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  1. Article ; Online: Mustadi Yapana Basti (medicated enema) in the management of oligozoospermia

    Ankur Kumar Tanwar / Sujata Rajan / Manoj Kumar Shamkuwar

    Indian Journal of Health Sciences and Biomedical Research KLEU, Vol 16, Iss 2, Pp 298-

    A case series

    2023  Volume 304

    Abstract: Infertility is a global issue of concern in the modern era, affecting 8%–12% of couples globally. Although the etiology of infertility is varied and difficult to determine, a good proportion of cases can be attributed to male. The most common cause of ... ...

    Abstract Infertility is a global issue of concern in the modern era, affecting 8%–12% of couples globally. Although the etiology of infertility is varied and difficult to determine, a good proportion of cases can be attributed to male. The most common cause of male infertility is oligozoospermia. Oligozoospermia is a decrease in sperm concentration below 15 million sperm/ml in semen ejaculate. Shukra Kshaya is a similar clinical condition mentioned in Ayurveda in which the Shukra Dhatu is diminished both qualitatively and quantitatively. Ayurveda has specified many therapeutic interventions and practices, including the Panchakarma procedure, Basti Karma, for the strengthening of Shukra Dhatu as well as the management of Shukra-Dusht. Mustadi Yapana Basti (MYB) was chosen for this study because of its significant Vatahara, Rasayana, and Vajikarana characteristics. A total of 05 patients who were diagnosed with oligozoospermia were managed with MYB for 15 consecutive days without any internal medications. The Shukra Kshaya assessment questionnaire was used in conjunction with objective parameters to determine the improvement. Data were collected twice before and after therapy. After the treatment, all five participants exhibited significant improvement in sperm count from a mean of 10.4–55. In this case series, all the patients demonstrated clinical improvement in symptoms of Shukra kshaya as well as in associated laboratory parameters. Basti treatment significantly improved all symptoms of Shukra Kshaya, as well as semen parameters (sperm count, sperm active motility, and semen volume) and serum testosterone. The reported cases demonstrate that MYB is a therapeutic option for the comprehensive care of men with a diagnosis of oligozoospermia.
    Keywords biomarkers ; infertility ; oligozoospermia ; shukra ; yapana basti ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Methanolic fraction from Tamala (Diospyros montana Roxb.) ameliorates anxiety like behaviour via 5-HT2A pathway in rats

    Ankur Kumar Tanwar / Ram Sharma / Sukesh Kumar Gupta

    Phytomedicine Plus, Vol 2, Iss 1, Pp 100150- (2022)

    2022  

    Abstract: Background: D. montana (Roxb.) is a medicinal plant cultivated throughout Eastern Asia, comprises several biologically active compounds, such as steroids, naphthoquinones, polyphenols, and flavonoids. Earlier reports revealed that D. montana has been ... ...

    Abstract Background: D. montana (Roxb.) is a medicinal plant cultivated throughout Eastern Asia, comprises several biologically active compounds, such as steroids, naphthoquinones, polyphenols, and flavonoids. Earlier reports revealed that D. montana has been used for anti-inflammatory, antiviral, anticancer, inhibitor of prostaglandin synthesis, hypolipidemic, and antileukemic agent. However, the anxiolytic activity of D. montana yet not explained. Therefore, the objective of this study is to investigate the anxiolytic effect of the methanolic extract of powder extracted from D. montana (Roxb.) leaves. Method: The anxiolytic activity was evaluated in an open-field test (OFT), hole board test (HBT) and elevated plus maze test (EPM). The rats received an oral pre-treatment of methanolic extract of Diospyros montana (MDM) (50, 100, 200 mg/kg; p.o.) for 7 days and the anxiolytic activity were estimated in experimental rat models. Result: MDM (100 and 200 mg/kg) and diazepam increased behaviour parameters in hole board test in terms of head-dip, a ratio of head-dip/sniffing, and decreased sniffing activity. Further, MDM (100 and 200 mg/kg) and diazepam increased behavioural performance in the EPM and OFT test paradigm. Treatment with MDM (100 and 200 mg/kg) and diazepam increased serotonin level and mRNA expression of the 5-HT2A receptor in the amygdala of experimental rats. In an additional set of experiments, in OFT, HBT and EPM studies, flumazenil attenuated the anxiolytic effect of the minimum effective dose of MDM (100 mg/kg), suggesting the mechanism mediated by the GABAA receptor. Furthermore, MDM-100 mg/kg has shown a lack of sedative-like effect relative to diazepam (6 mg/kg, p.o.) in the OFT and EPM test paradigm. Conclusion: The present findings indicate that anxiolytic effect of MDM may involve GABA and serotonin mediated mechanisms, and MDM can be a potential therapeutic agent for the management of anxiety illustrated in fig-11.
    Keywords D. montana (Roxb.) ; Ebenaceae ; Soxhlation ; Phytochemical investigation ; Methanolic extract ; Anxiety-like behaviour ; Other systems of medicine ; RZ201-999
    Subject code 621
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Yoga

    Ankur Kumar Tanwar / Sujata Rajan

    Journal of Ayurveda, Vol 14, Iss 4, Pp 143-

    A nonpharmacological approach against current pandemic of Coronavirus Disease-19

    2020  Volume 146

    Abstract: Introduction: In this current era of the pandemic, when the Covid-19 pandemic rapidly spread across the world, the population at a large scale suffered from fear, worry, and certain concern regarding himself/herself as well as for their families ... ...

    Abstract Introduction: In this current era of the pandemic, when the Covid-19 pandemic rapidly spread across the world, the population at a large scale suffered from fear, worry, and certain concern regarding himself/herself as well as for their families especially adults and children. A significant level of stress also developed in health care providers. Many people all over the world are suffering from loneliness, anxiety, and disturbed mental health issues during lockdown, quarantines, and isolation. Mental health is one of the important factors for overall health. No vaccination or treatment available for COVID-19 till today. The only approach is the preventive and promotive approach. Psychological issues also hamper our physical health and level of immunity. Objective: In this study, an attempt has been made to critically review the role of yoga against the current pandemic. Data Source and Review Methods: References are searched from various authoritative texts and worldwide accepted scientific databases concerning the effect of yoga in the different body systems, immune system as well as on mental health. Result: The psychophysical approach which helps in reducing the mental issue maintains mental health and reduces stress as well as boosts our immunity against communicable diseases like COVID-19 is Yoga. Discussion: Yoga is cost-effective, may be practiced as a self-care treatment against physical and mental health issues, enhance self-efficacy and self-confidence. Yoga may be effective as a supportive adjunct in some medical conditions. Conclusion: This review summarizes the effects of yoga interventions against the current pandemic as well as helps to understand the preventive and health promotive aspect of yoga on various components of mental and physical health.
    Keywords mental health ; pandemic ; stress ; yoga ; Other systems of medicine ; RZ201-999
    Subject code 360
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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