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  1. Article ; Online: Direct Prediction of the Number of Intensive Care Beds and Ventilators it Will be Needed for COVID-19 Outbreak in Turkey ; Türkiye’de COVID-19 Salgın Sürecinde İhtiyaç Duyulacak Yoğun Bakım Yatak ve Solunum Cihazı Sayılarının Direkt Tahmini

    ANKARALI, Handan

    Issue: Special Issue on COVID 19 59-62 ; 2149-5254 ; 2458-8849 ; Anatolian Clinic the Journal of Medical Sciences

    2020  

    Abstract: Introduction and Aim: Because the number of coronavirus cases has increased day by day in Turkey, , evidence-based prediction of the needs in the provision of health services and particularly critical/seriously patient needs is of paramount importance. ... ...

    Abstract Introduction and Aim: Because the number of coronavirus cases has increased day by day in Turkey, , evidence-based prediction of the needs in the provision of health services and particularly critical/seriously patient needs is of paramount importance. In this study, it was aimed to predict the number of intensive care beds and breathing apparatus with the help of two different models.Materials and Methods: Data were analyzed with Gompertz and Time series models.Results: The forecasting of the models used in the study were found similar. Since a few data are used in model development (13 days), only 1 week forecasts were given. While the total number of intensive care beds according to the Gompertz model on April 6 was 1474, this number was forecast as 1485 in the time series model. The number of ventilators that will be needed on the same date was 1000 according to the Gompertz model and 1004 according to the time series model.Conclusion: When the number of data (days) exceeds 30, the mathematical models used will increase the success in the future long-term forecasts as they will better catch the trend.

    Giriş ve Amaç: COVID-19 salgın sürecinde, Türkiye’ de vaka sayısının hızlı artış periyoduna girdiği bu günlerde, sunulan sağlık hizmetlerindeki ihtiyaçların ve özellikle hayati önem taşıyan hasta ihtiyaçlarının kanıta dayalı öngörüsü büyük önem taşımaktadır. Bu çalışmada, karşılaştırmalı olarak iki farklı model yardımıyla yoğun bakım yatak ve solunum cihazı sayılarının öngörülmesi amaçlandı. Gereç ve Yöntemler: Veriler, Gompertz ve Zaman serileri modelleri ile incelendi. Bulgular: Çalışmada kullanılan modellerin öngörü başarıları benzer bulundu. Ancak modellemede kullanılan veri sayısının az olması nedeniyle (13 gün) sadece 1 haftalık öngörüler verildi. Gompertz modeline göre 6 Nisan’ da öngörülen toplam yoğun bakım yatak sayısı 1474 iken zaman serisi modelinde 1485 bulundu. Aynı tarihte ihtiyaç duyulacak solunum cihazı sayısı Gompertz modeline göre 1000, zaman serisi modeline göre 1004 olarak hesaplandı.Sonuç: Veri sayısı (gün sayısı) 30’ un üzerine çıktığı zaman kullanılan matematiksel modeller, eğilimi daha iyi yakalayacağı için ileriye dönük uzun süreli tahminlerdeki başarıları artacaktır.
    Keywords COVID-19,intensive care unit,ventilator,Gomperz model,Time series ; COVID-19,Yoğun bakım ünitesi,ventilatör,Gomperz modeli,Zaman serileri ; covid19
    Language Turkish
    Publishing date 2020-03-20T00:00:00Z
    Publisher Hayat Sağlık ve Sosyal Hizmetler Vakfı
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Sars-Cov-2 virus and vaccination; biological and statistical framework.

    Arslan, Ferhat / Ankaralı, Handan

    Expert review of vaccines

    2021  Volume 20, Issue 9, Page(s) 1059–1063

    Abstract: Introduction: The Development of the SARS-CoV-2 virus vaccine and its update on an ongoing pandemic is the first subject of the world health agenda.: Areas covered: First, we will scrutinize the biological features of the measles virus (MV), variola ... ...

