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  1. Article ; Online: Lessons Learnt from the ICMR-INDIAB Study.

    Mohan, Viswanathan / Anjana, Ranjit Mohan / Tandon, Nikhil

    The National medical journal of India

    2024  Volume 36, Issue 3, Page(s) 137–139

    Language English
    Publishing date 2024-04-29
    Publishing country India
    Document type Editorial
    ZDB-ID 645116-0
    ISSN 2583-150X ; 0970-258X
    ISSN (online) 2583-150X
    ISSN 0970-258X
    DOI 10.25259/NMJI_655_23
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    Zs.A 2493: Show issues Location:
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  2. Article ; Online: Recent studies on hypertension prevalence and control in India 2023.

    Gupta, Rajeev / Gaur, Kiran / Ahuja, Shiva / Anjana, Ranjit Mohan

    Hypertension research : official journal of the Japanese Society of Hypertension

    2024  

    Abstract: Hypertension is the most important chronic disease risk factor in India. Recent epidemiological studies have reported that hypertension is increasing in India with a more rapid increase in rural and young populations. Fifth National Family Health Survey ( ...

    Abstract Hypertension is the most important chronic disease risk factor in India. Recent epidemiological studies have reported that hypertension is increasing in India with a more rapid increase in rural and young populations. Fifth National Family Health Survey (NFHS-5) and Indian Council of Medical Research-INDIAB surveys have reported that there are substantial geographic variations in hypertension prevalence with greater prevalence in more developed states and districts of the country. There is a high prevalence of young-age hypertension, especially in the less developed states. The incidence of adverse events from hypertension-related cardiovascular disease is significantly greater in India than in more developed countries. A low level of hypertension awareness, treatment, and control, especially in rural and underserved urban populations is an important finding. In this narrative review, we highlight recent nationwide studies and unique features of hypertension in India and suggest strategies for better hypertension management and control.
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-024-01585-y
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  3. Article ; Online: Comment on Rooney et al. Global Prevalence of Prediabetes. Diabetes Care 2023;46:1388-1394.

    Mohan, Viswanathan / Unnikrishnan, Ranjit / Anjana, Ranjit Mohan

    Diabetes care

    2023  Volume 46, Issue 12, Page(s) e220

    MeSH term(s) Humans ; Prediabetic State/epidemiology ; Prevalence ; Diabetes Mellitus, Type 2/epidemiology ; Glycated Hemoglobin
    Chemical Substances Glycated Hemoglobin
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc23-1606
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  4. Article: Early Gestational Diabetes Mellitus: An Update.

    Hannah, Wesely / Pradeepa, Rajendra / Anjana, Ranjit Mohan / Uma, Ram / Tiwaskar, Mangesh / Mohan, Viswanathan

    The Journal of the Association of Physicians of India

    2024  Volume 71, Issue 9, Page(s) 101–103

    Abstract: Hyperglycemia occurring in pregnancy is a growing burden worldwide. It is now standard of care to screen all women during pregnancy, both to detect preexisting diabetes as well as gestational diabetes mellitus (GDM). Traditionally, GDM was diagnosed at ... ...

    Abstract Hyperglycemia occurring in pregnancy is a growing burden worldwide. It is now standard of care to screen all women during pregnancy, both to detect preexisting diabetes as well as gestational diabetes mellitus (GDM). Traditionally, GDM was diagnosed at 24-28 weeks. However, with many international bodies recommending screening at first contact or booking, we are now diagnosing GDM earlier on in pregnancy. Based on the time of gestation at which it is diagnosed, GDM can be classified as conventional gestational diabetes mellitus (cGDM) or early gestational diabetes mellitus (eGDM). The cGDM is diagnosed between 24 and 28 weeks of gestation while eGDM is diagnosed in early pregnancy (<20 weeks). Till recently, there was little and conflicting evidence, on whether diagnosing and treating eGDM was beneficial or safe. The recent Treatment of BOoking Gestational diabetes Mellitus (ToBOGM) study, was a randomized control trial, showing clear benefits of diagnosing and treating eGDM. ToBOGM also showed that the best results were seen in those screened before 14 weeks of pregnancy and those in the higher band of glucose levels (FPG 95-109 mg/dL, 1-hour >191 mg/dL, and 2-hour glucose 162-199 mg/dL). In India, where the burden of hyperglycemia in pregnancy is high, the findings from the ToBOGM study further emphasize the need for screening for GDM at the time of first booking of the pregnancy followed by appropriate treatment for those detected to have eGDM. How to cite this article: Hannah W, Pradeepa R, Anjana RM, et al. Early Gestational Diabetes Mellitus: An Update. J Assoc Physicians India 2023;71(9):101-103.
    MeSH term(s) Humans ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/therapy ; Pregnancy ; Female ; India/epidemiology ; Glucose Tolerance Test ; Blood Glucose/analysis ; Early Diagnosis
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2024-05-03
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    DOI 10.59556/japi.71.0351
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  5. Article ; Online: Performance of European prediction models for classification of type 1 and type 2 diabetes in Indians.

