslam H

    Health policy (Amsterdam, Netherlands)

    2024  Volume 144, Page(s) 105064

    Abstract: Background: Canada's Patented Medicine Prices Review Board (PMPRB) uses external and internal reference pricing (IRP) to regulate patented drug list prices. PMPRB has changed external reference countries from 7 to 11 to include countries with prices ... ...

    Abstract Background: Canada's Patented Medicine Prices Review Board (PMPRB) uses external and internal reference pricing (IRP) to regulate patented drug list prices. PMPRB has changed external reference countries from 7 to 11 to include countries with prices closer to the OECD median. We examined the impact on the list prices for patented medicines had the amendment been implemented from 2013.
    Methods: Using IQVIA MIDAS® quarterly sales data, we selected branded products that were launched in Canada in 2013-2018. The list price for each product in each country was calculated as its average annual price during the 3rd year post Canadian launch. The median international price (MIP) was the median of the list prices of PMPRB7 (MIP7) and PMPRB11 (MIP11). We assumed the same IRP would be (scenario 1) or would not be used (scenario 2).
    Results: Among the selected 400 products, 80.3 % (321) had MIP7 and MIP11 (launched in at least one reference country); 18.3 % did not have MIP11. The total current expenditures were $7,134.4 M. In scenario 1, MIP11 would not be binding for most products and expenditures would decline only by 0.7 %. If IRP were abolished, expenditures might decline by 14.1 % if the launching sequence would not change.
    Conclusions: MIP11 might not be binding for most medicines. The impact depends on whether to retain the IRP and approaches taken for medicines without MIP11.
    Language English
    Publishing date 2024-04-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605805-x
    ISSN 1872-6054 ; 0168-8510
    ISSN (online) 1872-6054
    ISSN 0168-8510
    DOI 10.1016/j.healthpol.2024.105064
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2250: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Patient-reported mental health and well-being trajectories in oncology patients during radiation therapy: an exploratory retrospective cohort analysis using the Ontario Cancer Registry.

    Kwon, Jae-Yung / Kopec, Jacek / Sutherland, Jason M / Lambert, Leah K / Anis, Aslam H / Sawatzky, Richard

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

    2023  Volume 32, Issue 10, Page(s) 2899–2909

    Abstract: Purpose: Mental health and well-being trajectories are not expected to be homogeneous in diverse clinical populations. This exploratory study aims to identify subgroups of patients with cancer receiving radiation therapy who have different mental health ...

    Abstract Purpose: Mental health and well-being trajectories are not expected to be homogeneous in diverse clinical populations. This exploratory study aims to identify subgroups of patients with cancer receiving radiation therapy who have different mental health and well-being trajectories, and examine which socio-demographic, physical symptoms, and clinical variables are associated with such trajectories.
    Methods: Retrospective analysis of radiation therapy patients diagnosed with cancer in 2017 was conducted using data from the Ontario Cancer Registry (Canada) and linked with administrative health data. Mental health and well-being were measured using items from the Edmonton Symptom Assessment System-revised questionnaire. Patients completed up to 6 repeated measurements. We used latent class growth mixture models to identify heterogeneous mental health trajectories of anxiety, depression, and well-being. Bivariate multinomial logistic regressions were conducted to explore variables associated with the latent classes (subgroups).
    Results: The cohort (N = 3416) with a mean age of 64.5 years consisted of 51.7% females. Respiratory cancer was the most common diagnosis (30.4%) with moderate to severe comorbidity burden. Four latent classes with distinct anxiety, depression, and well-being trajectories were identified. Decreasing mental health and well-being trajectories are associated with being female; living in neighborhoods with lower income, greater population density, and higher proportion of foreign-born individuals; and having higher comorbidity burden.
    Conclusions: The findings highlight the importance of considering social determinants of mental health and well-being, in addition to symptoms and clinical variables, when providing care for patients undergoing radiation therapy.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Mental Health ; Retrospective Studies ; Ontario/epidemiology ; Quality of Life/psychology ; Cohort Studies ; Neoplasms/radiotherapy ; Patient Reported Outcome Measures ; Depression/epidemiology ; Depression/psychology
    Language English
    Publishing date 2023-05-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1161148-0
    ISSN 1573-2649 ; 0962-9343
    ISSN (online) 1573-2649
    ISSN 0962-9343
    DOI 10.1007/s11136-023-03430-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3796: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Distinguishing symptom patterns in adults newly diagnosed with cancer: a latent class analysis.

    Wallström, Sara / Sutherland, Jason M / Kopec, Jacek A / Anis, Aslam H / Sawatzky, Richard

    Journal of pain and symptom management

    2022  Volume 64, Issue 2, Page(s) 146–155

    Abstract: Context: Socio-demographic differences, including place of residence, socio-economic status, ethnicity, and gender, have been associated with various inequities in cancer care outcomes.: Objectives: The aims were to distinguish subgroups of patients ... ...

