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Article ; Online: Concise approach to γ-(het)aryl- and γ-alkenyl-γ-aminobutyric acids. Synthesis of vigabatrin.

Plodukhin, Andrey Yu / Boichenko, Maksim A / Andreev, Ivan A / Tarasenko, Elena A / Anisovich, Kanstantsin V / Ratmanova, Nina K / Zhokhov, Sergey S / Trushkov, Igor V / Ivanova, Olga A

Organic & biomolecular chemistry

2024 Volume 22, Issue 5, Page(s) 1027–1033

Abstract: γ-Aminobutyric acid (GABA) and GABA derivatives have attracted increased attention over the years in the fields of medicinal chemistry and chemical biology due to their interesting biological properties and synthetic relevance. Here, we report a short ... ...

Abstract	γ-Aminobutyric acid (GABA) and GABA derivatives have attracted increased attention over the years in the fields of medicinal chemistry and chemical biology due to their interesting biological properties and synthetic relevance. Here, we report a short synthetic route to γ-(het)aryl- and γ-alkenyl-γ-aminobutyric acids, including the antiepileptic drug
MeSH term(s)	Anticonvulsants/pharmacology ; gamma-Aminobutyric Acid ; Vigabatrin/pharmacology ; Pyrrolidines/chemistry ; Pyrrolidines/pharmacology
Chemical Substances	Anticonvulsants ; gamma-Aminobutyric Acid (56-12-2) ; Vigabatrin (GR120KRT6K) ; Pyrrolidines
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob01769a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: One-Step Synthesis of Magnetic Nanocomposite with Embedded Biologically Active Substance.

Ignatovich, Zhanna / Novik, Khristina / Abakshonok, Anna / Koroleva, Elena / Beklemisheva, Anna / Panina, Larisa / Kaniukov, Egor / Anisovich, Marina / Shumskaya, Alena

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 4

Abstract: Magnetic nanocomposites based on hydroxyapatite were prepared by a one-step process using the hydrothermal coprecipitation method to sinter iron oxides ( ... ...

Abstract	Magnetic nanocomposites based on hydroxyapatite were prepared by a one-step process using the hydrothermal coprecipitation method to sinter iron oxides (Fe
MeSH term(s)	Apoptosis ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Ferric Compounds/chemistry ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Magnetite Nanoparticles/administration & dosage ; Magnetite Nanoparticles/chemistry ; Nanocomposites/chemistry ; Pyrimidines/chemistry
Chemical Substances	Ferric Compounds ; Magnetite Nanoparticles ; Pyrimidines ; 2-aminopyrimidine (109-12-6) ; ferric oxide (1K09F3G675)
Language	English
Publishing date	2021-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26040937
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Boron and Gadolinium Loaded Fe

Korolkov, Ilya V / Zibert, Alexandr V / Lissovskaya, Lana I / Ludzik, K / Anisovich, M / Kozlovskiy, Artem L / Shumskaya, A E / Vasilyeva, M / Shlimas, Dmitriy I / Jażdżewska, Monika / Marciniak, Beata / Kontek, Renata / Chudoba, Dorota / Zdorovets, Maxim V

International journal of molecular sciences

2021 Volume 22, Issue 16

Abstract: In this article, a novel method of simultaneous carborane- and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency ... ...

Abstract	In this article, a novel method of simultaneous carborane- and gadolinium-containing compounds as efficient agents for neutron capture therapy (NCT) delivery via magnetic nanocarriers is presented. The presence of both Gd and B increases the efficiency of NCT and using nanocarriers enhances selectivity. These factors make NCT not only efficient, but also safe. Superparamagnetic Fe
MeSH term(s)	Boron/chemistry ; Boron/pharmacology ; Boron Neutron Capture Therapy/methods ; Cell Line, Tumor ; Cell Proliferation/radiation effects ; Cell Survival/radiation effects ; Dynamic Light Scattering ; Gadolinium/chemistry ; Gadolinium/pharmacology ; Humans ; MCF-7 Cells ; Magnetite Nanoparticles ; Microscopy, Electron, Scanning ; PC-3 Cells ; Particle Size ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
Chemical Substances	Magnetite Nanoparticles ; Gadolinium (AU0V1LM3JT) ; Boron (N9E3X5056Q)
Language	English
Publishing date	2021-08-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22168687
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Article ; Online: One-Step Synthesis of Magnetic Nanocomposite with Embedded Biologically Active Substance

Zhanna Ignatovich / Khristina Novik / Anna Abakshonok / Elena Koroleva / Anna Beklemisheva / Larisa Panina / Egor Kaniukov / Marina Anisovich / Alena Shumskaya

Molecules, Vol 26, Iss 4, p

2021 Volume 937

Abstract: Magnetic nanocomposites based on hydroxyapatite were prepared by a one-step process using the hydrothermal coprecipitation method to sinter iron oxides (Fe 3 O 4 and γ-Fe 2 O 3 ). The possibility of expanding the proposed technique for the synthesis of ... ...