    Abstract Introduction: The Development of the SARS-CoV-2 virus vaccine and its update on an ongoing pandemic is the first subject of the world health agenda.
    Areas covered: First, we will scrutinize the biological features of the measles virus (MV), variola virus (smallpox virus), influenza virus, and their vaccines to compare them with the SARS-CoV-2 virus and vaccine. Next, we will discuss the statistical details of measuring the effectiveness of an improved vaccine.
    Expert opinion: Amidst the pandemic, we ought to acknowledge our prior experiences with respiratory viruses and vaccines. In the planning stage of observational Phase-III vaccine effectiveness studies, the sample size, sampling method, statistical model, and selection of variables are crucial in obtaining high-quality and valid results.
    MeSH term(s) COVID-19/pathology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Humans ; Immunity, Cellular/immunology ; Influenza Vaccines/immunology ; Mass Vaccination/methods ; Measles virus/immunology ; Measles-Mumps-Rubella Vaccine/immunology ; Orthomyxoviridae/immunology ; SARS-CoV-2/immunology ; Smallpox Vaccine/immunology ; Vaccination ; Vaccines, Attenuated/immunology ; Variola virus/immunology
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines ; Measles-Mumps-Rubella Vaccine ; Smallpox Vaccine ; Vaccines, Attenuated
    Language English
    Publishing date 2021-08-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2021.1965884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Is increased activator protein 1 in cerebrospinal fluid as a potential biomarker that distinguishes idiopathic intracranial hypertension from multiple sclerosis?

    Karabork, Seyda / Celik, Humeyra / Dursun, Ali Dogan / Ankarali, Handan / Turkoglu, Sule Aydin

    Bratislavske lekarske listy

    2024  Volume 125, Issue 6, Page(s) 382–386

    Abstract: Objectives: To distinguish whether idiopathic intracranial hypertension (IIH) is a condition predisposing to multiple sclerosis (MS) or an isolated disease, the current gene transcription factor Activator Protein-1 (AP-1) was evaluated with its ... ...

    Abstract Objectives: To distinguish whether idiopathic intracranial hypertension (IIH) is a condition predisposing to multiple sclerosis (MS) or an isolated disease, the current gene transcription factor Activator Protein-1 (AP-1) was evaluated with its potential to differentiate both diseases.
    Background: The aim of this study was to investigate the use of AP-1 as biomarkers for the discrimination of IIH and MS.
    Methods: AP-1, TNF-α, and IL-6 protein values in the CSF of the cases were evaluated by the ELISA method. The numerical measures of the groups and the ability of AP-1 to distinguish the groups were analyzed with the ROC curve.
    Results: There was no difference between the groups in CSF TNF-α, IL-6, CSF, and serum biochemistry analyses. However, it was determined that the AP-1 concentration (pg/ml) was significantly higher in the IIH group, the sensitivity of AP-1 in separating those with IIH was 75%, and the specificity in separating those with MS was 60% in those with an AP-1 concentration of 606.5 and above.
    Conclusion: According to our results, the fact that CSF TNF-α and IL-6 values did not differ in IIH compared to MS revealed that IIH could not methodologically control MS, and AP-1 was a supportive parameter in differentiating both diseases (Tab. 2, Fig. 1, Ref. 31).
    MeSH term(s) Humans ; Biomarkers/cerebrospinal fluid ; Interleukin-6/cerebrospinal fluid ; Multiple Sclerosis/cerebrospinal fluid ; Multiple Sclerosis/diagnosis ; Adult ; Female ; Diagnosis, Differential ; Male ; Transcription Factor AP-1/cerebrospinal fluid ; Transcription Factor AP-1/metabolism ; Tumor Necrosis Factor-alpha/cerebrospinal fluid ; Pseudotumor Cerebri/cerebrospinal fluid ; Pseudotumor Cerebri/diagnosis ; Sensitivity and Specificity ; Middle Aged ; ROC Curve
    Language English
    Publishing date 2024-05-17
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 127421-1
    ISSN 0006-9248
    ISSN 0006-9248
    DOI 10.4149/BLL_2024_58
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Examination of posture and balance in children with primary monosymptomatic nocturnal enuresis.

    Inal, Busra / Ozengin, Nuriye / Bakar, Yesim / Ankaralı, Handan / Ozturk, Yusuf

    Journal of pediatric rehabilitation medicine

    2023  Volume 16, Issue 3, Page(s) 529–537

    Abstract: Purpose: This study aimed to examine symptom severity, posture, and balance of children with primary monosymptomatic nocturnal enuresis (PMNE) and compare to a healthy control group.: Methods: Thirty-five children with PMNE and 34 healthy children ... ...