    Abstract Context: Socio-demographic differences, including place of residence, socio-economic status, ethnicity, and gender, have been associated with various inequities in cancer care outcomes.
    Objectives: The aims were to distinguish subgroups of patients with different symptom patterns at the time of the initial oncology visit and determine which clinical and socio-demographic variables are associated the different symptom patterns.
    Method: Responses to the Edmonton Symptom Assessment Scale- revised and clinical and socio-demographic variables were obtained via the Ontario Cancer Registry and linked health data files. Latent class analyses were conducted to identify and compare the subgroups.
    Results: The cohort (n = 216,110) with a mean age of 64.5 years consisted of 54.1% women. The analyses identified six latent classes (proportions ranging from 0.09 to 0.31) with distinct symptom patterns, including: 1) many severe symptoms, 2) many less severe symptoms, 3) predominantly mild symptoms, 4) severe psychosocial symptoms, 5) severe somatic symptoms, 6) few symptoms. The subgroups were associated not only with clinical differences (diagnoses and functional status), but also with various socio-demographic (age, sex) and community characteristics (neighborhood income, proportion of foreign born, rurality).
    Conclusion: The results indicated that there were substantial differences in symptom patterns at the time of the initial oncology visit, which were associated with both clinical diagnoses and socio-demographic differences. These results point to the importance of taking the social situation of patients into account, and not just diagnosis, to better understand differences in symptom patterns of people living with cancer.
    MeSH term(s) Adult ; Cohort Studies ; Female ; Humans ; Latent Class Analysis ; Male ; Middle Aged ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/therapy ; Social Class ; Symptom Assessment
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639142-4
    ISSN 1873-6513 ; 0885-3924
    ISSN (online) 1873-6513
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2022.04.172
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Modeling Tiered Pricing Frameworks: A Simulation Approach.

    Moradpour, Javad / Zhang, Wei / Grootendorst, Paul / Anis, Aslam H / Hollis, Aidan

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2022  Volume 26, Issue 3, Page(s) 351–358

    Abstract: Objective: Drug plans take different approaches to determining reimbursement prices for generic drugs. One common approach is to set the maximum reimbursement price as a percentage of the price of the interchangeable branded drug. In many countries this ...

    Abstract Objective: Drug plans take different approaches to determining reimbursement prices for generic drugs. One common approach is to set the maximum reimbursement price as a percentage of the price of the interchangeable branded drug. In many countries this percentage depends on the number of generic entrants, a model we call "tiered pricing." This paper seeks to enhance understanding of how to set the tiers.
    Methods: We construct a simple model of tiered pricing and set parameters to match evidence on generic drug costs and the distribution of revenues. Using simulation methods, we then assess different tier structures in terms of total surplus and average drug cost.
    Results: We find when tiers are bunched tightly together welfare outcomes are poor. Moreover, there are large welfare gains from increasing the number of tiers from one to two, and only small welfare gains from increasing the number of tiers beyond four.
    Conclusions: The choice of tiers has substantial welfare and cost implications. While it is possible to refine the simulation analysis based on specific market characteristics, an optimal tier structure, such as the one we propose in the paper, should have at least two tiers.
    MeSH term(s) Humans ; Costs and Cost Analysis ; Drug Costs ; Drugs, Generic ; Social Welfare
    Chemical Substances Drugs, Generic
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2022.11.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5904: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Comparing the use of aggregate data and various methods of integrating individual patient data to network meta-analysis and its application to first-line ART.

    Kanters, Steve / Karim, Mohammad Ehsanul / Thorlund, Kristian / Anis, Aslam H / Zoratti, Michael / Bansback, Nick

    BMC medical research methodology

    2021  Volume 21, Issue 1, Page(s) 60

    Abstract: Background: The 2018 World Health Organization HIV guidelines were based on the results of a network meta-analysis (NMA) of published trials. This study employed individual patient-level data (IPD) and aggregate data (AgD) and meta-regression methods to ...