Abstract	Magnetic nanocomposites based on hydroxyapatite were prepared by a one-step process using the hydrothermal coprecipitation method to sinter iron oxides (Fe 3 O 4 and γ-Fe 2 O 3 ). The possibility of expanding the proposed technique for the synthesis of magnetic composite with embedded biologically active substance (BAS) of the 2-arylaminopyrimidine group was shown. The composition, morphology, structural features, and magnetic characteristics of the nanocomposites synthesized with and without BAS were studied. The introduction of BAS into the composite synthesis resulted in minor changes in the structural and physical properties. The specificity of the chemical bonds between BAS and the hydroxyapatite-magnetite core was revealed. The kinetics of the BAS release in a solution simulating the stomach environment was studied. The cytotoxicity of (HAP)FexOy and (HAP)FexOy + BAS composites was studied in vitro using the primary culture of human liver carcinoma cells HepG2. The synthesized magnetic composites with BAS have a high potential for use in the biomedical field, for example, as carriers for magnetically controlled drug delivery and materials for bone tissue engineering.
Keywords	magnetic nanoparticles ; hydroxyapatite ; magnetite ; 2-arylaminopyrimidine derivatives ; targeted drug delivery ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MODERN EDUCATIONAL APPROACHES TO STUDYING OF MATERIALS SCIENCE

A. A. Andrushevich / A. G. Anisovich

Litʹë i Metallurgiâ, Vol 0, Iss 3, Pp 133-

2016 Volume 136

Abstract: Modern educational approaches to studying of discipline «Materials science and technologies of constructional materials» in educational activity of technical colleges during training engineers are considered. ...

Abstract	Modern educational approaches to studying of discipline «Materials science and technologies of constructional materials» in educational activity of technical colleges during training engineers are considered.
Keywords	materials science ; education techniques ; engineering ; Mining engineering. Metallurgy ; TN1-997
Language	English
Publishing date	2016-12-01T00:00:00Z
Publisher	Belarusian National Technical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [No title information]

Pavlyushchik, O O / Afonin, V Yu / Sarokina, V N / Chak, T A / Khapaliuk, A V / Anisovich, M V

TSitologiia i genetika

2018 Volume 50, Issue 5, Page(s) 48–58

Title translation	Association of the ace I/D gene polymorphism with DNA damage in hypertensive men.
MeSH term(s)	Adult ; Aspartic Acid/genetics ; Aspartic Acid/metabolism ; Case-Control Studies ; Cell Cycle/genetics ; Cell Death ; DNA Damage ; Essential Hypertension/enzymology ; Essential Hypertension/genetics ; Essential Hypertension/physiopathology ; Gene Expression ; Humans ; Isoleucine/genetics ; Isoleucine/metabolism ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Male ; Micronucleus Tests ; Middle Aged ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Polymorphism, Genetic ; Primary Cell Culture
Chemical Substances	Isoleucine (04Y7590D77) ; Aspartic Acid (30KYC7MIAI) ; ACE protein, human (EC 3.4.15.1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
Language	Russian
Publishing date	2018-11-27
Publishing country	Ukraine
Document type	Journal Article
ZDB-ID	390716-8
ISSN	0564-3783
ISSN	0564-3783
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: TOWARDS THE CONCEPT OF GLOBULAR PEARLITE

A. G. Anisovich / M. K. Stepankova / A. A. Andrushevich

Litʹë i Metallurgiâ, Vol 0, Iss 4, Pp 78-

2017 Volume 81

Abstract: Explanatory imprecisions of concept of globular pearlite and ferrite-carbide-mixture are considered. The need of concept binding of globular pearlite to specific grain with 0.8% carbon content is explained with the assistance of exemplary data obtained ... ...

