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  1. Article ; Online: Evolving epidemiology and chemical analysis of urinary stones

    Parul Singla / Anjali Manocha / Seema Bhargava / Mamta Kankra / Anisha Sharma

    Current Medicine Research and Practice, Vol 13, Iss 2, Pp 50-

    A retrospective analysis

    2023  Volume 54

    Abstract: Background: Renal stones are a painful urological disorder resulting from the combined influence of epidemiological, biochemical and genetic risk factors. A high recurrence risk has been reported for renal stones, and 0.6%–3.2% cases may progress to end ... ...

    Abstract Background: Renal stones are a painful urological disorder resulting from the combined influence of epidemiological, biochemical and genetic risk factors. A high recurrence risk has been reported for renal stones, and 0.6%–3.2% cases may progress to end stage renal disease. Modern lifestyle, sedentary habits and unhealthy dietary practices are primary promoters of the stone boom in this millennium. Aims and Objectives: The aim of the present study is to evaluate the percentage of the stone type according to chemical composition and their association with epidemiological factors like sex and age. A retrospective analysis of the chemical composition of the stone samples received was done. Material and Methods: Stones samples were processed by Stone Analysis Set (BIOLABO S A, France). Qualitative chemical analysis was done for calcium, phosphorus, ammonium ion, oxalate, cystine, magnesium, carbonate and uric acid. Results: Type of renal stone and its incidence with age and sex have been evaluated. The total number of patients reporting to the hospital with renal stones was 123. Of these, 69.11% were male and 30.89% were female, with a male to female ratio of 2.23:1. The maximum occurrence was in the third and fourth decade of life. On analysis, 72.35% of total stones comprised calcium oxalate and 23.57% of nonoxalate (phosphate, magnesium, carbonate, ammonium ion) stones, whereas uric acid was positive in 4.06%. Conclusion: The occurrence of renal stones according to epidemiological factors such as age and sex in our study are similar to those reported in studies from developed countries. The data on urinary stones indicate that 98% were located in the upper urinary tract. Oxalate stones represent the main form of urolithiasis, affecting males more than females. The most important cause studied for renal stone formation is metabolic disturbances, but the genetic factors associated with the occurrence and recurrence of stone and mineral homeostasis of ions in kidney of stone formers should be further evaluated.
    Keywords calcium oxalate ; epidemiology ; urinary stones ; urolithiasis ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Serum levels of tumor necrosis factor -alpha and hsCRP in patients with breast cancer and correlation with histological parameters

    Anisha Sharma

    Asian Journal of Medical Sciences, Vol 6, Iss 6, Pp 6-

    2015  Volume 10

    Abstract: Background: Breast cancer is now the second most commonly cancer diagnosed in women after cervical cancer in India. Presentation at late stage further aggravates the problem. The outcome of breast cancer is usually determined by multiple factors. Aims ... ...

    Abstract Background: Breast cancer is now the second most commonly cancer diagnosed in women after cervical cancer in India. Presentation at late stage further aggravates the problem. The outcome of breast cancer is usually determined by multiple factors. Aims and Objectives:This study was designed with the aim to investigate any correlation between serum tumor necrosis factor alpha and hsCRP in breast cancer with histological parameters of tumor behavior. Materials and Methods: A total of 30 histological confirmed cases of locally advanced breast cancer were enrolled for study. Total duration of study was two years. HsCRP was determined by solid phase direct sandwich ELISA method (Diaclone, France).Similarly TNF-α was also determined by Enzyme-linked immunosorbent method. Three-dimensional tumor size was determined radiologically through mammography. CT scan and MRI scan were taken at the time of diagnosis to detect metastasis. The data on tumor size, estrogen receptors status, lymph node status and TNM staging were reviewed and recorded. Results: Levels of TNF-α and hsCRP in patients with more advanced TNM staging, more advanced lymph node status and high histological grade were significantly raised. Similarly, their levels were significantly raised with increasing grade of adipose tissue invasion. Levels of TNF-α and hs CRP were also significantly raised in patients with estrogen receptor status positive whereas increase in levels of these markers was not significant in progesterone receptor status positive. Conclusion: Preoperative evaluation of tumor necrosis factor alpha and high sensitivity C-reactive protein may be valuable parameters for reflecting the severity of invasive breast cancer.
    Keywords breast cancer ; tumor necrosis factor alpha ; crp ; estrogen receptor ; progesterone receptor ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2015-05-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The laboratory and hypertension - Novel approach for diagnosis and management

    Seema Bhargava / Anjali Manocha / Mamta Kankra / Parul Singla / Anisha Sharma / Rashmi Rasi Datta

    Current Medicine Research and Practice, Vol 12, Iss 5, Pp 217-

    2022  Volume 223

    Abstract: Hypertension remains one of the most significant causes of mortality, affecting more than 1 billion people worldwide. It is a significant public health concern and a major risk factor for renal disease, heart failure, stroke, coronary artery disease and ... ...