    Abstract Background: The 2018 World Health Organization HIV guidelines were based on the results of a network meta-analysis (NMA) of published trials. This study employed individual patient-level data (IPD) and aggregate data (AgD) and meta-regression methods to assess the evidence supporting the WHO recommendations and whether they needed any refinements.
    Methods: Access to IPD from three trials was granted through ClinicalStudyDataRequest.com (CSDR). Seven modelling approaches were applied and compared: 1) Unadjusted AgD network meta-analysis (NMA) - the original analysis; 2) AgD-NMA with meta-regression; 3) Two-stage IPD-AgD NMA; 4) Unadjusted one-stage IPD-AgD NMA; 5) One-stage IPD-AgD NMA with meta-regression (one-stage approach); 6) Two-stage IPD-AgD NMA with empirical-priors (empirical-priors approach); 7) Hierarchical meta-regression IPD-AgD NMA (HMR approach). The first two were the models used previously. Models were compared with respect to effect estimates, changes in the effect estimates, coefficient estimates, DIC and model fit, rankings and between-study heterogeneity.
    Results: IPD were available for 2160 patients, representing 6.5% of the evidence base and 3 of 24 edges. The aspect of the model affected by the choice of modeling appeared to differ across outcomes. HMR consistently generated larger intervals, often with credible intervals (CrI) containing the null value. Discontinuations due to adverse events and viral suppression at 96 weeks were the only two outcomes for which the unadjusted AgD NMA would not be selected. For the first, the selected model shifted the principal comparison of interest from an odds ratio of 0.28 (95% CrI: 10.17, 0.44) to 0.37 (95% CrI: 0.23, 0.58). Throughout all outcomes, the regression estimates differed substantially between AgD and IPD methods, with the latter being more often larger in magnitude and statistically significant.
    Conclusions: Overall, the use of IPD often impacted the coefficient estimates, but not sufficiently as to necessitate altering the final recommendations of the 2018 WHO Guidelines. Future work should examine the features of a network where adjustments will have an impact, such as how much IPD is required in a given size of network.
    MeSH term(s) Humans ; Network Meta-Analysis ; Odds Ratio ; Regression Analysis ; Research Design ; Research Report
    Language English
    Publishing date 2021-03-30
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ISSN 1471-2288
    ISSN (online) 1471-2288
    DOI 10.1186/s12874-021-01254-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Impact of Tiered-Pricing Framework on Generic Entry in Canada.

    Zhang, Wei / Sun, Huiying / Guh, Daphne P / Lynd, Larry D / Hollis, Aidan / Grootendorst, Paul / Anis, Aslam H

    International journal of health policy and management

    2022  Volume 11, Issue 6, Page(s) 768–776

    Abstract: Background: Generic drug prices have been capped at specified percentages of the interchangeable branded drug's price by the Canadian provincial public drug plans since 1993. The Pan-Canadian Pharmaceutical Alliance, formed as a coalition by the ... ...

    Abstract Background: Generic drug prices have been capped at specified percentages of the interchangeable branded drug's price by the Canadian provincial public drug plans since 1993. The Pan-Canadian Pharmaceutical Alliance, formed as a coalition by the provinces/territories in Canada, implemented an alternative approach, a tiered-pricing framework (TPF) for new generic drugs on April 1, 2014, under which the percentage varies with the number of generic firms in each market. We evaluate the impact of the TPF on generic entry, ie, listing in public drug plans in Canada.
    Methods: Our study compared the pre-TPF period (01/01/2012-03/31/2014) with the TPF period (04/01/2014- 06/30/2016). Prescription drugs from nine provincial public drug plans were grouped into a "market" if they had the same active ingredient and strength, route of administration, and dosage form. Each "market" was contestable by generics and met the eligibility criteria for TPF. At the "market" level, Cox proportional-hazards models with time-varying covariates were used to measure the impact of the TPF on the first generic listing in any provincial public drug plan in Canada relative to the first launch date worldwide.
    Results: A total of 189 markets in Canada were selected for the analyses. Generic drugs in small markets were more likely to be listed in Canada during the TPF period compared to the pre-TPF period (hazard ratio [HR], 95% CI: 3.81, 1.51-9.62). There was no significant difference in generic drug listings in large markets between the two policy periods.
    Conclusion: TPF speeds up generic entry in small markets and generates the benefits of generic competition while avoiding the pitfalls of the previously employed price-cap regulations.
    MeSH term(s) Canada ; Costs and Cost Analysis ; Drug Costs ; Drug Industry ; Drugs, Generic ; Economic Competition ; Humans
    Chemical Substances Drugs, Generic
    Language English
    Publishing date 2022-06-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2724317-5
    ISSN 2322-5939 ; 2322-5939
    ISSN (online) 2322-5939
    ISSN 2322-5939
    DOI 10.34172/ijhpm.2020.215
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  8. Article ; Online: Working From Home During the COVID-19 Pandemic: The Association With Work Productivity Loss Among Patients and Caregivers.

    Zhang, Wei / Sun, Huiying / Gelfand, Aaron / Sawatzky, Richard / Pearce, Alison / Anis, Aslam H / Prescott, Katrina / Lee, Christine

    Journal of occupational and environmental medicine

    2022  Volume 64, Issue 11, Page(s) e677–e684

    Abstract: Objective: The aim of this study was to measure the association of working from home (WFH) with work productivity loss due to caregiving responsibilities or health problems during the COVID-19 pandemic.: Methods: We conducted an online survey of ... ...