Abstract	Explanatory imprecisions of concept of globular pearlite and ferrite-carbide-mixture are considered. The need of concept binding of globular pearlite to specific grain with 0.8% carbon content is explained with the assistance of exemplary data obtained at the present metallographic equipment. The question of educational material presentation concerning the process of teaching of discipline «Materials and construction materials technology» is discussed in relation to the educational process of technical universities, in particular, the Belarusian State Agrarian Technical University.
Keywords	materials science ; globular pearlite ; ferrite-carbide-mixture ; construction materials technology ; Mining engineering. Metallurgy ; TN1-997
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Belarusian National Technical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Simultaneous Immobilization of Gadolinium Ions and Di(o-carborano-1,2-dimethyl)borate on Fe3O4 Nanoparticles

I.V. Korolkov / A.V. Zibert / L.I. Lisovskaya / K. Ludzik / M.V. Anisovich / M.M. Vasilyeva / A.E. Shumskaya / A. Usseinov / A.B. Yeszhanov / M.V. Zdorovets

Қарағанды университетінің хабаршысы. Химия сериясы, Vol 106, Iss 2, Pp 87-

2022 Volume 94

Abstract: Neutron capture therapy is a promising method for cancer treatment based on the targeted delivery of specific isotopes into cancer cells and subsequent irradiation with epithermal neutrons. As a result, a large amount of energy is released at a distance ... ...

Abstract	Neutron capture therapy is a promising method for cancer treatment based on the targeted delivery of specific isotopes into cancer cells and subsequent irradiation with epithermal neutrons. As a result, a large amount of energy is released at a distance comparable to the size of the cell, destroying it from the inside. Magnetic iron oxide nanoparticles can be used for the targeted delivery of isotopes. In this article, iron oxide nanoparticles (Fe3O4) were modified with silanes and polyelectrolyte complexes for simultaneous immobilization of gadolinium ions and carborane compounds through ionic interaction for potential application in targeted delivery into cancer cells for neutron capture therapy. Structure, size and element composition was elucidated by the Fourier-transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDA), dynamic light scattering (DLS) and X-ray diffraction (XRD) analysis. It was found that, according to EDA, resulting nanoparticles consist of 15.4 % boron and 1.5 % gadolinium, with average hydrodynamical size of 386 nm measured by DLS. An in vitro cytotoxicity test using HepG2 (a cancer cell line) and human skin fibroblasts (a normal cell line) showed minor cytotoxicity in concentration range from 0.05 to 1 mg/mL.
Keywords	fe3o4 nanoparticles ; silane ; surface modification ; targeted delivery of payload ; bnct ; carborane ; cytotoxicity ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Academician Ye.A. Buketov Karaganda University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Flow-cytometric analysis of reactive oxygen species in cancer cells under treatment with brassinosteroids.

Kisselev, Pyotr A / Panibrat, Olesya V / Sysa, Aliaksei R / Anisovich, Marina V / Zhabinskii, Vladimir N / Khripach, Vladimir A

Steroids

2017 Volume 117, Page(s) 11–15

Abstract: To explore the underlying mechanism of cancer cell growth inhibition by brassinosteroids (BS), reactive oxygen species (ROS) generation under treatment with 28-homocastasterone and its synthetic derivatives (22S,23S)-28-homocastasterone was measured in ... ...

Abstract	To explore the underlying mechanism of cancer cell growth inhibition by brassinosteroids (BS), reactive oxygen species (ROS) generation under treatment with 28-homocastasterone and its synthetic derivatives (22S,23S)-28-homocastasterone was measured in A549 human lung adenocarcinoma cells. BS induced ROS generation in A549 cells and their growth in a time and dose-dependent manner. The maximal effect was observed for (22S,23S)-28-homocastasterone which at 30μM concentration showed a 6-fold increase of ROS generation in comparison with the control.
MeSH term(s)	A549 Cells ; Antineoplastic Agents/pharmacology ; Brassinosteroids/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Flow Cytometry ; Humans ; Reactive Oxygen Species/metabolism
Chemical Substances	Antineoplastic Agents ; Brassinosteroids ; Reactive Oxygen Species
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80312-1
ISSN	1878-5867 ; 0039-128X
ISSN (online)	1878-5867
ISSN	0039-128X
DOI	10.1016/j.steroids.2016.06.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 87: Show issues

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Book: Mesons and baryons

Anisovich, A.V

systematization and methods and analysis

2008

Author's details	A.V. Anisovich
Keywords	Baryons ; Mesons ; Quantum chromodynamics
Language	English
Size	XXII, 580 S., graph. Darst.
Publisher	World Scientific
Publishing place	Singapore u.a.
Document type	Book
Note	Literaturangaben
ISBN	9789812818256 ; 9812818251
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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