    Abstract Hypertension remains one of the most significant causes of mortality, affecting more than 1 billion people worldwide. It is a significant public health concern and a major risk factor for renal disease, heart failure, stroke, coronary artery disease and peripheral vascular disease. In more than 90% of hypertensive patients, the cause of blood pressure elevation is unknown. Therefore, early diagnosis and timely interventions are crucial to prevent complications. Over the last four decades, various blood biomarkers have been identified, which can help in understanding the cause of the underlying processes involved in the onset, development and progression of hypertension (HT). It is our attempt, in this review, to suggest a more robust use of circulating biomarkers that may prove to be beneficial in better elucidating the pathophysiology, development, progression and therapeutic efficacy in the management of HT.
    Keywords biomarkers ; hypertension ; inflammation ; oxidative stress ; pathophysiology ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The medical diagnostic laboratory

    Seema Bhargava / Anjali Manocha / Mamta Kankra / Parul Singla / Anisha Sharma / Manushri Sharma

    Current Medicine Research and Practice, Vol 11, Iss 5, Pp 230-

    Bio-safety precautions for handling and processing of specimens during COVID-19 pandemic

    2021  Volume 236

    Abstract: The coronaviruses are single-stranded RNA viruses, one of which is responsible for the current outbreak of coronavirus disease-19. COVID-19 has affected health-care workers including laboratory personnel worldwide in an alarming and unprecedented manner. ...

    Abstract The coronaviruses are single-stranded RNA viruses, one of which is responsible for the current outbreak of coronavirus disease-19. COVID-19 has affected health-care workers including laboratory personnel worldwide in an alarming and unprecedented manner. In India too, the huge number of infected health-care staff has further weighed down our already over-burdened health-care system. While their protection is of paramount importance, it is also essential that these personnel adhere to the specific bio-safety practices to minimize their exposure to this disease. In this article, our objective is to provide guidelines for laboratories while working with COVID-19 samples to reduce the human and economic burden in the current pandemic. A risk assessment of all policies must be done and standard operating procedures on all 'Safe Laboratory Practices and Procedures' must be readily available for the staff. Dividing the laboratory functions into three broad phases, namely pre-examination, examination and post-examination, the precautions outlined for each stage must be followed stringently with the frequency defined as per the workload of the laboratory. The safety measures must cover all the laboratory processes including sample disposal. Decontamination too plays a major role and must be performed as per the standard national and international guidelines. Hence, following special precautions in the laboratory while working through the COVID-19 pandemic will not only minimize the risk of infection to the laboratory staff and but also help reduce the mortality and morbidity associated with this disease.
    Keywords covid-19 ; health-care workers ; laboratory ; precautions ; Medicine ; R
    Subject code 650
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: HAS THE EVOLUTION OF HOMO SAPIENS DOMESTICATED METABOLIC DISEASES LIKE DIABETES? A NARRATIVE REVIEW

    Dr Anand Shankar / Pallawee Choudhary / Dr. Vikas Shankar / Dr. Vivek Shankar / Dr. Anisha Sharma / Dr. Arati Shivhare / Dr. Mandavi / Dr Aushili Mahule

    Student's Journal of Health Research Africa, Vol 4, Iss

    2023  Volume 12

    Abstract: In this narrative review article, we attempt to review the information available to support the possible link between the evolution of Homo sapiens and the increase in metabolic diseases like diabetes. The Ardipithecus group, which lived around 6 million ...

    Abstract In this narrative review article, we attempt to review the information available to support the possible link between the evolution of Homo sapiens and the increase in metabolic diseases like diabetes. The Ardipithecus group, which lived around 6 million years ago, is considered the earliest humans closely linked to primates. The taxonomic assemblage encompasses Orrorin tugenensis, Sahelanthropus tchadensis, Ardipithecus ramidus, and Ardipithecus kadabba. Australopithecus anamensis, the initial reported member of the Australopithecines, inhabited the Earth approximately 4.2 to 3.8 million years in the past, demonstrating a combination of characteristics similar to both apes and human beings. They were bipedal and had an ankle joint that allowed them to walk upright. Australopithecus afarensis, another member of the group, had apelike traits such as long arms with curved fingers but was also bipedal and had a small brain case. Their capability to walk standing and climb trees assisted them in surviving for nearly 900,000 years. Various studies have shown that food, BMI, habits, early puberty, use of pesticides, and environmental changes can all impact the incidence of diabetes. Domestication has allowed us (Homo Sapiens) to survive more efficiently, civilize more effectively and socialize more adequately. This natural course of evolution has taken and will continue to take millions of years. Future research and policy development may benefit from interdisciplinary approaches and a deeper exploration of the evolutionary aspects of human health.
    Keywords Evolution ; Metabolic diseases ; Human evolution ; Diabetes ; General works ; R5-130.5 ; Infectious and parasitic diseases ; RC109-216 ; Surgery ; RD1-811 ; Public aspects of medicine ; RA1-1270
    Subject code 121
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Student's Journal of Health Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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