    Venkatesan, Ulagamadesan / Amutha, Anandakumar / Jones, Angus G / Shields, Beverley M / Anjana, Ranjit Mohan / Unnikrishnan, Ranjit / Mappillairaju, Bagavandas / Mohan, Viswanathan

    Diabetes & metabolic syndrome

    2024  Volume 18, Issue 4, Page(s) 103007

    Abstract: Aim: We aimed to determine the performance of European prediction models in an Indian population to classify type 1 diabetes(T1D) and type 2 diabetes(T2D).: Methods: We assessed discrimination and calibration of published models of diabetes ... ...

    Abstract Aim: We aimed to determine the performance of European prediction models in an Indian population to classify type 1 diabetes(T1D) and type 2 diabetes(T2D).
    Methods: We assessed discrimination and calibration of published models of diabetes classification, using retrospective data from electronic medical records of 83309 participants aged 18-50 years living in India. Diabetes type was defined based on C-peptide measurement and early insulin requirement. Models assessed combinations of clinical measurements: age at diagnosis, body mass index(mean = 26.6 kg/m
    Results: 67955 participants met inclusion criteria, of whom 0.8 % had T1D, which was markedly lower than model development cohorts. Model discrimination for clinical features was broadly similar in our Indian cohort compared to the European cohort: area under the receiver operating characteristic curve(AUC ROC) was 0.90 vs. 0.90 respectively, but was lower in the subset of young participants with measured GAD antibodies(n = 2404): and an AUC ROC of 0.87 when clinical features, sex, lipids and GAD antibodies were combined. All models substantially overestimated the likelihood of T1D, reflecting the lower prevalence of T1D in the Indian population. However, good model performance was achieved after recalibration by updating the model intercept and slope.
    Conclusion: Models for diabetes classification maintain the discrimination of T1D and T2D in this Indian population, where T2D is far more common, but require recalibration to obtain appropriate model probabilities. External validation and recalibration are needed before these tools can be used in non-European populations.
    Language English
    Publishing date 2024-04-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2024.103007
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  6. Article ; Online: Construct validity of the 12-item Short Form Health Survey (SF-12) version 2 and the impact of lifestyle modifications on the health-related quality of life among Indian adults with prediabetes: results from the D-CLIP trial.

    Pyo, Euisun / Weber, Mary Beth / Sivaram, Jayalakshmi / Staimez, Lisa R / Mohan, Viswanathan / Anjana, Ranjit Mohan / Haardörfer, Regine / Ranjani, Harish

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

    2024  

    Abstract: Purpose: This study aimed to validate the factor structure of the 12-item Short-Form (SF-12) health-related quality of life (HRQOL) survey for Indian adults and assess the impact of lifestyle modification on the SF-12 of Indian adults with prediabetes.!# ...

    Abstract Purpose: This study aimed to validate the factor structure of the 12-item Short-Form (SF-12) health-related quality of life (HRQOL) survey for Indian adults and assess the impact of lifestyle modification on the SF-12 of Indian adults with prediabetes.
    Methods: To validate the context-specific construct of the SF-12, two-factor confirmatory factor analysis (CFA) was performed using data from 1285 adults residing in Chennai, India, who screened for the Diabetes Community Lifestyle Improvement Program (D-CLIP). D-CLIP was a randomized controlled trial of 578 participants with prediabetes (283 treatment, 293 control), focusing on the effect of lifestyle modifications on the prevention of diabetes. Physical and mental component scores (PCS and MCS) were computed by using CFA standardized factor loadings. Multiple linear regression was subsequently conducted to estimate the effect of lifestyle modification on post-study changes of PCS and MCS among D-CLIP participants.
    Results: Cronbach's alpha and CFA fit indices demonstrated acceptable reliability and model fit of the SF-12 for Indian adults. The intervention group showed greater mean change in PCS after study participation compared to the controls (1.63 ± 0.82, p = 0.046); no significant difference was observed for MCS between two groups (1.00 ± 0.85, p = 0.242).
    Conclusion: The study confirmed that the SF-12 is suitable for assessing the physical and mental health dimensions of HRQOL for Indian adults. Our findings suggest that the benefits of diabetes prevention lifestyle modification strategies may primarily enhance the physical well-being of adults with prediabetes. Further studies validating the SF-12 in a broader Asian Indian population are needed.
    Trial registration: Clinicaltrials.gov, NCT01283308.
    Language English
    Publishing date 2024-04-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1161148-0
    ISSN 1573-2649 ; 0962-9343
    ISSN (online) 1573-2649
    ISSN 0962-9343
    DOI 10.1007/s11136-024-03648-6
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    Zs.A 3796: Show issues Location:
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  7. Article ; Online: Metabolic non-communicable diseases in India: time to act - Authors' reply.