    Abstract Purpose: This study aimed to examine symptom severity, posture, and balance of children with primary monosymptomatic nocturnal enuresis (PMNE) and compare to a healthy control group.
    Methods: Thirty-five children with PMNE and 34 healthy children were included in this study. Physical and sociodemographic characteristics of the children were recorded. Symptom severity was assessed with a Vancouver Non-Neurogenic Lower Urinary Tract Dysfunction/Dysfunctional Elimination Syndrome Questionnaire (NLUTD/DES), a four-day bladder diary and a seven-day bowel diary. Standing postural alignment was assessed with the Spinal Mouse device, and the sensory integration of static balance and dynamic standing balance was assessed with the Biodex Balance System SD.
    Results: Compared to healthy controls, children with PMNE demonstrated increased symptom severity (p = 0.001), increased upright lumbar lordosis (p = 0.018) and sacral-hip angles (p = 0.029), decreased static balance in the sensory condition of unstable surface with eyes closed (p = 0.001), and decreased mediolateral dynamic balance (p = 0.049).
    Conclusion: Children with PMNE demonstrate altered postural alignment, static and dynamic postural instability, and greater symptom severity on the Vancouver NLUTD/DES than age-matched controls.
    MeSH term(s) Humans ; Child ; Animals ; Mice ; Nocturnal Enuresis/diagnosis ; Urinary Bladder ; Physical Examination ; Posture ; Standing Position
    Language English
    Publishing date 2023-01-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2403637-7
    ISSN 1875-8894 ; 1874-5393
    ISSN (online) 1875-8894
    ISSN 1874-5393
    DOI 10.3233/PRM-210105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Statistical Model for Early Recognition of Patients Requiring Transfer to Palliative Care (ERPAC).

    Dogu, Cihangir / Karcioglu, Ayse Muge / Turan, Isil Ozkocak / Ankarali, Handan

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2023  Volume 33, Issue 3, Page(s) 261–265

    Abstract: Objective: To develop a scoring system to identify patients at an early stage who will need palliative care during intensive care follow-up.: Study design: Analytical study.: Place and duration of study: Ankara City Hospital, Neurology and ... ...

    Abstract Objective: To develop a scoring system to identify patients at an early stage who will need palliative care during intensive care follow-up.
    Study design: Analytical study.
    Place and duration of study: Ankara City Hospital, Neurology and Orthopaedics Hospital, General Intensive Care Unit, Ankara, Turkiye, from June 2019 to March 2020.
    Methodology: Intensive care patients were enrolled and divided into palliative care transfer (p1) and nontransfer groups (p2). The predicted logit value / probality score was calculated and a scoring system was developed, using the formula value, [logit= -3.275 + 0.194 (days of hospitalisation) - 0.345 (SOFAmax) +1.659 (ward admission) + 2.08 (cancer)].
    Results: One hundred and thirty five patients were analysed. Sixty-eight (50.4%) were males. The mean age was 67.2 ± 17.2 years. Length of hospital stay (p<0.001), highest sequential organ failure score (SOFAmax, p<0.001), previous hospitalisation (p=0.015), and cancer history (p=0.009) affect the need for palliative care significantly.  Predicted probability = epredicted togit / 1+epredicted logit If predicted probabilty >0.5, patient was candidate for palliative care transfer.
    Conclusion:  Every intensive care unit can calculate its own logit value and represent ERPAC score. ERPAC scores can predict which patients will be transferred to palliative care. Predictedlogit value will help to recognise which patients will need palliative care at an early stage.
    Key words: Palliative care, Scoring, Intensive care.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Palliative Care ; Hospitalization ; Intensive Care Units ; Models, Statistical ; Neoplasms/therapy ; Retrospective Studies
    Language English
    Publishing date 2023-03-22
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2023.03.261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Assessment of the dissimilarities of totally 186 countries and regions according to COVID-19 indicators at the end of March 2020.

    Ankarali, Handan / Uslu, Unal / Ankarali, Seyit / Cangur, Sengul

    Malawi medical journal : the journal of Medical Association of Malawi

    2022  Volume 34, Issue 2, Page(s) 73–86

    Abstract: Background: This study is aimed at evaluating the relationship between the number of days elapsed since a country's first case(s) of coronavirus disease 2019 (COVID-19), the total number of tests conducted, and outbreak indicators such as the total ... ...