    Abstract Objective: The aim of this study was to measure the association of working from home (WFH) with work productivity loss due to caregiving responsibilities or health problems during the COVID-19 pandemic.
    Methods: We conducted an online survey of family/friend caregivers (n = 150 WFH/75 non-WFH) and patients (n = 95/91) who worked during the past 7 days in May and July 2020, respectively. Absenteeism and presenteeism were measured using the Valuation of Lost Productivity questionnaire.
    Results: Working from home was associated with higher odds of absenteeism (odds ratio, 2.53; 95% confidence interval, 1.11 to 5.77) and presenteeism (2.79; 1.26 to 6.18) among caregivers and higher odds of presenteeism among patients (2.78; 1.13 to 6.84). However, among caregivers with absenteeism more than 0 days, WFH was significantly associated with fewer absent workdays.
    Conclusions: Working from home was not associated with overall absenteeism and presenteeism in caregivers or patients. Working from home allows a more flexible and inclusive workplace without impacting productivity, although further research is needed.
    MeSH term(s) Humans ; Caregivers ; COVID-19/epidemiology ; Pandemics ; Cross-Sectional Studies ; Efficiency ; Presenteeism ; Absenteeism ; Surveys and Questionnaires
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002663
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    Zs.B 155: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: A ban on "private label" generic pharmaceuticals

    Anis, Aslam H / Harvard, Stephanie

    International journal of the economics of business Vol. 22, No. 2 , p. 219-229

    legal and economic context

    2015  Volume 22, Issue 2, Page(s) 219–229

    Author's details Aslam H. Anis and Stephanie Harvard
    Keywords Generic ; Pharmaceuticals ; Drug Prices ; Regulations ; Vertical Integration ; Competition
    Language English
    Publisher Routledge
    Publishing place Abingdon, Oxfordshire
    Document type Article
    ZDB-ID 1196953-2 ; 2069487-8
    ISSN 0962-1369
    ISSN 0962-1369
    Database ECONomics Information System

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  10. Article ; Online: Effects of health status on work exit and absenteeism among the older working population in China: a secondary analysis of a cohort sample.

    Li, Xin / Zhang, Wei / Sun, Huiying / Anis, Aslam H

    BMJ open

    2019  Volume 9, Issue 9, Page(s) e024115

    Abstract: Objectives: To analyse the effects of health status on work exit and absenteeism among the older working population in China.: Design: Secondary analysis of a cohort sample.: Setting and participants: Community samples who engaged in either ... ...

    Abstract Objectives: To analyse the effects of health status on work exit and absenteeism among the older working population in China.
    Design: Secondary analysis of a cohort sample.
    Setting and participants: Community samples who engaged in either agricultural or non-agriculture work or both in the 2011 wave of the China Health and Retirement Longitudinal Study (CHARLS) and whose age was 45-55 years for women or 45-60 years for men in the 2013 wave.
    Outcome measures: Work exit and number of absent workdays due to health problems in 2013. To address the problems of measurement error of self-rated health status, we used disability condition, number of chronic diseases and functional limitation to construct an index of health. We divided the sample into four groups according to gender and work types (farmers who conducted any agricultural work in 2011 vs non-farmers who conducted non-agricultural work only) and conducted analyses separately.
    Results: Farmers (11.0% for women and 4.9% for men) were less likely to exit from work than non-farmers (18.5% and 12.0%, respectively) but took more absent workdays (16.6 days for women and 15.0 days for men) than non-farmers (5.6 and 4.9). Poor health status in 2011 was significantly associated with the work exit in 2013 of female and male farmers but not non-farmers. Older workers (except female non-farmers) with persistently poor health or recent health deterioration over time were significantly more likely to stop working or missed more workdays than those with persistently good health.
    Conclusions: Poor 2-year lagged health predicts work exit for both male and female farmers, and increases the absent work days in all older working population. Persistently poor health or recent health deterioration over time has detrimental impact on labour market in terms of work exit and absenteeism among all older Chinese workers except for female non-farmers.
    MeSH term(s) Absenteeism ; Age Factors ; Agricultural Workers' Diseases/epidemiology ; China ; Cohort Studies ; Female ; Health Status ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Occupational Health/statistics & numerical data ; Risk Factors ; Sick Leave/statistics & numerical data
    Language English
    Publishing date 2019-09-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2747269-3
    ISSN 2044-6055 ; 2044-6055 ; 2053-3624
    ISSN (online) 2044-6055
    ISSN 2044-6055 ; 2053-3624
    DOI 10.1136/bmjopen-2018-024115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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