    Anjana, Ranjit Mohan / Unnikrishnan, Ranjit / Pradeepa, Rajendra / Deepa, Mohan / Mohan, Viswanathan

    The lancet. Diabetes & endocrinology

    2023  Volume 11, Issue 12, Page(s) 898–899

    MeSH term(s) Humans ; Noncommunicable Diseases/epidemiology ; India/epidemiology
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Letter
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(23)00296-6
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  8. Article ; Online: Challenges in implementing nationwide epidemiological studies on metabolic non-communicable diseases in low-income and middle-income countries.

    Anjana, Ranjit Mohan / Elangovan, Nirmal / Pradeepa, Rajendra / Deepa, Mohan / Unnikrishnan, Ranjit / Mohan, Viswanathan

    The lancet. Diabetes & endocrinology

    2023  Volume 11, Issue 12, Page(s) 889–891

    MeSH term(s) Humans ; Developing Countries ; Noncommunicable Diseases/epidemiology ; Poverty ; Epidemiologic Studies
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(23)00284-X
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  9. Article: Remission of Type 2 Diabetes: How, When, and for Whom?

    Salis, Sheryl / Anjana, Ranjit Mohan / Unnikrishnan, Ranjit / Syed, Shefa / Mohan, Viswanathan

    The Journal of the Association of Physicians of India

    2022  Volume 70, Issue 8, Page(s) 11–12

    Abstract: Type 2 diabetes (T2DM) is conventionally considered a progressive disorder, with most patients requiring increasingly intensive therapy to control hyperglycemia over time. Recently, there has been a major paradigm shift towards trying to reverse T2DM. ... ...

    Abstract Type 2 diabetes (T2DM) is conventionally considered a progressive disorder, with most patients requiring increasingly intensive therapy to control hyperglycemia over time. Recently, there has been a major paradigm shift towards trying to reverse T2DM. Emerging evidence suggests that remission of T2DM is feasible in a subset of patients. Identification and careful selection of candidates for remission are crucial for the success of these programs. Among various dietary strategies, low-calorie diets (LCDs) and low-carbohydrate diets (LCBDs) have been demonstrated as being effective in facilitating remission of T2DM in a targeted population within a clinical setting. Remission with LCBDs may be maintained in the absence of weight loss, however, long-term evidence is limited and remission may not be maintained without long-term carbohydrate restriction, which poses major challenges. In very low-calorie diets (VLCDs), weight loss of 15 kg or greater and maintenance of weight loss is the main driver and predictor of remission. However, most individuals with T2DM were unable to maintain remission beyond 2 years, despite being on VLCDs. More data are required on the long-term sustainability of remission in an ethnically diverse population like Asian Indians with T2DM who have less obesity and hence less weight to lose. Moreover, "re-reversal" or "relapse" of diabetes can occur in a large percentage of individuals who discontinue the dietary restrictions. Hence, regular follow-up by a multi-disciplinary team to ensure sustainability of the lifestyle modification is crucial to the maintenance of remission of T2DM.
    MeSH term(s) Diabetes Mellitus, Type 2/therapy ; Humans ; Hyperglycemia ; Life Style ; Obesity ; Remission Induction ; Treatment Outcome ; Weight Loss
    Language English
    Publishing date 2022-09-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    DOI 10.5005/japi-11001-0078
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  10. Article: Severe acute respiratory syndrome coronavirus-2 IgG antibody response to coronavirus disease 2019 vaccination in South Indian health-care professionals with and without coronavirus disease 2019 exposure.

    Jayashri, Ramamoorthy / Velmurugan, Kaliyaperumal / Jayanthi, Chakrapani / Anjana, Ranjit Mohan / Unnikrishnan, Ranjit / Mohan, Viswanathan

    Perspectives in clinical research

    2022  Volume 13, Issue 3, Page(s) 174–175

    Language English
    Publishing date 2022-06-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2593231-7
    ISSN 2229-5488 ; 2229-3485
    ISSN (online) 2229-5488
    ISSN 2229-3485
    DOI 10.4103/picr.picr_62_22
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