    Abstract Background: This study is aimed at evaluating the relationship between the number of days elapsed since a country's first case(s) of coronavirus disease 2019 (COVID-19), the total number of tests conducted, and outbreak indicators such as the total numbers of cases, deaths, and patients who recovered. The study compares COVID-19 indicators among countries and clusters them according to similarities in the indicators.
    Methods: Descriptive statistics of the indicators were computed and the results were presented in figures and tables. A fuzzy
    Results: The highest numbers of COVID-19 cases were found in Gibraltar, Spain, Switzerland, Liechtenstein and Italy were also of that order with about 1500 cases per million population. Spain and Italy had the highest total number of deaths, which were about 140 and 165 per million population, respectively. In Japan, where exposure to the causative virus was longer than in most other countries, the total number of deaths per million population was less than 0.5. According to cluster analysis, the total numbers of deaths, patients who recovered, and active cases were higher in Western countries, especially in central and southern European countries, which had the highest numbers when compared with other countries.
    Conclusion: There may be various reasons for the differences between the clusters obtained by fuzzy
    MeSH term(s) COVID-19/epidemiology ; Health Policy ; Humans ; Quarantine
    Language English
    Publishing date 2022-01-18
    Publishing country Malawi
    Document type Journal Article
    ZDB-ID 2491952-4
    ISSN 1995-7270 ; 1995-7270
    ISSN (online) 1995-7270
    ISSN 1995-7270
    DOI 10.4314/mmj.v34i2.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The relationship between aerobic capacity and cognitive/academic performance in medical students.

    Bayramlar, Zeynep / Ankarali, Seyit / Ankarali, Handan

    General physiology and biophysics

    2022  Volume 41, Issue 6, Page(s) 579–590

    Abstract: The positive relationship between aerobic capacity and cognitive performance is well known, but there is little information regarding young adults. Therefore, we aimed to test the hypothesis that aerobic capacity (VO2max) correlates with cognitive and ... ...

    Abstract The positive relationship between aerobic capacity and cognitive performance is well known, but there is little information regarding young adults. Therefore, we aimed to test the hypothesis that aerobic capacity (VO2max) correlates with cognitive and academic performance in medical students who have higher academic achievement with academic performance. We included 65 volunteer medical students who were in term 2/6 in this descriptive, cross-sectional study. Body composition and the International Physical Activity Questionnaire and cardiopulmonary exercise test results of all participants were analyzed. Lumosity application with 6 categories of cognitive tests was applied to evaluate cognitive performance. The university entrance exam scores of the students were taken into consideration to assess their academic performance. We observed a significant "positive" relationship between aerobic capacity and some domains of cognitive performance, especially problem solving (p < 0.05), but we did not find a significant relationship between aerobic capacity and academic performance. Consequently, although we confirmed the existence of a positive effect of high aerobic capacity on cognitive performance stated in the literature, we couldn't confirm this for all cognitive domains or academic performance. These results suggest that more comprehensive studies on this subject are needed.
    MeSH term(s) Young Adult ; Humans ; Students, Medical ; Cross-Sectional Studies ; Academic Performance ; Cognition
    Language English
    Publishing date 2022-11-08
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 791184-1
    ISSN 0231-5882
    ISSN 0231-5882
    DOI 10.4149/gpb_2022031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Does Pilates effect on depression status, pain, functionality, and quality of life in university students? A randomized controlled study.

    Saltan, Asuman / Ankaralı, Handan

    Perspectives in psychiatric care

    2020  Volume 57, Issue 1, Page(s) 198–205

    Abstract: Purpose: The aim of this study is to investigate the effects of Pilates exercise program on health-related quality of life, pain, functional level, and depression status in university students.: Design and methods: The exercise programs were carried ... ...

    Abstract Purpose: The aim of this study is to investigate the effects of Pilates exercise program on health-related quality of life, pain, functional level, and depression status in university students.
    Design and methods: The exercise programs were carried out for 12 weeks. The scales of Nottingham Health Profile, Visual Analog Scale, Oswestry Disability Index, and Beck Depression Inventory were used at the baseline and after training.
    Findings: Exercise should be encouraged to reduce pain and depression and improve the quality of life in healthy university students. Both Pilates and therapeutic exercises approach can be preferred.
    Practice implications: The results of this study show the inability to identify clear different effects from therapeutic exercises on university students for Pilates exercises.
    MeSH term(s) Adolescent ; Adult ; Depression/psychology ; Depression/therapy ; Exercise Movement Techniques ; Female ; Humans ; Male ; Pain/psychology ; Pain Management ; Quality of Life ; Students/psychology ; Universities ; Young Adult
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 391097-0
    ISSN 1744-6163 ; 0031-5990
    ISSN (online) 1744-6163
    ISSN 0031-5990
    DOI 10.1111/ppc.12547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Anxiety and Depression among People Living with HIV During the COVID-19 Pandemic: A Face-to-Face Survey from Turkey.

    Ergen, Pınar / Görmez, Aynur / Ankaralı, Handan / Aydın, Özlem / Baysal, Naciye Betül / Çağ, Yasemin

    Psychiatria Danubina

    2023  Volume 35, Issue 1, Page(s) 103–111

    Abstract: Background: During the COVID-19 pandemic, there have been some difficulties in the routine care of people living with HIV (PLWH).: Subjects and methods: We aimed to evaluate the impact of COVID-19 on mental health of PLWH and their use of health ... ...

    Abstract Background: During the COVID-19 pandemic, there have been some difficulties in the routine care of people living with HIV (PLWH).
    Subjects and methods: We aimed to evaluate the impact of COVID-19 on mental health of PLWH and their use of health services. This study was conducted using the face-to-face interview method in the outpatient clinic of a university hospital, between 01.09.2020 and 30.11.2020. Hospital Anxiety and Depression Scale and survey instrument designed by the researchers investigating socio-demographic data and access to health services were used.
    Results: The study included 217 patients, 91.7% (n=199) of whom were male. All of the patients were postponed their hospital appointments, 60.8% were concerned about not being able to contact their physician and 53% had concerned about being stigmatized if they went to the hospital. Of the participants, 27.6% had depression, 12.9% had anxiety and 8.3% had both depression and anxiety. Low income, job loss, and fear of being stigmatized were associated with depression and anxiety. Lower level of education, discontinuation of medications and lack of opportunity to work remotely were associated with depression, while history of psychiatric illness, worry about not being able to contact their physician and cessation of antiretroviral therapy were associated with higher anxiety levels.
    Conclusion: It is important to develop strategies ensuring the continuity of care for PWLH and identify and support those with a higher mental health impact.
    MeSH term(s) Humans ; Male ; Female ; COVID-19/epidemiology ; COVID-19/complications ; Depression/epidemiology ; Depression/psychology ; Turkey/epidemiology ; Pandemics ; Anxiety/epidemiology ; Anxiety/psychology ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/complications
    Language English
    Publishing date 2023-04-15
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1067580-2
    ISSN 0353-5053
    ISSN 0353-5053
    DOI 10.24869/psyd.2023.103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The evaluation of risk factors related to reduced bone mineral density in young people living with HIV.

    Aydın, Özlem / Ankaralı, Handan / Ergen, Pınar / Baysal, Naciye Betül / Çağ, Yasemin

    African health sciences

    2023  Volume 22, Issue 4, Page(s) 461–469

    Abstract: Background: Low bone mineral density (BMD) is one of the comorbidities that develop in people living with HIV (PLWHIV).: Objective: This study was conducted to review the frequency and risk factors of reduced BMD according to age in HIV-infected ... ...

    Abstract Background: Low bone mineral density (BMD) is one of the comorbidities that develop in people living with HIV (PLWHIV).
    Objective: This study was conducted to review the frequency and risk factors of reduced BMD according to age in HIV-infected patients in Turkey.
    Material and method: This retrospective cohort study included HIV-infected patients aged 18-50. Bone density was analysed using dual-energy X-ray absorptiometry (DXA) according to the Z-score in three different regions including the lumbar, total-hip and femoral-neck.
    Results: The study included 224 PLWHIV with a mean age of 35.84-7.54, and 59.8% were ART naive. Of the patients, 40.6% had lower BMD than expected at least in one of the three examined regions including the lumbar, total hip and femoral neck. The low BMD ratios were found respectively as 11.6%, 11.6% and 28.6% in the femoral neck, total hip and lumbar regions. According to the logistic regression model, a high body mass index (p=0.003) and HIV-RNA level of ≥100.000IU/ml during the diagnosis in the ART-naive group (p=0.008) were associated with reduced bone demineralization. The low BMD frequency was high in the group that received ART for <24 months (p=0.001).
    Conclusion: Performing bone demineralization screening in the naive and young patient group, independently from ART status prior to making the diagnosis of HIV is important for organizing the bone health improvement methods.
    MeSH term(s) Adolescent ; Adult ; Humans ; Bone Density ; Bone Diseases, Metabolic/etiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Retrospective Studies ; Risk Factors ; Young Adult ; Middle Aged
    Language English
    Publishing date 2023-04-25
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2240308-5
    ISSN 1729-0503 ; 1680-6905
    ISSN (online) 1729-0503
    ISSN 1680-6905
    DOI 10.4314/ahs.v22i4.52
    Database MEDical Literature Analysis and Retrieval System OnLINE

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